Issei Komuro

66.9k total citations · 8 hit papers
1.2k papers, 42.9k citations indexed

About

Issei Komuro is a scholar working on Cardiology and Cardiovascular Medicine, Molecular Biology and Surgery. According to data from OpenAlex, Issei Komuro has authored 1.2k papers receiving a total of 42.9k indexed citations (citations by other indexed papers that have themselves been cited), including 697 papers in Cardiology and Cardiovascular Medicine, 375 papers in Molecular Biology and 258 papers in Surgery. Recurrent topics in Issei Komuro's work include Cardiovascular Function and Risk Factors (144 papers), Cardiac Fibrosis and Remodeling (94 papers) and Cardiac Imaging and Diagnostics (88 papers). Issei Komuro is often cited by papers focused on Cardiovascular Function and Risk Factors (144 papers), Cardiac Fibrosis and Remodeling (94 papers) and Cardiac Imaging and Diagnostics (88 papers). Issei Komuro collaborates with scholars based in Japan, United States and China. Issei Komuro's co-authors include Hiroshi Akazawa, Tohru Minamino, Yoshio Yazaki, Yunzeng Zou, Ichiro Shiojima, Hiroyuki Takano, Tsutomu Yamazaki, Ryozo Nagai, Sumiyo Kudoh and Toshio Nagai and has published in prestigious journals such as Nature, New England Journal of Medicine and Proceedings of the National Academy of Sciences.

In The Last Decade

Issei Komuro

1.2k papers receiving 42.2k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure

2012 928 citations Shungo Hikoso, Issei Komuro et al. profile →
Endothelial Cell Senescence in Human Atherosclerosis

2002 842 citations Tohru Minamino, Toshihiko Yoshida et al. Circulation profile →
p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload

2007 723 citations Tohru Minamino, Haruhiro Toko et al. profile →
A crucial role for adipose tissue p53 in the regulation of insulin resistance

2009 676 citations Tohru Minamino, Ippei Shimizu et al. profile →
Endothelin stimulates c‐fos and c‐myc expression and proliferation of vascular smooth muscle cells

1988 637 citations Issei Komuro et al. profile →
Oxidative stress activates extracellular signal-regulated kinases through Src and Ras in cultured cardiac myocytes of neonatal rats.

1997 599 citations Issei Komuro et al. Journal of Clinical Investigation profile →
Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II

2004 509 citations Yunzeng Zou, Hiroshi Akazawa et al. profile →
NLRP3 Inflammasome Activation Through Heart-Brain Interaction Initiates Cardiac Inflammation and Hypertrophy During Pressure Overload

2022 108 citations Issei Komuro et al. Circulation profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Issei Komuro Japan	103	20.5k	16.8k	6.8k	6.1k	3.9k	1.2k	42.9k
Toyoaki Murohara Japan	88	18.0k 0.9×	14.1k 0.8×	11.1k 1.6×	6.6k 1.1×	4.5k 1.2×	1.2k	45.3k
Ryozo Nagai Japan	104	18.1k 0.9×	11.3k 0.7×	7.4k 1.1×	8.1k 1.3×	8.8k 2.3×	859	45.6k
Jeffery D. Molkentin United States	124	39.3k 1.9×	19.7k 1.2×	7.5k 1.1×	5.6k 0.9×	3.8k 1.0×	430	54.9k
Edward G. Lakatta United States	123	20.0k 1.0×	32.6k 1.9×	4.9k 0.7×	7.9k 1.3×	2.2k 0.6×	758	54.8k
Jun Ren United States	98	15.9k 0.8×	7.9k 0.5×	3.7k 0.5×	6.5k 1.1×	7.5k 1.9×	926	38.2k
Ajay M. Shah United Kingdom	100	12.3k 0.6×	12.6k 0.7×	3.6k 0.5×	9.6k 1.6×	3.1k 0.8×	545	35.1k
Kazuwa Nakao Japan	106	14.9k 0.7×	16.8k 1.0×	6.2k 0.9×	10.8k 1.8×	5.9k 1.5×	863	50.3k
Hiroaki Shimokawa Japan	103	10.6k 0.5×	18.0k 1.1×	7.1k 1.0×	10.9k 1.8×	1.9k 0.5×	841	40.2k
Friedrich C. Luft Germany	112	12.8k 0.6×	16.9k 1.0×	6.8k 1.0×	8.8k 1.4×	3.5k 0.9×	1.1k	50.6k
James K. Liao United States	96	11.5k 0.6×	7.1k 0.4×	9.1k 1.3×	6.4k 1.0×	2.9k 0.7×	280	35.1k

Countries citing papers authored by Issei Komuro

Since Specialization

Citations

This map shows the geographic impact of Issei Komuro's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Issei Komuro with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Issei Komuro more than expected).

Fields of papers citing papers by Issei Komuro

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Issei Komuro. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Issei Komuro. The network helps show where Issei Komuro may publish in the future.

Co-authorship network of co-authors of Issei Komuro

This figure shows the co-authorship network connecting the top 25 collaborators of Issei Komuro. A scholar is included among the top collaborators of Issei Komuro based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Issei Komuro. Issei Komuro is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Kaneko, Hidehiro, Yuta Suzuki, Akira Okada, et al.. (2025). Effect of SGLT2i on kidney outcomes of individuals with type 2 diabetes according to body mass index: nationwide cohort study. European Heart Journal - Cardiovascular Pharmacotherapy. 11(2). 155–163. 4 indexed citations

Kaneko, Hidehiro, Yuta Suzuki, Akira Okada, et al.. (2024). Sex Differences in the Relationship Between Schizophrenia and the Development of Cardiovascular Disease. Journal of the American Heart Association. 13(5). e032625–e032625. 4 indexed citations

Katoh, Manami, et al.. (2024). Molecular Mechanisms of the Failing Heart: A Fatal Regression?. 3.

