Kinya Otsu

25.3k total citations · 10 hit papers
152 papers, 19.5k citations indexed

About

Kinya Otsu is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Epidemiology. According to data from OpenAlex, Kinya Otsu has authored 152 papers receiving a total of 19.5k indexed citations (citations by other indexed papers that have themselves been cited), including 98 papers in Molecular Biology, 43 papers in Cardiology and Cardiovascular Medicine and 34 papers in Epidemiology. Recurrent topics in Kinya Otsu's work include Autophagy in Disease and Therapy (29 papers), Signaling Pathways in Disease (20 papers) and Ion channel regulation and function (17 papers). Kinya Otsu is often cited by papers focused on Autophagy in Disease and Therapy (29 papers), Signaling Pathways in Disease (20 papers) and Ion channel regulation and function (17 papers). Kinya Otsu collaborates with scholars based in Japan, United Kingdom and United States. Kinya Otsu's co-authors include Osamu Yamaguchi, Kazuhiko Nishida, David H. MacLennan, Masatsugu Hori, Francesco Zorzato, Toshihiro Takeda, Shungo Hikoso, Hiroyuki Nakayama, Shizuo Akira and Junichi Fujii and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Kinya Otsu

150 papers receiving 19.2k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

2006 3.0k citations Osamu Yamaguchi, Kinya Otsu et al. profile →
Cyclophilin D-dependent mitochondrial permeability transition regulates some necrotic but not apoptotic cell death

2005 1.3k citations Tetsuya Watanabe, Osamu Yamaguchi et al. profile →
The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress

2007 1.2k citations Atsuko Nakai, Osamu Yamaguchi et al. Nature Medicine profile →
Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia

1991 1.1k citations Kinya Otsu, Francesco Zorzato et al. profile →
Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

2012 928 citations Takafumi Oka, Shungo Hikoso et al. profile →
Discovery of Atg5/Atg7-independent alternative macroautophagy

2009 899 citations Kinya Otsu et al. profile →
Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

1990 569 citations Francesco Zorzato, Kinya Otsu et al. Journal of Biological Chemistry profile →
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.

1990 516 citations Kinya Otsu, Francesco Zorzato et al. Journal of Biological Chemistry profile →
Bcl-2-like protein 13 is a mammalian Atg32 homologue that mediates mitophagy and mitochondrial fragmentation

2015 390 citations Tomokazu Murakawa, Osamu Yamaguchi et al. Nature Communications profile →
Mitochondrial Function, Biology, and Role in Disease

2016 357 citations Kinya Otsu et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Kinya Otsu Japan	57	10.8k	4.8k	4.3k	4.2k	1.9k	152	19.5k
Nobuyo Maeda United States	72	8.0k 0.7×	2.8k 0.6×	3.0k 0.7×	4.8k 1.2×	4.0k 2.1×	265	22.1k
Josef Pfeilschifter Germany	79	11.8k 1.1×	2.0k 0.4×	1.7k 0.4×	4.8k 1.2×	4.6k 2.4×	544	24.4k
Emilio Hirsch Italy	73	9.6k 0.9×	1.2k 0.2×	2.1k 0.5×	5.4k 1.3×	1.5k 0.8×	297	19.0k
John F. Engelhardt United States	79	11.1k 1.0×	2.4k 0.5×	1.3k 0.3×	2.2k 0.5×	1.7k 0.9×	315	21.6k
Marco E. Bianchi Italy	88	13.2k 1.2×	2.8k 0.6×	955 0.2×	11.6k 2.8×	1.6k 0.8×	225	31.0k
Andrew Murphy United States	61	6.2k 0.6×	1.8k 0.4×	1.3k 0.3×	4.5k 1.1×	2.4k 1.3×	143	16.8k
Tomoichiro Asano Japan	69	10.3k 1.0×	3.0k 0.6×	1.0k 0.2×	1.7k 0.4×	2.9k 1.5×	313	17.8k
Marek Michalak Canada	75	11.0k 1.0×	3.1k 0.7×	1.3k 0.3×	5.2k 1.2×	1.4k 0.7×	297	20.2k
Mathieu Laplante Canada	36	8.9k 0.8×	3.3k 0.7×	751 0.2×	1.6k 0.4×	3.8k 2.0×	78	15.1k
Beverly H. Koller United States	75	9.4k 0.9×	2.0k 0.4×	1.1k 0.3×	7.0k 1.7×	2.5k 1.3×	206	25.1k

Countries citing papers authored by Kinya Otsu

Since Specialization

Citations

This map shows the geographic impact of Kinya Otsu's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kinya Otsu with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kinya Otsu more than expected).

Fields of papers citing papers by Kinya Otsu

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kinya Otsu. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kinya Otsu. The network helps show where Kinya Otsu may publish in the future.

