Zena Werb

143.7k total citations · 48 hit papers
416 papers, 110.4k citations indexed

About

Zena Werb is a scholar working on Cancer Research, Molecular Biology and Oncology. According to data from OpenAlex, Zena Werb has authored 416 papers receiving a total of 110.4k indexed citations (citations by other indexed papers that have themselves been cited), including 185 papers in Cancer Research, 180 papers in Molecular Biology and 134 papers in Oncology. Recurrent topics in Zena Werb's work include Protease and Inhibitor Mechanisms (161 papers), Cell Adhesion Molecules Research (63 papers) and Cancer Cells and Metastasis (59 papers). Zena Werb is often cited by papers focused on Protease and Inhibitor Mechanisms (161 papers), Cell Adhesion Molecules Research (63 papers) and Cancer Cells and Metastasis (59 papers). Zena Werb collaborates with scholars based in United States, Japan and Canada. Zena Werb's co-authors include Lisa M. Coussens, Mikala Egeblad, Mark D. Sternlicht, Vicki Plaks, Kai Kessenbrock, Pengfei Lu, Valerie M. Weaver, Andrew J. Ewald, Thiennu H. Vu and Jonathan Chou and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Zena Werb

413 papers receiving 107.9k citations

Hit Papers

Inflammation and cancer 1975 2026 1992 2009 2002 2002 2010 2001 2014 4.0k 8.0k 12.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Inflammation and cancer
    2002 12.2k citations Zena Werb et al. profile →
  2. New functions for the matrix metalloproteinases in cancer progression
    2002 5.0k citations Zena Werb et al. profile →
  3. Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
    2010 4.0k citations Vicki Plaks, Zena Werb et al. profile →
  4. How Matrix Metalloproteinases Regulate Cell Behavior
    2001 3.2k citations Mark D. Sternlicht, Zena Werb profile →
  5. Remodelling the extracellular matrix in development and disease
    2014 3.1k citations Jonathan Chou, Zena Werb et al. profile →
  6. The extracellular matrix: A dynamic niche in cancer progression
    2012 2.3k citations Valerie M. Weaver, Zena Werb et al. The Journal of Cell Biology profile →
  7. Matrix metalloproteinases and the regulation of tissue remodelling
    2007 2.3k citations Zena Werb et al. profile →
  8. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis
    2000 2.2k citations Zena Werb et al. profile →
  9. Lifeact: a versatile marker to visualize F-actin
    2008 1.7k citations Zena Werb et al. Nature Methods profile →
  10. Extracellular Matrix Degradation and Remodeling in Development and Disease
    2011 1.7k citations Valerie M. Weaver, Zena Werb et al. profile →
  11. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
    1999 1.6k citations Zena Werb et al. profile →
  12. MMP-9/Gelatinase B Is a Key Regulator of Growth Plate Angiogenesis and Apoptosis of Hypertrophic Chondrocytes
    1998 1.5k citations Robert M. Senior, Zena Werb et al. profile →
  13. Roles of the immune system in cancer: from tumor initiation to metastatic progression
    2018 1.4k citations Zena Werb et al. profile →
