Virginia M.‐Y. Lee

158.0k total citations · 36 hit papers
668 papers, 97.8k citations indexed

About

Virginia M.‐Y. Lee is a scholar working on Physiology, Neurology and Molecular Biology. According to data from OpenAlex, Virginia M.‐Y. Lee has authored 668 papers receiving a total of 97.8k indexed citations (citations by other indexed papers that have themselves been cited), including 399 papers in Physiology, 322 papers in Neurology and 208 papers in Molecular Biology. Recurrent topics in Virginia M.‐Y. Lee's work include Alzheimer's disease research and treatments (388 papers), Parkinson's Disease Mechanisms and Treatments (247 papers) and Amyotrophic Lateral Sclerosis Research (110 papers). Virginia M.‐Y. Lee is often cited by papers focused on Alzheimer's disease research and treatments (388 papers), Parkinson's Disease Mechanisms and Treatments (247 papers) and Amyotrophic Lateral Sclerosis Research (110 papers). Virginia M.‐Y. Lee collaborates with scholars based in United States, Germany and Japan. Virginia M.‐Y. Lee's co-authors include John Q. Trojanowski, Benoit I. Giasson, Kelvin C. Luk, Linda K. Kwong, Bin Zhang, Michel Goedert, Jing Guo, Carlo Ballatore, Bin Zhang and Murray Grossman and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Virginia M.‐Y. Lee

667 papers receiving 96.4k citations

Hit Papers

Ubiquitinated TDP-43 in Frontotemporal Lobar Dege... 1991 2026 2002 2014 2006 2001 2012 2007 2007 1000 2.0k 3.0k 4.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis
    2006 4.8k citations Manuela Neumann, Deepak M. Sampathu et al. Science profile →
  2. Neurodegenerative Tauopathies
    2001 1.9k citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. profile →
  3. Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice
    2012 1.9k citations Kelvin C. Luk, Victoria Kehm et al. Science profile →
  4. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders
    2007 1.7k citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. profile →
  5. Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model
    2007 1.6k citations Yasumasa Yoshiyama, Makoto Higuchi et al. Neuron profile →
  6. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects
    2009 1.6k citations Christopher M. Clark, Virginia M.‐Y. Lee et al. Annals of Neurology profile →
  7. Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions
    2000 1.3k citations Benoit I. Giasson, John E. Duda et al. Science profile →
  8. A68: a Major Subunit of Paired Helical Filaments and Derivatized Forms of Normal Tau
    1991 1.2k citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. Science profile →
  9. Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death
    2011 1.2k citations Kelvin C. Luk, Dawn M. Riddle et al. Neuron profile →
  10. Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease
    2002 993 citations Pavan K. Auluck, Ho Yin Edwin Chan et al. Science profile →
  11. GSK-3α regulates production of Alzheimer's disease amyloid-β peptides
    2003 983 citations Virginia M.‐Y. Lee et al. profile →
  12. Neuronal α-Synucleinopathy with Severe Movement Disorder in Mice Expressing A53T Human α-Synuclein
    2002 971 citations Benoit I. Giasson, Bin Zhang et al. Neuron profile →
  13. A Hydrophobic Stretch of 12 Amino Acid Residues in the Middle of α-Synuclein Is Essential for Filament Assembly
    2001 854 citations Benoit I. Giasson, Ian Murray et al. Journal of Biological Chemistry profile →
  14. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice
    2012 819 citations Kelvin C. Luk, Victoria Kehm et al. profile →
  15. Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein
    2016 777 citations Virginia M.‐Y. Lee et al. profile →
  16. Abnormal tau phosphorylation at Ser396 in alzheimer's disease recapitulates development and contributes to reduced microtubule binding
    1993 758 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. Neuron profile →
  17. Stages of pTDP‐43 pathology in amyotrophic lateral sclerosis
    2013 750 citations Johannes Brettschneider, Kelly Del Tredici et al. Annals of Neurology profile →
