Charles W. Locuson

1.3k citations

44 papers · 989 indexed · h-index 22

Pharmacology top 0.5%
Molecular Biology
Oncology top 10%
Computational Theory and Mathematics top 5%
Pharmacology top 10%

Co-authors: Timothy S. Tracy Jeffrey P. Jones Peter M. Gannett J. Matthew Hutzler Allan E. Rettie Craig W. Lindsley T. S. Tracy Denise A. Rock
Topics: Pharmacogenetics and Drug Metabolism (25 papers)Drug Transport and Resistance Mechanisms (17 papers)Receptor Mechanisms and Signaling (9 papers)
Cited by: Pharmacology Oncology Computational Theory and Mathematics
Journals: Journal of the American Chemical Society Analytical Chemistry Biochemistry
Partner nations: United States France Australia

In The Last Decade

Charles W. Locuson

44 papers receiving 965 citations

Peers

Countries citing papers authored by Charles W. Locuson

Since Specialization

Citations

This map shows the geographic impact of Charles W. Locuson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Charles W. Locuson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Charles W. Locuson more than expected).

Fields of papers citing papers by Charles W. Locuson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Charles W. Locuson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Charles W. Locuson. The network helps show where Charles W. Locuson may publish in the future.

Co-authorship network of co-authors of Charles W. Locuson

This figure shows the co-authorship network connecting the top 25 collaborators of Charles W. Locuson. A scholar is included among the top collaborators of Charles W. Locuson based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Charles W. Locuson. Charles W. Locuson is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	The effect of fluconazole on oral methadone in dogs 2019 ·Veterinary Anaesthesia and Analgesia ·Butch KuKanich,Kate S. KuKanich,(unknown),Charles W. Locuson	9
2	Progress towards small molecule menin-mixed lineage leukemia (MLL) interaction inhibitors with in vivo utility 2015 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Rocco D. Gogliotti,Changho Han,Charles W. Locuson,Ryan D. Morrison,J. Scott Daniels,Tomasz Cierpicki,Jolanta Grembecka,Craig W. Lindsley,Shaun R. Stauffer	11
3	VFV as a New Effective CYP51 Structure-Derived Drug Candidate for Chagas Disease and Visceral Leishmaniasis 2015 ·The Journal of Infectious Diseases ·Galina I. Lepesheva,Tatiana Y. Hargrove,Girish Rachakonda,Z. Wawrzak,Sébastien Pomel,Sandrine Cojean,Pius N. Nde,W. David Nes,Charles W. Locuson,M. Wade Calcutt,Michael R. Waterman,J. Scott Daniels,Philippe M. Loiseau,Fernando Villalta	51
4	A Screen of Approved Drugs Identifies the Androgen Receptor Antagonist Flutamide and Its Pharmacologically Active Metabolite 2-Hydroxy-Flutamide as Heterotropic Activators of Cytochrome P450 3A In Vitro and In Vivo 2015 ·Drug Metabolism and Disposition ·Anna L. Blobaum,Frank W. Byers,Thomas M. Bridges,Charles W. Locuson,P. Jeffrey Conn,Craig W. Lindsley,J. Scott Daniels	8
5	Synthesis and structure–activity relationships of a series of 4-methoxy-3-(piperidin-4-yl)oxy benzamides as novel inhibitors of the presynaptic choline transporter 2015 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),Darren W. Engers,E Ennis,Jane Wright,Charles W. Locuson,Craig W. Lindsley,Randy Blakely,Corey R. Hopkins	4
6	Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354 2014 ·Bioorganic & Medicinal Chemistry Letters ·(unknown),(unknown),Matthew T. Duvernay,M. Schulte,Kellie D. Nance,Bruce J. Melancon,Julie L. Engers,Charles W. Locuson,(unknown),J. Scott Daniels,Wenjun Wu,Craig W. Lindsley,Heidi E. Hamm,Shaun R. Stauffer	29
7	Discovery of a Highly Selective PLD2 Inhibitor (ML395): A New Probe with Improved Physiochemical Properties and Broad‐Spectrum Antiviral Activity against Influenza Strains 2014 ·ChemMedChem ·Matthew C. O’Reilly,Thomas H. Oguin,Sarah Scott,Paul G. Thomas,Charles W. Locuson,Ryan D. Morrison,J. Scott Daniels,H. Alex Brown,Craig W. Lindsley	15
