Sichen Chang

827 total citations
34 papers, 463 citations indexed

About

Sichen Chang is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Computational Theory and Mathematics. According to data from OpenAlex, Sichen Chang has authored 34 papers receiving a total of 463 indexed citations (citations by other indexed papers that have themselves been cited), including 31 papers in Molecular Biology, 17 papers in Cellular and Molecular Neuroscience and 6 papers in Computational Theory and Mathematics. Recurrent topics in Sichen Chang's work include Receptor Mechanisms and Signaling (24 papers), Neuroscience and Neuropharmacology Research (16 papers) and Pharmacological Receptor Mechanisms and Effects (12 papers). Sichen Chang is often cited by papers focused on Receptor Mechanisms and Signaling (24 papers), Neuroscience and Neuropharmacology Research (16 papers) and Pharmacological Receptor Mechanisms and Effects (12 papers). Sichen Chang collaborates with scholars based in United States, Australia and Denmark. Sichen Chang's co-authors include Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Alice L. Rodriguez, Carrie K. Jones, Anna L. Blobaum, Julie L. Engers, Hyekyung P. Cho, Thomas M. Bridges and Vincent B. Luscombe and has published in prestigious journals such as Journal of Medicinal Chemistry, Chemistry - A European Journal and Journal of Natural Products.

In The Last Decade

Sichen Chang

31 papers receiving 461 citations

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Sichen Chang United States	13	341	287	97	43	38	34	463
Frank W. Byers United States	14	275 0.8×	283 1.0×	59 0.6×	37 0.9×	32 0.8×	21	416
Sándor Kolok Hungary	14	210 0.6×	195 0.7×	124 1.3×	28 0.7×	30 0.8×	27	424
Nicholas D. Smith United States	8	234 0.7×	256 0.9×	194 2.0×	26 0.6×	27 0.7×	9	529
François Bischoff Belgium	13	365 1.1×	345 1.2×	170 1.8×	63 1.5×	58 1.5×	22	681
William D. Shipe United States	10	243 0.7×	158 0.6×	241 2.5×	37 0.9×	58 1.5×	13	497
Gentaroh Suzuki Japan	12	425 1.2×	441 1.5×	134 1.4×	12 0.3×	16 0.4×	18	640
Sheri Smith United States	9	404 1.2×	358 1.2×	72 0.7×	32 0.7×	29 0.8×	10	651
John T. Lazzaro United States	10	275 0.8×	226 0.8×	153 1.6×	14 0.3×	35 0.9×	15	435
Christoph van Amsterdam Germany	12	166 0.5×	183 0.6×	128 1.3×	30 0.7×	80 2.1×	16	435
Ara M. Abramyan United States	15	334 1.0×	214 0.7×	71 0.7×	35 0.8×	40 1.1×	21	437

Countries citing papers authored by Sichen Chang

Since Specialization

Citations

This map shows the geographic impact of Sichen Chang's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Sichen Chang with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Sichen Chang more than expected).

Fields of papers citing papers by Sichen Chang

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Sichen Chang. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Sichen Chang. The network helps show where Sichen Chang may publish in the future.

Co-authorship network of co-authors of Sichen Chang

This figure shows the co-authorship network connecting the top 25 collaborators of Sichen Chang. A scholar is included among the top collaborators of Sichen Chang based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Sichen Chang. Sichen Chang is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Spearing, Paul K., Sichen Chang, Analisa D. Thompson, et al.. (2025). Discovery of a Novel sp³-Rich M₁ Positive Allosteric Modulators (PAMs) Chemotype via Scaffold Hopping. ACS Medicinal Chemistry Letters. 16(7). 1231–1238.

Engers, Julie L., Sichen Chang, Vincent B. Luscombe, et al.. (2024). Discovery of VU6008677: A Structurally Distinct Tricyclic M₄ Positive Allosteric Modulator with Improved CYP450 Profile. ACS Medicinal Chemistry Letters. 15(8). 1358–1366. 2 indexed citations

Engers, Julie L., Sichen Chang, Vincent B. Luscombe, et al.. (2024). Discovery of VU6016235: A Highly Selective, Orally Bioavailable, and Structurally Distinct Tricyclic M₄ Muscarinic Acetylcholine Receptor Positive Allosteric Modulator (PAM). ACS Chemical Neuroscience. 1 indexed citations

Chang, Sichen, Emily Days, Joshua A. Bauer, et al.. (2023). Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS. Bioorganic & Medicinal Chemistry Letters. 87. 129256–129256.

