Kenneth W. Kinzler

248.2k total citations · 76 hit papers
381 papers, 131.7k citations indexed

About

Kenneth W. Kinzler is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, Kenneth W. Kinzler has authored 381 papers receiving a total of 131.7k indexed citations (citations by other indexed papers that have themselves been cited), including 188 papers in Molecular Biology, 166 papers in Oncology and 138 papers in Cancer Research. Recurrent topics in Kenneth W. Kinzler's work include Cancer Genomics and Diagnostics (125 papers), Genetic factors in colorectal cancer (114 papers) and Cancer-related Molecular Pathways (43 papers). Kenneth W. Kinzler is often cited by papers focused on Cancer Genomics and Diagnostics (125 papers), Genetic factors in colorectal cancer (114 papers) and Cancer-related Molecular Pathways (43 papers). Kenneth W. Kinzler collaborates with scholars based in United States, Australia and Japan. Kenneth W. Kinzler's co-authors include Bert Vogelstein, Victor E. Velculescu, Christoph Lengauer, Nickolas Papadopoulos, Luis A. Díaz, Shibin Zhou, Lin Zhang, Patrice J. Morin, Jian Yu and Scott E. Kern and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Kenneth W. Kinzler

375 papers receiving 128.9k citations

Hit Papers

Cancer Genome Landscapes 1987 2026 2000 2013 2013 2009 1997 1998 2004 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Cancer Genome Landscapes
    2013 5.3k citations Bert Vogelstein, Nickolas Papadopoulos et al. Science profile →
  2. IDH1andIDH2Mutations in Gliomas
    2009 4.2k citations Hai Yan, D. Williams Parsons et al. New England Journal of Medicine profile →
  3. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
    1997 3.3k citations Bert Vogelstein, Kenneth W. Kinzler et al. Science profile →
  4. Genetic instabilities in human cancers
    1998 3.2k citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  5. Cancer genes and the pathways they control
    2004 3.0k citations Bert Vogelstein, Kenneth W. Kinzler profile →
  6. A simplified system for generating recombinant adenoviruses
    1998 3.0k citations Shibin Zhou, Jian Yu et al. Proceedings of the National Academy of Sciences profile →
  7. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
    1997 2.9k citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  8. Serial Analysis of Gene Expression
    1995 2.7k citations Victor E. Velculescu, Lin Zhang et al. Science profile →
  9. High Frequency of Mutations of the PIK3CA Gene in Human Cancers
    2004 2.7k citations Yardena Samuels, Zhenghe Wang et al. Science profile →
  10. Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
    1998 2.5k citations Fred Bunz, Kenneth W. Kinzler et al. Science profile →
  11. A model for p53-induced apoptosis
    1997 2.1k citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  12. Circulating mutant DNA to assess tumor dynamics
    2008 2.0k citations Frank Diehl, Nishant Agrawal et al. profile →
  13. Distant metastasis occurs late during the genetic evolution of pancreatic cancer
    2010 1.8k citations Siân Jones, Tibor Antal et al. profile →
  14. Definition of a consensus binding site for p53
    1992 1.7k citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  15. Amplification of a gene encoding a p53-associated protein in human sarcomas
    1992 1.6k citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  16. Genetic instability in colorectal cancers
    1997 1.6k citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  17. Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma
    1998 1.5k citations Sanford D. Markowitz, James K. V. Willson et al. Proceedings of the National Academy of Sciences profile →
  18. Genes Expressed in Human Tumor Endothelium
    2000 1.5k citations Carlo Rago, Victor E. Velculescu et al. Science profile →
  19. Mutation of a mutL Homolog in Hereditary Colon Cancer
    1994 1.4k citations Nickolas Papadopoulos, Kenneth W. Kinzler et al. Science profile →
  20. Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
    1990 1.4k citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  21. The multistep nature of cancer
    1993 1.4k citations Bert Vogelstein, Kenneth W. Kinzler profile →
  22. Digital PCR
    1999 1.3k citations Bert Vogelstein, Kenneth W. Kinzler Proceedings of the National Academy of Sciences profile →
  23. The molecular evolution of acquired resistance to targeted EGFR blockade in colorectal cancers
    2012 1.3k citations Luis A. Díaz, Jian Wu et al. profile →
  24. Multiple Intestinal Neoplasia Caused by a Mutation in the Murine Homolog of the APC Gene
    1992 1.3k citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  25. DAXX / ATRX , MEN1 , and mTOR Pathway Genes Are Frequently Altered in Pancreatic Neuroendocrine Tumors
    2011 1.2k citations Yuchen Jiao, Barish H. Edil et al. Science profile →