Co-authorship network of co-authors of Kinya Otsu

This figure shows the co-authorship network connecting the top 25 collaborators of Kinya Otsu. A scholar is included among the top collaborators of Kinya Otsu based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kinya Otsu. Kinya Otsu is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Murakawa, Tomokazu, Jumpei Ito, Manabu Taneike, et al.. (2024). AMPK regulates Bcl2-L-13-mediated mitophagy induction for cardioprotection. Cell Reports. 43(12). 115001–115001. 7 indexed citations

Taneike, Manabu, Tomokazu Murakawa, Takahito Tamai, et al.. (2023). Lysophosphatidylserine induces necrosis in pressure overloaded male mouse hearts via G protein coupled receptor 34. Nature Communications. 14(1). 4494–4494. 3 indexed citations

Miyazaki, Takuro, Yoshitaka Taketomi, Hirokazu Ohtaki, et al.. (2022). Hypercholesterolemic Dysregulation of Calpain in Lymphatic Endothelial Cells Interferes With Regulatory T-Cell Stability and Trafficking. Arteriosclerosis Thrombosis and Vascular Biology. 43(2). e66–e82. 13 indexed citations

Miyazaki, Takuro, Yuki Sugiura, Shogo Haraguchi, et al.. (2022). Calpain-mediated proteolytic production of free amino acids in vascular endothelial cells augments obesity-induced hepatic steatosis. Journal of Biological Chemistry. 298(6). 101953–101953. 4 indexed citations

Abe, Hajime, Yohei Tanada, Shigemiki Omiya, et al.. (2021). NF-κB activation in cardiac fibroblasts results in the recruitment of inflammatory Ly6C ^hi monocytes in pressure-overloaded hearts. Science Signaling. 14(704). eabe4932–eabe4932. 19 indexed citations

Karigane, Daiki, Hiroshi Kobayashi, Takayuki Morikawa, et al.. (2021). p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts. Journal of Biological Chemistry. 296. 100563–100563. 7 indexed citations

Ueda, Hiromichi, Osamu Yamaguchi, Manabu Taneike, et al.. (2019). Administration of a TLR9 Inhibitor Attenuates the Development and Progression of Heart Failure in Mice. JACC Basic to Translational Science. 4(3). 348–363. 29 indexed citations

Zhan, Hong, Kenichi Aizawa, Junqing Sun, et al.. (2016). Ataxia telangiectasia mutated in cardiac fibroblasts regulates doxorubicin-induced cardiotoxicity. Figshare. 1 indexed citations

Morimoto, Satoshi, Kenichi Hongo, Yoichiro Kusakari, et al.. (2013). Genetic modulation of the SERCA activity does not affect the Ca2+ leak from the cardiac sarcoplasmic reticulum. Cell Calcium. 55(1). 17–23. 5 indexed citations

10.

Okuno, Yuji, Ayako Nakamura‐Ishizu, Kinya Otsu, Toshio Suda, & Yoshiaki Kubota. (2012). Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nature Medicine. 18(8). 1208–1216. 123 indexed citations

11.

Kuramoto, Kenta, Tomoo Okamura, Tomohiro Yamaguchi, et al.. (2012). Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation. Journal of Biological Chemistry. 287(28). 23852–23863. 194 indexed citations

12.

Takeda, Norifumi, Ichiro Manabe, Yuichi Uchino, et al.. (2009). Cardiac fibroblasts are essential for the adaptive response of the murine heart to pressure overload. Journal of Clinical Investigation. 120(1). 254–265. 314 indexed citations

13.

Kim, Chun, Yasuyo Sano, Kristina Todorova, et al.. (2008). The kinase p38α serves cell type–specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nature Immunology. 9(9). 1019–1027. 233 indexed citations

14.

Watanabe, Tetsuya, Toshihiro Takeda, Shigemiki Omiya, et al.. (2008). Reduction in Hemoglobin–Oxygen Affinity Results in the Improvement of Exercise Capacity in Mice With Chronic Heart Failure. Journal of the American College of Cardiology. 52(9). 779–786. 26 indexed citations

15.

Hikoso, Shungo, Yasuhiro Ikeda, Osamu Yamaguchi, et al.. (2007). Progression of Heart Failure Was Suppressed by Inhibition of Apoptosis Signal-Regulating Kinase 1 Via Transcoronary Gene Transfer. Journal of the American College of Cardiology. 50(5). 453–462. 35 indexed citations

16.

Hikoso, Shungo, Yasuhiro Ikeda, Osamu Yamaguchi, et al.. (2006). FRS-074 Overexpression of Mitochondrial Peroxiredoxin-3 Ameliorates Left Ventricular Remodeling and Failure after Myocardial Infarction in Mice(Heart Failure Research (M) FRS15,Featured Research Session,The 70th Anniversary Annual Scientific Meeting of the Japanese Circulation Society). Japanese Circulation Journal-english Edition. 70. 130–131. 2 indexed citations

17.

Park, Jin Mo, Florian R. Greten, Athena W. Wong, et al.. (2005). Signaling Pathways and Genes that Inhibit Pathogen-Induced Macrophage Apoptosis— CREB and NF-κB as Key Regulators. Immunity. 23(3). 319–329. 263 indexed citations

18.

Otsu, Kinya, et al.. (1996). Direct cardiotoxic effects of cocaine and cocaethylene on isolated cardiomyocytes. International Journal of Cardiology. 53(1). 15–23. 7 indexed citations

19.

MacLennan, David H., Kinya Otsu, Jun Fujii, et al.. (1992). The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia.. PubMed. 46. 189–201. 57 indexed citations

20.

Otsu, Kinya, et al.. (1992). Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia. Genomics. 13(3). 835–837. 81 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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