Bryan L. Roth

82.9k total citations · 30 hit papers
503 papers, 50.5k citations indexed

About

Bryan L. Roth is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Organic Chemistry. According to data from OpenAlex, Bryan L. Roth has authored 503 papers receiving a total of 50.5k indexed citations (citations by other indexed papers that have themselves been cited), including 378 papers in Molecular Biology, 323 papers in Cellular and Molecular Neuroscience and 64 papers in Organic Chemistry. Recurrent topics in Bryan L. Roth's work include Receptor Mechanisms and Signaling (308 papers), Neurotransmitter Receptor Influence on Behavior (145 papers) and Neuropeptides and Animal Physiology (140 papers). Bryan L. Roth is often cited by papers focused on Receptor Mechanisms and Signaling (308 papers), Neurotransmitter Receptor Influence on Behavior (145 papers) and Neuropeptides and Animal Physiology (140 papers). Bryan L. Roth collaborates with scholars based in United States, China and Canada. Bryan L. Roth's co-authors include Wesley K. Kroeze, J.A. Gray, Xi‐Ping Huang, Brian K. Shoichet, Blaine N. Armbruster, Douglas J. Sheffler, Vincent Setola, John J. Irwin, Miles Berger and Herbert Y. Meltzer and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Bryan L. Roth

483 papers receiving 49.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Relating protein pharmacology by ligand chemistry

2007 1.6k citations Bryan L. Roth, Blaine N. Armbruster et al. profile →
Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand

2007 1.5k citations Blaine N. Armbruster, Xiang Li et al. Proceedings of the National Academy of Sciences profile →
The Expanded Biology of Serotonin

2009 1.5k citations Bryan L. Roth et al. profile →
Predicting new molecular targets for known drugs

2009 1.3k citations Vincent Setola, John J. Irwin et al. profile →
Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression∗∗See accompanying Editorial, in this issue.

1999 1.2k citations Bryan L. Roth et al. profile →
Rapid, reversible activation of AgRP neurons drives feeding behavior in mice

2011 1.1k citations Bryan L. Roth et al. profile →
DREADDs for Neuroscientists

2016 1.1k citations Bryan L. Roth profile →
Magic shotguns versus magic bullets: selectively non-selective drugs for mood disorders and schizophrenia

2004 893 citations Bryan L. Roth, Wesley K. Kroeze et al. profile →
Functional Selectivity and Classical Concepts of Quantitative Pharmacology

2006 883 citations Jonathan A. Javitch, Bryan L. Roth et al. profile →
Aripiprazole, A Novel Atypical Antipsychotic Drug with a Unique and Robust Pharmacology

2003 771 citations Bryan L. Roth et al. profile →
Structure of the human κ-opioid receptor in complex with JDTic

2012 718 citations Daniel Wacker, Vsevolod Katritch et al. profile →
Remote Control of Neuronal Activity in Transgenic Mice Expressing Evolved G Protein-Coupled Receptors

2009 713 citations Blaine N. Armbruster, John Allen et al. profile →
Structure-based discovery of opioid analgesics with reduced side effects

2016 697 citations John D. McCorvy, Xi‐Ping Huang et al. profile →
Parkin-deficient Mice Exhibit Nigrostriatal Deficits but Not Loss of Dopaminergic Neurons

2003 686 citations Anushree Bhatnagar, Bryan L. Roth et al. profile →
H1-Histamine Receptor Affinity Predicts Short-Term Weight Gain for Typical and Atypical Antipsychotic Drugs

2003 637 citations Wesley K. Kroeze, Bryan L. Roth et al. profile →
Salvinorin A: A potent naturally occurring nonnitrogenous κ opioid selective agonist

2002 621 citations Bryan L. Roth, Kenner C. Rice et al. Proceedings of the National Academy of Sciences profile →
Ultra-large library docking for discovering new chemotypes

2019 619 citations Tao Che, Brian K. Shoichet et al. profile →
Structural Features for Functional Selectivity at Serotonin Receptors

2013 543 citations Daniel Wacker, Chong Wang et al. Science profile →
Evidence for Possible Involvement of 5-HT_2BReceptors in the Cardiac Valvulopathy Associated With Fenfluramine and Other Serotonergic Medications

2000 541 citations Michael H. Baumann, Bryan L. Roth et al. profile →
PRESTO-Tango as an open-source resource for interrogation of the druggable human GPCRome

2015 519 citations Wesley K. Kroeze, Maria F. Sassano et al. profile →
DREADDs (Designer Receptors Exclusively Activated by Designer Drugs): Chemogenetic Tools with Therapeutic Utility

