Thomas C. Irving

10.4k citations

205 papers · 7.6k indexed · 2 hit papers · h-index 44

Impact in

Cardiology and Cardiovascular Medicine top 0.2%
- Cardiomyopathy and Myosin Studies
- Cardiovascular Effects of Exercise
- Cardiovascular Function and Risk Factors
- Cardiac electrophysiology and arrhythmias
Biomaterials top 1%
- Collagen: Extraction and Characterization

Papers in

Cardiology and Cardiovascular Medicine 135
- Cardiomyopathy and Myosin Studies 133
- Cardiovascular Effects of Exercise 63
- Cardiovascular Function and Risk Factors 17
Structural Biology 5

Co-authors: Henk L. Granzier Tim J. Wess Pieter P. de Tombe Joseph Orgel Andrew Miller Gerrie P. Farman John P. Konhilas Weikang Ma
Journals: Biophysical Journal (31 papers)Proceedings of the National Academy of Sciences (22 papers)The Journal of Physiology (11 papers)The Journal of General Physiology (10 papers)International Journal of Molecular Sciences (9 papers)
Partner nations: United States United Kingdom Canada

In The Last Decade

Thomas C. Irving

202 papers receiving 7.5k citations

Hit Papers

align trajectories log scale

Microfibrillar structure of type I collagen in situ 2006 · 739 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2006 Proceedings of the National Academy of Sciences
1995 Biophysical Journal

Peers

Countries citing papers authored by Thomas C. Irving

Since Specialization

Citations

This map shows the geographic impact of Thomas C. Irving's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Thomas C. Irving with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Thomas C. Irving more than expected).

Fields of papers citing papers by Thomas C. Irving

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Thomas C. Irving. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Thomas C. Irving. The network helps show where Thomas C. Irving may publish in the future.