Kaneko, Hidehiro, Yuta Suzuki, Akira Okada, et al.. (2024). Differences in the association of lifestyle-related modifiable risk factors with incident cardiovascular disease between individuals with and without diabetes. European Journal of Preventive Cardiology. 32(5). 376–383. 4 indexed citations

Sotomi, Yohei, Shungo Hikoso, Sho Komukai, et al.. (2023). Individual acute-phase bleeding and thrombotic risk balance assessment in patients undergoing percutaneous coronary intervention for acute myocardial infarction. SHILAP Revista de lepidopterología. 28. 100292–100292.

Nakanishi, Koki, Marco R. Di Tullio, Shunichi Homma, et al.. (2023). Association between non-alcoholic fatty liver disease and subclinical left ventricular dysfunction in the general population. European Heart Journal Open. 3(6). oead108–oead108. 3 indexed citations

Kaneko, Hidehiro, Yuichiro Yano, Yuta Suzuki, et al.. (2023). Sex Differences in the Association Between Hypertension and Incident Atrial Fibrillation. Journal of the American Heart Association. 12(5). e026240–e026240. 9 indexed citations

Suzuki, Yuta, Hidehiro Kaneko, Akira Okada, et al.. (2023). Sex-Specific Differences in the Risk of Heart Failure following Anti-HER2 Monoclonal Antibody Therapy. Oncology. 101(6). 358–361. 2 indexed citations

Kaneko, Hidehiro, Kensuke Ueno, Kojiro Morita, et al.. (2023). Association Between Early Initiation of Cardiac Rehabilitation and Short-Term Outcomes of Patients With Acute Heart Failure Admitted to the Intensive Care Unit. The American Journal of Cardiology. 206. 285–291. 2 indexed citations

10.

Watanabe, Ryo, Jun-ichi Suzuki, Kouji Wakayama, et al.. (2015). Angiotensin II receptor blocker irbesartan attenuates cardiac dysfunction induced by myocardial infarction in the presence of renal failure. Hypertension Research. 39(4). 237–244. 21 indexed citations

11.

Tada, Yuko, Masahito Ogawa, Ryo Watanabe, et al.. (2013). Neovascularization induced by hypoxia inducible transcription factor is associated with the improvement of cardiac dysfunction in experimental autoimmune myocarditis. Expert Opinion on Investigational Drugs. 23(2). 149–162. 6 indexed citations

12.

Naito, Atsuhiko T. & Issei Komuro. (2013). [Chronic inflammation and organismal aging].. PubMed. 23(1). 51–8. 1 indexed citations

13.

Nakatani, Kazuhiro, Daisaku Masuda, Toru Oka, et al.. (2013). Abstract 12900: Pressure Overload Induces Hypertrophy and Impaired Cardiac Function in Long-chain Fatty Acid Transporter CD36 Knockout Mice. Circulation. 128. 1 indexed citations

14.

Kayama, Yosuke, Tohru Minamino, Haruhiro Toko, et al.. (2009). Cardiac 12/15 lipoxygenase–induced inflammation is involved in heart failure. The Journal of Experimental Medicine. 206(7). 1565–1574. 128 indexed citations

15.

Akazawa, Hiroshi, Masaji Tamagawa, Kaoru Ito, et al.. (2009). Cardiac mast cells cause atrial fibrillation through PDGF-A–mediated fibrosis in pressure-overloaded mouse hearts. Journal of Clinical Investigation. 120(1). 242–253. 156 indexed citations

16.

Miyauchi, Hideyuki, Tohru Minamino, Kaoru Tateno, et al.. (2004). Akt negatively regulates the in vitro lifespan of human endothelial cells via a p53/p21‐dependent pathway. The EMBO Journal. 23(1). 212–220. 272 indexed citations

17.

Ohtsuka, Masashi, Hiroyuki Takano, Masashi Suzuki, et al.. (2004). Role of Na+–Ca2+ exchanger in myocardial ischemia/reperfusion injury: evaluation using a heterozygous Na+–Ca2+ exchanger knockout mouse model. Biochemical and Biophysical Research Communications. 314(3). 849–853. 33 indexed citations

18.

Akazawa, Hiroshi & Issei Komuro. (2003). Roles of Cardiac Transcription Factors in Cardiac Hypertrophy. Circulation Research. 92(10). 1079–1088. 310 indexed citations

19.

Minamino, Tohru, Toshihiko Yoshida, Hideyuki Miyauchi, & Issei Komuro. (2002). Pathophysiological role of telomerase activation in vascular remodeling. Japanese Circulation Journal-english Edition. 66. 153. 1 indexed citations

20.

Hasegawa, Rei, Masao Daimon, Tomohiko Toyoda, et al.. (2002). Noninvasive Assessment of Coronary Flow Velocity and Coronary Flow Velocity Reserve in the Right Coronary Artery by Transthoracic Doppler Echocardiography. Japanese Circulation Journal-english Edition. 66. 419. 3 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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