Vincent B. Luscombe

583 citations

30 papers · 363 · h-index 12

Impact in

Cellular and Molecular Neuroscience top 10%
- Neuroscience and Neuropharmacology Research
- Neuropeptides and Animal Physiology
Molecular Biology
- Receptor Mechanisms and Signaling
- Nicotinic Acetylcholine Receptors Study
- Chemical Synthesis and Analysis
- Pharmacological Receptor Mechanisms and Effects
- Phosphodiesterase function and regulation

Papers in

Molecular Biology 28
- Receptor Mechanisms and Signaling 23
- Pharmacological Receptor Mechanisms and Effects 12
- Nicotinic Acetylcholine Receptors Study 6
- Chemical Synthesis and Analysis 4
- Ion channel regulation and function 3
Cellular and Molecular Neuroscience 15
- Neuroscience and Neuropharmacology Research 13
- Neuropeptides and Animal Physiology 3

Co-authors: Colleen M. Niswender (24 shared papers)Craig W. Lindsley (25 shared papers)P. Jeffrey Conn (25 shared papers)Darren W. Engers (19 shared papers)Alice L. Rodriguez (19 shared papers)Sichen Chang (15 shared papers)Angela J. Russell (4 shared papers)David R. Greaves (4 shared papers)
Journals: Bioorganic & Medicinal Chemistry Letters (12 papers)ACS Chemical Neuroscience (5 papers)Journal of Medicinal Chemistry (4 papers)ACS Medicinal Chemistry Letters (4 papers)ACS Omega (1 paper)
Partner nations: United States United Kingdom Australia

In The Last Decade

Vincent B. Luscombe

30 papers receiving 360 citations

Peers

Countries citing papers authored by Vincent B. Luscombe

Since Specialization

Citations

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Fields of papers citing papers by Vincent B. Luscombe

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Vincent B. Luscombe. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Vincent B. Luscombe. The network helps show where Vincent B. Luscombe may publish in the future.

