Frank A. Middleton

25.5k total citations · 6 hit papers
156 papers, 12.2k citations indexed

About

Frank A. Middleton is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Genetics. According to data from OpenAlex, Frank A. Middleton has authored 156 papers receiving a total of 12.2k indexed citations (citations by other indexed papers that have themselves been cited), including 61 papers in Molecular Biology, 28 papers in Cellular and Molecular Neuroscience and 24 papers in Genetics. Recurrent topics in Frank A. Middleton's work include Genetics and Neurodevelopmental Disorders (13 papers), Neuroscience and Neuropharmacology Research (12 papers) and Autism Spectrum Disorder Research (11 papers). Frank A. Middleton is often cited by papers focused on Genetics and Neurodevelopmental Disorders (13 papers), Neuroscience and Neuropharmacology Research (12 papers) and Autism Spectrum Disorder Research (11 papers). Frank A. Middleton collaborates with scholars based in United States, Australia and Norway. Frank A. Middleton's co-authors include Peter L. Strick, Pat Levitt, David A. Lewis, Károly Mirnics, Stephen V. Faraone, Steven D. Hicks, P L Strick, Tania Das Banerjee, Yanli Zhang‐James and Gregg D. Stanwood and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Journal of Biological Chemistry.

In The Last Decade

Frank A. Middleton

153 papers receiving 11.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Basal ganglia and cerebellar loops: motor and cognitive circuits

2000 1.4k citations Frank A. Middleton profile →
Anatomical Evidence for Cerebellar and Basal Ganglia Involvement in Higher Cognitive Function

1994 1.0k citations Frank A. Middleton, Peter L. Strick profile →
Cerebellar Projections to the Prefrontal Cortex of the Primate

2001 791 citations Frank A. Middleton, Peter L. Strick profile →
Molecular Characterization of Schizophrenia Viewed by Microarray Analysis of Gene Expression in Prefrontal Cortex

2000 706 citations Károly Mirnics, Frank A. Middleton et al. profile →
Basal Ganglia Output and Cognition: Evidence from Anatomical, Behavioral, and Clinical Studies

2000 520 citations Frank A. Middleton, Peter L. Strick profile →
Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation

2024 52 citations Nick Huang, Thomas Winans et al. Nature Communications profile →

Peers

Countries citing papers authored by Frank A. Middleton

Since Specialization

Citations

This map shows the geographic impact of Frank A. Middleton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank A. Middleton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank A. Middleton more than expected).

Fields of papers citing papers by Frank A. Middleton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank A. Middleton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank A. Middleton. The network helps show where Frank A. Middleton may publish in the future.

