Peter J. O’Brien

28.1k total citations · 7 hit papers
403 papers, 22.4k citations indexed

About

Peter J. O’Brien is a scholar working on Molecular Biology, Pharmacology and Cardiology and Cardiovascular Medicine. According to data from OpenAlex, Peter J. O’Brien has authored 403 papers receiving a total of 22.4k indexed citations (citations by other indexed papers that have themselves been cited), including 149 papers in Molecular Biology, 62 papers in Pharmacology and 49 papers in Cardiology and Cardiovascular Medicine. Recurrent topics in Peter J. O’Brien's work include Pharmacogenetics and Drug Metabolism (41 papers), Free Radicals and Antioxidants (32 papers) and Drug-Induced Hepatotoxicity and Protection (31 papers). Peter J. O’Brien is often cited by papers focused on Pharmacogenetics and Drug Metabolism (41 papers), Free Radicals and Antioxidants (32 papers) and Drug-Induced Hepatotoxicity and Protection (31 papers). Peter J. O’Brien collaborates with scholars based in Canada, United States and Ireland. Peter J. O’Brien's co-authors include Giuseppe Galati, Nandita Shangari, Arno G. Siraki, Tom S. Chan, Majid Moridani, Anver D. Rahimtula, Eugene G. Hrycay, Shahrzad Tafazoli, C. H. A. Little and Jalal Pourahmad and has published in prestigious journals such as Nature, Science and Proceedings of the National Academy of Sciences.

In The Last Decade

Peter J. O’Brien

398 papers receiving 21.4k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Identification of a Mutation in Porcine Ryanodine Receptor Associated with Malignant Hyperthermia

1991 1.1k citations Kinya Otsu, Francesco Zorzato et al. profile →
Molecular mechanisms of quinone cytotoxicity

1991 905 citations Peter J. O’Brien Chemico-Biological Interactions profile →
Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties

2004 883 citations Peter J. O’Brien et al. profile →
Aldehyde Sources, Metabolism, Molecular Toxicity Mechanisms, and Possible Effects on Human Health

2005 595 citations Peter J. O’Brien, Nandita Shangari et al. profile →
Fit-for-Purpose Method Development and Validation for Successful Biomarker Measurement

2006 504 citations Peter J. O’Brien et al. profile →
High concordance of drug-induced human hepatotoxicity with in vitro cytotoxicity measured in a novel cell-based model using high content screening

2006 472 citations Peter J. O’Brien et al. profile →
An intracellular GSH-peroxidase with a lipid peroxide substrate

1968 365 citations Peter J. O’Brien et al. profile →

Peers

Countries citing papers authored by Peter J. O’Brien

Since Specialization

Citations

This map shows the geographic impact of Peter J. O’Brien's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Peter J. O’Brien with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Peter J. O’Brien more than expected).

Fields of papers citing papers by Peter J. O’Brien

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Peter J. O’Brien. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Peter J. O’Brien. The network helps show where Peter J. O’Brien may publish in the future.

