John Q. Trojanowski

278.4k citations
1.1k papers · 151.7k indexed · 53 hit papers · h-index 193
Co-authors
Virginia M.‐Y. LeeLeslie M. ShawMichael W. WeinerClifford R. JackRonald C. PetersenBenoit I. GiassonWilliam J. JagustMurray Grossman
Topics
Alzheimer's disease research and treatments (588 papers)Parkinson's Disease Mechanisms and Treatments (330 papers)Dementia and Cognitive Impairment Research (249 papers)
Cited by
NeurologyPhysiology
Journals
NatureScienceNew England Journal of Medicine
Partner nations
United StatesUnited KingdomGermany

In The Last Decade

John Q. Trojanowski

1.1k papers receiving 149.1k citations

Hit Papers

Ubiquitinated TDP-43 in Frontotemporal Lobar Dege...19912026200220142006200920132008201210002.0k3.0k4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
    2006 4.8k citations Manuela Neumann, Deepak M. Sampathu et al. Science profile →
  2. Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade
    2009 3.4k citations Clifford R. Jack, Leslie M. Shaw et al. profile →
  3. Tracking pathophysiological processes in Alzheimer's disease: an updated hypothetical model of dynamic biomarkers
    2013 3.1k citations Clifford R. Jack, Michael W. Weiner et al. profile →
  4. Second consensus statement on the diagnosis of multiple system atrophy
    2008 2.3k citations John Q. Trojanowski et al. Neurology profile →
  5. National Institute on Aging–Alzheimer's Association guidelines for the neuropathologic assessment of Alzheimer's disease
    2012 2.1k citations Eliezer Masliah, John Q. Trojanowski et al. profile →
  6. National Institute on Aging–Alzheimer’s Association guidelines for the neuropathologic assessment of Alzheimer’s disease: a practical approach
    2011 1.9k citations Eliezer Masliah, John Q. Trojanowski et al. Acta Neuropathologica profile →
  7. Neurodegenerative Tauopathies
    2001 1.9k citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. profile →
  8. Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
    2012 1.9k citations Kelvin C. Luk, Victoria Kehm et al. Science profile →
  9. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    2007 1.7k citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. profile →
  10. Transplantation of Embryonic Dopamine Neurons for Severe Parkinson's Disease
    2001 1.7k citations John Q. Trojanowski et al. profile →
  11. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
    2007 1.6k citations Bin Zhang, John Q. Trojanowski et al. profile →
  12. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    2009 1.6k citations Leslie M. Shaw, Hugo Vanderstichele et al. profile →
  13. Alzheimer's Disease Neuroimaging Initiative (ADNI)
    2009 1.6k citations Paul Aisen, Clifford R. Jack et al. Neurology profile →
  14. Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline
    2012 1.4k citations Konrad Talbot, John Q. Trojanowski et al. Journal of Clinical Investigation profile →
  15. Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.
    1998 1.4k citations John Q. Trojanowski et al. profile →
  16. Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions
    2000 1.3k citations Benoit I. Giasson, John E. Duda et al. Science profile →
  17. A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
    1991 1.2k citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. Science profile →
  18. Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
    2002 993 citations Pavan K. Auluck, Ho Yin Edwin Chan et al. Science profile →
  19. The Alzheimer's Disease Neuroimaging Initiative
    2005 973 citations Michael W. Weiner, Clifford R. Jack et al. profile →
  20. Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
    2002 971 citations Benoit I. Giasson, Bin Zhang et al. profile →
  21. A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly
    2001 854 citations Benoit I. Giasson, John Q. Trojanowski et al. Journal of Biological Chemistry profile →
  22. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    2012 819 citations Kelvin C. Luk, Victoria Kehm et al. The Journal of Experimental Medicine profile →
  23. Ways toward an early diagnosis in Alzheimer's disease: The Alzheimer's Disease Neuroimaging Initiative (ADNI)
    2005 812 citations Michael W. Weiner, Clifford R. Jack et al. profile →
  24. Inflammation and white matter degeneration persist for years after a single traumatic brain injury
    2013 776 citations John Q. Trojanowski et al. Brain profile →
