Bruce J. Melancon

2.4k total citations
36 papers, 1.4k citations indexed

About

Bruce J. Melancon is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Organic Chemistry. According to data from OpenAlex, Bruce J. Melancon has authored 36 papers receiving a total of 1.4k indexed citations (citations by other indexed papers that have themselves been cited), including 28 papers in Molecular Biology, 14 papers in Cellular and Molecular Neuroscience and 5 papers in Organic Chemistry. Recurrent topics in Bruce J. Melancon's work include Receptor Mechanisms and Signaling (19 papers), Neuroscience and Neuropharmacology Research (12 papers) and Pharmacological Receptor Mechanisms and Effects (7 papers). Bruce J. Melancon is often cited by papers focused on Receptor Mechanisms and Signaling (19 papers), Neuroscience and Neuropharmacology Research (12 papers) and Pharmacological Receptor Mechanisms and Effects (7 papers). Bruce J. Melancon collaborates with scholars based in United States, China and Switzerland. Bruce J. Melancon's co-authors include Craig W. Lindsley, Michael R. Wood, P. Jeffrey Conn, Colleen M. Niswender, Gary A. Sulikowski, James C. Tarr, Corey R. Hopkins, Kyle A. Emmitte, Arthur Christopoulos and Paul Helquist and has published in prestigious journals such as Journal of the American Chemical Society, Nature Communications and The FASEB Journal.

In The Last Decade

Bruce J. Melancon

35 papers receiving 1.4k citations

Peers

Countries citing papers authored by Bruce J. Melancon

Since Specialization

Citations

This map shows the geographic impact of Bruce J. Melancon's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Bruce J. Melancon with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Bruce J. Melancon more than expected).

Fields of papers citing papers by Bruce J. Melancon

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Bruce J. Melancon. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Bruce J. Melancon. The network helps show where Bruce J. Melancon may publish in the future.

