David M. Thal

4.6k citations

41 papers · 2.5k indexed · 1 hit paper · h-index 22

Impact in

Cellular and Molecular Neuroscience top 2%
- Neuropeptides and Animal Physiology
- Neuroscience and Neuropharmacology Research
Structural Biology top 2%

Papers in

Cellular and Molecular Neuroscience 18
- Neuropeptides and Animal Physiology 16
- Neuroscience and Neuropharmacology Research 4
Physiology 4
- Adenosine and Purinergic Signaling 4

Co-authors: Arthur Christopoulos Patrick M. Sexton Alisa Glukhova Denise Wootten Radostin Danev J.J.G. Tesmer Sebastian G. B. Furness Maryam Khoshouei
Journals: Nature (5 papers)Nature Communications (4 papers)Journal of Biological Chemistry (4 papers)ACS Chemical Neuroscience (3 papers)Science Advances (2 papers)
Partner nations: Australia United States United Kingdom

In The Last Decade

David M. Thal

37 papers receiving 2.5k citations

Hit Papers

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Phase-plate cryo-EM structure of a class B GPCR–G-protein complex 2017 · 362 citations

Peers

Countries citing papers authored by David M. Thal

Since Specialization

Citations

This map shows the geographic impact of David M. Thal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by David M. Thal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites David M. Thal more than expected).

Fields of papers citing papers by David M. Thal

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by David M. Thal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by David M. Thal. The network helps show where David M. Thal may publish in the future.

