Costas A. Lyssiotis

32.5k citations

144 papers · 13.3k indexed · 11 hit papers · h-index 50

Cancer Research top 0.1%
- Cancer, Hypoxia, and Metabolism 46
Oncology top 0.5%
- Pancreatic and Hepatic Oncology Research 18
Molecular Biology top 0.5%
- Epigenetics and DNA Methylation 29
- Mitochondrial Function and Pathology 14
- Metabolism, Diabetes, and Cancer 12
- Metabolomics and Mass Spectrometry Studies 10
- Pluripotent Stem Cells Research 10
Biochemistry top 0.5%
Immunology top 1%
- Immune cells in cancer 11

Co-authors: Lewis C. Cantley Alec C. Kimmelman Christopher J. Halbrook John M. Asara Marina Pasca di Magliano Haoqiang Ying Xiaoxu Wang Anirban Maitra
Cited by: Cancer Research Oncology Molecular Biology
Partner nations: United States China Japan

In The Last Decade

Costas A. Lyssiotis

140 papers receiving 13.2k citations

Hit Papers

11 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2023 Arginase 1 is a key driver of immune suppression in pancreatic cancer
2023 Pancreatic cancer: Advances and challenges
2021 Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balance
2017 Metabolic Interactions in the Tumor Microenvironment
2017 Oxidative stress controls regulatory T cell apoptosis and suppressor activity and PD-L1-blockade resistance in tumor
2016 Pancreatic stellate cells support tumour metabolism through autophagic alanine secretion
2013 Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
2013 A regenerative approach to the treatment of multiple sclerosis
2013 A colorectal cancer classification system that associates cellular phenotype and responses to therapy
2012 Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylation
2012 ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect

Peers

Countries citing papers authored by Costas A. Lyssiotis

Since Specialization

Citations

This map shows the geographic impact of Costas A. Lyssiotis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Costas A. Lyssiotis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Costas A. Lyssiotis more than expected).