Co-authors

The 25 scholars most cited alongside Vincent B. Luscombe, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Vincent B. Luscombe Line = papers co-authored together Vincent B. Luscombe links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 30 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	20 Years an Orphan: Is GPR84 a Plausible Medium-Chain Fatty Acid-Sensing Receptor? DNA and Cell Biology ·Vincent B. Luscombe, Daniel Lucy, Carole J. R. Bataille, Angela J. Russell, David R. Greaves	2020	42
2	Diverse Effects on M₁ Signaling and Adverse Effect Liability within a Series of M₁ Ago-PAMs ACS Chemical Neuroscience ·Jerri M. Rook, Masahito Abe, Hyekyung P. Cho, Kellie D. Nance, Vincent B. Luscombe, Jeffrey J. Adams, Jonathan W. Dickerson, Daniel H. Remke, Pedro M. García-Barrantes, Darren W. Engers, Julie L. Engers, Sichen Chang, Jarrett J. Foster, Anna L. Blobaum, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley	2016	41
3	Discovery of VU6005649, a CNS Penetrant mGlu_7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines ACS Medicinal Chemistry Letters ·Masahito Abe, Mabel Seto, Rocco G. Gogliotti, Matthew T. Loch, Katrina A. Bollinger, Sichen Chang, Eileen M. Engelberg, Vincent B. Luscombe, Joel M. Harp, Michael Bubser, Darren W. Engers, Carrie K. Jones, Alice L. Rodriguez, Anna L. Blobaum, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley	2017	29
4	Challenges in the development of an M4 PAM in vivo tool compound: The discovery of VU0467154 and unexpected DMPK profiles of close analogs Bioorganic & Medicinal Chemistry Letters ·Michael R. Wood, Meredith J. Noetzel, Michael S. Poslusney, Bruce J. Melancon, James C. Tarr, Atin Lamsal, Sichen Chang, Vincent B. Luscombe, Rebecca L. Weiner, Hyekyung P. Cho, Michael Bubser, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood, Darren W. Engers, Nicholas J. Brandon, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley	2016	27
5	Discovery of N-(5-Fluoropyridin-2-yl)-6-methyl-4-(pyrimidin-5-yloxy)picolinamide (VU0424238): A Novel Negative Allosteric Modulator of Metabotropic Glutamate Receptor Subtype 5 Selected for Clinical Evaluation Journal of Medicinal Chemistry ·Andrew S. Felts, Alice L. Rodriguez, Anna L. Blobaum, Ryan D. Morrison, Brittney S. Bates, Analisa Thompson Gray, Jerri M. Rook, Mohammed Noor Tantawy, Frank W. Byers, Sichen Chang, Daryl F. Venable, Vincent B. Luscombe, Gilles Tamagnan, Colleen M. Niswender, J. Scott Daniels, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley, Kyle A. Emmitte	2017	24
6	Discovery of an Orally Bioavailable and Central Nervous System (CNS) Penetrant mGlu₇ Negative Allosteric Modulator (NAM) in Vivo Tool Compound: N-(2-(1H-1,2,4-triazol-1-yl)-5-(trifluoromethoxy)phenyl)-4-(cyclopropylmethoxy)-3-methoxybenzamide (VU6012962) Journal of Medicinal Chemistry ·Carson W. Reed, Samantha E. Yohn, Jordan P. Washecheck, Hanna F. Roenfanz, Marc Quitalig, Vincent B. Luscombe, Matthew T. Jenkins, Alice L. Rodriguez, Darren W. Engers, Anna L. Blobaum, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley	2019	23
7	VU6010608, a Novel mGlu₇ NAM from a Series of N-(2-(1H-1,2,4-Triazol-1-yl)-5-(trifluoromethoxy)phenyl)benzamides ACS Medicinal Chemistry Letters ·Carson W. Reed, Kevin McGowan, Paul K. Spearing, Branden J. Stansley, Hanna F. Roenfanz, Darren W. Engers, Alice L. Rodriguez, Eileen M. Engelberg, Vincent B. Luscombe, Matthew T. Loch, Daniel H. Remke, Jerri M. Rook, Anna L. Blobaum, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley	2017	21
8	Discovery of Novel Central Nervous System Penetrant Metabotropic Glutamate Receptor Subtype 2 (mGlu ₂ ) Negative Allosteric Modulators (NAMs) Based on Functionalized Pyrazolo[1,5- a ]pyrimidine-5-carboxamide and Thieno[3,2- b ]pyridine-5-carboxamide Cores Journal of Medicinal Chemistry ·Elizabeth S. Childress, Joshua M. Wieting, Andrew S. Felts, Megan M. Breiner, Madeline F. Long, Vincent B. Luscombe, Alice L. Rodriguez, Hyekyung P. Cho, Anna L. Blobaum, Colleen M. Niswender, Kyle A. Emmitte, P. Jeffrey Conn, Craig W. Lindsley	2018	20
9	Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping Bioorganic & Medicinal Chemistry Letters ·Madeline F. Long, Julie L. Engers, Sichen Chang, Xiaoyan Zhan, Rebecca L. Weiner, Vincent B. Luscombe, Alice L. Rodriguez, Hyekyung P. Cho, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Darren W. Engers, Craig W. Lindsley	2017	15
10	Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides Bioorganic & Medicinal Chemistry Letters ·James C. Tarr, Michael R. Wood, Meredith J. Noetzel, Bruce J. Melancon, Atin Lamsal, Vincent B. Luscombe, Alice L. Rodriguez, Frank W. Byers, Sichen Chang, Hyekyung P. Cho, Darren W. Engers, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood, Nicholas J. Brandon, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley	2017	13
