Arthur Christopoulos

41.0k citations

367 papers · 30.0k indexed · 14 hit papers · h-index 82

Impact in

Cellular and Molecular Neuroscience top 0.02%
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
Physiology top 0.05%

Papers in

Cellular and Molecular Neuroscience 227
- Neuropeptides and Animal Physiology 163
- Neuroscience and Neuropharmacology Research 70
Physiology 34
- Adenosine and Purinergic Signaling 34

Co-authors: Patrick M. Sexton Harvey Motulsky Denise Wootten Terry Kenakin Katie Leach Céline Valant Lauren T. May P. Jeffrey Conn
Journals: Molecular Pharmacology (50 papers)Journal of Medicinal Chemistry (24 papers)Journal of Biological Chemistry (22 papers)Biochemical Pharmacology (21 papers)British Journal of Pharmacology (20 papers)
Partner nations: Australia United States United Kingdom

In The Last Decade

Arthur Christopoulos

361 papers receiving 29.4k citations

Hit Papers

14 papers align trajectories log scale

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: G protein‐coupled receptors 2019 · 639 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2019 British Journal of Pharmacology
2019 British Journal of Pharmacology
2018 Nature Reviews Molecular Cell Biology
2017 British Journal of Pharmacology
2017 Nature
2013 Nature
2012 Nature Reviews Drug Discovery
2008 Nature Reviews Drug Discovery
2006 The Annual Review of Pharmacology and Toxicology
2006 Journal of Pharmacology and Experimental Therapeutics
2004 Oxford University Press eBooks
2004 Fitting Models to Biological Data Using Linear and Nonlinear Regression
2002 Nature Reviews Drug Discovery
2002 Pharmacological Reviews

Peers

Countries citing papers authored by Arthur Christopoulos

Since Specialization

Citations

This map shows the geographic impact of Arthur Christopoulos's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Arthur Christopoulos with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Arthur Christopoulos more than expected).

Fields of papers citing papers by Arthur Christopoulos

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Arthur Christopoulos. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Arthur Christopoulos. The network helps show where Arthur Christopoulos may publish in the future.