Fields of papers citing papers by Costas A. Lyssiotis

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Costas A. Lyssiotis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Costas A. Lyssiotis. The network helps show where Costas A. Lyssiotis may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Costas A. Lyssiotis, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Costas A. Lyssiotis Line = papers co-authored together Costas A. Lyssiotis links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Gut sulfide metabolism modulates behavior and brain bioenergetics Roshan Kumar,David B. Sykes,Victor I. Band,Megan L. Schaller,R. B. Patel,Victor Vitvitsky,Peter Sajjakulnukit,Rashi Singhal,Harrison Wong,Suchitra K. Hourigan,Fumito Ichinose,Costas A. Lyssiotis,Yatrik M. Shah,Ruma Banerjee	2025	2
2	Multidimensional analyses identify genes of high priority for pancreatic cancer research Zeribe C. Nwosu,Heather Giza,Maya Nassif,Verodia Charlestin,Rosa E. Menjivar,Dae-Ho Kim,Samantha B. Kemp,Peter Sajjakulnukit,Anthony Andren,Li Zhang,William Lai,Ian M. Loveless,Nina G. Steele,Jiantao Hu,Biao Hu,Shaomeng Wang,Marina Pasca di Magliano,Costas A. Lyssiotis	2025	3
3	A luminescent-based protocol for NAD+/NADH detection in C. elegans, mice, and human whole blood Heling Wang,Jianying Zhang,Shuqin Cao,Mariá José Lagartos-Donate,Shiqi Zhang,Sofie Lautrup,Zeping Hu,Costas A. Lyssiotis,Riekelt H. Houtkooper,Evandro Fei Fang	2024	2
4	De Novo Purine Metabolism is a Metabolic Vulnerability of Cancers with Low p16 Expression Naveen Kumar Tangudu,Raquel Buj,Hui Wang,Jiefei Wang,Aidan R. Cole,Apoorva Uboveja,Richard Fang,Amandine Amalric,Baixue Yang,Adam Chatoff,Claudia V. Crispim,Peter Sajjakulnukit,Maureen A. Lyons,Kristine Cooper,Nadine Hempel,Costas A. Lyssiotis,Uma Chandran,Nathaniel W. Snyder,Katherine M. Aird	2024	4
5	Quiescence enables unrestricted cell fate in naive embryonic stem cells Le Tran Phuc Khoa,Wentao Yang,Mengrou Shan,Li Zhang,Fengbiao Mao,Bo Zhou,Qiang Li,Rebecca M. Malcore,Clair Harris,Lili Zhao,Rajesh C. Rao,Shigeki Iwase,Sundeep Kalantry,Stephanie Bielas,Costas A. Lyssiotis,Yali Dou	2024	8
6	Glutamine catabolism supports amino acid biosynthesis and suppresses the integrated stress response to promote photoreceptor survival Moloy T. Goswami,Eric Weh,Shubha Subramanya,Katherine M. Weh,Hima Bindu Durumutla,Heather Hager,Nicholas J. Miller,Sraboni Chaudhury,Anthony Andren,Peter Sajjakulnukit,Li Zhang,Cagri G. Besirli,Costas A. Lyssiotis,Thomas J. Wubben	2024	2
7	Neutrophil glucose flux as a therapeutic target in antiphospholipid syndrome Ajay Tambralli,Alyssa Harbaugh,Somanathapura K. NaveenKumar,Megan D. Radyk,Christine E. Rysenga,Kaitlyn Sabb,Julia M. Hurley,Gautam Sule,Srilakshmi Yalavarthi,Shanea K. Estes,Claire K. Hoy,Tristin Smith,Cyrus Sarosh,Jacqueline A. Madison,Jordan K. Schaefer,Suman L. Sood,Yu Zuo,Amr H. Sawalha,Costas A. Lyssiotis,Jason S. Knight	2024	7
8	Spotlight on GOT2 in Cancer Metabolism Samuel A. Kerk,Javier García‐Bermúdez,Kıvanç Birsoy,Mara H. Sherman,Yatrik M. Shah,Costas A. Lyssiotis	2023	10
9	Arginase 1 is a key driver of immune suppression in pancreatic cancerbreakdown → Rosa E. Menjivar,Zeribe C. Nwosu,Wenting Du,Katelyn L. Donahue,Hanna S. Hong,Carlos E. Espinoza,Kristee Brown,Ashley Velez-Delgado,Wei Yan,Fatima Lima,Allison C. Bischoff,Padma Kadiyala,Daniel James Salas-Escabillas,Howard C. Crawford,Filip Bednar,Eileen S. Carpenter,Yaqing Zhang,Christopher J. Halbrook,Costas A. Lyssiotis,Marina Pasca di Magliano	2023	96
10	NetrinG1+ Cancer-Associated Fibroblasts Generate Unique Extracellular Vesicles that Support the Survival of Pancreatic Cancer Cells Under Nutritional Stress Kristopher S. Raghavan,Ralph Francescone,Janusz Franco‐Barraza,Jaye C. Gardiner,Débora B. Vendramini‐Costa,Tiffany Luong,Narges Pourmandi,Anthony Andren,Alison Kurimchak,Charline Ogier,Paul M. Campbell,James S. Duncan,Costas A. Lyssiotis,Lucia R. Languino,Edna Cukierman	2022	27
11	EWS-FLI1 and Menin Converge to Regulate ATF4 Activity in Ewing Sarcoma Jennifer A. Jiménez,April A. Apfelbaum,Allegra G. Hawkins,Laurie K. Svoboda,Abhijay Kumar,Ramón Ocádiz-Ruiz,Alessandra X. Garcia,Elena Haarer,Zeribe C. Nwosu,Joshua Bradin,Trupta Purohit,Dong Chen,Tomasz Cierpicki,Jolanta Grembecka,Costas A. Lyssiotis,Elizabeth R. Lawlor	2021	10