Co-authorship network of co-authors of Bruce J. Melancon

This figure shows the co-authorship network connecting the top 25 collaborators of Bruce J. Melancon. A scholar is included among the top collaborators of Bruce J. Melancon based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Bruce J. Melancon. Bruce J. Melancon is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Structural basis of positive allosteric modulation of metabotropic glutamate receptor activation and internalization 2024 ·Nature Communications ·(unknown), Alberto J. Gonzalez-Hernandez, Joon Lee, Nohely Abreu, (unknown), (unknown), (unknown), (unknown), Kevin W. Huynh, Dagan C. Marx, (unknown), Bruce J. Melancon, Marta Filizola, Joel R. Meyerson, Joshua Levitz	7
2	mGlu1-mediated restoration of prefrontal cortex inhibitory signaling reverses social and cognitive deficits in an NMDA hypofunction model in mice 2022 ·Neuropsychopharmacology ·(unknown), (unknown), (unknown), Daniel J. Foster, Bruce J. Melancon, Craig W. Lindsley, Colleen M. Niswender, P. Jeffrey Conn	5
3	Development of a target-free high-throughput screening platform for the discovery of antileishmanial compounds 2019 ·International Journal of Antimicrobial Agents ·(unknown), Douglas A. Shoue, (unknown), Bruce J. Melancon, Miguel A. Morales, Mary Ann McDowell	11
4	Novel M4 positive allosteric modulators derived from questioning the role and impact of a presumed intramolecular hydrogen-bonding motif in β-amino carboxamide-harboring ligands 2018 ·Bioorganic & Medicinal Chemistry Letters ·Michael S. Poslusney, James M. Salovich, Michael R. Wood, Bruce J. Melancon, (unknown), Vincent B. Luscombe, Alice L. Rodriguez, Darren W. Engers, Thomas M. Bridges, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley	3
5	Challenges in the development of an M4 PAM preclinical candidate: The discovery, SAR, and biological characterization of a series of azetidine-derived tertiary amides 2017 ·Bioorganic & Medicinal Chemistry Letters ·James C. Tarr, Michael R. Wood, Meredith J. Noetzel, Bruce J. Melancon, Atin Lamsal, Vincent B. Luscombe, Alice L. Rodriguez, Frank W. Byers, Sichen Chang, Hyekyung P. Cho, Darren W. Engers, Carrie K. Jones, Colleen M. Niswender, Michael W. Wood, Nicholas J. Brandon, Mark E. Duggan, P. Jeffrey Conn, Thomas M. Bridges, Craig W. Lindsley	11
6	Structural insights into HDAC6 tubulin deacetylation and its selective inhibition 2016 ·Nature Chemical Biology ·Y. Miyake, J.J. Keusch, Longlong Wang, Makoto Saito, Daniel Heß, Xiao‐Ning Wang, Bruce J. Melancon, Paul Helquist, H. Gut, Patrick Matthias	234
7	Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model 2015 ·Neuropsychopharmacology ·Ayan Ghoshal, Jerri M. Rook, Jonathan W. Dickerson, (unknown), Ryan D. Morrison, Nidhi Jalan‐Sakrikar, Atin Lamsal, Meredith J. Noetzel, Michael S. Poslusney, Michael R. Wood, Bruce J. Melancon, Shaun R. Stauffer, Zixiu Xiang, J. Scott Daniels, Colleen M. Niswender, Carrie K. Jones, Craig W. Lindsley, P. Jeffrey Conn	81
8	Substituted indoles as selective protease activated receptor 4 (PAR-4) antagonists: Discovery and SAR of ML354 2014 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), (unknown), Matthew T. Duvernay, M. Schulte, Kellie D. Nance, Bruce J. Melancon, Julie L. Engers, Charles W. Locuson, (unknown), J. Scott Daniels, Wenjun Wu, Craig W. Lindsley, Heidi E. Hamm, Shaun R. Stauffer	29
9	Influence of M ₁ muscarinic acetylcholine receptor activation on arousal and cognitive performance using electroencephalography and novel touchscreen cognition assessment (845.5) 2014 ·The FASEB Journal ·Robert W. Gould, Michael T. Nedelcovych, Ditte Dencker, Bruce J. Melancon, Shaun R. Stauffer, Michael R. Wood, Jürgen Wess, Zixiu Xiang, Craig W. Lindsley, P. Jeffrey Conn, Carrie K. Jones	1
10	Allosteric modulation of the M1 muscarinic acetylcholine receptor: improving cognition and a potential treatment for schizophrenia and Alzheimer's disease 2013 ·Drug Discovery Today ·Bruce J. Melancon, James C. Tarr, Joseph D. Panarese, Michael R. Wood, Craig W. Lindsley	102