Co-authorship network of co-authors of Peter J. O’Brien

This figure shows the co-authorship network connecting the top 25 collaborators of Peter J. O’Brien. A scholar is included among the top collaborators of Peter J. O’Brien based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Peter J. O’Brien. Peter J. O’Brien is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	High-content analysis for drug delivery and nanoparticle applications 2015 ·Drug Discovery Today ·David J. Brayden, Sally‐Ann Cryan, Kenneth A. Dawson, Peter J. O’Brien, Jeremy C. Simpson	32
2	Risk factors for colorectal cancer in man induce aberrant crypt foci in rats: Preliminary findings 2015 ·Nutrition and Cancer ·Kai Yang, (unknown), Rudolf Furrer, Michael C. Archer, W. Robert Bruce, HoYin Lip, Rhea Mehta, Peter J. O’Brien, Adria Giacca, Wendy E. Ward, Angelo Pietro Femia, Giovanna Caderni, Alan Medline, Kate Banks	7
3	Risk factors for acute compartment syndrome of the leg associated with tibial diaphyseal fractures in adults 2014 ·Journal of Orthopaedics and Traumatology ·Babak Shadgan, Gavin Pereira, Matthew Rg Menon, Siavash Jafari, W. Darlene Reid, Peter J. O’Brien	42
4	[18F]FLT–PET Imaging Does Not Always “Light Up” Proliferating Tumor Cells 2011 ·Clinical Cancer Research ·Cathy C. Zhang, Zhengming Yan, Wenlin Li, Kyle Kuszpit, Cory L. Painter, Qin Zhang, Patrick B. Lappin, Tim Nichols, Maruja E. Lira, Timothy Affolter, (unknown), Carleen Cullinane, Mary E. Spilker, Kenneth Zasadny, Peter J. O’Brien, (unknown), Anthony Wong, James G. Christensen	62
5	Endogenous toxins : diet, genetics, disease and treatment 2010 ·Wiley-VCH eBooks ·Peter J. O’Brien, W. Robert Bruce	3
6	Pregnancy outcome in women with congenital heart disease and residual haemodynamic lesions of the right ventricular outflow tract 2010 ·European Heart Journal ·Matthias Greutmann, (unknown), Rachel Brooks, Donald Peebles, Peter J. O’Brien, Fiona Walker	45
7	Structure–activity relationships for thiol reactivity and rat or human hepatocyte toxicity induced by substituted p‐benzoquinone compounds 2007 ·Journal of Applied Toxicology ·Katie Chan, Neil S. Jensen, Peter J. O’Brien	51
8	Does weight loss improve survival? Comparison of a bariatric surgical cohort with an obese community-based control group. 2006 ·Obesity Surgery ·Peter J. O’Brien, Anna Peeters, Cheryl Laurie, (unknown), J. H. Dixon, Daniel F. English, (unknown)	1
9	Mitochondrial involvement in genetically determined transition metal toxicity 2006 ·Chemico-Biological Interactions ·Rhea Mehta, Douglas M. Templeton, Peter J. O’Brien	80
10	Mechanism of Mitochondrial Uncouplers, Inhibitors, and Toxins: Focus on Electron Transfer, Free Radicals, and Structure -Activity Relationships 2005 ·Current Medicinal Chemistry ·Peter Kovacic, Robert S. Pozos, Ratnasamy Somanathan, Nandita Shangari, Peter J. O’Brien	134
11	Thrombin Receptors and Protease-Activated Receptor-2 in Human Placentation 2003 ·American Journal Of Pathology ·Peter J. O’Brien, Hideki Koi, Samuel Parry, Lawrence F. Brass, Jerome F. Strauss, Lipeng Wang, John E. Tomaszewski, Lane K. Christenson	36
12	The formaldehyde metabolic detoxification enzyme systems and molecular cytotoxic mechanism in isolated rat hepatocytes 2001 ·Chemico-Biological Interactions ·Shirley Teng, K Beard, Jalal Pourahmad, Majid Moridani, (unknown), Raymond Poon, Peter J. O’Brien	175
13	Thrombin Responses in Human Endothelial Cells 2000 ·Journal of Biological Chemistry ·Peter J. O’Brien, Nicolas Prévost, Marina Molino, (unknown), Marílyn J. Woolkalís, Donna S. Woulfe, Lawrence F. Brass	259
14	Role of the cellular redox state in modulating acute ethanol toxicity in isolated hepatocytes 1999 ·Clinical Biochemistry ·Sumsullah Khan, Peter J. O’Brien	15
15	Molecular mechanisms of chloroacetaldehyde-induced cytotoxicity in isolated rat hepatocytes 1993 ·Biochemical Pharmacology ·(unknown), Peter J. O’Brien	61
16	The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia. 1992 ·PubMed ·David H. MacLennan, Kinya Otsu, Jun Fujii, Francesco Zorzato, Michael Phillips, Peter J. O’Brien, Alan Archibald, Beverley A. Britt, Elizabeth F. Gillard, Ronald G. Worton	57
17	Changes in erythrocyte deformability in NaCl-induced right-sided cardiac failure in broiler chickens 1992 ·American Journal of Veterinary Research ·(unknown), Peter J. O’Brien, R. J. Julian	25
18	Toxicity of nitrobenzene compounds towards isolated hepatocytes: dependence on reduction potential 1990 ·Xenobiotica ·Peter J. O’Brien, (unknown), (unknown), Saifur R. Khan	30
19	Canine malignant hyperthermia: diagnosis of susceptibility in a breeding colony. 1983 ·PubMed Central ·Peter J. O’Brien, Peter H. Cribb, R. White, Ernest D. Olfert, J. E. Steiss	30
20	Structural and biochemical changes in vitamin A--deficient rat retinas. 1979 ·PubMed ·Louvenia Carter‐Dawson, Toichiro Kuwabara, Peter J. O’Brien, J.G. Bieri	57

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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