Co-authors

The 25 scholars most cited alongside Arthur Christopoulos, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Arthur Christopoulos Line = papers co-authored together Arthur Christopoulos links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Structure–Activity Relationships of Highly Potent and Selective A _2B Adenosine Receptor Agonists Journal of Medicinal Chemistry ·Christopher J. Smedley, Jon Kyle Awalt, Thi Nguyen, Bing H. Wang, Arthur Christopoulos, Manuela Jörg, Lauren T. May, Peter J. Scammells	2025	0
2	Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein Biochemistry ·Jianjun Cao, Matthew J. Belousoff, Radostin Danev, Arthur Christopoulos, Denise Wootten, Patrick M. Sexton	2024	4
3	Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR Nature Communications ·Wessel A. C. Burger, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Yianni Laloudakis, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Céline Valant, David M. Thal	2023	24
4	The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor Journal of Medicinal Chemistry ·Owindeep Deo, Sadia Alvi, Vi Pham, Arthur Christopoulos, David M. Thal, Manuela Jörg, Ben Capuano, Céline Valant, Peter J. Scammells	2022	4
5	Structural Features of Iperoxo–BQCA Muscarinic Acetylcholine Receptor Hybrid Ligands Determining Subtype Selectivity and Efficacy ACS Chemical Neuroscience ·Matthew Charles Linford Wakeham, Briana J. Davie, David K. Chalmers, Arthur Christopoulos, Ben Capuano, Céline Valant, Peter J. Scammells	2021	5
6	Structure and dynamics of the CGRP receptor in apo and peptide-bound forms Science ·Tracy M. Josephs, Matthew J. Belousoff, Yi-Lynn Liang, Sarah Piper, Jianjun Cao, Daniel J. Garama, Katie Leach, Karen J. Gregory, Arthur Christopoulos, Debbie L. Hay, Radostin Danev, Denise Wootten, Patrick M. Sexton	2021	63
7	Acetylcholine Muscarinic M4 Receptors as a Therapeutic Target for Alcohol Use Disorder: Converging Evidence From Humans and Rodents Biological Psychiatry ·Leigh C. Walker, Alice E. Berizzi, Nicola A. Chen, Patricia Rueda, Victoria M. Perreau, Katherine Huckstep, Jirawoot Srisontiyakul, Piyarat Govitrapong, Xiaojian Jia, Craig W. Lindsley, Carrie K. Jones, Darren Riddy, Arthur Christopoulos, Christopher J. Langmead, Andrew J. Lawrence	2020	30
8	Development of Novel 4‐Arylpyridin‐2‐one and 6‐Arylpyrimidin‐4‐one Positive Allosteric Modulators of the M₁ Muscarinic Acetylcholine Receptor ChemMedChem ·Manuela Jörg, Elham Khajehali, Emma T. van der Westhuizen, Kwok Ho Christopher Choy, David M. Shackleford, Andrew B. Tobin, Patrick M. Sexton, Céline Valant, Ben Capuano, Arthur Christopoulos, Peter J. Scammells	2020	6
9	Crystal structure of the M ₅ muscarinic acetylcholine receptor Proceedings of the National Academy of Sciences ·Ziva Vuckovic, Patrick R. Gentry, Alice E. Berizzi, Kunio Hirata, Swapna Varghese, Geoff Thompson, Emma T. van der Westhuizen, Wessel A. C. Burger, Raphaël Rahmani, Céline Valant, Christopher J. Langmead, Craig W. Lindsley, Jonathan B. Baell, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos, David M. Thal	2019	53
10	Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole ACS Chemical Biology ·Carmen Klein Herenbrink, Ravi Kumar Verma, Herman D. Lim, Anitha Kopinathan, Alastair C. Keen, Jeremy Shonberg, Christopher J. Draper-Joyce, Peter J. Scammells, Arthur Christopoulos, Jonathan A. Javitch, Ben Capuano, Lei Shi, J. Robert Lane	2019	18
11	Structure-based discovery of selective positive allosteric modulators of antagonists for the M ₂ muscarinic acetylcholine receptor Proceedings of the National Academy of Sciences ·Magdalena Korczynska, Mary J. Clark, Céline Valant, Jun Xu, Ee Von Moo, Sabine Albold, Dahlia R. Weiss, Hayarpi Torosyan, Weijiao Huang, Andrew C. Kruse, Brent Lyda, Lauren T. May, Jo‐Anne Baltos, Patrick M. Sexton, Brian K. Kobilka, Arthur Christopoulos, Brian K. Shoichet, Roger K. Sunahara	2018	54
12	Muscarinic M5 receptors modulate ethanol seeking in rats Neuropsychopharmacology ·Alice E. Berizzi, Christina J. Perry, David M. Shackleford, Craig W. Lindsley, Carrie K. Jones, Nicola A. Chen, Patrick M. Sexton, Arthur Christopoulos, Christopher J. Langmead, Andrew J. Lawrence	2018	31
13	Structure-Based Design and Discovery of New M₂Receptor Agonists Journal of Medicinal Chemistry ·I. Fish, Anne Stößel, Katrin Eitel, Céline Valant, Sabine Albold, Harald Huebner, Dorothée Möller, Mary J. Clark, Roger K. Sunahara, Arthur Christopoulos, Brian K. Shoichet, Peter Gmeiner	2017	21
14	Microglial activation and progressive brain changes in schizophrenia British Journal of Pharmacology ·Liliana Laskaris, Maria A. Di Biase, Ian Everall, Gursharan Chana, Arthur Christopoulos, Efstratios Skafidas, Vanessa Cropley, Christos Pantelis	2015	173
15	Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics British Journal of Pharmacology ·Anne Cook, Shailesh N. Mistry, Karen J. Gregory, Sebastian G. B. Furness, Patrick M. Sexton, Peter J. Scammells, Arthur D. Conigrave, Arthur Christopoulos, Katie Leach	2014	67
16	Structure–Activity Relationships of Privileged Structures Lead to the Discovery of Novel Biased Ligands at the Dopamine D ₂ Receptor Journal of Medicinal Chemistry ·Mónika Szabó, Carmen Klein Herenbrink, Arthur Christopoulos, J. Robert Lane, Ben Capuano	2014	61
17	Emerging paradigms in GPCR allostery: implications for drug discovery Nature Reviews Drug Discovery ·Denise Wootten, Arthur Christopoulos, Patrick M. Sexton	2013	375
18	Allosteric modulation of the muscarinic M ₄ receptor as an approach to treating schizophrenia Proceedings of the National Academy of Sciences ·Wai‐Yee Chan, David L. McKinzie, Suchira Bose, S.N. Mitchell, Jeffrey M. Witkin, R. C. Thompson, Arthur Christopoulos, Sebastian Lazareno, N.J.M. Birdsall, Frank P. Bymaster, Christian C. Felder	2008	170
19	Involvement of the sigma₁(σ₁) receptor in the anti‐amnesic, but not antidepressant‐like, effects of the aminotetrahydrofuran derivative ANAVEX1‐41 British Journal of Pharmacology ·Julie Espallergues, P Lapalud, Arthur Christopoulos, Vimesh A. Avlani, Patrick M. Sexton, A Vamvakidès, Tangui Maurice	2007	26
20	Effective GPCR screening using ERK 1/2: applying SureFire to detect ERK 1/2 phosphorylation Ronald W Osmond, Anthony R Dyer, Patrick M. Sexton, Arthur Christopoulos, Michael F. Crouch	2006	1

About Arthur Christopoulos

Arthur Christopoulos is a scholar working on Cellular and Molecular Neuroscience, Physiology, Molecular Biology, Endocrinology, Diabetes and Metabolism and Computational Theory and Mathematics, having authored 367 papers that have together received 30.0k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (309 papers), Neuropeptides and Animal Physiology (163 papers), Neuroscience and Neuropharmacology Research (70 papers), Ion channel regulation and function (35 papers), Adenosine and Purinergic Signaling (34 papers), Pharmacological Receptor Mechanisms and Effects (32 papers), Diabetes Treatment and Management (31 papers) and Protein Kinase Regulation and GTPase Signaling (30 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (14.5k citations), Physiology (1.5k citations), Molecular Biology (21.8k citations), Computational Theory and Mathematics (2.6k citations) and Endocrinology, Diabetes and Metabolism (2.4k citations). Arthur Christopoulos has collaborated with scholars based in Australia, United States and United Kingdom. Frequent co-authors include Patrick M. Sexton, Harvey Motulsky, Denise Wootten, Terry Kenakin, Katie Leach, Céline Valant, Lauren T. May, P. Jeffrey Conn, Craig W. Lindsley and J. Robert Lane. Their work appears in journals such as Molecular Pharmacology, Journal of Medicinal Chemistry, Journal of Biological Chemistry, Biochemical Pharmacology and British Journal of Pharmacology.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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