Tyler Jacks

125.6k total citations · 47 hit papers
338 papers, 87.8k citations indexed

About

Tyler Jacks is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Tyler Jacks has authored 338 papers receiving a total of 87.8k indexed citations (citations by other indexed papers that have themselves been cited), including 213 papers in Molecular Biology, 167 papers in Oncology and 69 papers in Cancer Research. Recurrent topics in Tyler Jacks's work include Cancer-related Molecular Pathways (107 papers), Cancer Research and Treatments (45 papers) and Epigenetics and DNA Methylation (41 papers). Tyler Jacks is often cited by papers focused on Cancer-related Molecular Pathways (107 papers), Cancer Research and Treatments (45 papers) and Epigenetics and DNA Methylation (41 papers). Tyler Jacks collaborates with scholars based in United States, Netherlands and United Kingdom. Tyler Jacks's co-authors include Roderick T. Bronson, Scott W. Lowe, Denise Crowley, Earlene M. Schmitt, David E. Housman, David A. Tuveson, Robert A. Weinberg, H. Earl Ruley, Bart O. Williams and Lee Ann Remington and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Tyler Jacks

337 papers receiving 86.3k citations

Hit Papers

MicroRNA expression profiles classify human ... 1985 2026 1998 2012 2005 2009 1992 1993 1993 2.5k 5.0k 7.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. MicroRNA expression profiles classify human cancers
    2005 7.8k citations E. Alejandro Sweet‐Cordero, James R. Downing et al. profile →
  2. Chromatin signature reveals over a thousand highly conserved large non-coding RNAs in mammals
    2009 3.3k citations Tyler Jacks et al. profile →
  3. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    1992 2.7k citations Tyler Jacks et al. profile →
  4. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    1993 2.5k citations Tyler Jacks, David E. Housman et al. profile →
  5. p53 is required for radiation-induced apoptosis in mouse thymocytes
    1993 2.5k citations Tyler Jacks et al. profile →
  6. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumours
    1996 1.9k citations Tyler Jacks, David E. Housman et al. profile →
  7. Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse
    2003 1.8k citations Sunil R. Hingorani, Emanuel F. Petricoin et al. Cancer Cell profile →
  8. A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
    2010 1.7k citations Laura D. Attardi, Tyler Jacks et al. profile →
  9. Tumor spectrum analysis in p53-mutant mice
    1994 1.7k citations Tyler Jacks, Roderick T. Bronson et al. profile →
  10. Identification of Bronchioalveolar Stem Cells in Normal Lung and Lung Cancer
    2005 1.6k citations Carla F. Bender Kim, Denise Crowley et al. profile →
  11. Effects of an Rb mutation in the mouse
    1992 1.4k citations Tyler Jacks, Roderick T. Bronson et al. profile →
  12. Restoration of p53 function leads to tumour regression in vivo
    2007 1.4k citations David G. Kirsch, Margaret E. McLaughlin et al. profile →
