Patrick M. Sexton

30.6k total citations · 6 hit papers
351 papers, 22.4k citations indexed

About

Patrick M. Sexton is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Endocrinology, Diabetes and Metabolism. According to data from OpenAlex, Patrick M. Sexton has authored 351 papers receiving a total of 22.4k indexed citations (citations by other indexed papers that have themselves been cited), including 313 papers in Molecular Biology, 242 papers in Cellular and Molecular Neuroscience and 71 papers in Endocrinology, Diabetes and Metabolism. Recurrent topics in Patrick M. Sexton's work include Receptor Mechanisms and Signaling (281 papers), Neuropeptides and Animal Physiology (211 papers) and Diabetes Treatment and Management (53 papers). Patrick M. Sexton is often cited by papers focused on Receptor Mechanisms and Signaling (281 papers), Neuropeptides and Animal Physiology (211 papers) and Diabetes Treatment and Management (53 papers). Patrick M. Sexton collaborates with scholars based in Australia, United States and United Kingdom. Patrick M. Sexton's co-authors include Arthur Christopoulos, Denise Wootten, Katie Leach, Céline Valant, Lauren T. May, Laurence J. Miller, George Christopoulos, J. Robert Lane, Debbie L. Hay and Peter J. Scammells and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Patrick M. Sexton

347 papers receiving 22.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

2006 883 citations Brian K. Kobilka, Bryan L. Roth et al. profile →
Activation and allosteric modulation of a muscarinic acetylcholine receptor

2013 712 citations Andrew C. Kruse, Céline Valant et al. profile →
Allosteric Modulation of G Protein–Coupled Receptors

2006 566 citations Lauren T. May, Katie Leach et al. profile →
Mechanisms of signalling and biased agonism in G protein-coupled receptors

2018 490 citations Denise Wootten, Arthur Christopoulos et al. profile →
Phase-plate cryo-EM structure of a class B GPCR–G-protein complex

2017 362 citations Maryam Khoshouei, Alisa Glukhova et al. profile →
Glucagon-Like Peptide-1 and Its Class B G Protein–Coupled Receptors: A Long March to Therapeutic Successes

2016 288 citations Denise Wootten, Patrick M. Sexton et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Patrick M. Sexton Australia	77	17.4k	12.2k	3.2k	1.8k	1.7k	351	22.4k
Graeme Milligan United Kingdom	85	21.1k 1.2×	11.8k 1.0×	2.2k 0.7×	2.4k 1.4×	693 0.4×	555	27.7k
Michel Bouvier Canada	94	22.4k 1.3×	13.1k 1.1×	1.5k 0.5×	2.7k 1.5×	1.2k 0.7×	483	30.2k
Martin J. Lohse Germany	91	22.2k 1.3×	10.9k 0.9×	1.3k 0.4×	1.4k 0.8×	669 0.4×	355	29.4k
Jürgen Wess United States	78	14.9k 0.9×	10.6k 0.9×	980 0.3×	1.6k 0.9×	656 0.4×	309	20.8k
Jeffrey Benovic United States	94	23.8k 1.4×	13.5k 1.1×	919 0.3×	1.0k 0.6×	1.0k 0.6×	290	28.8k
Jonathan A. Javitch United States	90	16.9k 1.0×	15.0k 1.2×	551 0.2×	793 0.4×	1.2k 0.7×	272	24.7k
Terry Kenakin United States	57	10.0k 0.6×	6.6k 0.5×	685 0.2×	693 0.4×	1.4k 0.9×	205	12.9k
Laurence J. Miller United States	59	8.7k 0.5×	6.4k 0.5×	2.3k 0.7×	2.7k 1.5×	323 0.2×	329	13.1k
Roger K. Sunahara United States	59	15.7k 0.9×	10.2k 0.8×	518 0.2×	644 0.4×	1.0k 0.6×	132	20.2k
William M. Pardridge United States	103	17.2k 1.0×	6.3k 0.5×	2.2k 0.7×	1.2k 0.7×	720 0.4×	495	40.4k

Countries citing papers authored by Patrick M. Sexton

Since Specialization

Citations

This map shows the geographic impact of Patrick M. Sexton's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick M. Sexton with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick M. Sexton more than expected).

Fields of papers citing papers by Patrick M. Sexton

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick M. Sexton. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick M. Sexton. The network helps show where Patrick M. Sexton may publish in the future.

Co-authorship network of co-authors of Patrick M. Sexton

This figure shows the co-authorship network connecting the top 25 collaborators of Patrick M. Sexton. A scholar is included among the top collaborators of Patrick M. Sexton based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Patrick M. Sexton. Patrick M. Sexton is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Lu, Jessica Bo Li, Giuseppe Deganutti, Miaomiao Li, et al.. (2025). Structural basis of modified ligand selectivity from N-terminal PAC1R alternative splicing. Proceedings of the National Academy of Sciences. 122(47). e2521157122–e2521157122.

