David H. MacLennan

34.4k total citations · 10 hit papers
266 papers, 27.2k citations indexed

About

David H. MacLennan is a scholar working on Molecular Biology, Cardiology and Cardiovascular Medicine and Cellular and Molecular Neuroscience. According to data from OpenAlex, David H. MacLennan has authored 266 papers receiving a total of 27.2k indexed citations (citations by other indexed papers that have themselves been cited), including 236 papers in Molecular Biology, 104 papers in Cardiology and Cardiovascular Medicine and 36 papers in Cellular and Molecular Neuroscience. Recurrent topics in David H. MacLennan's work include Ion channel regulation and function (156 papers), Cardiac electrophysiology and arrhythmias (92 papers) and Mitochondrial Function and Pathology (42 papers). David H. MacLennan is often cited by papers focused on Ion channel regulation and function (156 papers), Cardiac electrophysiology and arrhythmias (92 papers) and Mitochondrial Function and Pathology (42 papers). David H. MacLennan collaborates with scholars based in Canada, United States and Japan. David H. MacLennan's co-authors include Evangelia G. Kranias, Christopher J. Brandl, Jonathan Lytton, Kinya Otsu, Bożena Korczak, Alexander Tzagoloff, Kazimierz Kurzydlowski, Vijay K. Khanna, Junichi Fujii and Michihiko Tada and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

David H. MacLennan

265 papers receiving 26.1k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia

1991 1.1k citations Junichi Fujii, Kinya Otsu et al. Science profile →
Amino-acid sequence of a Ca2+ + Mg2+ -dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequence

1985 969 citations David H. MacLennan, Christopher J. Brandl et al. profile →
Phospholamban: a crucial regulator of cardiac contractility

2003 832 citations David H. MacLennan, Evangelia G. Kranias Nature Reviews Molecular Cell Biology profile →
Purification and Properties of an Adenosine Triphosphatase from Sarcoplasmic Reticulum

1970 716 citations David H. MacLennan Journal of Biological Chemistry profile →
Two Ca2+ ATPase genes: Homologies and mechanistic implications of deduced amino acid sequences

1986 709 citations Christopher J. Brandl, David H. MacLennan et al. profile →
Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum.

1990 569 citations Francesco Zorzato, Junichi Fujii et al. Journal of Biological Chemistry profile →
Functional comparisons between isoforms of the sarcoplasmic or endoplasmic reticulum family of calcium pumps.

1992 557 citations Jonathan Lytton, David H. MacLennan et al. Journal of Biological Chemistry profile →
Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum.

1990 516 citations Kinya Otsu, Francesco Zorzato et al. Journal of Biological Chemistry profile →
Location of high affinity Ca2 +-binding sites within the predicted transmembrahe domain of the sarco-plasmic reticulum Ca2+-ATPase

1989 496 citations David M. Clarke, Tip W. Loo et al. profile →
Isolation of a Calcium-Sequestering Protein from Sarcoplasmic Reticulum

1971 426 citations David H. MacLennan et al. profile →

Peers

Countries citing papers authored by David H. MacLennan

Since Specialization

Citations

This map shows the geographic impact of David H. MacLennan's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David H. MacLennan with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David H. MacLennan more than expected).

Fields of papers citing papers by David H. MacLennan

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David H. MacLennan. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David H. MacLennan. The network helps show where David H. MacLennan may publish in the future.