  13. Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-ras
    2001 1.4k citations Kim L. Mercer, Roderick T. Bronson et al. profile →
  14. Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters
    2008 1.3k citations Monte M. Winslow, Roderick T. Bronson et al. profile →
  15. p53 Status and the Efficacy of Cancer Therapy in Vivo
    1994 1.3k citations David E. Housman, Tyler Jacks et al. Science profile →
  16. Sunburn and p53 in the onset of skin cancer
    1994 1.2k citations Tyler Jacks et al. profile →
  17. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
    1992 1.2k citations Tyler Jacks et al. profile →
  18. Radiation-induced cell cycle arrest compromised by p21 deficiency
    1995 1.1k citations Tyler Jacks et al. profile →
  19. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
    1995 980 citations Tyler Jacks et al. profile →
  20. Mutant p53 Gain of Function in Two Mouse Models of Li-Fraumeni Syndrome
    2004 974 citations David A. Tuveson, Roderick T. Bronson et al. profile →
  21. Treating metastatic cancer with nanotechnology
    2011 952 citations Monte M. Winslow, James E. Dahlman et al. profile →
  22. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice
    2001 906 citations Kim L. Mercer, Roderick T. Bronson et al. profile →
  23. p53-Dependent apoptosis suppresses tumor growth and progression in vivo
    1994 758 citations Tyler Jacks et al. profile →
  24. Characterization of ribosomal frameshifting in HIV-1 gag-pol expression
    1988 750 citations Tyler Jacks et al. profile →
  25. MicroRNAs and Cancer: Short RNAs Go a Long Way
    2009 739 citations Tyler Jacks et al. profile →
  26. Commensal Microbiota Promote Lung Cancer Development via γδ T Cells
    2019 711 citations Arjun Bhutkar, Tyler Jacks et al. profile →
  27. Suppression of non-small cell lung tumor development by the let-7 microRNA family
    2008 707 citations Tyler Jacks et al. Proceedings of the National Academy of Sciences profile →
  28. p63 and p73 are required for p53-dependent apoptosis in response to DNA damage
    2002 651 citations Kenneth Y. Tsai, Denise Crowley et al. profile →
  29. Endogenous oncogenic K-rasG12D stimulates proliferation and widespread neoplastic and developmental defects
    2004 626 citations David A. Tuveson, Alice T. Shaw et al. Cancer Cell profile →
  30. Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1
    1996 603 citations Tyler Jacks, Roderick T. Bronson et al. profile →
  31. Tumour predisposition in mice heterozygous for a targeted mutation in Nf1
    1994 597 citations Tyler Jacks, Roderick T. Bronson et al. profile →
  32. Role for the p53 homologue p73 in E2F-1-induced apoptosis
    2000 592 citations Kenneth Y. Tsai, Tyler Jacks et al. profile →
  33. Conditional mouse lung cancer models using adenoviral or lentiviral delivery of Cre recombinase
    2009 589 citations Michel DuPage, Tyler Jacks et al. profile →
  34. CRISPR-mediated direct mutation of cancer genes in the mouse liver