  14. Concepts of extracellular matrix remodelling in tumour progression and metastasis
    2020 1.4k citations Juliane Winkler, Kevin J. Metcalf et al. profile →
  15. Recruitment of Stem and Progenitor Cells from the Bone Marrow Niche Requires MMP-9 Mediated Release of Kit-Ligand
    2002 1.4k citations Zena Werb et al. profile →
  16. Netting neutrophils in autoimmune small-vessel vasculitis
    2009 1.3k citations Zena Werb et al. profile →
  17. The Cancer Stem Cell Niche: How Essential Is the Niche in Regulating Stemness of Tumor Cells?
    2015 1.2k citations Vicki Plaks, Zena Werb et al. profile →
  18. Implantation and the placenta: key pieces of the development puzzle
    1994 1.1k citations James C. Cross, Zena Werb et al. profile →
  19. ECM and Cell Surface Proteolysis: Regulating Cellular Ecology
    1997 1.1k citations Zena Werb profile →
  20. MMP-9 Supplied by Bone Marrow–Derived Cells Contributes to Skin Carcinogenesis
    2000 1.1k citations Zena Werb et al. profile →
  21. Suppression of ICE and Apoptosis in Mammary Epithelial Cells by Extracellular Matrix
    1995 1.0k citations Zena Werb, Mina J. Bissell et al. profile →
  22. Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    2005 1.0k citations Laurie E. Littlepage, Zena Werb et al. profile →
  23. Matrix metalloproteinases: effectors of development and normal physiology
    2000 1.0k citations Zena Werb et al. profile →
  24. Signal transduction through the fibronectin receptor induces collagenase and stromelysin gene expression.
    1989 943 citations Zena Werb et al. The Journal of Cell Biology profile →
  25. Wound Macrophages Express TGF-α and Other Growth Factors in Vivo: Analysis by mRNA Phenotyping
    1988 925 citations Michael J. Banda, Zena Werb et al. profile →
  26. Tumors as Organs: Complex Tissues that Interface with the Entire Organism
    2010 918 citations Zena Werb et al. profile →
  27. HIF1α Induces the Recruitment of Bone Marrow-Derived Vascular Modulatory Cells to Regulate Tumor Angiogenesis and Invasion
    2008 902 citations Zena Werb et al. profile →
  28. Regulation of matrix biology by matrix metalloproteinases
    2004 871 citations Zena Werb et al. profile →
  29. Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury
    2012 796 citations Zena Werb et al. Journal of Clinical Investigation profile →
  30. The Stromal Proteinase MMP3/Stromelysin-1 Promotes Mammary Carcinogenesis
    1999 722 citations Mark D. Sternlicht, Joe W. Gray et al. profile →
  31. Single-cell analysis reveals a stem-cell program in human metastatic breast cancer cells
    2015 690 citations Devon A. Lawson, Ying Yu et al. profile →
  32. Targeted deletion of matrix metalloproteinase-9 attenuates left ventricular enlargement and collagen accumulation after experimental myocardial infarction
    2000 667 citations Zena Werb et al. Journal of Clinical Investigation profile →
  33. Correlation between synthesis of heat shock proteins and development of thermotolerance in Chinese hamster fibroblasts.
    1982 666 citations Zena Werb et al. Proceedings of the National Academy of Sciences profile →