  25. Pathological TDP‐43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
    2007 761 citations Ian R. Mackenzie, Manuela Neumann et al. profile →
  26. Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    1993 758 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  27. Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
    2013 750 citations John Robinson, David J. Irwin et al. profile →
  28. Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    2009 742 citations Kelvin C. Luk, Patrick O’Brien et al. profile →
  29. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.
    2000 705 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  30. The Alzheimer's Disease Neuroimaging Initiative: A review of papers published since its inception
    2013 698 citations Michael W. Weiner, Clifford R. Jack et al. profile →
  31. Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
    2003 698 citations Benoit I. Giasson, John Q. Trojanowski et al. Science profile →
  32. Intranuclear Inclusions of Expanded Polyglutamine Protein in Spinocerebellar Ataxia Type 3
    1997 692 citations John Q. Trojanowski et al. profile →
  33. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
    2013 685 citations David J. Irwin, Virginia M.‐Y. Lee et al. profile →
  34. Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons
    2000 654 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  35. Molecular basis of phenotypic variability in sporadc creudeldt‐jakob disease
    1996 638 citations John Q. Trojanowski et al. profile →
  36. Spreading of pathology in neurodegenerative diseases: a focus on human studies
    2015 584 citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. profile →
  37. Contribution of cerebrovascular disease in autopsy confirmed neurodegenerative disease cases in the National Alzheimer’s Coordinating Centre
    2013 577 citations Steven E. Arnold, Sharon X. Xie et al. Brain profile →
  38. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
    1998 558 citations Benoit I. Giasson, John Q. Trojanowski et al. profile →
  39. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
    2004 547 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  40. The acetylation of tau inhibits its function and promotes pathological tau aggregation
    2011 533 citations Linda K. Kwong, John Q. Trojanowski et al. profile →
  41. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
    2011 515 citations Edward B. Lee, Virginia M.‐Y. Lee et al. profile →
  42. Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
    2013 502 citations Bin Zhang, John Q. Trojanowski et al. profile →
  43. CSF biomarkers of Alzheimer's disease concord with amyloid‐β PET and predict clinical progression: A study of fully automated immunoassays in BioFINDER and ADNI cohorts
    2018 485 citations John Q. Trojanowski, Kaj Blennow et al. profile →
  44. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
    2017 449 citations Zhuohao He, Lakshmi Changolkar et al. profile →
  45. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
    2018 439 citations Anna Stieber, John Robinson et al. profile →
  46. Protein transmission in neurodegenerative disease
    2020 412 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  47. Plasma tau in Alzheimer disease
    2016 378 citations Philip S. Insel, Leslie M. Shaw et al. Neurology profile →
  48. Current state of Alzheimer’s fluid biomarkers
    2018 375 citations Leslie M. Shaw, Holly Soares et al. Acta Neuropathologica profile →
  49. Association of Cerebrospinal Fluid Neurofilament Light Concentration With Alzheimer Disease Progression
    2015 347 citations John Q. Trojanowski, Leslie M. Shaw et al. profile →
  50. Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative
    2018 324 citations Michael W. Weiner, Clifford R. Jack et al. profile →
  51. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
    2020 320 citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. Journal of Clinical Investigation profile →
  52. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration
    2015 285 citations Kelvin C. Luk, John Q. Trojanowski et al. Neurobiology of Disease profile →
  53. Diagnostic performance and prediction of clinical progression of plasma phospho-tau181 in the Alzheimer’s Disease Neuroimaging Initiative
    2020 218 citations Andréa Lessa Benedet, Nicholas J. Ashton et al. profile →