  26. Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    1993 1.2k citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  27. Mutations of mitotic checkpoint genes in human cancers
    1998 1.2k citations Daniel P. Cahill, Jian Yu et al. profile →
  28. The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints
    2014 1.1k citations Nicolás J. Llosa, Michael Cruise et al. Cancer Discovery profile →
  29. PUMA Induces the Rapid Apoptosis of Colorectal Cancer Cells
    2001 1.0k citations Jian Yu, Lin Zhang et al. profile →
  30. Is a p53-Regulated Inhibitor of G2/M Progression
    1997 1.0k citations Lin Zhang, Kenneth W. Kinzler et al. profile →
  31. Gene Expression Profiles in Normal and Cancer Cells
    1997 1.0k citations Lin Zhang, Victor E. Velculescu et al. Science profile →
  32. Association of the APC Tumor Suppressor Protein with Catenins
    1993 1.0k citations Bert Vogelstein, Kenneth W. Kinzler et al. Science profile →
  33. RAF/RAS oncogenes and mismatch-repair status
    2002 990 citations Alberto Bardelli, Kenneth W. Kinzler et al. profile →
  34. p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage.
    1995 980 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  35. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    2002 979 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  36. Detection and quantification of mutations in the plasma of patients with colorectal tumors
    2005 939 citations Frank Diehl, Dong Shen et al. Proceedings of the National Academy of Sciences profile →
  37. Identification of p53 as a Sequence-Specific DNA-Binding Protein
    1991 935 citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  38. Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma
    2010 923 citations Siân Jones, Tian‐Li Wang et al. Science profile →
  39. Bioleaching review part A:
    2003 903 citations Kenneth W. Kinzler et al. profile →
  40. The Genetic Basis of Human Cancer
    1997 885 citations Bert Vogelstein, Kenneth W. Kinzler profile →
  41. Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    1999 883 citations Fred Bunz, Kenneth W. Kinzler et al. profile →
  42. Hypermutability and mismatch repair deficiency in RER+ tumor cells
    1993 871 citations Nickolas Papadopoulos, Kenneth W. Kinzler et al. profile →
  43. Detection and quantification of rare mutations with massively parallel sequencing
    2011 857 citations Isaac Kinde, Jian Wu et al. Proceedings of the National Academy of Sciences profile →
  44. Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators
    1998 849 citations Leigh Zawel, Shibin Zhou et al. profile →
  45. Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
    1998 836 citations Bert Vogelstein, Kenneth W. Kinzler et al. profile →
  46. Oncogenic forms of p53 inhibit p53-regulated gene expression
    1992 812 citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  47. Scrambled exons
    1991 774 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  48. The colorectal microRNAome
    2006 757 citations Jordan M. Cummins, Yiping He et al. Proceedings of the National Academy of Sciences profile →
  49. Role of BAX in the Apoptotic Response to Anticancer Agents
    2000 757 citations Lin Zhang, Jian Yu et al. Science profile →
  50. Characterization of the Yeast Transcriptome
    1997 752 citations Victor E. Velculescu, Lin Zhang et al. profile →
  51. Analysis of mismatch repair genes in hereditary non–polyposis colorectal cancer patients
    1996 749 citations Nickolas Papadopoulos, Kenneth W. Kinzler et al. profile →
  52. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
    1999 740 citations Timothy A. Chan, Kenneth W. Kinzler et al. profile →
  53. Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    2005 727 citations Yardena Samuels, Luis A. Díaz et al. profile →
  54. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
    2009 724 citations Carlo Rago, James K. V. Willson et al. Science profile →
  55. The Molecular Basis of Turcot's Syndrome
    1995 719 citations Nickolas Papadopoulos, Steven M. Powell et al. New England Journal of Medicine profile →
  56. Mismatch repair gene defects in sporadic colorectal cancers with microsatellite instability
    1995 678 citations Sanford D. Markowitz, James K. V. Willson et al. profile →
  57. A protocol for rapid generation of recombinant adenoviruses using the AdEasy system
    2007 649 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  58. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    1996 637 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  59. Identification of a Gene Located at Chromosome 5q21 that Is Mutated in Colorectal Cancers
    1991 606 citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  60. Comparative lesion sequencing provides insights into tumor evolution
    2008 596 citations Siân Jones, Wei-Dong Chen et al. Proceedings of the National Academy of Sciences profile →
  61. Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations
