Alexander Hoffmann

23.5k total citations · 6 hit papers
192 papers, 18.5k citations indexed

About

Alexander Hoffmann is a scholar working on Immunology, Molecular Biology and Cancer Research. According to data from OpenAlex, Alexander Hoffmann has authored 192 papers receiving a total of 18.5k indexed citations (citations by other indexed papers that have themselves been cited), including 121 papers in Immunology, 92 papers in Molecular Biology and 92 papers in Cancer Research. Recurrent topics in Alexander Hoffmann's work include NF-κB Signaling Pathways (88 papers), Immune Response and Inflammation (83 papers) and Cytokine Signaling Pathways and Interactions (38 papers). Alexander Hoffmann is often cited by papers focused on NF-κB Signaling Pathways (88 papers), Immune Response and Inflammation (83 papers) and Cytokine Signaling Pathways and Interactions (38 papers). Alexander Hoffmann collaborates with scholars based in United States, Japan and Germany. Alexander Hoffmann's co-authors include David Baltimore, Andre Levchenko, Robert G. Roeder, Gourisankar Ghosh, Martin Scott, Simon Mitchell, Jesse D. Vargas, Shannon L. Werner, Ellen L O'Dea and Soumen Basak and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Alexander Hoffmann

187 papers receiving 18.2k citations

Hit Papers

The IκB-NF-κB Signaling Module: Temporal Control and Sele... 2002 2026 2010 2018 2002 2016 2006 2005 2006 400 800 1.2k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation
    2002 1.5k citations Alexander Hoffmann, Andre Levchenko et al. Science profile →
  2. Signaling via the NFκB system
    2016 807 citations Simon Mitchell, Alexander Hoffmann et al. profile →
  3. Circuitry of nuclear factor κB signaling
    2006 748 citations Alexander Hoffmann, David Baltimore profile →
  4. Molecular Determinants of Crosstalk between Nuclear Receptors and Toll-like Receptors
    2005 533 citations Alexander Hoffmann et al. profile →
  5. Transcriptional regulation via the NF-κB signaling module
    2006 525 citations Alexander Hoffmann et al. profile →
  6. Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
    2010 501 citations Alexander Hoffmann et al. Genes & Development profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Alexander Hoffmann United States 73 9.8k 7.7k 5.6k 2.7k 1.3k 192 18.5k
Gioacchino Natoli Italy 65 10.9k 1.1× 9.7k 1.3× 5.0k 0.9× 2.8k 1.0× 2.2k 1.7× 140 20.7k
Russell G. Jones Canada 57 11.2k 1.1× 8.1k 1.1× 5.6k 1.0× 3.8k 1.4× 2.3k 1.8× 112 20.4k
Philip N. Tsichlis United States 71 14.4k 1.5× 4.9k 0.6× 3.9k 0.7× 4.6k 1.7× 1.2k 1.0× 196 21.5k
Ranjan Sen United States 49 7.1k 0.7× 6.5k 0.8× 3.7k 0.7× 1.9k 0.7× 847 0.7× 157 13.9k
Doreen A. Cantrell United Kingdom 81 10.0k 1.0× 12.6k 1.6× 2.2k 0.4× 5.1k 1.9× 1.0k 0.8× 217 21.7k
Éric Solary France 75 12.5k 1.3× 5.3k 0.7× 2.2k 0.4× 4.9k 1.8× 1.9k 1.5× 369 21.5k
Stefan Wyder Switzerland 18 15.6k 1.6× 2.8k 0.4× 4.2k 0.7× 2.3k 0.9× 1.6k 1.2× 26 25.5k
David M. Hockenbery United States 50 10.5k 1.1× 3.2k 0.4× 2.1k 0.4× 3.6k 1.3× 1.3k 1.0× 124 16.7k
Jason W. Locasale United States 74 16.2k 1.7× 4.1k 0.5× 9.2k 1.6× 4.0k 1.5× 2.0k 1.6× 182 24.8k
Hao Wu United States 80 20.3k 2.1× 11.0k 1.4× 3.7k 0.6× 2.8k 1.0× 2.6k 2.1× 268 28.1k

Countries citing papers authored by Alexander Hoffmann

Since Specialization
Citations

This map shows the geographic impact of Alexander Hoffmann's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Alexander Hoffmann with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Alexander Hoffmann more than expected).

Fields of papers citing papers by Alexander Hoffmann

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Alexander Hoffmann. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Alexander Hoffmann. The network helps show where Alexander Hoffmann may publish in the future.

