Jacques Pouysségur

52.8k total citations · 14 hit papers
369 papers, 42.1k citations indexed

About

Jacques Pouysségur is a scholar working on Molecular Biology, Cancer Research and Oncology. According to data from OpenAlex, Jacques Pouysségur has authored 369 papers receiving a total of 42.1k indexed citations (citations by other indexed papers that have themselves been cited), including 286 papers in Molecular Biology, 124 papers in Cancer Research and 52 papers in Oncology. Recurrent topics in Jacques Pouysségur's work include Cancer, Hypoxia, and Metabolism (104 papers), Ion Transport and Channel Regulation (49 papers) and Protein Kinase Regulation and GTPase Signaling (48 papers). Jacques Pouysségur is often cited by papers focused on Cancer, Hypoxia, and Metabolism (104 papers), Ion Transport and Channel Regulation (49 papers) and Protein Kinase Regulation and GTPase Signaling (48 papers). Jacques Pouysségur collaborates with scholars based in France, United States and Monaco. Jacques Pouysségur's co-authors include Gilles Pagès, Gilles L’Allemain, Guido Kroemer, Edurne Berra, Philippe Lenormand, S Paris, Sylvain Meloche, M. Christiane Brahimi-Horn, Jean‐Claude Chambard and Johanna Chiche and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Jacques Pouysségur

369 papers receiving 41.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Tumor Cell Metabolism: Cancer's Achilles' Heel

2008 1.8k citations Jacques Pouysségur et al. profile →
Hypoxia signalling in cancer and approaches to enforce tumour regression

2006 1.4k citations Jacques Pouysségur, Frédéric Dayan et al. profile →
Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 1.1k citations Jacques Pouysségur et al. Journal of Biological Chemistry profile →
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 899 citations Gilles Pagès, Philippe Lenormand et al. Proceedings of the National Academy of Sciences profile →
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1- to S-phase transition

2007 890 citations Jacques Pouysségur et al. profile →
p42/p44 Mitogen-activated Protein Kinases Phosphorylate Hypoxia-inducible Factor 1α (HIF-1α) and Enhance the Transcriptional Activity of HIF-1

1999 676 citations Danièle Roux, Jacques Pouysségur et al. Journal of Biological Chemistry profile →
ERK implication in cell cycle regulation

2006 638 citations Renaud LeFloch, Jacques Pouysségur et al. profile →
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity

2006 627 citations Jacques Pouysségur et al. Proceedings of the National Academy of Sciences profile →
Hypoxia and cancer

2007 620 citations Johanna Chiche, Jacques Pouysségur et al. profile →
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 587 citations Philippe Lenormand, Jacques Pouysségur et al. profile →
Defective Thymocyte Maturation in p44 MAP Kinase (Erk 1) Knockout Mice

1999 544 citations Gilles Pagès, Jacques Pouysségur et al. profile →
Molecular physiology of vertebrate Na+/H+ exchangers

1997 527 citations Jacques Pouysségur et al. profile →
Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer

2010 523 citations Johanna Chiche, Jacques Pouysségur et al. Journal of Cellular and Molecular Medicine profile →
Disrupting proton dynamics and energy metabolism for cancer therapy

2013 499 citations Scott K. Parks, Johanna Chiche et al. profile →

Peers

Countries citing papers authored by Jacques Pouysségur

Since Specialization

Citations

This map shows the geographic impact of Jacques Pouysségur's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Jacques Pouysségur with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Jacques Pouysségur more than expected).

Fields of papers citing papers by Jacques Pouysségur

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Jacques Pouysségur. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Jacques Pouysségur. The network helps show where Jacques Pouysségur may publish in the future.