8	Pharmacokinetic Interaction of the Antiparasitic Agents Ivermectin and Spinosad in Dogs 2011 ·Drug Metabolism and Disposition ·(unknown),(unknown),Kathleen E. Sampson,Yurong Lai,Sean P. Mahabir,Larissa M. Balogh,Charles W. Locuson	42
9	Distribution, metabolism, and excretion of toceranib phosphate (Palladia™, SU11654), a novel tyrosine kinase inhibitor, in dogs 2010 ·Journal of Veterinary Pharmacology and Therapeutics ·Mark Yancey,Dawn A. Merritt,Julie White,Susan A. Marsh,Charles W. Locuson	23
10	CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis 2009 ·Drug Metabolism and Disposition ·Murali Subramanian,(unknown),Charles W. Locuson,Timothy S. Tracy	41
11	In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition 2008 ·Drug Metabolism and Disposition ·(unknown),Matthew J. Zaya,Phyllis B. Malpas,Charles W. Locuson	27
12	Visible Spectra of Type II Cytochrome P450-Drug Complexes: Evidence that “Incomplete” Heme Coordination Is Common 2007 ·Drug Metabolism and Disposition ·Charles W. Locuson,J. Matthew Hutzler,Timothy S. Tracy	63
13	Comparative modelling of the human UDP-glucuronosyltransferases: Insights into structure and mechanism 2007 ·Xenobiotica ·Charles W. Locuson,T. S. Tracy	33
14	Polymorphic Variants of CYP2C9: Mechanisms Involved in Reduced Catalytic Activity 2007 ·Molecular Pharmacology ·(unknown),Charles W. Locuson,Timothy S. Tracy	49
15	Identification of Binding Sites of Non-I-Helix Water Molecules in Mammalian Cytochromes P450 2006 ·Drug Metabolism and Disposition ·Charles W. Locuson,Timothy S. Tracy	6
16	Heteroactivator effects on the coupling and spin state equilibrium of CYP2C9 2006 ·Archives of Biochemistry and Biophysics ·Charles W. Locuson,Peter M. Gannett,Timothy S. Tracy	32
17	Inhibition of Cytochrome P450 3A4 by a Pyrimidineimidazole: Evidence for Complex Heme Interactions 2006 ·Chemical Research in Toxicology ·J. Matthew Hutzler,Roger J. Melton,Jeanne M. Rumsey,Mark E. Schnute,Charles W. Locuson,Larry C. Wienkers	28
18	THREE-DIMENSIONAL QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP ANALYSIS OF CYTOCHROMES P450: EFFECT OF INCORPORATING HIGHER-AFFINITY LIGANDS AND POTENTIAL NEW APPLICATIONS 2005 ·Drug Metabolism and Disposition ·Charles W. Locuson,Jan L. Wahlstrom	15
19	CYP2C9 Genotype-Dependent Effects on in Vitro Drug-Drug Interactions: Switching of Benzbromarone Effect from Inhibition to Activation in the CYP2C9.3 Variant 2005 ·Molecular Pharmacology ·Matthew A. Hummel,Charles W. Locuson,Peter M. Gannett,Dan A. Rock,Carrie M. Mosher,Allan E. Rettie,Timothy S. Tracy	39
20	A NEW CLASS OF CYP2C9 INHIBITORS: PROBING 2C9 SPECIFICITY WITH HIGH-AFFINITY BENZBROMARONE DERIVATIVES 2003 ·Drug Metabolism and Disposition ·Charles W. Locuson,Jan L. Wahlstrom,Denise A. Rock,Dan A. Rock,Jeffrey P. Jones	30

About Charles W. Locuson

Charles W. Locuson is a scholar working on Pharmacology, Oncology and Small Animals, having authored 44 papers that have together received 989 indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (25 papers), Drug Transport and Resistance Mechanisms (17 papers) and Receptor Mechanisms and Signaling (9 papers). The work is most often cited by research in Pharmacology (513 citations), Oncology (297 citations) and Computational Theory and Mathematics (161 citations). Charles W. Locuson has collaborated with scholars based in United States, France and Australia. Frequent co-authors include Timothy S. Tracy, Jeffrey P. Jones, Peter M. Gannett, J. Matthew Hutzler, Allan E. Rettie, Craig W. Lindsley, T. S. Tracy, Denise A. Rock, Larry C. Wienkers and J. Scott Daniels. Their work appears in journals such as Journal of the American Chemical Society, Analytical Chemistry and Biochemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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