Cao, Jianjun, Matthew J. Belousoff, Rachel M. Johnson, et al.. (2025). Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors. Nature Communications. 16(1). 3389–3389. 3 indexed citations

Zhang, Xin, Fabian Bumbak, Tracy M. Josephs, et al.. (2024). Lipid-Dependent Activation of the Orphan G Protein-Coupled Receptor, GPR3. Biochemistry. 63(5). 625–631. 12 indexed citations

Deganutti, Giuseppe, Yi-Lynn Liang, Xin Zhang, et al.. (2022). Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation. Nature Communications. 13(1). 92–92. 49 indexed citations

Cao, Jianjun, Matthew J. Belousoff, Yi-Lynn Liang, et al.. (2022). A structural basis for amylin receptor phenotype. Science. 375(6587). eabm9609–eabm9609. 53 indexed citations

Zhao, Peishen, Tin T. Truong, Jon Merlin, Patrick M. Sexton, & Denise Wootten. (2022). Implications of ligand-receptor binding kinetics on GLP-1R signalling. Biochemical Pharmacology. 199. 114985–114985. 15 indexed citations

Mobbs, Jesse I., Matthew J. Belousoff, Kaleeckal G. Harikumar, et al.. (2021). Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity. PLoS Biology. 19(6). e3001295–e3001295. 47 indexed citations

Dong, Maoqing, Kaleeckal G. Harikumar, Carolyn E. Clark, et al.. (2020). Rational development of a high-affinity secretin receptor antagonist. Biochemical Pharmacology. 177. 113929–113929. 9 indexed citations

Ramírez-Aportela, Erney, José Luis Vilas, Alisa Glukhova, et al.. (2019). Automatic local resolution-based sharpening of cryo-EM maps. Bioinformatics. 36(3). 765–772. 91 indexed citations

10.

Vuckovic, Ziva, Patrick R. Gentry, Kunio Hirata, et al.. (2019). Crystal structure of the M ₅ muscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences. 116(51). 26001–26007. 53 indexed citations

11.

Korczynska, Magdalena, Mary J. Clark, Céline Valant, et al.. (2018). Structure-based discovery of selective positive allosteric modulators of antagonists for the M ₂ muscarinic acetylcholine receptor. Proceedings of the National Academy of Sciences. 115(10). E2419–E2428. 54 indexed citations

12.

Jörg, Manuela, Alisa Glukhova, Elizabeth A. Vecchio, et al.. (2016). Novel Irreversible Agonists Acting at the A₁Adenosine Receptor. Journal of Medicinal Chemistry. 59(24). 11182–11194. 18 indexed citations

13.

Malone, Daniel T., et al.. (2014). Detection and Quantification of Allosteric Modulation of Endogenous M4 Muscarinic Acetylcholine Receptor Using Impedance-Based Label-Free Technology in a Neuronal Cell Line. SLAS DISCOVERY. 20(5). 646–654. 7 indexed citations

14.

Cook, Anne, Shailesh N. Mistry, Karen J. Gregory, et al.. (2014). Biased allosteric modulation at the CaS receptor engendered by structurally diverse calcimimetics. British Journal of Pharmacology. 172(1). 185–200. 67 indexed citations

15.

Dong, Maoqing, Cassandra Koole, Denise Wootten, Patrick M. Sexton, & L J Miller. (2013). Structural and functional insights into the juxtamembranous amino‐terminal tail and extracellular loop regions of class B GPCRs. British Journal of Pharmacology. 171(5). 1085–1101. 18 indexed citations

16.

Willard, Francis S., Denise Wootten, Aaron D. Showalter, et al.. (2012). Small Molecule Allosteric Modulation of the Glucagon-Like Peptide-1 Receptor Enhances the Insulinotropic Effect of Oxyntomodulin. Molecular Pharmacology. 82(6). 1066–1073. 44 indexed citations

17.

Canals, Meritxell, et al.. (2011). A Monod-Wyman-Changeux Mechanism Can Explain G Protein-coupled Receptor (GPCR) Allosteric Modulation. Journal of Biological Chemistry. 287(1). 650–659. 94 indexed citations

18.

Nawaratne, Vindhya, Katie Leach, Richard Loiacono, et al.. (2008). New Insights into the Function of M4 Muscarinic Acetylcholine Receptors Gained Using a Novel Allosteric Modulator and a DREADD (Designer Receptor Exclusively Activated by a Designer Drug). Molecular Pharmacology. 74(4). 1119–1131. 90 indexed citations

19.

Espallergues, Julie, Arthur Christopoulos, Vimesh A. Avlani, et al.. (2007). Involvement of the sigma₁(σ₁) receptor in the anti‐amnesic, but not antidepressant‐like, effects of the aminotetrahydrofuran derivative ANAVEX1‐41. British Journal of Pharmacology. 152(2). 267–279. 26 indexed citations

20.

Sexton, Patrick M., et al.. (2006). Effective GPCR screening using ERK 1/2: applying SureFire to detect ERK 1/2 phosphorylation. 26(1). 27–28. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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