Eckhard Mandelkow�

49.7k citations

276 papers · 32.7k indexed · 15 hit papers · h-index 100

Molecular Biology top 0.1%
Physiology top 0.01%
Cell Biology top 0.02%
Cellular and Molecular Neuroscience top 0.1%
Pharmacology top 0.05%

Co-authors: Jacek Biernat Eva‐Maria Mandelkow Yipeng Wang Martin von Bergen�Markus Zweckstetter Marcus Pickhardt Stefan Barghorn Bernhard Trinczek
Topics: Alzheimer's disease research and treatments (148 papers)Microtubule and mitosis dynamics (107 papers)Protein Structure and Dynamics (45 papers)
Cited by: Physiology Cell Biology Neurology
Journals: Nature Science Cell
Partner nations: Germany United States Switzerland

In The Last Decade

Eckhard Mandelkow�

276 papers receiving 32.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Tau in physiology and pathology

2015 1.5k citations Yipeng Wang, Eckhard Mandelkow� profile →
Assembly of τ protein into Alzheimer paired helical filaments depends on a local sequence motif ( ³⁰⁶ VQIVYK ³¹¹ ) forming β structure

2000 805 citations Peter Friedhoff, Jacek Biernat et al. profile →
Tau protein liquid–liquid phase separation can initiate tau aggregation

2018 769 citations Susanne Wegmann, Katharina Tepper et al. profile →
Tau blocks traffic of organelles, neurofilaments, and APP vesicles in neurons and enhances oxidative stress

2002 721 citations Edda Thies, Eckhard Mandelkow� et al. profile →
MARK, a Novel Family of Protein Kinases That Phosphorylate Microtubule-Associated Proteins and Trigger Microtubule Disruption

1997 712 citations Gerard Drewes, Eva‐Maria Mandelkow et al. Cell profile →
Overexpression of Tau Protein Inhibits Kinesin-dependent Trafficking of Vesicles, Mitochondria, and Endoplasmic Reticulum: Implications for Alzheimer's Disease

1998 654 citations Susanne Illenberger, Bernhard Trinczek et al. profile →
Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding

1993 633 citations Jacek Biernat, Gerard Drewes et al. profile →
Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau

2017 569 citations Jacek Biernat, Eckhard Mandelkow� et al. Nature Communications profile →
Aβ Oligomers Cause Localized Ca ²⁺ Elevation, Missorting of Endogenous Tau into Dendrites, Tau Phosphorylation, and Destruction of Microtubules and Spines

2010 531 citations Hans Zempel, Edda Thies et al. profile →
Domains of tau Protein and Interactions with Microtubules

1994 530 citations Bernhard Trinczek, Jacek Biernat et al. profile →
Structural Polymorphism of 441-Residue Tau at Single Residue Resolution

2009 511 citations Sadasivam Jeganathan�, Jacek Biernat et al. profile →
The release and trans-synaptic transmission of Tau via exosomes

2017 505 citations Senthilvelrajan Kaniyappan, Katharina Tepper et al. profile →
Tau fragmentation, aggregation and clearance: the dual role of lysosomal processing

2009 488 citations Yipeng Wang, Eva‐Maria Mandelkow et al. profile →
Tau stabilizes microtubules by binding at the interface between tubulin heterodimers

2015 394 citations Jacek Biernat, Satish Kumar et al. profile →
A current view on Tau protein phosphorylation in Alzheimer's disease

2021 288 citations Susanne Wegmann, Jacek Biernat et al. profile →

Peers

Countries citing papers authored by Eckhard Mandelkow�

Since Specialization

Citations

This map shows the geographic impact of Eckhard Mandelkow�'s research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Eckhard Mandelkow� with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Eckhard Mandelkow� more than expected).

Fields of papers citing papers by Eckhard Mandelkow�

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Eckhard Mandelkow�. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Eckhard Mandelkow�. The network helps show where Eckhard Mandelkow� may publish in the future.

