William L. Klein

31.9k citations

187 papers · 25.1k indexed · 14 hit papers · h-index 73

Impact in

Physiology top 0.01%
- Alzheimer's disease research and treatments
Biological Psychiatry top 0.1%
- Tryptophan and brain disorders

Papers in

Physiology 121
- Alzheimer's disease research and treatments 120
Cellular and Molecular Neuroscience 68
- Neuroscience and Neuropharmacology Research 53

Co-authors: Kirsten L. Viola Mary P. Lambert Grant A. Krafft Pascale N. Lacor Lei Chang Pauline T. Velasco Sérgio T. Ferreira Caleb E. Finch
Journals: Journal of Neurochemistry (16 papers)Proceedings of the National Academy of Sciences (11 papers)Journal of Biological Chemistry (10 papers)Alzheimer s & Dementia (9 papers)Neurobiology of Aging (8 papers)
Partner nations: United States Brazil Canada

In The Last Decade

William L. Klein

186 papers receiving 24.6k citations

Hit Papers

14 papers align trajectories log scale

The Amyloid-β Oligomer Hypothesis: Beginning of the Third Decade 2018 · 651 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2018 Journal of Alzheimer s Disease
2015 Acta Neuropathologica
2012 Journal of Clinical Investigation
2009 Proceedings of the National Academy of Sciences
2007 Journal of Neuroscience
2007 Journal of Biological Chemistry
2005 Journal of the American Chemical Society
2005 Proceedings of the National Academy of Sciences
2004 Journal of Neuroscience
2004 Nano Letters
2003 Proceedings of the National Academy of Sciences
2001 Trends in Neurosciences
1998 Proceedings of the National Academy of Sciences
1972 Journal of Biological Chemistry

Peers

Countries citing papers authored by William L. Klein

Since Specialization

Citations

This map shows the geographic impact of William L. Klein's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by William L. Klein with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites William L. Klein more than expected).

Fields of papers citing papers by William L. Klein

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by William L. Klein. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by William L. Klein. The network helps show where William L. Klein may publish in the future.