    2014 580 citations Wen Xue, Nikhil S. Joshi et al. profile →
  35. KRAS and YAP1 Converge to Regulate EMT and Tumor Survival
    2014 573 citations Wen Xue, Arjun Bhutkar et al. profile →
  36. Environment Impacts the Metabolic Dependencies of Ras-Driven Non-Small Cell Lung Cancer
    2016 554 citations Tyler Jacks et al. profile →
  37. STI571 inactivation of the gastrointestinal stromal tumor c-KIT oncoprotein: biological and clinical implications
    2001 550 citations David A. Tuveson, Tyler Jacks et al. profile →
  38. Signals for ribosomal frameshifting in the rous sarcoma virus gag-pol region
    1988 512 citations Tyler Jacks et al. profile →
  39. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    1994 509 citations Tyler Jacks et al. profile →
  40. Cre-lox-regulated conditional RNA interference from transgenes
    2004 500 citations Tyler Jacks et al. Proceedings of the National Academy of Sciences profile →
  41. Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
    2013 471 citations Tyler Jacks et al. profile →
  42. Tissue of origin dictates branched-chain amino acid metabolism in mutantKras-driven cancers
    2016 438 citations Tyler Jacks, Brian M. Wolpin et al. Science profile →
  43. Autophagy Is Required for Glucose Homeostasis and Lung Tumor Maintenance
    2014 437 citations Tyler Jacks et al. Cancer Discovery profile →
  44. Circadian Rhythm Disruption Promotes Lung Tumorigenesis
    2016 398 citations Arjun Bhutkar, Tyler Jacks et al. profile →
  45. Expression of the Rous Sarcoma Virus pol Gene by Ribosomal Frameshifting
    1985 366 citations Tyler Jacks et al. Science profile →
  46. Anatomically and Functionally Distinct Lung Mesenchymal Populations Marked by Lgr5 and Lgr6
    2017 256 citations Tyler Jacks, Carla F. Kim et al. profile →
  47. SOX17 enables immune evasion of early colorectal adenomas and cancers
    2024 47 citations Tyler Jacks et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Tyler Jacks United States 129 59.4k 34.2k 26.6k 7.2k 7.2k 338 87.8k
Adrian L. Harris United Kingdom 164 64.9k 1.1× 34.9k 1.0× 45.7k 1.7× 13.0k 1.8× 10.5k 1.5× 1.2k 109.9k
Ronald A. DePinho United States 149 56.0k 0.9× 23.0k 0.7× 13.7k 0.5× 4.4k 0.6× 9.8k 1.4× 417 86.1k
Kenneth W. Kinzler United States 163 79.7k 1.3× 49.2k 1.4× 37.4k 1.4× 12.6k 1.7× 8.0k 1.1× 381 131.7k
Scott W. Lowe United States 123 50.1k 0.8× 23.0k 0.7× 16.9k 0.6× 3.6k 0.5× 8.5k 1.2× 325 69.6k
Judah Folkman United States 141 62.8k 1.1× 24.5k 0.7× 29.5k 1.1× 10.9k 1.5× 8.3k 1.2× 395 105.2k
Roderick T. Bronson United States 139 46.0k 0.8× 23.2k 0.7× 11.6k 0.4× 5.7k 0.8× 11.5k 1.6× 544 77.8k
Joan Massagué United States 184 95.5k 1.6× 47.2k 1.4× 22.6k 0.9× 12.3k 1.7× 12.3k 1.7× 362 137.5k
Zena Werb United States 151 45.6k 0.8× 35.3k 1.0× 33.6k 1.3× 9.8k 1.4× 18.5k 2.6× 416 110.4k
Carlos Cordon‐Cardo United States 129 41.4k 0.7× 22.8k 0.7× 12.8k 0.5× 11.0k 1.5× 7.1k 1.0× 564 68.1k
Douglas Hanahan United States 109 79.7k 1.3× 43.8k 1.3× 36.5k 1.4× 12.6k 1.8× 19.2k 2.7× 230 137.2k