Co-authorship network of co-authors of Jacques Pouysségur

This figure shows the co-authorship network connecting the top 25 collaborators of Jacques Pouysségur. A scholar is included among the top collaborators of Jacques Pouysségur based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Jacques Pouysségur. Jacques Pouysségur is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Inhibition of the amino‐acid transporter LAT1 demonstrates anti‐neoplastic activity in medulloblastoma 2019 ·Journal of Cellular and Molecular Medicine ·Yann Cormerais, (unknown), (unknown), Sandy Giuliano, Éric Tambutté, Hitoshi Endou, Michael F. Wempe, Gilles Pagès, Jacques Pouysségur, Vincent Picco	37
2	Genetic Ablation of the Cystine Transporter xCT in PDAC Cells Inhibits mTORC1, Growth, Survival, and Tumor Formation via Nutrient and Oxidative Stresses 2019 ·Cancer Research ·Boutaina Daher, Scott K. Parks, Jérôme Durivault, Yann Cormerais, (unknown), Éric Tambutté, Jacques Pouysségur, Milica Vučetić	160
3	Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth 2016 ·Cancer Research ·Yann Cormerais, Sandy Giuliano, Renaud LeFloch, (unknown), Jérôme Durivault, Éric Tambutté, (unknown), Laura Rodríguez de la Ballina, Hitoshi Endou, Michael F. Wempe, Manuel Palacı́n, Scott K. Parks, Jacques Pouysségur	140
4	Knock out of the BASIGIN/CD147 chaperone of lactate/H+ symporters disproves its pro-tumour actionviaextracellular matrix metalloproteases (MMPs) induction 2015 ·Oncotarget ·Ibtissam Marchiq, Jean Albrengues, Sara Granja, Cédric Gaggioli, Jacques Pouysségur, Marie‐Pierre Simon	32
5	Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin 2014 ·Cancer Research ·Ibtissam Marchiq, Renaud Le Floch, Danièle Roux, Marie‐Pierre Simon, Jacques Pouysségur	143
6	Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis 2013 ·Cancer Research ·Norbert W. Lutz, Yann Le Fur, Johanna Chiche, Jacques Pouysségur, Patrick J. Cozzone	40
7	The HIF-1–Inducible Lysyl Oxidase Activates HIF-1 via the Akt Pathway in a Positive Regulation Loop and Synergizes with HIF-1 in Promoting Tumor Cell Growth 2011 ·Cancer Research ·Floriane Pez, Frédéric Dayan, Jérôme Durivault, Bastien Kaniewski, (unknown), Gabrielle S. Le Provost, Blandine Deux, Philippe Clézardin, Pascal Sommer, Jacques Pouysségur, Caroline Reynaud	131
8	CD147 subunit of lactate/H ⁺ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors 2011 ·Proceedings of the National Academy of Sciences ·Renaud Le Floch, Johanna Chiche, Ibtissam Marchiq, Tanesha Naiken, Karine Ilc, Clare Murray, Susan E. Critchlow, Danièle Roux, Marie‐Pierre Simon, Jacques Pouysségur	354
9	Cutting Edge: Extracellular Signal-Related Kinase Is Not Required for Negative Selection of Developing T Cells 2009 ·The Journal of Immunology ·Maureen A. McGargill, Irene L. Ch’en, Carol D. Katayama, Gilles Pagès, Jacques Pouysségur, Stephen Μ. Hedrick	25
10	Total ERK1/2 activity regulates cell proliferation 2009 ·Cell Cycle ·Renaud LeFloch, Jacques Pouysségur, Philippe Lenormand	86
11	The angiopoietin‐2 gene of endothelial cells is up‐regulated in hypoxia by a HIF binding site located in its first intron and by the central factors GATA‐2 and Ets‐1 2008 ·Journal of Cellular Physiology ·Marie‐Pierre Simon, Roselyne Tournaire, Jacques Pouysségur	163
12	Physical Interactions and Functional Coupling between Daxx and Sodium Hydrogen Exchanger 1 in Ischemic Cell Death 2007 ·Journal of Biological Chemistry ·Yong‐Sam Jung, Hye‐Young Kim, Juno Kim, Min Goo Lee, Jacques Pouysségur, Eunhee Kim	22
13	A Novel Role for IκB Kinase (IKK) α and IKKβ in ERK-Dependent Up-Regulation of MUC5AC Mucin Transcription by Streptococcus pneumoniae 2007 ·The Journal of Immunology ·Un‐Hwan Ha, Jae Hyang Lim, Hirofumi Jono, Tomoaki Koga, Amit Srivastava, Richard Malley, Gilles Pagès, Jacques Pouysségur, Jiandong Li	61
14	The role of the hypoxia-inducible factor in tumor metabolism growth and invasion. 2006 ·PubMed ·Christiane Brahimi‐Horn, Jacques Pouysségur	123
15	Complete Structure of an Increasing Capillary Permeability Protein (ICPP) Purified from Vipera lebetina Venom 2002 ·Journal of Biological Chemistry ·(unknown), Christine Bourcier, (unknown), (unknown), Sandrine Marchetti, Clotilde Gimond, Stephen R. Wedge, Laurent Hennequin, Jacques Pouysségur	34
16	The Expanding Family of Eucaryotic Na+/H+Exchangers 2000 ·Journal of Biological Chemistry ·Laurent Counillon, Jacques Pouysségur	319
17	Confluence of Vascular Endothelial Cells Induces Cell Cycle Exit by Inhibiting p42/p44 Mitogen-Activated Protein Kinase Activity 1999 ·Molecular and Cellular Biology ·Francesc Viñals, Jacques Pouysségur	93
18	Le récepteur de la thrombine et ses implications dans la prolifération des cellules vasculaires 1993 ·médecine/sciences ·(unknown), Jacques Pouysségur	1
19	α-Thrombin Receptors and Growth Signaling 1993 ·Seminars in Thrombosis and Hemostasis ·Ellen Van Obberghen‐Schilling, Jacques Pouysségur	14
20	Structure/function studies of the epithelial isoforms of the mammalian Na+/H+ exchanger gene family 1993 ·The Journal of Membrane Biology ·Ming Tse, (unknown), C. Chris Yun, Steven R. Brant, (unknown), Jacques Pouysségur, Mark Donowitz	120

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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