Brendan D. Manning

41.9k total citations · 19 hit papers
118 papers, 30.9k citations indexed

About

Brendan D. Manning is a scholar working on Molecular Biology, Physiology and Cancer Research. According to data from OpenAlex, Brendan D. Manning has authored 118 papers receiving a total of 30.9k indexed citations (citations by other indexed papers that have themselves been cited), including 97 papers in Molecular Biology, 30 papers in Physiology and 22 papers in Cancer Research. Recurrent topics in Brendan D. Manning's work include PI3K/AKT/mTOR signaling in cancer (58 papers), Tuberous Sclerosis Complex Research (27 papers) and Metabolism, Diabetes, and Cancer (21 papers). Brendan D. Manning is often cited by papers focused on PI3K/AKT/mTOR signaling in cancer (58 papers), Tuberous Sclerosis Complex Research (27 papers) and Metabolism, Diabetes, and Cancer (21 papers). Brendan D. Manning collaborates with scholars based in United States, Spain and United Kingdom. Brendan D. Manning's co-authors include Lewis C. Cantley, Alex Toker, Gerta Hoxhaj, Jingxiang Huang, Issam Ben‐Sahra, Christian C. Dibble, Andrew R. Tee, John Blenis, John M. Asara and David J. Kwiatkowski and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Brendan D. Manning

114 papers receiving 30.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

AKT/PKB Signaling: Navigating Downstream

2007 4.9k citations Brendan D. Manning, Lewis C. Cantley Cell profile →
AKT/PKB Signaling: Navigating the Network

2017 2.6k citations Brendan D. Manning et al. Cell profile →
Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1

2010 1.6k citations Katrin Düvel, Jessica L. Yecies et al. Molecular Cell profile →
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism

2019 1.4k citations Gerta Hoxhaj, Brendan D. Manning profile →
Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway

2002 1.3k citations Brendan D. Manning, Andrew R. Tee et al. Molecular Cell profile →
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex

2004 1.1k citations Brendan D. Manning et al. profile →
Targeting the PI3K-Akt pathway in human cancer

2003 1.1k citations Brendan D. Manning, Lewis C. Cantley et al. profile →
The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

2008 962 citations Jingxiang Huang, Brendan D. Manning profile →
Tuberous Sclerosis Complex Gene Products, Tuberin and Hamartin, Control mTOR Signaling by Acting as a GTPase-Activating Protein Complex toward Rheb

2003 949 citations Andrew R. Tee, Brendan D. Manning et al. profile →
The LKB1 tumor suppressor negatively regulates mTOR signaling

2004 870 citations Brendan D. Manning, Lewis C. Cantley et al. profile →
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling

2002 647 citations Andrew R. Tee, Diane C. Fingar et al. Proceedings of the National Academy of Sciences profile →
Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

2014 613 citations Suchithra Menon, Christian C. Dibble et al. Cell profile →
mTORC1 induces purine synthesis through control of the mitochondrial tetrahydrofolate cycle

2016 594 citations Issam Ben‐Sahra, Gerta Hoxhaj et al. Science profile →
A complex interplay between Akt, TSC2 and the two mTOR complexes

2009 572 citations Jingxiang Huang, Brendan D. Manning profile →
Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

2013 567 citations Christian C. Dibble, Brendan D. Manning profile →
Stimulation of de Novo Pyrimidine Synthesis by Growth Signaling Through mTOR and S6K1

2013 555 citations Issam Ben‐Sahra, John M. Asara et al. Science profile →
Akt Stimulates Hepatic SREBP1c and Lipogenesis through Parallel mTORC1-Dependent and Independent Pathways

2011 514 citations Jessica L. Yecies, Huihui Zhang et al. Cell Metabolism profile →
TBC1D7 Is a Third Subunit of the TSC1-TSC2 Complex Upstream of mTORC1

2012 483 citations Christian C. Dibble, Suchithra Menon et al. Molecular Cell profile →
mTORC1 signaling and the metabolic control of cell growth

2017 472 citations Issam Ben‐Sahra, Brendan D. Manning Current Opinion in Cell Biology profile →

Peers

Countries citing papers authored by Brendan D. Manning

Since Specialization

Citations

This map shows the geographic impact of Brendan D. Manning's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Brendan D. Manning with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Brendan D. Manning more than expected).

Fields of papers citing papers by Brendan D. Manning

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Brendan D. Manning. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Brendan D. Manning. The network helps show where Brendan D. Manning may publish in the future.