Chang, Sichen, Analisa D. Thompson, Aidong Qi, et al.. (2023). Development of Potent and Selective Negative Allosteric Modulators of the Metabotropic Glutamate Receptor 2 for the Potential Treatment of Alzheimer’s Disease. Alzheimer s & Dementia. 19(S21). 2 indexed citations

Rodriguez, Alice L., Mabel Seto, Anna L. Blobaum, et al.. (2022). Development and profiling of mGlu7 NAMs with a range of saturable inhibition of agonist responses in vitro. Bioorganic & Medicinal Chemistry Letters. 74. 128923–128923. 2 indexed citations

Orsi, Douglas L., Andrew S. Felts, Alice L. Rodriguez, et al.. (2022). Discovery of a potent M5 antagonist with improved clearance profile. Part 2: Pyrrolidine amide-based antagonists. Bioorganic & Medicinal Chemistry Letters. 78. 129021–129021. 1 indexed citations

Bender, Aaron M., Alice L. Rodriguez, Jonathan W. Dickerson, et al.. (2021). Synthesis and characterization of chiral 6-azaspiro[2.5]octanes as potent and selective antagonists of the M4 muscarinic acetylcholine receptor. Bioorganic & Medicinal Chemistry Letters. 56. 128479–128479. 3 indexed citations

Spearing, Paul K., Julie L. Engers, Alison R. Gregro, et al.. (2021). Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes – Part 2. Bioorganic & Medicinal Chemistry Letters. 53. 128416–128416. 4 indexed citations

10.

Temple, Kayla J., Julie L. Engers, Alison R. Gregro, et al.. (2019). Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorganic & Medicinal Chemistry Letters. 29(21). 126678–126678. 9 indexed citations

11.

Temple, Kayla J., Julie L. Engers, Sichen Chang, et al.. (2019). Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype. Bioorganic & Medicinal Chemistry Letters. 30(3). 126812–126812. 4 indexed citations

12.

Temple, Kayla J., Julie L. Engers, Sichen Chang, et al.. (2019). Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes. Bioorganic & Medicinal Chemistry Letters. 30(4). 126811–126811. 6 indexed citations

13.

Rook, Jerri M., Hyekyung P. Cho, Pedro M. García-Barrantes, et al.. (2018). A Novel M ₁ PAM VU0486846 Exerts Efficacy in Cognition Models without Displaying Agonist Activity or Cholinergic Toxicity. ACS Chemical Neuroscience. 9(9). 2274–2285. 45 indexed citations

14.

Engers, Julie L., Sichen Chang, Xiaoyan Zhan, et al.. (2017). Discovery of a novel 2,4-dimethylquinoline-6-carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping. Bioorganic & Medicinal Chemistry Letters. 27(22). 4999–5001. 14 indexed citations

15.

Tarr, James C., Michael R. Wood, Meredith J. Noetzel, et al.. (2017). Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and in vivo characterization of a series of 3-aminoazetidine-derived amides. Bioorganic & Medicinal Chemistry Letters. 27(13). 2990–2995. 16 indexed citations

16.

Spearing, Paul K., Rebecca L. Weiner, Vincent B. Luscombe, et al.. (2017). Discovery of a novel, CNS penetrant M4 PAM chemotype based on a 6-fluoro-4-(piperidin-1-yl)quinoline-3-carbonitrile core. Bioorganic & Medicinal Chemistry Letters. 27(18). 4274–4279. 6 indexed citations

17.

Tarr, James C., Michael R. Wood, Meredith J. Noetzel, et al.. (2017). Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides. Bioorganic & Medicinal Chemistry Letters. 27(23). 5179–5184. 11 indexed citations

18.

Bender, Aaron M., Rebecca L. Weiner, Vincent B. Luscombe, et al.. (2017). Discovery and optimization of 3-(4-aryl/heteroarylsulfonyl)piperazin-1-yl)-6-(piperidin-1-yl)pyridazines as novel, CNS penetrant pan-muscarinic antagonists. Bioorganic & Medicinal Chemistry Letters. 27(15). 3576–3581. 9 indexed citations

19.

Wood, Michael R., Meredith J. Noetzel, James C. Tarr, et al.. (2016). Discovery and SAR of a novel series of potent, CNS penetrant M4 PAMs based on a non-enolizable ketone core: Challenges in disposition. Bioorganic & Medicinal Chemistry Letters. 26(17). 4282–4286. 7 indexed citations

20.

Panarese, Joseph D., Kellie D. Nance, Pedro M. García-Barrantes, et al.. (2016). Further optimization of the M1 PAM VU0453595: Discovery of novel heterobicyclic core motifs with improved CNS penetration. Bioorganic & Medicinal Chemistry Letters. 26(15). 3822–3825. 9 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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