Countries citing papers authored by Tyler Jacks

Since Specialization
Citations

This map shows the geographic impact of Tyler Jacks's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Tyler Jacks with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Tyler Jacks more than expected).

Fields of papers citing papers by Tyler Jacks

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Tyler Jacks. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Tyler Jacks. The network helps show where Tyler Jacks may publish in the future.

Co-authorship network of co-authors of Tyler Jacks

This figure shows the co-authorship network connecting the top 25 collaborators of Tyler Jacks. A scholar is included among the top collaborators of Tyler Jacks based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Tyler Jacks. Tyler Jacks is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Guo, Jimmy A., Hannah I. Hoffman, Stuti G. Shroff, et al.. (2021). Pan-cancer Transcriptomic Predictors of Perineural Invasion Improve Occult Histopathologic Detection. Clinical Cancer Research. 27(10). 2807–2815. 16 indexed citations
2.
Schmidt, Leah, et al.. (2019). Enhanced adaptive immune responses in lung adenocarcinoma through natural killer cell stimulation. Proceedings of the National Academy of Sciences. 116(35). 17460–17469. 54 indexed citations
3.
Lo, Justin H., Liangliang Hao, Mandar D. Muzumdar, et al.. (2018). iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Molecular Cancer Therapeutics. 17(11). 2377–2388. 65 indexed citations
4.
Chen, Panyu, Mandar D. Muzumdar, Kimberly Judith Dorans, et al.. (2017). Adaptive and Reversible Resistance to Kras Inhibition in Pancreatic Cancer Cells. Cancer Research. 78(4). 985–1002. 29 indexed citations
5.
Barnés, Carmen M., Omar F. Khan, Edmond W. Zaia, et al.. (2014). Dendrimer-Inspired Nanomaterials for the in Vivo Delivery of siRNA to Lung Vasculature. DSpace@MIT (Massachusetts Institute of Technology). 5 indexed citations
6.
McFadden, David G., Amanda Vernon, Philip M. Santiago, et al.. (2014). p53 constrains progression to anaplastic thyroid carcinoma in a Braf -mutant mouse model of papillary thyroid cancer. Proceedings of the National Academy of Sciences. 111(16). E1600–9. 120 indexed citations
7.
Xu, Jin, Kevin M. Haigis, Ari J. Firestone, et al.. (2013). Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras- Driven Hematopoietic Transformation. Cancer Discovery. 3(9). 993–1001. 47 indexed citations
8.
Shaw, Alice T., Monte M. Winslow, Margaret Magendantz, et al.. (2011). Selective killing of K-ras mutant cancer cells by small molecule inducers of oxidative stress. Proceedings of the National Academy of Sciences. 108(21). 8773–8778. 200 indexed citations
9.
Cellurale, Cristina, Guadalupe Sabio, Norman J. Kennedy, et al.. (2011). Requirement of c-Jun NH 2 -Terminal Kinase for Ras-Initiated Tumor Formation. Molecular and Cellular Biology. 31(7). 1565–1576. 84 indexed citations
10.
11.
Young, Nathan P. & Tyler Jacks. (2010). Tissue-specific p19 Arf regulation dictates the response to oncogenic K-ras. Proceedings of the National Academy of Sciences. 107(22). 10184–10189. 40 indexed citations
12.
Wong, Kwok‐Kin, Tyler Jacks, & Glenn Dranoff. (2010). NF-κB Fans the Flames of Lung Carcinogenesis. Cancer Prevention Research. 3(4). 403–405. 25 indexed citations
13.
Kirsch, David G., Philip M. Santiago, Emmanuelle di Tomaso, et al.. (2009). p53 Controls Radiation-Induced Gastrointestinal Syndrome in Mice Independent of Apoptosis. Science. 327(5965). 593–596. 1 indexed citations
14.
Cheung, Ann, Michel DuPage, Han Dong, Jianzhu Chen, & Tyler Jacks. (2008). Regulated Expression of a Tumor-Associated Antigen Reveals Multiple Levels of T-Cell Tolerance in a Mouse Model of Lung Cancer. Cancer Research. 68(22). 9459–9468. 37 indexed citations
15.
Kissil, Joseph L., Marita J. Walmsley, Linda Hanlon, et al.. (2007). Requirement for Rac1 in a K-ras–Induced Lung Cancer in the Mouse. Cancer Research. 67(17). 8089–8094. 129 indexed citations
16.
Wijnhoven, S., Ewoud N. Speksnijder, Xiaoling Liu, et al.. (2007). Dominant-Negative but not Gain-of-Function Effects of a p53.R270H Mutation in Mouse Epithelium Tissue after DNA Damage. Cancer Research. 67(10). 4648–4656. 39 indexed citations
17.
Charest, Al, Erik Wilker, Margaret E. McLaughlin, et al.. (2006). ROS Fusion Tyrosine Kinase Activates a SH2 Domain–Containing Phosphatase-2/Phosphatidylinositol 3-Kinase/Mammalian Target of Rapamycin Signaling Axis to Form Glioblastoma in Mice. Cancer Research. 66(15). 7473–7481. 120 indexed citations
18.
Daikoku, Takiko, Susanne Tranguch, Ирина Трофимова, et al.. (2006). Cyclooxygenase-1 Is Overexpressed in Multiple Genetically Engineered Mouse Models of Epithelial Ovarian Cancer. Cancer Research. 66(5). 2527–2531. 64 indexed citations
19.
Hingorani, Sunil R., Emanuel F. Petricoin, Anirban Maitra, et al.. (2003). Preinvasive and invasive ductal pancreatic cancer and its early detection in the mouse. Cancer Cell. 4(6). 437–450. 1774 indexed citations breakdown →
20.
Tsai, Kenneth Y., David MacPherson, Douglas A. Rubinson, et al.. (2002). ARF mutation accelerates pituitary tumor development in Rb +/− mice. Proceedings of the National Academy of Sciences. 99(26). 16865–16870. 35 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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