Co-authorship network of co-authors of Brendan D. Manning

This figure shows the co-authorship network connecting the top 25 collaborators of Brendan D. Manning. A scholar is included among the top collaborators of Brendan D. Manning based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Brendan D. Manning. Brendan D. Manning is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Evolution of growth factor signaling to the TSC complex to regulate mTORC1 2025 ·Science Signaling ·Kun Wang, (unknown), Brendan D. Manning	0
2	James R. Mitchell (1971–2020) 2021 ·Cell Metabolism ·Michael Ristow, Chih‐Hao Lee, Katrien De Bock, Vadim N. Gladyshev, Gökhan S. Hotamışlıgil, Brendan D. Manning	1
3	Direct stimulation of NADP ⁺ synthesis through Akt-mediated phosphorylation of NAD kinase 2019 ·Science ·Gerta Hoxhaj, Issam Ben‐Sahra, (unknown), Rebecca C. Timson, Vanessa Byles, (unknown), Peng Gao, Laura M. Selfors, John M. Asara, Brendan D. Manning	113
4	Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling 2019 ·Nature Immunology ·Flavian D. Brown, Debattama R. Sen, Martin W. LaFleur, Jernej Godec, Veronika Lukacs‐Kornek, Frank A. Schildberg, Hye‐Jung Kim, Kathleen B. Yates, Stéphane J. H. Ricoult, Kevin Bi, Justin D. Trombley, Varun N. Kapoor, (unknown), Viviana Cremasco, Nika N. Danial, Brendan D. Manning, Arlene H. Sharpe, W. Nicholas Haining, Shannon J. Turley	55
5	Improved detection of synthetic lethal interactions in Drosophila cells using variable dose analysis (VDA) 2017 ·Proceedings of the National Academy of Sciences ·Benjamin E. Housden, Zhongchi Li, Colleen Kelley, Yuan-li Wang, Yanhui Hu, Alexander J. Valvezan, Brendan D. Manning, Norbert Perrimon	5
6	mTORC1 signaling and the metabolic control of cell growth breakdown → 2017 ·Current Opinion in Cell Biology ·Issam Ben‐Sahra, Brendan D. Manning	472
7	Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP 2015 ·Oncogene ·Stéphane J. H. Ricoult, Jessica L. Yecies, Issam Ben‐Sahra, Brendan D. Manning	224
8	Tuberous Sclerosis Complex 2 Loss Increases Lysophosphatidylcholine Synthesis in Lymphangioleiomyomatosis 2015 ·American Journal of Respiratory Cell and Molecular Biology ·Carmen Priolo, Stéphane J. H. Ricoult, Damir Khabibullin, Harilaos Filippakis, Jane Yu, Brendan D. Manning, Clary B. Clish, Elizabeth P. Henske	24
9	Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome breakdown → 2014 ·Cell ·Suchithra Menon, Christian C. Dibble, George Talbott, Gerta Hoxhaj, Alexander J. Valvezan, Hidenori Takahashi, Lewis C. Cantley, Brendan D. Manning	613
10	Nutrient sensing lost in cancer 2013 ·Nature ·Suchithra Menon, Brendan D. Manning	8
11	Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 2010 ·DSpace@MIT (Massachusetts Institute of Technology) ·Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Ellen Triantafellow, Qicheng Ma, (unknown), (unknown), Jeffrey P. MacKeigan, Peter M. Finan, Leon O. Murphy, Brendan D. Manning, Alex Lipovsky, Amanda Souza, Matthew G. Vander Heiden, Clary B. Clish	2
12	Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1 breakdown → 2010 ·Molecular Cell ·Katrin Düvel, Jessica L. Yecies, Suchithra Menon, Pichai Raman, Alex Lipovsky, Amanda L. Souza, Ellen Triantafellow, Qicheng Ma, (unknown), (unknown), Matthew G. Vander Heiden, Jeffrey P. MacKeigan, Peter M. Finan, Clary B. Clish, Leon O. Murphy, Brendan D. Manning	1582
13	The TSC1-TSC2 Complex Is Required for Proper Activation of mTOR Complex 2 2008 ·Molecular and Cellular Biology ·Jingxiang Huang, Christian C. Dibble, Mika Matsuzaki, Brendan D. Manning	399
14	Loss of the Tuberous Sclerosis Complex Tumor Suppressors Triggers the Unfolded Protein Response to Regulate Insulin Signaling and Apoptosis 2008 ·Molecular Cell ·Umut Özcan, Lale Özcan, Erkan Yılmaz, Katrin Düvel, Mustafa Şahin, Brendan D. Manning, Gökhan S. Hotamışlıgil	353
15	AKT/PKB Signaling: Navigating Downstream breakdown → 2007 ·Cell ·Brendan D. Manning, Lewis C. Cantley	4947
16	S6K1 Regulates GSK3 under Conditions of mTOR-Dependent Feedback Inhibition of Akt 2006 ·Molecular Cell ·Huihui Zhang, Alex Lipovsky, Christian C. Dibble, Mustafa Şahin, Brendan D. Manning	243
17	Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling breakdown → 2002 ·Proceedings of the National Academy of Sciences ·Andrew R. Tee, Diane C. Fingar, Brendan D. Manning, David J. Kwiatkowski, Lewis C. Cantley, John Blenis	647
18	Hitting the Target: Emerging Technologies in the Search for Kinase Substrates 2002 ·Science s STKE ·Brendan D. Manning, Lewis C. Cantley	85
19	Identification of the Tuberous Sclerosis Complex-2 Tumor Suppressor Gene Product Tuberin as a Target of the Phosphoinositide 3-Kinase/Akt Pathway breakdown → 2002 ·Molecular Cell ·Brendan D. Manning, Andrew R. Tee, (unknown), John Blenis, Lewis C. Cantley	1281
20	Genomic complexity and plasticity ofBurkholderia cepacia 1996 ·FEMS Microbiology Letters ·T G Lessie, William Hendrickson, Brendan D. Manning, Richard B. Devereux	151

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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