11	Spirocyclic replacements for the isatin in the highly selective, muscarinic M1 PAM ML137: The continued optimization of an MLPCN probe molecule 2013 ·Bioorganic & Medicinal Chemistry Letters ·Michael S. Poslusney, Bruce J. Melancon, Patrick R. Gentry, Douglas J. Sheffler, Thomas M. Bridges, Thomas J. Utley, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Michael R. Wood	27
12	Isatin replacements applied to the highly selective, muscarinic M1 PAM ML137: Continued optimization of an MLPCN probe molecule 2012 ·Bioorganic & Medicinal Chemistry Letters ·Bruce J. Melancon, Michael S. Poslusney, Patrick R. Gentry, James C. Tarr, Douglas J. Sheffler, Margrith E. Mattmann, Thomas M. Bridges, Thomas J. Utley, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Michael R. Wood	17
13	Continued optimization of the MLPCN probe ML071 into highly potent agonists of the hM1 muscarinic acetylcholine receptor 2012 ·Bioorganic & Medicinal Chemistry Letters ·Bruce J. Melancon, Rocco D. Gogliotti, James C. Tarr, (unknown), Brian A. Chauder, Evan P. Lebois, Hyekyung P. Cho, Thomas J. Utley, Douglas J. Sheffler, Thomas M. Bridges, Ryan D. Morrison, J. Scott Daniels, Colleen M. Niswender, P. Jeffrey Conn, Craig W. Lindsley, Michael R. Wood	14
14	Discovery of a selective M4 positive allosteric modulator based on the 3-amino-thieno[2,3-b]pyridine-2-carboxamide scaffold: Development of ML253, a potent and brain penetrant compound that is active in a preclinical model of schizophrenia 2012 ·Bioorganic & Medicinal Chemistry Letters ·(unknown), Bruce J. Melancon, Thomas M. Bridges, Paige N. Vinson, Thomas J. Utley, Atin Lamsal, Alice L. Rodriguez, Daryl F. Venable, Douglas J. Sheffler, Carrie K. Jones, Anna L. Blobaum, Michael R. Wood, J. Scott Daniels, P. Jeffrey Conn, Colleen M. Niswender, Craig W. Lindsley, Corey R. Hopkins	31
15	Development of novel M1 antagonist scaffolds through the continued optimization of the MLPCN probe ML012 2012 ·Bioorganic & Medicinal Chemistry Letters ·Bruce J. Melancon, Thomas J. Utley, (unknown), Margrith E. Mattmann, Yiu‐Yin Cheung, Thomas M. Bridges, Ryan D. Morrison, Douglas J. Sheffler, Colleen M. Niswender, J. Scott Daniels, P. Jeffrey Conn, Craig W. Lindsley, Michael R. Wood	13
16	Development of a more highly selective M1 antagonist from the continued optimization of the MLPCN Probe ML012 2011 ·Bioorganic & Medicinal Chemistry Letters ·Bruce J. Melancon, (unknown), Thomas M. Bridges, Gary A. Sulikowski, Thomas J. Utley, Douglas J. Sheffler, Meredith J. Noetzel, Ryan D. Morrison, (unknown), Colleen M. Niswender, Carrie K. Jones, (unknown), (unknown), Michael R. Wood	6
17	Allosteric Modulation of Seven Transmembrane Spanning Receptors: Theory, Practice, and Opportunities for Central Nervous System Drug Discovery 2011 ·Journal of Medicinal Chemistry ·Bruce J. Melancon, Corey R. Hopkins, Michael R. Wood, Kyle A. Emmitte, Colleen M. Niswender, Arthur Christopoulos, P. Jeffrey Conn, Craig W. Lindsley	188
18	A Structural Model for Binding of the Serine-Rich Repeat Adhesin GspB to Host Carbohydrate Receptors 2011 ·PLoS Pathogens ·(unknown), Barbara A. Bensing, Yan Q. Xiong, Bruce J. Melancon, Thomas Tomasiak, Nicholas J. Ward, Victoria Yankovskaya, (unknown), Gary Cecchini, Gary A. Sulikowski, Matthew J. Tyska, Paul M. Sullam, T.M. Iverson	72
19	Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071 2011 ·Bioorganic & Medicinal Chemistry Letters ·Evan P. Lebois, Gregory J. Digby, Douglas J. Sheffler, Bruce J. Melancon, James C. Tarr, Hyekyung P. Cho, Nicole Miller, Ryan D. Morrison, Thomas M. Bridges, Zixiu Xiang, J. Scott Daniels, Michael R. Wood, P. Jeffrey Conn, Craig W. Lindsley	28
20	Small-molecule inhibition of Wnt signaling through activation of casein kinase 1α 2010 ·Nature Chemical Biology ·Curtis A. Thorne, Alison Hanson, (unknown), Emilios Tahinci, Darren Orton, (unknown), Kristin K. Jernigan, (unknown), Brian Hang, Alex G. Waterson, Kwangho Kim, Bruce J. Melancon, Victor P. Ghidu, Gary A. Sulikowski, Bonnie LaFleur, Adrian Salic, Laura A. Lee, David M. Miller, Ethan Lee	397

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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