Co-authorship network of co-authors of David H. MacLennan

This figure shows the co-authorship network connecting the top 25 collaborators of David H. MacLennan. A scholar is included among the top collaborators of David H. MacLennan based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with David H. MacLennan. David H. MacLennan is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Design and Economic Analysis of 275 kV HTS Cable for U.K. Transmission Network 2024 ·IEEE Transactions on Applied Superconductivity ·Weijia Yuan, (unknown), Qiteng Hong, (unknown), Min Zhang, David H. MacLennan, (unknown), Kevin R. Ward, (unknown), (unknown), A. Allais, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), (unknown)	2
2	Reduced threshold for store overload-induced Ca2+ release is a common defect of RyR1 mutations associated with malignant hyperthermia and central core disease 2017 ·Biochemical Journal ·Wenqian Chen, (unknown), Yingjie Liu, Wenting Guo, Jinhong Wei, Ruiwu Wang, David H. MacLennan, Robert T. Dirksen, (unknown)	18
3	Variable protease-sensitive prionopathy; a unique prion variant with inefficient transmission properties 2014 ·Prion ·Abigail B. Diack, Diane Ritchie, Alexander Peden, Deborah Brown, Aileen Boyle, (unknown), David H. MacLennan, Paul S. Burgoyne, Pedro Piccardo, James W. Ironside, Jean Manson	1
4	CASQ1 Gene Is an Unlikely Candidate for Malignant Hyperthermia Susceptibility in the North American Population 2013 ·Anesthesiology ·Natalia Kraeva, Elena Zvaritch, Wanda Frodis, Olga Sizova, Alexander Kraev, David H. MacLennan, Sheila Riazi	21
5	Cardiovascular Proteomics 2006 ·Journal of the American College of Cardiology ·Sara Arab, Anthony O. Gramolini, Peipei Ping, Thomas Kislinger, Brian A. Stanley, Jennifer E. Van Eyk, Maral Ouzounian, David H. MacLennan, Andrew Emili, Peter P. Liu	103
6	Interactions of the calcium ATPase with phospholamban and sarcolipin: structure, physiology and pathophysiology. 2004 ·PubMed ·David H. MacLennan	7
7	Phospholamban: a crucial regulator of cardiac contractility breakdown → 2003 ·Nature Reviews Molecular Cell Biology ·David H. MacLennan, Evangelia G. Kranias	832
8	Structure/Function Analysis of the Ca²⁺ Binding and Translocation Domain of SERCA1 and the Role in Brody Disease of the ATP2A1 Gene Encoding SERCA1^a 1997 ·Annals of the New York Academy of Sciences ·David H. MacLennan, William J. Rice, Alex Odermatt	20
9	Site-directed Disulfide Mapping of Helices M4 and M6 in the Ca2+ Binding Domain of SERCA1a, the Ca2+ ATPase of Fast Twitch Skeletal Muscle Sarcoplasmic Reticulum 1997 ·Journal of Biological Chemistry ·William J. Rice, (unknown), David H. MacLennan	27
10	Discordance between phenotype and genotype in malignant hyperthermia 1995 ·Current Opinion in Neurology ·David H. MacLennan	36
11	Chromosome Mapping of Five Human Cardiac and Skeletal Muscle Sarcoplasmic Reticulum Protein Genes 1993 ·Genomics ·(unknown), Junichi Fujii, Muthu Periasamy, Michael J. Difilippantonio, (unknown), David C. Ward, David H. MacLennan	55
12	Deletion of NH₂⁻ and COOH‐terminal sequences destroys function of the Ca²⁺ ATPase of rabbit fast‐twitch skeletal muscle sarcoplasmic reticulum 1993 ·FEBS Letters ·Ilona S. Skerjanc, David M. Clarke, Tip W. Loo, David H. MacLennan	15
13	Multipoint Mapping of the Central Core Disease Locus 1993 ·Genomics ·Sabine Schwemmle, K. Wolff, L. Palmucci, T. Grimm, F. Lehmann‐Horn, (unknown), Elizabeth R. Hauser, David Iles, David H. MacLennan, C R Müller	11
14	Functional expression of cDNA encoding the calcium release channel (ryanodine receptor) of rabbit skeletal muscle sarcoplasmic reticulum in COS-1 cells 1993 ·Biochemistry ·S. R. Wayne Chen, Donna M. Vaughan, Judith A. Airey, Roberto Coronado, David H. MacLennan	55
15	The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia. 1992 ·PubMed ·David H. MacLennan, Kinya Otsu, Jun Fujii, Francesco Zorzato, Michael Phillips, Peter J. O’Brien, Alan Archibald, Beverley A. Britt, Elizabeth F. Gillard, Ronald G. Worton	57
16	Structure‐Function Relationships in Sarcoplasmic or Endoplasmic Reticulum Type Ca²⁺ Pumps^a 1992 ·Annals of the New York Academy of Sciences ·David H. MacLennan, Toshihiko Toyofuku, Jonathan Lytton	51
17	Refinement of diagnostic assays for a probable causal mutation for porcine and human malignant hyperthermia 1992 ·Genomics ·Kinya Otsu, Michael Phillips, (unknown), Stella de Leon, David H. MacLennan	81
18	Malignant hyperthermia 1992 ·Science ·David H. MacLennan, (unknown)	261
19	Isolation of the calmodulin‐dependent protein kinase system from rabbit skeletal muscle sarcoplasmic reticulum 1988 ·FEBS Letters ·Balwant S. Tuana, David H. MacLennan	23
20	Fast-twitch and slow-twitch/cardiac Ca2+ ATPase genes map to human chromosomes 16 and 12 1987 ·Somatic Cell and Molecular Genetics ·David H. MacLennan, Christopher J. Brandl, (unknown), Paul C. Holland, Vicki E. C. Powers, Huntington F. Willard	24

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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