  34. Stromal Effects on Mammary Gland Development and Breast Cancer
    2002 658 citations Zena Werb et al. profile →
  35. β4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium
    2002 627 citations Valerie M. Weaver, Sophie A. Lelièvre et al. profile →
  36. 92-kD type IV collagenase mediates invasion of human cytotrophoblasts.
    1991 622 citations Zena Werb et al. The Journal of Cell Biology profile →
  37. Collective Invasion in Breast Cancer Requires a Conserved Basal Epithelial Program
    2013 618 citations Zena Werb et al. profile →
  38. Endogenous Activation of Latent Collagenase by Rheumatoid Synovial Cells
    1977 615 citations Zena Werb et al. profile →
  39. Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos
    1988 583 citations Zena Werb et al. profile →
  40. Circulating Tumor Cells
    2013 582 citations Vicki Plaks, Zena Werb et al. profile →
  41. The many faces of metalloproteases: cell growth, invasion, angiogenesis and metastasis
    2001 561 citations Zena Werb et al. profile →
  42. GATA-3 Maintains the Differentiation of the Luminal Cell Fate in the Mammary Gland
    2006 535 citations Hosein Kouros‐Mehr, Mark D. Sternlicht et al. profile →
  43. Oxygen Tension Regulates the Expression of Angiogenesis Factor by Macrophages
    1983 534 citations Zena Werb, Michael J. Banda et al. profile →
  44. Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development
    2009 517 citations Zena Werb et al. profile →
  45. Secretion of metalloproteinases by stimulated capillary endothelial cells. II. Expression of collagenase and stromelysin activities is regulated by endogenous inhibitors.
    1986 498 citations Michael J. Banda, Zena Werb et al. profile →
  46. Tumour heterogeneity and metastasis at single-cell resolution
    2018 413 citations Devon A. Lawson, Zena Werb et al. profile →
  47. Elastase secretion by stimulated macrophages. Characterization and regulation.
    1975 412 citations Zena Werb et al. profile →
  48. MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices
    2019 340 citations Christopher S. McGinnis, David M. Patterson et al. Nature Methods profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author Last Decade Papers Cites
Zena Werb 45.6k 35.3k 33.6k 18.5k 12.3k 416 110.4k
Judah Folkman 62.8k 1.4× 24.5k 0.7× 29.5k 0.9× 8.3k 0.4× 10.9k 0.9× 395 105.2k
Joan Massagué 95.5k 2.1× 47.2k 1.3× 22.6k 0.7× 12.3k 0.7× 9.3k 0.8× 362 137.5k
Douglas Hanahan 79.7k 1.7× 43.8k 1.2× 36.5k 1.1× 19.2k 1.0× 5.0k 0.4× 230 137.2k
Peter Carmeliet 53.1k 1.2× 15.0k 0.4× 27.4k 0.8× 11.7k 0.6× 5.0k 0.4× 729 100.0k
Napoleone Ferrara 61.5k 1.3× 20.6k 0.6× 23.9k 0.7× 10.1k 0.5× 5.1k 0.4× 259 99.3k
Raghu Kalluri 49.4k 1.1× 21.0k 0.6× 25.3k 0.8× 10.1k 0.5× 6.1k 0.5× 321 83.3k
George D. Yancopoulos 55.1k 1.2× 14.3k 0.4× 11.9k 0.4× 16.0k 0.9× 6.4k 0.5× 430 103.1k
Adrian L. Harris 64.9k 1.4× 34.9k 1.0× 45.7k 1.4× 10.5k 0.6× 3.0k 0.2× 1.2k 109.9k
Kari Alitalo 56.8k 1.2× 45.5k 1.3× 12.5k 0.4× 8.3k 0.4× 4.8k 0.4× 716 94.3k
Irving L. Weissman 59.2k 1.3× 30.0k 0.9× 11.4k 0.3× 47.2k 2.6× 4.9k 0.4× 836 131.7k