Co-authors

The 25 scholars most cited alongside David M. Thal, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with David M. Thal Line = papers co-authored together David M. Thal links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A Structure–Activity Relationship Study of Novel Positive Allosteric Modulators for the δ-Opioid Receptor ACS Chemical Neuroscience ·Alexis VRIGNON, Vi Pham, Hepeng Ye, Nicholas M. Barnes, Arisbel B. Gondin, Arthur Christopoulos, Daniel P. Poole, Simona Carbone, David M. Thal, Manuela Jörg, Ben Capuano, Céline Valant, Peter J. Scammells	2025	1
2	Molecular basis of ligand binding and receptor activation at the human A3 adenosine receptor Nature Communications ·Liudi Zhang, Jesse I. Mobbs, Rizwana Begum, Hariprasad Venugopal, Thi Nguyen, Arthur Christopoulos, Daan van der Es, Laura H. Heitman, Lauren T. May, Alisa Glukhova, David M. Thal	2025	0
3	High-resolution cryo-EM using a common LaB ₆ 120-keV electron microscope equipped with a sub–200-keV direct electron detector Science Advances ·Hariprasad Venugopal, Jesse I. Mobbs, Cyntia Taveneau, Daniel Fox, Ziva Vuckovic, Sahil Gulati, Gavin J. Knott, Rhys Grinter, David M. Thal, Sunjida Amin Promi, Cory Czarnik, Georg Ramm	2025	0
4	Structural insights into the human P2X1 receptor and ligand interactions Nature Communications ·Rizwana Begum, Hariprasad Venugopal, Alisa Glukhova, Jesse I. Mobbs, Sabatino Ventura, David M. Thal	2024	3
5	Ligand bias at the muscarinic acetylcholine receptor family: Opportunities and challenges Neuropharmacology ·J. Janssen, David M. Thal, Arthur Christopoulos, Céline Valant	2024	7
6	Positive allosteric modulation of a GPCR ternary complex Science Advances ·尚子佐々木, Christopher J. Draper-Joyce, Céline Valant, Arthur Christopoulos, David M. Thal	2024	2
7	Cryo-EM structures of human arachidonate 12S-lipoxygenase bound to endogenous and exogenous inhibitors Blood ·Jesse I. Mobbs, Gregory Bernstein, Greifswald Mach, 尚子佐々木, Hariprasad Venugopal, Theodore R. Holman, Michael Holinstat, David M. Thal, Alisa Glukhova	2023	11
8	Xanomeline displays concomitant orthosteric and allosteric binding modes at the M4 mAChR Nature Communications ·尚子佐々木, Vi Pham, Ziva Vuckovic, Alexander S. Powers, Jesse I. Mobbs, Fabien Bernard Roman Zablocki, Alisa Glukhova, Denise Wootten, Andrew B. Tobin, Patrick M. Sexton, Steven M. Paul, Christian C. Felder, Radostin Danev, Ron O. Dror, Arthur Christopoulos, Céline Valant, David M. Thal	2023	24
9	Design, synthesis and evaluation of novel 2-phenyl-3-(1H-pyrazol-4-yl)pyridine positive allosteric modulators for the M4 mAChR European Journal of Medicinal Chemistry ·Manuela Jörg, Emma T. van der Westhuizen, Yao Lu, Kwok Ho Christopher Choy, David M. Shackleford, Elham Khajehali, Andrew B. Tobin, David M. Thal, Ben Capuano, Arthur Christopoulos, Céline Valant, Peter J. Scammells	2023	0
10	Role of Conserved Tyrosine Lid Residues in the Activation of the M2 Muscarinic Acetylcholine Receptor Molecular Pharmacology ·Vi Pham, Patrik Oleksak, Geoff Thompson, Laura H. Heitman, Arthur Christopoulos, David M. Thal, Céline Valant	2023	4
11	The impact of cryo-EM on determining allosteric modulator-bound structures of G protein-coupled receptors Current Opinion in Structural Biology ·Liudi Zhang, Jesse I. Mobbs, Lauren T. May, Alisa Glukhova, David M. Thal	2023	20
12	Structural basis of efficacy-driven ligand selectivity at GPCRs Nature Chemical Biology ·Alexander S. Powers, Vi Pham, 尚子佐々木, Geoff Thompson, Fabien Bernard Roman Zablocki, Tcm Hniversity, Patrick M. Sexton, Steven M. Paul, Arthur Christopoulos, David M. Thal, Christian C. Felder, Céline Valant, Ron O. Dror	2023	28
13	The Design, Synthesis, and Evaluation of Novel 9-Arylxanthenedione-Based Allosteric Modulators for the δ-Opioid Receptor Journal of Medicinal Chemistry ·Alexis VRIGNON, Hepeng Ye, Vi Pham, Arthur Christopoulos, David M. Thal, Manuela Jörg, Ben Capuano, Céline Valant, Peter J. Scammells	2022	4
14	The P2X1 receptor as a therapeutic target Purinergic Signalling ·Rizwana Begum, Jesse I. Mobbs, Sabatino Ventura, David M. Thal	2022	14
15	Structures of the human cholecystokinin 1 (CCK1) receptor bound to Gs and Gq mimetic proteins provide insight into mechanisms of G protein selectivity PLoS Biology ·Jesse I. Mobbs, Matthew J. Belousoff, Kaleeckal G. Harikumar, Sarah Piper, Thomas W. Anderson, Sebastian G. B. Furness, Hariprasad Venugopal, Arthur Christopoulos, Radostin Danev, Denise Wootten, David M. Thal, Laurence J. Miller, Patrick M. Sexton	2021	47
16	Crystal structure of the M ₅ muscarinic acetylcholine receptor Proceedings of the National Academy of Sciences ·Ziva Vuckovic, Patrick R. Gentry, P. Kordus, Kunio Hirata, Swapna Varghese, Geoff Thompson, Emma T. van der Westhuizen, 尚子佐々木, Raphaël Rahmani, Céline Valant, Christopher J. Langmead, Craig W. Lindsley, Jonathan B. Baell, Andrew B. Tobin, Patrick M. Sexton, Arthur Christopoulos, David M. Thal	2019	53
17	The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions Scientific Reports ·Christopher J. Draper-Joyce, Ravi Kumar Verma, Mayako Michino, Jeremy Shonberg, C. J. H. van den Bosch, Carmen Klein Herenbrink, Peter J. Scammells, Ben Capuano, Ara M. Abramyan, David M. Thal, Jonathan A. Javitch, Arthur Christopoulos, Lei Shi, J. Robert Lane	2018	17
18	Structural insights into G-protein-coupled receptor allostery Nature ·David M. Thal, Alisa Glukhova, Patrick M. Sexton, Arthur Christopoulos	2018	235
19	Phase-plate cryo-EM structure of a class B GPCR–G-protein complex Nature ·Yi-Lynn Liang, Maryam Khoshouei, Mazdak Radjainia, Yan Zhang, Alisa Glukhova, Jeffrey Tarrasch, David M. Thal, Sebastian G. B. Furness, George Christopoulos, Thomas Coudrat, Radostin Danev, Wolfgang Baumeister, Laurence J. Miller, Arthur Christopoulos, Brian K. Kobilka, Denise Wootten, Georgios Skiniotis, Patrick M. Sexton Hit paper breakdown →	2017	362
20	Crystal structures of the M1 and M4 muscarinic acetylcholine receptors Nature ·David M. Thal, Bingfa Sun, Dan Feng, Vindhya Nawaratne, Katie Leach, Christian C. Felder, Mark G. Bures, David A. Evans, William I. Weis, Olabisi Aluko, Tong Sun Kobilka, Patrick M. Sexton, Brian K. Kobilka, Arthur Christopoulos	2016	264

About David M. Thal

David M. Thal is a scholar working on Cellular and Molecular Neuroscience, Physiology, Structural Biology, Molecular Biology and Spectroscopy, having authored 41 papers that have together received 2.5k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (33 papers), Neuropeptides and Animal Physiology (16 papers), Monoclonal and Polyclonal Antibodies Research (8 papers), Protein Kinase Regulation and GTPase Signaling (7 papers), Mass Spectrometry Techniques and Applications (6 papers), Pharmacological Receptor Mechanisms and Effects (5 papers), Neuroscience and Neuropharmacology Research (4 papers) and Adenosine and Purinergic Signaling (4 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (1.1k citations), Structural Biology (83 citations), Physiology (243 citations), Molecular Biology (2.2k citations) and Computational Theory and Mathematics (250 citations). David M. Thal has collaborated with scholars based in Australia, United States and United Kingdom. Frequent co-authors include Arthur Christopoulos, Patrick M. Sexton, Alisa Glukhova, Denise Wootten, Radostin Danev, J.J.G. Tesmer, Sebastian G. B. Furness, Maryam Khoshouei, Wolfgang Baumeister and Yi-Lynn Liang. Their work appears in journals such as Nature, Nature Communications, Journal of Biological Chemistry, ACS Chemical Neuroscience and Science Advances.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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