Co-authorship network of co-authors of Frank A. Middleton

This figure shows the co-authorship network connecting the top 25 collaborators of Frank A. Middleton. A scholar is included among the top collaborators of Frank A. Middleton based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Frank A. Middleton. Frank A. Middleton is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Discovery of novel blood–brain barrier neuropathology in schizophrenia and bipolar disorder midbrain 2026 ·Brain Behavior and Immunity ·(unknown), (unknown), Maree J. Webster, Frank A. Middleton, (unknown), (unknown), (unknown)	0
2	Rab4A-directed endosome traffic shapes pro-inflammatory mitochondrial metabolism in T cells via mitophagy, CD98 expression, and kynurenine-sensitive mTOR activation breakdown → 2024 ·Nature Communications ·Nick Huang, Thomas Winans, (unknown), Zachary Oaks, (unknown), (unknown), Zhi‐Wei Lai, Joshua R. Lewis, (unknown), (unknown), (unknown), (unknown), (unknown), Tiffany Caza, (unknown), Laurence Morel, Mark Haas, Frank A. Middleton, Katalin Bánki, András Perl	52
3	Dengue Virus Structural Proteins Are Expressed on the Surface of DENV-Infected Cells and Are a Target for Antibody-Dependent Cellular Phagocytosis 2024 ·Open Forum Infectious Diseases ·(unknown), (unknown), (unknown), (unknown), Frank A. Middleton, Nathan H. Roy, Jeffrey R. Currier, Adam T. Waickman	2
4	Molecular Evidence for Altered Angiogenesis in Neuroinflammation-Associated Schizophrenia and Bipolar Disorder Implicate an Abnormal Midbrain Blood-Brain Barrier 2024 ·Schizophrenia Bulletin ·Yunting Zhu, Maree J. Webster, (unknown), Frank A. Middleton, Paul T. Massa, (unknown)	2
5	mTOR-dependent loss of PON1 secretion and antiphospholipid autoantibody production underlie autoimmunity-mediated cirrhosis in transaldolase deficiency 2023 ·Journal of Autoimmunity ·Thomas Winans, Zachary Oaks, (unknown), (unknown), Nick Huang, (unknown), (unknown), James P. Nolan, Jacob S. Lewis, Sarah L. Blair, Zhi‐Wei Lai, S.K. Landas, Frank A. Middleton, John M. Asara, (unknown), (unknown), Parastoo Azadi, Katalin Bánki, András Perl	24
6	Systemic proteome phenotypes reveal defective metabolic flexibility in Mecp2 mutants 2023 ·Human Molecular Genetics ·Stephanie A. Zlatic, Erica Werner, (unknown), (unknown), Avanti Gokhale, (unknown), Duc M. Duong, Amanda Crocker, Karen Gentile, Frank A. Middleton, (unknown), (unknown), Anupam Patgiri, Daniel Tarquinio, (unknown), Victor Faúndez	4
7	Quantification and persistence of COVID‐19 virus in recently deceased individuals before and after embalming 2023 ·Anatomical Sciences Education ·Lorenzo Gitto, Frank A. Middleton, (unknown), Saravanan Thangamani, D. Jaeger, (unknown)	1
8	Mitochondrial protein import clogging as a mechanism of disease 2023 ·eLife ·(unknown), Xiaowen Wang, Jiyao Song, Ebbing P. de Jong, Karin Schneider, Paul T. Massa, Frank A. Middleton, Thomas Becker, Xin Jie Chen	24
9	Increased prefrontal cortical cells positive for macrophage/microglial marker CD163 along blood vessels characterizes a neuropathology of neuroinflammatory schizophrenia 2023 ·Brain Behavior and Immunity ·Yunting Zhu, Maree J. Webster, Adam K. Walker, Paul T. Massa, Frank A. Middleton, Cynthia Shannon Weickert	13
10	Changes in cytokine and cytokine receptor levels during postnatal development of the human dorsolateral prefrontal cortex 2023 ·Brain Behavior and Immunity ·(unknown), Adam K. Walker, Frank A. Middleton, Kate Robinson, Maree J. Webster, Karen Gentile, Ma‐Li Wong, Cynthia Shannon Weickert	4
11	Coupling freedom from disease principles and early warning from wastewater surveillance to improve health security 2022 ·PNAS Nexus ·David A. Larsen, Mary B. Collins, (unknown), Dustin Hill, Tabassum Z. Insaf, Pruthvi Kilaru, Brittany Kmush, Frank A. Middleton, (unknown), (unknown), Teng Zeng, Hyatt Green	18
12	Development and Validation of Two RT-qPCR Diagnostic Assays for Detecting Severe Acute Respiratory Syndrome Coronavirus 2 Genomic Targets across Two Specimen Types 2022 ·Journal of Molecular Diagnostics ·Eric Miller, (unknown), (unknown), Scott W. Riddell, Frank A. Middleton, Michel R. Nasr, Scott C. Smith, Steven M. Sperber	5
13	Saliva microRNA Biomarkers of Cumulative Concussion 2020 ·International Journal of Molecular Sciences ·Steven D. Hicks, Robert P. Olympia, Cayce Onks, (unknown), (unknown), (unknown), (unknown), (unknown), (unknown), Hallie Zwibel, (unknown), Zofia E. Gagnon, (unknown), Jason R. Randall, (unknown), (unknown), (unknown), Michael N. Dretsch, Christopher Neville, Frank A. Middleton	21
14	Trajectory of change in brain complement factors from neonatal to young adult humans 2020 ·Journal of Neurochemistry ·(unknown), Adam K. Walker, Frank A. Middleton, Kate Robinson, Maree J. Webster, Cynthia Shannon Weickert	12
15	Validation of a Salivary RNA Test for Childhood Autism Spectrum Disorder 2018 ·Frontiers in Genetics ·Steven D. Hicks, (unknown), Kayla E. Wagner, (unknown), Randall L. Carpenter, Frank A. Middleton	38
16	Ethanol‐induced methylation of cell cycle genes in neural stem cells 2010 ·Journal of Neurochemistry ·Steven D. Hicks, Frank A. Middleton, Michael W. Miller	67
17	Activation of Mammalian Target of Rapamycin Controls the Loss of TCRζ in Lupus T Cells through HRES-1/Rab4-Regulated Lysosomal Degradation 2009 ·The Journal of Immunology ·David Fernández, Tiffany Telarico, Eduardo Bonilla, Qing Li, S. K. Banerjee, Frank A. Middleton, Paul E. M. Phillips, Mary K. Crow, Stefanie Oess, Werner Müller‐Esterl, András Perl	198
18	Disease-specific changes in regulator of G-protein signaling 4 (RGS4) expression in schizophrenia 2001 ·Molecular Psychiatry ·Károly Mirnics, Frank A. Middleton, Gregg D. Stanwood, David A. Lewis, Pat Levitt	363
19	Cerebellar Output Channels 1997 ·International review of neurobiology ·Frank A. Middleton, Peter L. Strick	211
20	Chapter 32 Dentate output channels: motor and cognitive components 1997 ·Progress in brain research ·Frank A. Middleton, Peter L. Strick	112

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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