Countries citing papers authored by Zena Werb

Since Specialization
Citations

This map shows the geographic impact of Zena Werb's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Zena Werb with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Zena Werb more than expected).

Fields of papers citing papers by Zena Werb

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Zena Werb. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Zena Werb. The network helps show where Zena Werb may publish in the future.

Co-authorship network of co-authors of Zena Werb

This figure shows the co-authorship network connecting the top 25 collaborators of Zena Werb. A scholar is included among the top collaborators of Zena Werb based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Zena Werb. Zena Werb is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Metcalf, Kevin J., Justin A. Modica, Kelly Parker, et al.. (2020). Synthetic Tuning of Domain Stoichiometry in Nanobody–Enzyme Megamolecules. Bioconjugate Chemistry. 32(1). 143–152. 11 indexed citations
2.
McGinnis, Christopher S., David M. Patterson, Juliane Winkler, et al.. (2019). MULTI-seq: sample multiplexing for single-cell RNA sequencing using lipid-tagged indices. Nature Methods. 16(7). 619–626. 340 indexed citations breakdown →
3.
Lohela, Marja, Amy-Jo Casbon, Aleksandra Olow, et al.. (2014). Intravital imaging reveals distinct responses of depleting dynamic tumor-associated macrophage and dendritic cell subpopulations. Proceedings of the National Academy of Sciences. 111(47). E5086–95. 73 indexed citations
4.
Plaks, Vicki, Julie L. Rinkenberger, Joanne Dai, et al.. (2013). Matrix metalloproteinase-9 deficiency phenocopies features of preeclampsia and intrauterine growth restriction. Proceedings of the National Academy of Sciences. 110(27). 11109–11114. 138 indexed citations
5.
Littlepage, Laurie E., Adam S. Adler, Hosein Kouros‐Mehr, et al.. (2012). The Transcription Factor ZNF217 Is a Prognostic Biomarker and Therapeutic Target during Breast Cancer Progression. Cancer Discovery. 2(7). 638–651. 54 indexed citations
6.
Phillips, Joanna J., Emmanuelle Huillard, Aaron E. Robinson, et al.. (2012). Heparan sulfate sulfatase SULF2 regulates PDGFRα signaling and growth in human and mouse malignant glioma. Journal of Clinical Investigation. 122(3). 911–922. 76 indexed citations
7.
Littlepage, Laurie E., Mark D. Sternlicht, Nathalie Rougier, et al.. (2010). Matrix Metalloproteinases Contribute Distinct Roles in Neuroendocrine Prostate Carcinogenesis, Metastasis, and Angiogenesis Progression. Cancer Research. 70(6). 2224–2234. 169 indexed citations
8.
Adler, Adam S., Laurie E. Littlepage, Meihong Lin, et al.. (2008). CSN5 Isopeptidase Activity Links COP9 Signalosome Activation to Breast Cancer Progression. Cancer Research. 68(2). 506–515. 56 indexed citations
9.
Zeisberg, Michael, Mona Khurana, Velidi H. Rao, et al.. (2006). Stage-Specific Action of Matrix Metalloproteinases Influences Progressive Hereditary Kidney Disease. PLoS Medicine. 3(4). e100–e100. 113 indexed citations
10.
Sternlicht, Mark D., Susan W. Sunnarborg, Hosein Kouros‐Mehr, et al.. (2005). Mammary ductal morphogenesis requires paracrine activation of stromal EGFR via ADAM17-dependent shedding of epithelial amphiregulin. Development. 132(17). 3923–3933. 242 indexed citations
11.
Liu, Zhi, Ning Li, Luis A. Díaz, et al.. (2005). Synergy between a plasminogen cascade and MMP-9 in autoimmune disease. Journal of Clinical Investigation. 115(4). 879–887. 84 indexed citations
12.
Yoon, Bong-June, M J Preston, Brian N. Bundy, et al.. (2004). Tissue Inhibitor of Metalloproteinase 1 Regulates Resistance to Infection. Infection and Immunity. 73(1). 661–665. 45 indexed citations
13.
Weaver, Valerie M., Sophie A. Lelièvre, Johnathon N. Lakins, et al.. (2002). Beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium. University of North Texas Digital Library (University of North Texas). 183 indexed citations
14.
Chen, Ruoyan, Gang Ning, Ming‐Lang Zhao, et al.. (2001). Mast cells play a key role in neutrophil recruitment in experimental bullous pemphigoid. Journal of Clinical Investigation. 108(8). 1151–1158. 15 indexed citations
15.
Cross, James C., et al.. (1999). Defective Induction of the Transcription Factor Interferon-StimulatedGene Factor-3 and Interferon α Insensitivity in Human Trophoblast Cells1. Biology of Reproduction. 60(2). 312–321. 14 indexed citations
16.
Sebastian, Joseph, et al.. (1998). Activation and function of the epidermal growth factor receptor and erbB-2 during mammary gland morphogenesis.. PubMed. 9(9). 777–85. 122 indexed citations
17.
Fleischmajer, Raúl, Rupert Timpl, & Zena Werb. (1998). Morphogenesis : cellular interactions. Andalas University Repository (Andalas University). 12 indexed citations
18.
Sakakura, Y., Yasuyuki Sasano, Lillian Shum, et al.. (1992). Endogenous epidermal growth factor regulates the timing and pattern of embryonic mouse molar tooth morphogenesis. The International Journal of Developmental Biology. 36(4). 505–516. 38 indexed citations
19.
Banda, Michael J., Zena Werb, & James H. McKerrow. (1987). [15] Elastin degradation. Methods in enzymology on CD-ROM/Methods in enzymology. 144. 288–305. 26 indexed citations
20.
Aggeler, Judith, Steven M. Frisch, & Zena Werb. (1984). Changes in cell shape correlate with collagenase gene expression in rabbit synovial fibroblasts.. The Journal of Cell Biology. 98(5). 1662–1671. 198 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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