2014 478 citations Daniel J. Urban, Bryan L. Roth profile →
Endocrine Regulation of Male Fertility by the Skeleton

2011 466 citations Bryan L. Roth et al. profile →
How Ligands Illuminate GPCR Molecular Pharmacology

2017 400 citations Daniel Wacker, Raymond C. Stevens et al. profile →
TRUPATH, an open-source biosensor platform for interrogating the GPCR transducerome

2020 339 citations Reid H. J. Olsen, Jeffrey F. DiBerto et al. profile →
Structure of the D2 dopamine receptor bound to the atypical antipsychotic drug risperidone

2018 331 citations Tao Che, Brian K. Shoichet et al. profile →
Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

2020 306 citations Tao Che, Jeffrey F. DiBerto et al. profile →
Synthon-based ligand discovery in virtual libraries of over 11 billion compounds

2021 254 citations Yongfeng Liu, Xi‐Ping Huang et al. profile →
The neural basis of psychedelic action

2022 163 citations Bryan L. Roth et al. profile →
The promises and perils of psychedelic pharmacology for psychiatry

2022 131 citations Bryan L. Roth et al. profile →
Structures of the entire human opioid receptor family

2023 106 citations Jeffrey F. DiBerto, Gavin P. Schmitz et al. profile →

Peers

Countries citing papers authored by Bryan L. Roth

Since Specialization

Citations

This map shows the geographic impact of Bryan L. Roth's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bryan L. Roth with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bryan L. Roth more than expected).

Fields of papers citing papers by Bryan L. Roth

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bryan L. Roth. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bryan L. Roth. The network helps show where Bryan L. Roth may publish in the future.