11	VU6007477, a Novel M₁ PAM Based on a Pyrrolo[2,3-b]pyridine Carboxamide Core Devoid of Cholinergic Adverse Events ACS Medicinal Chemistry Letters ·Julie L. Engers, Elizabeth S. Childress, Madeline F. Long, Rory A. Capstick, Vincent B. Luscombe, Hekyung P. Cho, Jonathan W. Dickerson, Jerri M. Rook, Anna L. Blobaum, Colleen M. Niswender, Darren W. Engers, P. Jeffrey Conn, Craig W. Lindsley	2018	13
12	Discovery and Optimization of Potent and CNS Penetrant M₅-Preferring Positive Allosteric Modulators Derived from a Novel, Chiral N-(Indanyl)piperidine Amide Scaffold ACS Chemical Neuroscience ·Aaron M. Bender, Hyekyung P. Cho, Kellie D. Nance, Kaelyn S. Lingenfelter, Vincent B. Luscombe, Patrick R. Gentry, Karl R. Voigtritter, Alice E. Berizzi, Patrick M. Sexton, Christopher J. Langmead, Arthur Christopoulos, Charles W. Locuson, Thomas M. Bridges, Sichen Chang, Jordan C. O’Neill, Xiaoyan Zhan, Colleen M. Niswender, Carrie K. Jones, P. Jeffrey Conn, Craig W. Lindsley	2018	12
13	Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping Bioorganic & Medicinal Chemistry Letters ·Kayla J. Temple, Julie L. Engers, Madeline F. Long, Alison R. Gregro, Katherine J. Watson, Sichen Chang, Matthew T. Jenkins, Vincent B. Luscombe, Alice L. Rodriguez, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Darren W. Engers, Craig W. Lindsley	2019	11
14	Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists Bioorganic & Medicinal Chemistry Letters ·Aaron M. Bender, Rebecca L. Weiner, Vincent B. Luscombe, Sonia Ajmera, Hyekyung P. Cho, Sichen Chang, Xiaoyan Zhan, Alice L. Rodriguez, Colleen M. Niswender, Darren W. Engers, Thomas M. Bridges, P. Jeffrey Conn, Craig W. Lindsley	2017	9
15	Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core Bioorganic & Medicinal Chemistry Letters ·Blake R. Bewley, Paul K. Spearing, Rebecca L. Weiner, Vincent B. Luscombe, Xiaoyan Zhan, Sichen Chang, Hyekyung P. Cho, Alice L. Rodriguez, Colleen M. Niswender, P. Jeffrey Conn, Thomas M. Bridges, Darren W. Engers, Craig W. Lindsley	2017	7
16	Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes Bioorganic & Medicinal Chemistry Letters ·Kayla J. Temple, Madeline F. Long, Julie L. Engers, Katherine J. Watson, Sichen Chang, Vincent B. Luscombe, Alice L. Rodriguez, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Darren W. Engers, Craig W. Lindsley	2019	7
17	Kinetic insights into agonist-dependent signalling bias at the pro-inflammatory G-protein coupled receptor GPR84 European Journal of Pharmacology ·Vincent B. Luscombe, Luis Alberto Baena-López, Carole J. R. Bataille, Angela J. Russell, David R. Greaves	2023	6
18	Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2 Bioorganic & Medicinal Chemistry Letters ·Madeline F. Long, Rory A. Capstick, Paul K. Spearing, Julie L. Engers, Alison R. Gregro, Sean R. Bollinger, Sichen Chang, Vincent B. Luscombe, Alice L. Rodriguez, Hyekyung P. Cho, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Craig W. Lindsley, Darren W. Engers, Kayla J. Temple	2021	5
19	Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype Bioorganic & Medicinal Chemistry Letters ·Kayla J. Temple, Julie L. Engers, Madeline F. Long, Katherine J. Watson, Sichen Chang, Vincent B. Luscombe, Matthew T. Jenkins, Alice L. Rodriguez, Colleen M. Niswender, Thomas M. Bridges, P. Jeffrey Conn, Darren W. Engers, Craig W. Lindsley	2019	5
20	Development of Highly Potent, G-Protein Pathway Biased, Selective, and Orally Bioavailable GPR84 Agonists Journal of Medicinal Chemistry ·Pinqi Wang, Arun Raja, Vincent B. Luscombe, Carole J. R. Bataille, Daniel Lucy, Vanessa V. Rogga, David R. Greaves, Angela J. Russell	2023	5

About Vincent B. Luscombe

Vincent B. Luscombe is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience, Computational Theory and Mathematics, Organic Chemistry and Spectroscopy, having authored 30 papers that have together received 363 indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (23 papers), Neuroscience and Neuropharmacology Research (13 papers), Pharmacological Receptor Mechanisms and Effects (12 papers), Computational Drug Discovery Methods (6 papers), Nicotinic Acetylcholine Receptors Study (6 papers), Chemical Synthesis and Analysis (4 papers), Ion channel regulation and function (3 papers) and Neuropeptides and Animal Physiology (3 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (182 citations), Molecular Biology (268 citations), Computational Theory and Mathematics (51 citations), Organic Chemistry (76 citations) and Toxicology (5 citations). Vincent B. Luscombe has collaborated with scholars based in United States, United Kingdom and Australia. Frequent co-authors include Colleen M. Niswender, Craig W. Lindsley, P. Jeffrey Conn, Darren W. Engers, Alice L. Rodriguez, Sichen Chang, Angela J. Russell, David R. Greaves, Anna L. Blobaum and Carole J. R. Bataille. Their work appears in journals such as Bioorganic & Medicinal Chemistry Letters, ACS Chemical Neuroscience, Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters and ACS Omega.

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