Peers

John Q. Trojanowski
Comparison fields: 5 of 214
  • Physiology 69.9k
  • Neurology 59.9k
  • Molecular Biology 46.3k
  • Cellular and Molecular Neuroscience 31.9k
  • Neurology 29.4k
Replace Dennis W. Dickson with:
Dennis W. Dickson United States
Virginia M.‐Y. Lee United States
Eliezer Masliah United States
Kaj Blennow Sweden
Henrik Zetterberg Sweden
Bradley T. Hyman United States
John Hardy United Kingdom
Heiko Braak Germany
Bruce L. Miller United States
David M. Holtzman United States
John Q. Trojanowski relative to Dennis W. Dickson United States Dennis W. Dickson's profile →
Citations per field
00.5×1.5×1.9×
Dennis W. Dickson · 1×
Citations per year

Countries citing papers authored by John Q. Trojanowski

Since Specialization
Citations

This map shows the geographic impact of John Q. Trojanowski's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by John Q. Trojanowski with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites John Q. Trojanowski more than expected).

Fields of papers citing papers by John Q. Trojanowski

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by John Q. Trojanowski. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by John Q. Trojanowski. The network helps show where John Q. Trojanowski may publish in the future.

Co-authorship network of co-authors of John Q. Trojanowski

This figure shows the co-authorship network connecting the top 25 collaborators of John Q. Trojanowski. A scholar is included among the top collaborators of John Q. Trojanowski based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with John Q. Trojanowski. John Q. Trojanowski is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
#WorkIndexed citations
1
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons
2024 ·Acta Neuropathologica ·Hong Xu,Qi Qiu,Peng Hu,(unknown),(unknown),(unknown),Christopher Kim,Zhuohao He,Nicholas P. Marotta,Lakshmi Changolkar,Bin Zhang,Hao Wu,Gerard D. Schellenberg,Brian C. Kraemer,Kelvin C. Luk,Edward B. Lee,John Q. Trojanowski,Kurt R. Brunden,Virginia M.‐Y. Lee
3
2
Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP‐43 inclusions and ageing‐related tau astrogliopathy in a family with a GBE1 mutation
2022 ·Neuropathology and Applied Neurobiology ·Maiko Uemura,Eun Ran Suh,John Robinson,Kurt R. Brunden,Murray Grossman,David J. Irwin,Virginia M.‐Y. Lee,John Q. Trojanowski,Edward B. Lee,Vivianna M. Van Deerlin
4
3
Association of CSF GAP-43 With the Rate of Cognitive Decline and Progression to Dementia in Amyloid-Positive Individuals
2022 ·Neurology ·Annika Öhrfelt,Andréa Lessa Benedet,Nicholas J. Ashton,Hlin Kvartsberg,Manu Vandijck,Michael W. Weiner,John Q. Trojanowski,Leslie M. Shaw,Henrik Zetterberg,Kaj Blennow,(unknown)
19
4
Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo
2021 ·Neuropathology and Applied Neurobiology ·Sílvia Porta,Yan Xu,(unknown),Bin Zhang,Emily S. Meymand,Modupe F. Olufemi,Anna Stieber,Edward B. Lee,John Q. Trojanowski,Virginia M.‐Y. Lee
33
5
ATN status in amnestic and non-amnestic Alzheimer’s disease and frontotemporal lobar degeneration
2020 ·Brain ·Katheryn A Q Cousins,David J. Irwin,David A. Wolk,Edward B. Lee,Leslie M. Shaw,John Q. Trojanowski,Fulvio Da Re,Garrett S. Gibbons,Murray Grossman,Jeffrey S. Phillips
28
6
Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays
2020 ·Journal of Biological Chemistry ·Alex Crowe,Mark J. Henderson,Johnathon D. Anderson,Steven A. Titus,Alexey Zakharov,Anton Simeonov,Arjan Buist,Charlotte Delay,Diederik Moechars,John Q. Trojanowski,Virginia M.‐Y. Lee,Kurt R. Brunden
14
7
Neuroimmune interactions in Alzheimer's disease—New frontier with old challenges?
2019 ·Progress in molecular biology and translational science ·Stefan Prokop,Virginia M.‐Y. Lee,John Q. Trojanowski
17
8
Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice
2018 ·Neurobiology of Disease ·Krista J. Spiller,Tahiyana Khan,Myrna A. Dominique,Clark R. Restrepo,(unknown),(unknown),Paymaan Jafar‐Nejad,Bin Zhang,Armand Soriano,Frank Rigo,John Q. Trojanowski,Virginia M.‐Y. Lee
29
9
Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt–Jakob Disease and Synucleinopathy