  18. Exogenous α-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells
    2009 742 citations Kelvin C. Luk, Patrick O’Brien et al. profile →
  19. Synucleins are developmentally expressed, and alpha-synuclein regulates the size of the presynaptic vesicular pool in primary hippocampal neurons.
    2000 705 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  20. Environmental Enrichment Reduces Aβ Levels and Amyloid Deposition in Transgenic Mice
    2005 701 citations Virginia M.‐Y. Lee et al. profile →
  21. Initiation and Synergistic Fibrillization of Tau and Alpha-Synuclein
    2003 698 citations Benoit I. Giasson, Makoto Higuchi et al. Science profile →
  22. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies
    2013 685 citations David J. Irwin, Virginia M.‐Y. Lee et al. profile →
  23. Synucleins Are Developmentally Expressed, and α-Synuclein Regulates the Size of the Presynaptic Vesicular Pool in Primary Hippocampal Neurons
    2000 654 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. Journal of Neuroscience profile →
  24. Spreading of pathology in neurodegenerative diseases: a focus on human studies
    2015 584 citations Johannes Brettschneider, Kelly Del Tredici et al. profile →
  25. Glial cytoplasmic inclusions in white matter oligodendrocytes of multiple system atrophy brains contain insoluble α‐synuclein
    1998 558 citations Benoit I. Giasson, John Q. Trojanowski et al. Annals of Neurology profile →
  26. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs
    2004 547 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  27. Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons
    2013 547 citations Anna Stieber, Bin Zhang et al. profile →
  28. The acetylation of tau inhibits its function and promotes pathological tau aggregation
    2011 533 citations Linda K. Kwong, John Q. Trojanowski et al. profile →
  29. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration
    2011 515 citations Edward B. Lee, Virginia M.‐Y. Lee et al. profile →
  30. Synthetic Tau Fibrils Mediate Transmission of Neurofibrillary Tangles in a Transgenic Mouse Model of Alzheimer's-Like Tauopathy
    2013 502 citations Bin Zhang, John Q. Trojanowski et al. Journal of Neuroscience profile →
  31. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates
    2014 502 citations Kelvin C. Luk, Virginia M.‐Y. Lee et al. profile →
  32. Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases
    2014 492 citations Virginia M.‐Y. Lee et al. profile →
  33. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation
    2017 449 citations Sneha Narasimhan, Lakshmi Changolkar et al. profile →
  34. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies
    2018 439 citations Anna Stieber, John Robinson et al. profile →
  35. Protein transmission in neurodegenerative disease
    2020 412 citations John Q. Trojanowski, Virginia M.‐Y. Lee et al. profile →
  36. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease
    2020 320 citations Virginia M.‐Y. Lee, John Q. Trojanowski et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Virginia M.‐Y. Lee United States 161 48.2k 43.8k 34.2k 24.0k 19.6k 668 97.8k
Eliezer Masliah United States 156 47.0k 1.0× 33.6k 0.8× 34.2k 1.0× 29.4k 1.2× 23.3k 1.2× 841 104.9k
Dennis W. Dickson United States 153 48.5k 1.0× 40.0k 0.9× 25.2k 0.7× 16.5k 0.7× 23.9k 1.2× 1.3k 103.6k
John Q. Trojanowski United States 193 69.9k 1.4× 59.9k 1.4× 46.3k 1.4× 31.9k 1.3× 29.4k 1.5× 1.1k 151.7k
John Hardy United Kingdom 132 49.9k 1.0× 22.3k 0.5× 34.8k 1.0× 20.6k 0.9× 18.0k 0.9× 884 93.4k
Mark P. Mattson United States 193 53.0k 1.1× 9.4k 0.2× 51.4k 1.5× 29.0k 1.2× 18.3k 0.9× 955 128.3k
Henrik Zetterberg Sweden 135 46.4k 1.0× 22.4k 0.5× 26.3k 0.8× 10.8k 0.5× 17.0k 0.9× 2.0k 96.1k
Kaj Blennow Sweden 158 65.7k 1.4× 24.3k 0.6× 33.4k 1.0× 13.3k 0.6× 22.0k 1.1× 2.0k 122.7k
Bradley T. Hyman United States 156 60.6k 1.3× 14.8k 0.3× 32.6k 1.0× 23.1k 1.0× 21.1k 1.1× 730 114.1k
Heiko Braak Germany 107 32.3k 0.7× 26.6k 0.6× 14.3k 0.4× 16.5k 0.7× 13.8k 0.7× 362 68.5k
Michel Goedert United Kingdom 130 39.3k 0.8× 18.9k 0.4× 28.8k 0.8× 18.2k 0.8× 11.8k 0.6× 394 64.2k