Co-authors

The 25 scholars most cited alongside William L. Klein, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with William L. Klein Line = papers co-authored together William L. Klein links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Pharmacological inhibition of plasminogen activator inhibitor-1 prevents memory deficits and reduces neuropathology in APP/PS1 mice Psychopharmacology ·Guadalupe Rodríguez, Mesut Eren, Christian Brackmann, Kirsten L. Viola, Erika N. Cline, Toshio Miyata, William L. Klein, Douglas E. Vaughan, Hongxin Dong	2023	6
2	Altered succinylation of mitochondrial proteins, APP and tau in Alzheimer’s disease Nature Communications ·Yun Yang, Vı́ctor Tapias, Diana Acosta, Hui Xu, Huan‐Lian Chen, Ruchika Bhawal, Elizabeth T. Anderson, Elena Ivanova, Hening Lin, Botir T. Sagdullaev, 振兴刘, William L. Klein, Kirsten L. Viola, Sam Gandy, Vahram Haroutunian, M. Flint Beal, David Eliezer, Sheng Zhang, Gary E. Gibson	2022	72
3	Diet‐induced Alzheimer's‐like syndrome in the rabbit Alzheimer s & Dementia Translational Research & Clinical Interventions ·Craig Weiss, Nicola Bertolino, Daniele Procissi, Grazia Aleppo, KS Wipularathna, Kirsten L. Viola, Hitoshi Aoki, William L. Klein, John F. Disterhoft	2022	6
4	Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer’s patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability Neuropathology and Applied Neurobiology ·KO ORNO, Mohsen Seifi, Rosa Nurmalita, Scott J. Mitchell, Uwe Rudolph, Kirsten L. Viola, William L. Klein, Jeremy J. Lambert, Jerome D. Swinny	2020	28
5	Rifampicin is a candidate preventive medicine against amyloid-β and tau oligomers Brain ·Tomohiro Umeda, Kenjiro Ono, Friska Diah Mukaromah, M. Yamashita, Mineyuki Mizuguchi, William L. Klein, Masahito Yamada, Hiroshi Mori, Takami Tomiyama	2016	100
6	Alzheimer's Disease-Like Pathology Induced by Amyloid-β Oligomers in Nonhuman Primates Journal of Neuroscience ·Letícia Forny‐Germano, Natalia M. Lyra e Silva, André F. Batista, Jordano Brito‐Moreira, Matthias Gralle, Susan E. Boehnke, Brian C. Coe, María Concepción Rodríguez Ceja, Suelen Adriani Marques, Ana Maria Blanco Martinez, William L. Klein, Jean‐Christophe Houzel, Sérgio T. Ferreira, Douglas P. Munoz, Fernanda G. De Felice	2014	198
7	Modulation of Amyloid‐β Aggregation by Histidine‐Coordinating Cobalt(III) Schiff Base Complexes ChemBioChem ·Marie C. Heffern, Pauline T. Velasco, Lauren M. Matosziuk, M. Efe, Constantine L. Karras, Mark A. Ratner, William L. Klein, Amanda L. Eckermann, Thomas J. Meade	2014	40
8	Nanodisc-solubilized membrane protein library reflects the membrane proteome Analytical and Bioanalytical Chemistry ·Michael T. Marty, Kyle C. Wilcox, William L. Klein, Stephen G. Sligar	2013	50
9	Inhibition of Choline Acetyltransferase as a Mechanism for Cholinergic Dysfunction Induced by Amyloid-β Peptide Oligomers Journal of Biological Chemistry ·J. J. Cui, Luís E. Santos, Bernardo Stutz, Jordano Brito‐Moreira, William L. Klein, Sérgio T. Ferreira, Fernando G. de Mello	2012	82
10	Endoplasmic reticulum stress occurs downstream of GluN2B subunit ofN‐methyl‐D‐aspartate receptor in mature hippocampal cultures treated with amyloid‐β oligomers Aging Cell ·Rui O. Costa, Pascale N. Lacor, Ildete L. Ferreira, Rosa Resende, Yves P. Auberson, William L. Klein, Catarina R. Oliveira, A. Cristina Rego, Cláudia Pereira	2012	92
11	Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease Neurobiology of Aging ·Maria Teresa Ferretti, Martín A. Bruno, Adriana Ducatenzeiler, William L. Klein, A. Claudio Cuello	2011	126
12	N‐Methyl‐d‐aspartate receptors are required for synaptic targeting of Alzheimer’s toxic amyloid‐β peptide oligomers Journal of Neurochemistry ·Helena Decker, Sofia Jürgensen, Martín F. Adrover, Jordano Brito‐Moreira, Theresa R. Bomfim, William L. Klein, Alberto L. Epstein, Fernanda G. De Felice, Diana Jerusalinsky, Sérgio T. Ferreira	2010	138
13	Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers Acta Neuropathologica ·Anna Nogalska, Carla D’Agostino, W. King Engel, William L. Klein, Valerie Askanas	2010	38
14	Protection of synapses against Alzheimer's-linked toxins: Insulin signaling prevents the pathogenic binding of Aβ oligomers Proceedings of the National Academy of Sciences ·Fernanda G. De Felice, Marcelo N. N. Vieira, Theresa R. Bomfim, Helena Decker, Pauline T. Velasco, Mary P. Lambert, Kirsten L. Viola, Linos Ad, Sérgio T. Ferreira, William L. Klein Hit paper breakdown →	2009	532
15	Targeting Generation of Antibodies Specific to Conformational Epitopes of Amyloid β-Derived Neurotoxins CNS & Neurological Disorders - Drug Targets ·Mary P. Lambert, Pauline T. Velasco, Kirsten L. Viola, William L. Klein	2009	26
16	PGH₂‐derived levuglandin adducts increase the neurotoxicity of amyloid β1–42 Journal of Neurochemistry ·Olivier Boutaud, Thomas J. Montine, Lei Chang, William L. Klein, John A. Oates	2006	38
17	Monoclonal antibodies that target pathological assemblies of Aβ Journal of Neurochemistry ·Mary P. Lambert, Pauline T. Velasco, Lei Chang, Kirsten L. Viola, Julio C. Arango-Tobón, Pascale N. Lacor, А. Г. Гречканева, Yuesong Gong, Eileen H. Bigio, Pamela L Shaw, Fernanda G. De Felice, Grant A. Krafft, William L. Klein	2006	274
18	Small assemblies of unmodified amyloid β-protein are the proximate neurotoxin in Alzheimer’s disease Neurobiology of Aging ·William L. Klein, W. Blaine Stine, David B. Teplow	2004	392
19	Iron Levels Modulate α‐Secretase Cleavage of Amyloid Precursor Protein Journal of Neurochemistry ·Mohammad Karimian, Michael T. Falduto, Donald E. Frail, William L. Klein	1995	70
20	Particulate forms of APP in the extracellular milieu of cultured cells Experimental Neurology ·Inc. Smule, Sahnila Enam, Mohammad Karimian, Michael T. Falduto, D E Frail, William L. Klein	1995	6

About William L. Klein

William L. Klein is a scholar working on Physiology, Cellular and Molecular Neuroscience, Neurology, Pharmacology and Computational Theory and Mathematics, having authored 187 papers that have together received 25.1k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (120 papers), Neuroscience and Neuropharmacology Research (53 papers), Cholinesterase and Neurodegenerative Diseases (41 papers), Receptor Mechanisms and Signaling (28 papers), Neuroinflammation and Neurodegeneration Mechanisms (27 papers), Computational Drug Discovery Methods (26 papers), Prion Diseases and Protein Misfolding (14 papers) and Retinal Development and Disorders (11 papers). The work is most often cited by research in Physiology (17.4k citations), Biological Psychiatry (1.3k citations), Neurology (4.0k citations), Cellular and Molecular Neuroscience (6.6k citations) and Pharmacology (4.8k citations). William L. Klein has collaborated with scholars based in United States, Brazil and Canada. Frequent co-authors include Kirsten L. Viola, Mary P. Lambert, Grant A. Krafft, Pascale N. Lacor, Lei Chang, Pauline T. Velasco, Sérgio T. Ferreira, Caleb E. Finch, Fernanda G. De Felice and Brett A. Chromy. Their work appears in journals such as Journal of Neurochemistry, Proceedings of the National Academy of Sciences, Journal of Biological Chemistry, Alzheimer s & Dementia and Neurobiology of Aging.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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