Co-authors

The 25 scholars most cited alongside Thomas C. Irving, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Thomas C. Irving Line = papers co-authored together Thomas C. Irving links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states PNAS Nexus ·Vivek Jani, Taejeong Song, Neusvaldo Lira de Almeida, Henry Gong, Sakthivel Sadayappan, David A. Kass, Thomas C. Irving, Weikang Ma	2024	15
2	Load‐dependence of the activation of myosin filaments in heart muscle The Journal of Physiology ·Yanhong Wang, Luca Fusi, Jesús G. Ovejero, Cameron Hill, Fernando Luis Rossi, Ki-Nam Shim, Andrea Ghisleni, So‐Jin Park‐Holohan, Weikang Ma, Thomas C. Irving, Theyencheri Narayanan, Malcolm Irving, Elisabetta Brunello	2024	1
3	Mechanisms of a novel regulatory light chain–dependent cardiac myosin inhibitor The Journal of General Physiology ·Kristina B. Kooiker, Crisna Kemala, Altshuler, M. Moors, Ahmad ALhaji, Yuanhua Cheng, Galina Flint, 우종근, Neusvaldo Lira de Almeida, Samuel Dalton, Timothy S. McMillen, 中崎公仁, Weikang Ma, Thomas C. Irving, Farid Moussavi‐Harami, Michael Regnier	2024	1
4	Myosin in autoinhibited off state(s), stabilized by mavacamten, can be recruited in response to inotropic interventions Proceedings of the National Academy of Sciences ·Weikang Ma, Carlos del Río, Leonora Davies, Mairobys null Socorro, Srboljub M. Mijailovich, Zhou Zhen-guo, Henry Gong, Rafael Shimkunas, Sampath K. Gollapudi, Suman Nag, Thomas C. Irving	2024	5
5	Differences in thick filament activation in fast rodent skeletal muscle and slow porcine cardiac muscle The Journal of Physiology ·Jing Zhao, Leonora Davies, Beatriz Holanda Gonçalves, Thomas C. Irving, Weikang Ma	2024	3
6	Right Ventricular Sarcomere Contractile Depression and the Role of Thick Filament Activation in Human Heart Failure With Pulmonary Hypertension Circulation ·Vivek Jani, Mohammed Aslam, Sumeinika Fitria Lizmah, Weikang Ma, Henry Gong, JG Wade, Samuel Dalton, Elen Hughes, В.С. Попов, Monica Mukherjee, Marc K. Halushka, Kenneth B. Margulies, Kenneth S. Campbell, Thomas C. Irving, David A. Kass, Steven Hsu	2023	9
7	Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function Proceedings of the National Academy of Sciences ·Maicon Landim-Vieira, Weikang Ma, Taejeong Song, Asko Soukka, Henry Gong, 孝高本, Sylvia J. P. Bogaards, K. Warburton, Coen A. C. Ottenheijm, Wenwei Wang, Maria Papadaki, Björn C. Knollmann, Sakthivel Sadayappan, Thomas C. Irving, Vitold E. Galkin, P. Bryant Chase, José R. Pinto	2023	15
8	Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2 International Journal of Molecular Sciences ·A. B. Moustafa, Jeffrey Schmeckpeper, Maicon Landim-Vieira, 孝高本, 万小进, Weikang Ma, K.S. van Dooren, Beatriz Holanda Gonçalves, Leonora Davies, Laura Zieger, M. Benjamin Shoemaker, James B. Atkinson, Peter M. Kekenes–Huskey, Thomas C. Irving, P. Bryant Chase, Björn C. Knollmann, José R. Pinto	2023	2
9	The structural and functional integrities of porcine myocardium are mostly preserved by cryopreservation The Journal of General Physiology ·Weikang Ma, Kyoung Hwan Lee, 浩一高橋, Angelica Castro-Salazar, Nimas Putri Kinanti, Henry Gong, Jonathan A. Kirk, Roger Craig, Thomas C. Irving	2023	9
10	Thick filament activation is different in fast‐ and slow‐twitch skeletal muscle The Journal of Physiology ·Henry Gong, Weikang Ma, Michael Regnier, Thomas C. Irving	2022	11
11	The stoic tooth root: how the mineral and extracellular matrix counterbalance to keep aged dentin stable Acta Biomaterialia ·鈴木道子, Yvette Alania, Ariene A. Leme‐Kraus, Vishal Kandagatla, Derk Joester, Weikang Ma, Thomas C. Irving, Ana K. Bedran‐Russo	2021	6
12	Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing The Journal of General Physiology ·Marco Caremani, Luca Fusi, Marco Linari, Massimo Reconditi, Gabriella Piazzesi, Thomas C. Irving, Theyencheri Narayanan, Malcolm Irving, Vincenzo Lombardi, Elisabetta Brunello	2021	25
13	Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism Nature Communications ·Johan Lindqvist, Weikang Ma, Frank Li, 久貴望月, Justin Kolb, Balázs Kiss, Paola Tonino, Robbert van der Pijl, 秦卞, Henry Gong, Joshua Strom, Kengo Tukahara, John E. Smith, Stephen B.J. Odhiambo, Thomas C. Irving, Henk Granzier	2020	11
14	Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity The Journal of General Physiology ·Srboljub M. Mijailovich, Boban Stojanović, Pan-Cheng Lu, Уваров Игорь Александрович, Michael A. Geeves, Thomas C. Irving, Henk Granzier	2019	27
15	Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation The Journal of General Physiology ·Marco Caremani, Elisabetta Brunello, Marco Linari, Luca Fusi, Thomas C. Irving, David Gore, Gabriella Piazzesi, Malcolm Irving, Vincenzo Lombardi, Massimo Reconditi	2019	43
16	Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers Proceedings of the National Academy of Sciences ·Robert L. Anderson, Darshan V. Trivedi, Saswata S. Sarkar, Marcus Henze, Weikang Ma, Henry Gong, Christopher S. Rogers, Joshua Gorham, Fiona L. Wong, Makenna M. Morck, Jonathan G. Seidman, Kathleen M. Ruppel, Thomas C. Irving, Roger Cooke, Eric M. Green, James A. Spudich	2018	262
17	Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle Journal of Molecular and Cellular Cardiology ·王宏巍, 日本乳酸菌学会誌編集委員会, Maicon Landim-Vieira, Weikang Ma, Anita Nikzad, 蔡放, Thomas C. Irving, P. Bryant Chase, José R. Pinto	2018	23
18	In Vitro Chromatin Assembly Methods in enzymology on CD-ROM/Methods in enzymology ·Uma M. Muthurajan, Francesca Mattiroli, Petr Lašák, Keda Zhou, Yajie Gu, Srinivas Chakravarthy, Pamela N. Dyer, Thomas C. Irving, Karolin Luger	2016	38
19	X-ray interference measurements of myosin head motions during isotonic shortening of skeletal muscle fibers Biophysical Journal ·Malcolm Irving, Massimo Reconditi, Marco Linari, L Lucii, Yin‐Biao Sun, Theyencheri Narayanan, Peter Boesecke, Andrew Stewart, Robert F. Fischetti, Thomas C. Irving, Gabriella Piazzesi, John Geoffrey Walker	2002	1
20	Small-angle x-ray scattering from lipid bilayers is well described by modified Caillé theory but not by paracrystalline theory Biophysical Journal ·R. Zhang, Stephanie Tristram‐Nagle, Wenjun Sun, Randall L. Headrick, Thomas C. Irving, Robert M. Suter, John F. Nagle	1996	106

About Thomas C. Irving

Thomas C. Irving is a scholar working on Cardiology and Cardiovascular Medicine, Structural Biology, Radiation, Molecular Biology and Cell Biology, having authored 205 papers that have together received 7.6k indexed citations. Recurring topics across this work include Cardiomyopathy and Myosin Studies (133 papers), Muscle Physiology and Disorders (73 papers), Cardiovascular Effects of Exercise (63 papers), Force Microscopy Techniques and Applications (23 papers), Cardiovascular Function and Risk Factors (17 papers), Enzyme Structure and Function (15 papers), Protein Structure and Dynamics (14 papers) and Cellular Mechanics and Interactions (14 papers). The work is most often cited by research in Cardiology and Cardiovascular Medicine (4.4k citations), Biomaterials (861 citations), Structural Biology (90 citations), Molecular Biology (3.5k citations) and Cell Biology (817 citations). Thomas C. Irving has collaborated with scholars based in United States, United Kingdom and Canada. Frequent co-authors include Henk L. Granzier, Tim J. Wess, Pieter P. de Tombe, Joseph Orgel, Andrew Miller, Gerrie P. Farman, John P. Konhilas, Weikang Ma, Yiming Wu and Robert F. Fischetti. Their work appears in journals such as Biophysical Journal, Proceedings of the National Academy of Sciences, The Journal of Physiology, The Journal of General Physiology and International Journal of Molecular Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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