Co-authorship network of co-authors of Eckhard Mandelkow�

This figure shows the co-authorship network connecting the top 25 collaborators of Eckhard Mandelkow�. A scholar is included among the top collaborators of Eckhard Mandelkow� based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Eckhard Mandelkow�. Eckhard Mandelkow� is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Assessment of the In Vivo Relationship Between Cerebral Hypometabolism, Tau Deposition, TSPO Expression, and Synaptic Density in a Tauopathy Mouse Model: a Multi-tracer PET Study 2022 ·Molecular Neurobiology ·Heike Endepols,Marta Anglada‐Huguet,Eckhard Mandelkow�,(unknown),Philipp Krapf,Boris D. Zlatopolskiy,Bernd Neumaier,Eva‐Maria Mandelkow,Alexander Drzezga	12
2	Pathological missorting of endogenous MAPT/Tau in neurons caused by failure of protein degradation systems 2018 ·Autophagy ·(unknown),Senthilvelrajan Kaniyappan,Eckhard Mandelkow�,(unknown),Yipeng Wang,(unknown),(unknown)	27
3	Glutamatergic nervous system degeneration in a C. elegans TauA152T tauopathy model involves pathways of excitotoxicity and Ca2+ dysregulation 2018 ·Neurobiology of Disease ·Bikash Choudhary,Eckhard Mandelkow�,(unknown),(unknown),Ghulam Jeelani Pir	18
4	A mechanistic model of tau amyloid aggregation based on direct observation of oligomers 2015 ·Nature Communications ·Sarah L. Shammas,Gonzalo Garcia,Satish Kumar,Magnus Kjærgaard,Mathew H. Horrocks,(unknown),Eva‐Maria Mandelkow,Tuomas P. J. Knowles,Eckhard Mandelkow�,David Klenerman	163
5	Hsp90-Tau Complex Reveals Molecular Basis for Specificity in Chaperone Action 2014 ·Cell ·G Elif Karagöz,Afonso M.S. Duarte,Elias Akoury,Hans Ippel,Jacek Biernat,Tania Morán Luengo,Martina Radli,Tatiana Didenko,Bryce A. Nordhues,Dmitry B. Veprintsev,Chad A. Dickey,Eckhard Mandelkow�,Markus Zweckstetter,Rolf Boelens,Tobias Madl,Stefan Rüdiger	241
6	Oligomer Formation of Tau Protein Hyperphosphorylated in Cells 2014 ·Journal of Biological Chemistry ·Katharina Tepper,Jacek Biernat,Satish Kumar,Susanne Wegmann,Thomas Timm,(unknown),Lars Redecke,Eva‐Maria Mandelkow,Daniel J. Müller,Eckhard Mandelkow�	123
7	Alzheimer disease in 2020 2012 ·Cold Spring Harbor Perspectives in Biology ·David M. Holtzman,Eckhard Mandelkow�,Dennis J. Selkoe	1
8	The biology of Alzheimer disease 2012 ·Dennis J. Selkoe,Eckhard Mandelkow�,David M. Holtzman	18
9	Microtubule Affinity Regulating Kinase Activity in Living Neurons Was Examined by a Genetically Encoded Fluorescence Resonance Energy Transfer/Fluorescence Lifetime Imaging-based Biosensor 2011 ·Journal of Biological Chemistry ·Thomas Timm,Jens Peter von Kries,Xiaoyu Li,Hans Zempel,Eckhard Mandelkow�,Eva‐Maria Mandelkow,(unknown),(unknown)	34
10	Proline-directed Pseudo-phosphorylation at AT8 and PHF1 Epitopes Induces a Compaction of the Paperclip Folding of Tau and Generates a Pathological (MC-1) Conformation 2008 ·Journal of Biological Chemistry ·Sadasivam Jeganathan�,Antje Hascher,Subashchandrabose Chinnathambi,Jacek Biernat,Eva‐Maria Mandelkow,Eckhard Mandelkow�	205
11	Inhibition of APP Trafficking by Tau Protein Does Not Increase the Generation of Amyloid‐β Peptides 2006 ·Traffic ·Claire Goldsbury,Maria‐Magdalena Mocanu,Edda Thies,Christoph Kaether,Christian Haass,Patrick Keller,Jacek Biernat,Eckhard Mandelkow�,Eva‐Maria Mandelkow,(unknown),(unknown)	68
12	Structure of the Catalytic and Ubiquitin-Associated Domains of the Protein Kinase MARK/Par-1 2006 ·Structure ·S. Panneerselvam,Alexander Marx,Eva‐Maria Mandelkow,Eckhard Mandelkow�	67
13	Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses 2003 ·Neurobiology of Aging ·Eckhard Mandelkow�,(unknown)	309
14	Interaction of monomeric and dimeric kinesin with microtubules 1 1Edited by M. F. Moody 1998 ·Journal of Molecular Biology ·Manfred Thormählen,Alexander Marx,Sabina Müller,Young‐Hwa Song,Eckhard Mandelkow�,Ueli Aebi,(unknown),(unknown)	32
15	Phosphorylation of Microtubule-associated Proteins MAP2 and MAP4 by the Protein Kinase p110mark 1996 ·Journal of Biological Chemistry ·Susanne Illenberger,Gerard Drewes,Bernhard Trinczek,Jacek Biernat,Helmut E. Meyer,J.B. Olmsted,Eva‐Maria Mandelkow,Eckhard Mandelkow�	158
16	RNA stimulates aggregation of microtubule‐associated protein tau into Alzheimer‐like paired helical filaments 1996 ·FEBS Letters ·(unknown),Peter Friedhoff,Jacek Biernat,Eckhard Mandelkow�,Eva‐Maria Mandelkow,(unknown),(unknown)	427
17	Microtubule oscillations 1992 ·Cell Motility and the Cytoskeleton ·Eva‐Maria Mandelkow,(unknown),Eckhard Mandelkow�	42
18	Domain structure and antiparallel dimers of microtubule-associated protein 2 (MAP2) 1992 ·Journal of Structural Biology ·Holger Wille,Eckhard Mandelkow�,Jane Dingus,Richard B. Vallee,Lester I. Binder	40
19	Synchrotron radiation in chemistry and biology 1988 ·Springer eBooks ·Eckhard Mandelkow�,Dominique Bazin,(unknown)	9
20	Die Struktur des Tabakmosaikvirus bei 4 A Auflösung 1977 ·Biological Chemistry ·S. Warren,Gerald Stubbs,Kenneth C. Holmes,Eckhard Mandelkow�	1

About Eckhard Mandelkow�

Eckhard Mandelkow� is a scholar working on Cell Biology, Structural Biology and Physiology, having authored 276 papers that have together received 32.7k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (148 papers), Microtubule and mitosis dynamics (107 papers) and Protein Structure and Dynamics (45 papers). The work is most often cited by research in Physiology (17.9k citations), Cell Biology (8.9k citations) and Neurology (3.5k citations). Eckhard Mandelkow� has collaborated with scholars based in Germany, United States and Switzerland. Frequent co-authors include Jacek Biernat, Eva‐Maria Mandelkow, Yipeng Wang, Martin von Bergen�, Markus Zweckstetter, Marcus Pickhardt, Stefan Barghorn, Bernhard Trinczek, Gerard Drewes and Peter Friedhoff. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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