Co-authorship network of co-authors of Alexander Hoffmann

This figure shows the co-authorship network connecting the top 25 collaborators of Alexander Hoffmann. A scholar is included among the top collaborators of Alexander Hoffmann based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Alexander Hoffmann. Alexander Hoffmann is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Chia, Dennis J., Yi Liu, Tiffany Tran, et al.. (2025). Distinct roles for NF-κB in hematopoietic stem cells and the bone marrow milieu in promoting hematopoietic aging. Cell Reports. 44(9). 116193–116193. 1 indexed citations
2.
Huang, Helen J., et al.. (2025). Synergy and antagonism in the integration of BCR and CD40 signals that control B-cell population expansion. Molecular Systems Biology. 21(8). 1119–1146.
3.
Kueh, Hao Yuan, Andreas Handel, Alexander Hoffmann, et al.. (2024). What unique insights can modeling approaches capture about the immune system?. Cell Systems. 15(12). 1148–1152.
4.
Sheu, Katherine M., et al.. (2024). Dynamical and combinatorial coding by MAPK p38 and NFκB in the inflammatory response of macrophages. Molecular Systems Biology. 20(8). 898–932. 4 indexed citations
5.
Huang, Helen J., et al.. (2024). The noncanonical NFκB pathway: Regulatory mechanisms in health and disease. PubMed. 16(6). e1646–e1646. 8 indexed citations
6.
Huang, Helen J., et al.. (2024). Direct observation correlates NFκB cRel in B cells with activating and terminating their proliferative program. Proceedings of the National Academy of Sciences. 121(30). e2309686121–e2309686121. 2 indexed citations
7.
Hoffmann, Alexander. (2023). Designer genes courtesy of artificial intelligence. Genes & Development. 37(9-10). 351–353. 1 indexed citations
8.
Mitchell, Simon, et al.. (2023). The NF-κB multidimer system model: A knowledge base to explore diverse biological contexts. Science Signaling. 16(776). eabo2838–eabo2838. 16 indexed citations
9.
Wang, Yan, Mandy I. Cheng, Willy Hugo, et al.. (2022). Pathogenic TNF-α drives peripheral nerve inflammation in an Aire-deficient model of autoimmunity. Proceedings of the National Academy of Sciences. 119(4). 22 indexed citations
10.
Wang, Ning, et al.. (2021). Identifying the combinatorial control of signal-dependent transcription factors. PLoS Computational Biology. 17(6). e1009095–e1009095. 17 indexed citations
11.
Pickering, Harry, Subha Sen, Janice Arakawa‐Hoyt, et al.. (2021). NK and CD8+ T cell phenotypes predict onset and control of CMV viremia after kidney transplant. JCI Insight. 6(21). 20 indexed citations
12.
Son, Minjun, Hsiung‐Lin Tu, Marie Oliver Metzig, et al.. (2021). NF-κB responds to absolute differences in cytokine concentrations. Science Signaling. 14(666). 34 indexed citations
13.
Mognol, Giuliana P., Roberto Spreafico, Victor Wong, et al.. (2017). Exhaustion-associated regulatory regions in CD8 + tumor-infiltrating T cells. Proceedings of the National Academy of Sciences. 114(13). E2776–E2785. 232 indexed citations
14.
Liu, Wen‐Hsien, Seung Goo Kang, Zhe Huang, et al.. (2016). A miR-155–Peli1–c-Rel pathway controls the generation and function of T follicular helper cells. The Journal of Experimental Medicine. 213(9). 1901–1919. 52 indexed citations
15.
Selimkhanov, Jangir, Brooks Taylor, Jason Yao, et al.. (2014). Accurate information transmission through dynamic biochemical signaling networks. Science. 346(6215). 1370–1373. 262 indexed citations
16.
Vogel, Christoph F. A., Elaine M. Khan, Patrick S.C. Leung, et al.. (2013). Cross-talk between Aryl Hydrocarbon Receptor and the Inflammatory Response. Journal of Biological Chemistry. 289(3). 1866–1875. 219 indexed citations
17.
Ch’en, Irene L., Daniel R. Beisner, Alexei Degterev, et al.. (2008). Antigen-mediated T cell expansion regulated by parallel pathways of death. Proceedings of the National Academy of Sciences. 105(45). 17463–17468. 117 indexed citations
18.
Ch’en, Irene L., Stephen Μ. Hedrick, & Alexander Hoffmann. (2008). Chapter 10 NF‐κB as a Determinant of Distinct Cell Death Pathways. Methods in enzymology on CD-ROM/Methods in enzymology. 446. 175–187. 6 indexed citations
19.
Shapira, Sagi, Omar S. Harb, Mariana Matrajt, et al.. (2005). Initiation and termination of NF-κB signaling by the intracellular protozoan parasite Toxoplasma gondii. Journal of Cell Science. 118(15). 3501–3508. 55 indexed citations
20.
Hoffmann, Alexander, Andre Levchenko, Martin Scott, & David Baltimore. (2002). The IκB-NF-κB Signaling Module: Temporal Control and Selective Gene Activation. Science. 298(5596). 1241–1245. 1477 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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