Co-authorship network of co-authors of Bryan L. Roth

This figure shows the co-authorship network connecting the top 25 collaborators of Bryan L. Roth. A scholar is included among the top collaborators of Bryan L. Roth based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bryan L. Roth. Bryan L. Roth is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Chemogenetics for sensing antigens 2025 ·Cell Research ·(unknown), Bryan L. Roth	0
2	Psychedelic compounds directly excite 5-HT2A layer V medial prefrontal cortex neurons through 5-HT2A Gq activation 2025 ·Translational Psychiatry ·Gavin P. Schmitz, (unknown), (unknown), (unknown), (unknown), Gabriele M. König, Evi Kostenis, (unknown), (unknown), Bryan L. Roth, Melissa A. Herman	0
3	Molecular glues as potential GPCR therapeutics 2024 ·Biochemical Pharmacology ·Bryan L. Roth, B. Krumm	7
4	Structural insights into angiotensin receptor signaling modulation by balanced and biased agonists 2023 ·The EMBO Journal ·(unknown), Yongfeng Liu, Saheem A. Zaidi, Lingyi Xu, (unknown), Anqi Chen, Jiangtao Guo, Xi‐Ping Huang, Bryan L. Roth, Vsevolod Katritch, Vadim Cherezov, Haitao Zhang	24
5	Catalytic site mutations confer multiple states of G protein activation 2023 ·Science Signaling ·(unknown), Ning Ma, Nadia Arang, (unknown), Ajit Prakash, Jeffrey F. DiBerto, (unknown), Soumadwip Ghosh, Reid H. J. Olsen, Bryan L. Roth, J. Silvio Gutkind, Nagarajan Vaidehi, Sharon L. Campbell, Henrik Dohlman	11
6	Community guidelines for GPCR ligand bias: IUPHAR review 32 2022 ·British Journal of Pharmacology ·Peter Kolb, Terry Kenakin, S P H Alexander, Marcel Bermúdez, Laura Bohn, (unknown), Michel Bouvier, Stephen J. Hill, Evi Kostenis, Kirill A. Martemyanov, (unknown), H. Ongun Onaran, Sudarshan Rajagopal, Bryan L. Roth, Jana Selent, Arun K. Shukla, M. Sommer, David E. Gloriam	121
7	Molecular insights into the regulation of constitutive activity by RNA editing of 5HT2C serotonin receptors 2022 ·Cell Reports ·Ryan H. Gumpper, Jonathan F. Fay, Bryan L. Roth	35
8	Structure-based discovery of potent and selective melatonin receptor agonists 2020 ·eLife ·Nilkanth Patel, Xi‐Ping Huang, Jessica M. Grandner, Linda C. Johansson, Benjamin Stauch, John D. McCorvy, Yongfeng Liu, Bryan L. Roth, Vsevolod Katritch	25
9	Fentanyl-related designer drugs W-18 and W-15 lack appreciable opioid activity in vitro and in vivo 2017 ·JCI Insight ·Xi‐Ping Huang, Tao Che, Thomas J. Mangano, Valerie Le Rouzic, Ying‐Xian Pan, Michael D. Cameron, Michael H. Baumann, Gavril W. Pasternak, Bryan L. Roth	17
10	Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation 2016 ·Proceedings of the National Academy of Sciences ·Peter M. Grace, Keith A. Strand, Erika L. Galer, Daniel J. Urban, Xiaohui Wang, Michael V. Baratta, Timothy Fabisiak, Nathan D. Anderson, Kejun Cheng, Lisa I. Greene, Debra Berkelhammer, Yingning Zhang, Amanda Ellis, Hang Yin, Serge Campeau, Kenner C. Rice, Bryan L. Roth, Steven F. Maier, Linda R. Watkins	299
11	Structural Features for Functional Selectivity at Serotonin Receptors breakdown → 2013 ·Science ·Daniel Wacker, Chong Wang, Vsevolod Katritch, Gye Won Han, Xi‐Ping Huang, Eyal Vardy, John D. McCorvy, Yi Jiang, Meihua Chu, Fai Siu, Wei Liu, H. Eric Xu, Vadim Cherezov, Bryan L. Roth, Raymond C. Stevens	543
12	Identifying mechanism-of-action targets for drugs and probes 2012 ·Proceedings of the National Academy of Sciences ·Elisabet Gregori‐Puigjané, Vincent Setola, Jérôme Hert, (unknown), John J. Irwin, Eugen Lounkine, Lawrence J. Marnett, Bryan L. Roth, Brian K. Shoichet	134
13	Generation of a Synthetic Memory Trace 2012 ·Science ·Aleena R. Garner, David C Rowland, (unknown), Karsten Baumgaertel, Bryan L. Roth, Clifford G. Kentros, Mark Mayford	288
14	Discovery of β-Arrestin–Biased Dopamine D ₂ Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy 2011 ·Proceedings of the National Academy of Sciences ·John Allen, Julianne M. Yost, Vincent Setola, Xin Chen, Maria F. Sassano, Meng Chen, Sean M. Peterson, Prem N. Yadav, Xi‐Ping Huang, Bo Feng, Niels Jensen, Xin Che, Xu Bai, Stephen V. Frye, William C. Wetsel, Marc G. Caron, Jonathan A. Javitch, Bryan L. Roth, Jian Jin	281
15	Identification of Human Ether-à-go-go Related Gene Modulators by Three Screening Platforms in an Academic Drug-Discovery Setting 2010 ·Assay and Drug Development Technologies ·Xi‐Ping Huang, Thomas J. Mangano, Sandy Hufeisen, Vincent Setola, Bryan L. Roth	58
16	A chemical-genetic approach for precise spatio-temporal control of cellular signaling 2010 ·Molecular BioSystems ·Shuyun Dong, John Allen, Martilias S. Farrell, Bryan L. Roth	43
17	A chemical-genetic approach to study G protein regulation of β cell function in vivo 2009 ·Proceedings of the National Academy of Sciences ·(unknown), Dinesh Gautam, Marco Scarselli, Iñigo Ruı́z de Azúa, Jian Hua Li, Erica Rosemond, Xiaochao Ma, Frank J. Gonzalez, Blaine N. Armbruster, Huiyan Lü, Bryan L. Roth, Jürgen Wess	256
18	Evolving the lock to fit the key to create a family of G protein-coupled receptors potently activated by an inert ligand breakdown → 2007 ·Proceedings of the National Academy of Sciences ·Blaine N. Armbruster, Xiang Li, Mark H. Pausch, Stefan Herlitze, Bryan L. Roth	1467
19	The Serotonin Receptors 2006 ·Digital Access to Libraries (Université catholique de Louvain (UCL), l'Université de Namur (UNamur) and the Université Saint-Louis (USL-B)) ·Bryan L. Roth, (unknown)	32
20	The Human Polyomavirus, JCV, Uses Serotonin Receptors to Infect Cells 2004 ·Science ·Gwendolyn F. Elphick, William Querbes, (unknown), Gretchen V. Gee, Sylvia Eash, Kate Manley, Aisling S. Dugan, Megan L. Stanifer, Anushree Bhatnagar, Wesley K. Kroeze, Bryan L. Roth, Walter J. Atwood	331

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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