2018 ·Molecular Neurobiology ·Matthias Schmitz,Anna Villar‐Piqué,Franc Llorens,Karin Gmitterová,Péter Hermann,Daniela Varges,Saima Zafar,Paul Lingor,Hugo Vanderstichele,(unknown),Erik Stoops,John Q. Trojanowski,Virginia M.‐Y. Lee,Inga Zerr
23
10
Neocortical origin and progression of gray matter atrophy in nonamnestic Alzheimer's disease
2017 ·Neurobiology of Aging ·Jeffrey S. Phillips,Fulvio Da Re,(unknown),Sharon X. Xie,David J. Irwin,Corey T. McMillan,Sanjeev Vaishnavi,Carlo Ferrarese,Edward B. Lee,Leslie M. Shaw,John Q. Trojanowski,David A. Wolk,Murray Grossman
52
11
Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease
2016 ·The Journal of Experimental Medicine ·Nolwen L. Rey,Jennifer A. Steiner,Nazia Maroof,Kelvin C. Luk,Zachary Madaj,John Q. Trojanowski,Virginia M.‐Y. Lee,Patrik Brundin
288
12
Variables associated with hippocampal atrophy rate in normal aging and mild cognitive impairment
2014 ·Neurobiology of Aging ·Rachel L. Nosheny,Philip S. Insel,Diana Truran,Norbert Schuff,Clifford R. Jack,Paul Aisen,Leslie M. Shaw,John Q. Trojanowski,Michael W. Weiner
33
13
2013 Emerging Science Abstracts
2013 ·Neurology ·William T. Hu,Kelly D. Watts,(unknown),(unknown),James J. Lah,John Q. Trojanowski,Allan I. Levey,(unknown),(unknown),(unknown),(unknown),(unknown),Juha O. Rinne,(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown),(unknown)
2
14
Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Micebreakdown →
2012 ·Science ·Kelvin C. Luk,Victoria Kehm,Jenna C. Carroll,Bin Zhang,Patrick O’Brien,John Q. Trojanowski,Virginia M.‐Y. Lee
1855
15
CSF amyloid β 1-42 predicts cognitive decline in Parkinson disease
2010 ·Neurology ·Andrew Siderowf,Sharon X. Xie,Howard I. Hurtig,Daniel Weintraub,John E. Duda,Alice Chen‐Plotkin,Leslie M. Shaw,Vivianna M. Van Deerlin,John Q. Trojanowski,C. Clark
281
16
Novel CSF biomarkers for frontotemporal lobar degenerations
2010 ·Neurology ·William T. Hu,Alice Chen‐Plotkin,Owen A. Ross,Steven E. Arnold,Christopher M. Clark,Les Shaw,Leo McCluskey,Igor Elman,Howard I. Hurtig,Andrew Siderowf,(unknown),Holly Soares,John Q. Trojanowski
74
17
Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosisbreakdown →
2006 ·Science ·Manuela Neumann,Deepak M. Sampathu,Linda K. Kwong,(unknown),Matthew C. Micsenyi,Thomas T. Chou,Jennifer Bruce,Theresa Schuck,Murray Grossman,Christopher M. Clark,Leo McCluskey,Bruce L. Miller,Eliezer Masliah,Ian R. Mackenzie,Howard Feldman,W. Feiden,Hans A. Kretzschmar,John Q. Trojanowski,Virginia M.‐Y. Lee
4830
18
Glucocerebrosidase mutations are an important risk factor for Lewy body disorders
2006 ·Neurology ·Özlem Göker-Alpan,Benoit I. Giasson,Michael J. Eblan,(unknown),Howard I. Hurtig,(unknown),John Q. Trojanowski,Ellen Sidransky
168
19
Dysbindin-1 is reduced in intrinsic, glutamatergic terminals of the hippocampal formation in schizophrenia
2004 ·Journal of Clinical Investigation ·Konrad Talbot,(unknown),Caroline L. Tinsley,Matthew A. Benson,(unknown),Rachel J. Smith,Chang-Gyu Hahn,Steven J. Siegel,John Q. Trojanowski,Raquel E. Gur,Derek J. Blake,Steven E. Arnold
331
20
Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Diseasebreakdown →
2002 ·Science ·Pavan K. Auluck,Ho Yin Edwin Chan,John Q. Trojanowski,Virginia M.‐Y. Lee,Nancy M. Bonini
993

About John Q. Trojanowski

John Q. Trojanowski is a scholar working on Neurology, Neurology and Physiology, having authored 1.1k papers that have together received 151.7k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (588 papers), Parkinson's Disease Mechanisms and Treatments (330 papers) and Dementia and Cognitive Impairment Research (249 papers). The work is most often cited by research in Neurology (59.9k citations), Neurology (29.4k citations) and Physiology (69.9k citations). John Q. Trojanowski has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Virginia M.‐Y. Lee, Leslie M. Shaw, Michael W. Weiner, Clifford R. Jack, Ronald C. Petersen, Benoit I. Giasson, William J. Jagust, Murray Grossman, Linda K. Kwong and Bin Zhang. Their work appears in journals such as Nature, Science and New England Journal of Medicine.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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