12	Reuterin in the healthy gut microbiome suppresses colorectal cancer growth through altering redox balancebreakdown → Hannah N. Bell,Ryan J. Rebernick,Joshua Goyert,Rashi Singhal,Miljan Kuljanin,Samuel A. Kerk,Wesley Huang,Nupur K. Das,Anthony Andren,Sumeet Solanki,Shannon L. Miller,Peter K. Todd,Eric R. Fearon,Costas A. Lyssiotis,Steven P. Gygi,Joseph D. Mancias,Yatrik M. Shah	2021	188
13	HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron Rashi Singhal,Sreedhar R. Mitta,Nupur K. Das,Samuel A. Kerk,Peter Sajjakulnukit,Sumeet Solanki,Anthony Andren,Roshan Kumar,Kenneth P. Olive,Ruma Banerjee,Costas A. Lyssiotis,Yatrik M. Shah	2021	147
14	Endoplasmic reticulum–associated degradation regulates mitochondrial dynamics in brown adipocytes Zhangsen Zhou,Mauricio Torres,Haibo Sha,Christopher J. Halbrook,Françoise Van den Bergh,Rachel B. Reinert,Tatsuya Yamada,Siwen Wang,Yingying Luo,Allen H. Hunter,Chunqing Wang,Thomas H. Sanderson,Meilian Liu,Aaron B. Taylor,Hiromi Sesaki,Costas A. Lyssiotis,Jun Wu,Sander Kersten,Daniel Beard,Ling Qi	2020	147
15	Biochemical Characterization and Structure-Based Mutational Analysis Provide Insight into the Binding and Mechanism of Action of Novel Aspartate Aminotransferase Inhibitors Melissa C. Holt,Zahra Assar,Reza Beheshti Zavareh,Lin Lin,Justin L. Anglin,Oksana Mashadova,Saurav D. Haldar,Edouard Mullarky,Daniel M. Kremer,Lewis C. Cantley,Alec C. Kimmelman,Adam J. Stein,Luke L. Lairson,Costas A. Lyssiotis	2018	27
16	Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis Daniel Wahl,Joseph Dresser,Kari Wilder-Romans,Joshua D. Parsels,Shuang G. Zhao,Mary A. Davis,Lili Zhao,Maureen Kachman,Stefanie Wernisch,Charles Burant,Meredith A. Morgan,Felix Y. Feng,Corey Speers,Costas A. Lyssiotis,Theodore S. Lawrence	2016	67
17	Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers Edouard Mullarky,Natasha C. Lucki,Reza Beheshti Zavareh,Justin L. Anglin,Ana P. Gomes,Brandon Nicolay,Jenny C. Y. Wong,Stefan Christen,Hidenori Takahashi,Pradeep K. Singh,John Blenis,J. David Warren,Sarah‐Maria Fendt,John M. Asara,Gina M. DeNicola,Costas A. Lyssiotis,Luke L. Lairson,Lewis C. Cantley	2016	251
18	A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics Anguraj Sadanandam,Stephan Wullschleger,Costas A. Lyssiotis,Carsten Grötzinger,Stefano Barbi,Samantha Bersani,Jan Körner,Ismael Wafy,Andrea Mafficini,Rita T. Lawlor,Michele Simbolo,John M. Asara,Hendrik Bläker,Lewis C. Cantley,Bertram Wiedenmann,Aldo Scarpa,Douglas Hanahan	2015	139
19	Influence of Threonine Metabolism on S -Adenosylmethionine and Histone Methylationbreakdown → Ng Shyh‐Chang,Jason W. Locasale,Costas A. Lyssiotis,Yu-Xiang Zheng,Ren Yi Teo,Sutheera Ratanasirintrawoot,Jin Zhang,Tamer T. Önder,Juli Unternaehrer,Hao Zhu,John M. Asara,George Q. Daley,Lewis C. Cantley	2012	506
20	Combining a PI3K Inhibitor with a PARP Inhibitor Provides an Effective Therapy for BRCA1-Related Breast Cancer Ashish Juvekar,Laura N. Burga,Hai Hu,Elaine P. Lunsford,Yasir H. Ibrahim,Judith Balmañà,Anbazhagan Rajendran,Antonella Papa,Katherine Spencer,Costas A. Lyssiotis,Caterina Nardella,Pier Paolo Pandolfi,José Baselga,Ralph Scully,John M. Asara,Lewis C. Cantley,Gerburg M. Wulf	2012	336

About Costas A. Lyssiotis

Costas A. Lyssiotis is a scholar working on Cancer Research, Biochemistry and Physiology, having authored 144 papers that have together received 13.3k indexed citations. Recurring topics across this work include Cancer, Hypoxia, and Metabolism (46 papers), Epigenetics and DNA Methylation (29 papers), Pancreatic and Hepatic Oncology Research (18 papers), Mitochondrial Function and Pathology (14 papers), Metabolism, Diabetes, and Cancer (12 papers), Immune cells in cancer (11 papers), Metabolomics and Mass Spectrometry Studies (10 papers) and Pluripotent Stem Cells Research (10 papers). The work is most often cited by research in Cancer Research (4.8k citations), Oncology (3.7k citations) and Molecular Biology (8.2k citations). Costas A. Lyssiotis has collaborated with scholars based in United States, China and Japan. Frequent co-authors include Lewis C. Cantley, Alec C. Kimmelman, Christopher J. Halbrook, John M. Asara, Marina Pasca di Magliano, Haoqiang Ying, Xiaoxu Wang, Anirban Maitra, Ng Shyh‐Chang and Peter G. Schultz.

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