Countries citing papers authored by Virginia M.‐Y. Lee

Since Specialization
Citations

This map shows the geographic impact of Virginia M.‐Y. Lee's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Virginia M.‐Y. Lee with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Virginia M.‐Y. Lee more than expected).

Fields of papers citing papers by Virginia M.‐Y. Lee

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Virginia M.‐Y. Lee. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Virginia M.‐Y. Lee. The network helps show where Virginia M.‐Y. Lee may publish in the future.

Co-authorship network of co-authors of Virginia M.‐Y. Lee

This figure shows the co-authorship network connecting the top 25 collaborators of Virginia M.‐Y. Lee. A scholar is included among the top collaborators of Virginia M.‐Y. Lee based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Virginia M.‐Y. Lee. Virginia M.‐Y. Lee is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Venkatesh, Yarra, Nicholas P. Marotta, Virginia M.‐Y. Lee, & E. James Petersson. (2024). Highly tunable bimane-based fluorescent probes: design, synthesis, and application as a selective amyloid binding dye. Chemical Science. 15(16). 6053–6063. 5 indexed citations
2.
Brynildsen, Julia K., Cheryl E. G. Leyns, Lakshmi Changolkar, et al.. (2024). LRRK2 kinase inhibition reverses G2019S mutation-dependent effects on tau pathology progression. Translational Neurodegeneration. 13(1). 13–13. 7 indexed citations
3.
Uemura, Maiko, Eun Ran Suh, John Robinson, et al.. (2022). Abundant copathologies of polyglucosan bodies, frontotemporal lobar degeneration with TDP‐43 inclusions and ageing‐related tau astrogliopathy in a family with a GBE1 mutation. Neuropathology and Applied Neurobiology. 49(1). e12865–e12865. 4 indexed citations
4.
Porta, Sílvia, Yan Xu, Bin Zhang, et al.. (2021). Distinct brain‐derived TDP‐43 strains from FTLD‐TDP subtypes induce diverse morphological TDP‐43 aggregates and spreading patterns in vitro and in vivo. Neuropathology and Applied Neurobiology. 47(7). 1033–1049. 33 indexed citations
5.
Ferrie, John J., Zsofia Lengyel‐Zhand, Bieneke Janssen, et al.. (2020). Identification of a nanomolar affinity α-synuclein fibril imaging probe by ultra-high throughput in silico screening. Chemical Science. 11(47). 12746–12754. 35 indexed citations
6.
Crowe, Alex, Mark J. Henderson, Johnathon D. Anderson, et al.. (2020). Compound screening in cell-based models of tau inclusion formation: Comparison of primary neuron and HEK293 cell assays. Journal of Biological Chemistry. 295(12). 4001–4013. 14 indexed citations
7.
Wu, Qihui, Hajime Takano, Dawn M. Riddle, et al.. (2019). α-Synuclein (αSyn) Preformed Fibrils Induce Endogenous αSyn Aggregation, Compromise Synaptic Activity and Enhance Synapse Loss in Cultured Excitatory Hippocampal Neurons. Journal of Neuroscience. 39(26). 5080–5094. 78 indexed citations
8.
Leyns, Cheryl E. G., Maud Gratuze, Sneha Narasimhan, et al.. (2019). TREM2 function impedes tau seeding in neuritic plaques. Nature Neuroscience. 22(8). 1217–1222. 199 indexed citations
9.
Saito, Takashi, Naomi Mihira, Yukio Matsuba, et al.. (2019). Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation. Journal of Biological Chemistry. 294(34). 12754–12765. 132 indexed citations
10.
Brettschneider, Johannes, Kimihito Arai, Kelly Del Tredici, et al.. (2014). TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128(3). 423–437. 201 indexed citations
11.
Luk, Kelvin C., Victoria Kehm, Jenna C. Carroll, et al.. (2012). Pathological α-Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice. Science. 338(6109). 949–953. 1855 indexed citations breakdown →
12.
Yoshiyama, Yasumasa, Makoto Higuchi, Bin Zhang, et al.. (2007). Synapse Loss and Microglial Activation Precede Tangles in a P301S Tauopathy Mouse Model. Neuron. 53(3). 337–351. 1600 indexed citations breakdown →
13.
Winton, Matthew J., Sonali Joyce, Victoria Zhukareva, et al.. (2006). Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex. Acta Neuropathologica. 111(5). 401–412. 24 indexed citations
14.
Neumann, Manuela, Deepak M. Sampathu, Linda K. Kwong, et al.. (2006). Ubiquitinated TDP-43 in Frontotemporal Lobar Degeneration and Amyotrophic Lateral Sclerosis. Science. 314(5796). 130–133. 4830 indexed citations breakdown →
15.
Higuchi, Makoto, et al.. (2004). Olfactory dysfunction occurs in transgenic mice overexpressing human τ protein. Brain Research. 1000(1-2). 174–178. 44 indexed citations
16.
Sobrido, María-Jesús, Bruce L. Miller, Necat Havlioglu, et al.. (2003). Novel Tau Polymorphisms, Tau Haplotypes, and Splicing in Familial and Sporadic Frontotemporal Dementia. Archives of Neurology. 60(5). 698–698. 44 indexed citations
17.
Auluck, Pavan K., Ho Yin Edwin Chan, John Q. Trojanowski, Virginia M.‐Y. Lee, & Nancy M. Bonini. (2002). Chaperone Suppression of α-Synuclein Toxicity in a Drosophila Model for Parkinson's Disease. Science. 295(5556). 865–868. 993 indexed citations breakdown →
18.
Giasson, Benoit I., John E. Duda, Ian Murray, et al.. (2000). Oxidative Damage Linked to Neurodegeneration by Selective α-Synuclein Nitration in Synucleinopathy Lesions. Science. 290(5493). 985–989. 1280 indexed citations breakdown →
19.
Lai, Fang, Chunxia Chen, Virginia M.‐Y. Lee, & Kazuko Nishikura. (1997). Dramatic Increase of the RNA Editing for Glutamate Receptor Subunits During Terminal Differentiation of Clonal Human Neurons. Journal of Neurochemistry. 69(1). 43–52. 39 indexed citations
20.
Ginsberg, Stephen D., Peter B. Crino, Virginia M.‐Y. Lee, James Eberwine, & John Q. Trojanowski. (1997). Sequestration of RNA in Alzheimer's disease neurofibrillary tangles and senile plaques. Annals of Neurology. 41(2). 200–209. 129 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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