    2003 591 citations Kenneth W. Kinzler, Bert Vogelstein et al. Proceedings of the National Academy of Sciences profile →
  62. Accumulation of driver and passenger mutations during tumor progression
    2010 565 citations Tibor Antal, Sining Chen et al. Proceedings of the National Academy of Sciences profile →
  63. Exomic Sequencing Identifies PALB2 as a Pancreatic Cancer Susceptibility Gene
    2009 565 citations Siân Jones, Ralph H. Hruban et al. Science profile →
  64. Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development
    2011 562 citations Jian Wu, Hanno Matthaei et al. Science Translational Medicine profile →
  65. Identification of ras Oncogene Mutations in the Stool of Patients with Curable Colorectal Tumors
    1992 555 citations Kenneth W. Kinzler, Bert Vogelstein et al. Science profile →
  66. Allelic Loss of Chromosome 18q and Prognosis in Colorectal Cancer
    1994 552 citations Kenneth W. Kinzler, Bert Vogelstein et al. New England Journal of Medicine profile →
  67. Genetic instability and darwinian selection in tumours
    1999 546 citations Daniel P. Cahill, Kenneth W. Kinzler et al. profile →
  68. Allelic Variation in Human Gene Expression
    2002 546 citations Victor E. Velculescu, Bert Vogelstein et al. Science profile →
  69. Identification of an Amplified, Highly Expressed Gene in a Human Glioma
    1987 541 citations Kenneth W. Kinzler, Darell D. Bigner et al. Science profile →
  70. A Phosphatase Associated with Metastasis of Colorectal Cancer
    2001 537 citations Alberto Bardelli, Victor E. Velculescu et al. Science profile →
  71. Presence of Somatic Mutations in Most Early-Stage Pancreatic Intraepithelial Neoplasia
    2012 534 citations Hanno Matthaei, Jian Wu et al. profile →
  72. Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells
    2014 513 citations Ada Tam, Richard L. Blosser et al. Proceedings of the National Academy of Sciences profile →
  73. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
    1998 504 citations Timothy A. Chan, Bert Vogelstein et al. Proceedings of the National Academy of Sciences profile →
  74. Detection of Chromosomal Alterations in the Circulation of Cancer Patients with Whole-Genome Sequencing
    2012 474 citations Rebecca Leary, Mark Sausen et al. Science Translational Medicine profile →
  75. Circulating tumor DNA as an early marker of therapeutic response in patients with metastatic colorectal cancer
    2015 464 citations Isaac Kinde, Luis A. Díaz et al. profile →
  76. Addressing overdiagnosis and overtreatment in cancer: a prescription for change
    2014 351 citations Kenneth W. Kinzler et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Kenneth W. Kinzler United States 163 79.7k 49.2k 37.4k 25.2k 14.8k 381 131.7k
Joan Massagué United States 184 95.5k 1.2× 47.2k 1.0× 22.6k 0.6× 9.0k 0.4× 9.3k 0.6× 362 137.5k
Hans Clevers Netherlands 190 98.0k 1.2× 53.3k 1.1× 18.5k 0.5× 10.8k 0.4× 24.3k 1.6× 728 159.5k
Douglas Hanahan United States 109 79.7k 1.0× 43.8k 0.9× 36.5k 1.0× 6.1k 0.2× 13.4k 0.9× 230 137.2k
Bert Vogelstein United States 204 134.2k 1.7× 91.6k 1.9× 56.8k 1.5× 44.5k 1.8× 28.7k 1.9× 553 229.5k
Lewis C. Cantley United States 183 104.9k 1.3× 27.4k 0.6× 29.7k 0.8× 7.4k 0.3× 7.3k 0.5× 710 150.4k
Robert A. Weinberg United States 176 135.1k 1.7× 95.3k 1.9× 56.3k 1.5× 10.6k 0.4× 18.3k 1.2× 382 223.8k
Adrian L. Harris United Kingdom 164 64.9k 0.8× 34.9k 0.7× 45.7k 1.2× 4.8k 0.2× 8.0k 0.5× 1.2k 109.9k
Gordon B. Mills United States 141 57.8k 0.7× 26.6k 0.5× 20.8k 0.6× 6.3k 0.2× 6.3k 0.4× 1.0k 89.6k
Michael Karin United States 229 113.1k 1.4× 45.8k 0.9× 56.6k 1.5× 9.5k 0.4× 15.3k 1.0× 652 212.6k
Carlo M. Croce United States 180 112.3k 1.4× 18.6k 0.4× 84.2k 2.3× 10.1k 0.4× 11.7k 0.8× 988 146.8k

Countries citing papers authored by Kenneth W. Kinzler

Since Specialization
Citations

This map shows the geographic impact of Kenneth W. Kinzler's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kenneth W. Kinzler with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kenneth W. Kinzler more than expected).

Fields of papers citing papers by Kenneth W. Kinzler

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kenneth W. Kinzler. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kenneth W. Kinzler. The network helps show where Kenneth W. Kinzler may publish in the future.

Co-authorship network of co-authors of Kenneth W. Kinzler

This figure shows the co-authorship network connecting the top 25 collaborators of Kenneth W. Kinzler. A scholar is included among the top collaborators of Kenneth W. Kinzler based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kenneth W. Kinzler. Kenneth W. Kinzler is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Bettegowda, Chetan, et al.. (2025). Molecular Evidence of Multiorgan Damage in Patients with Immune-Related Adverse Events. New England Journal of Medicine. 393(23). 2377–2379.
2.
Sur, Surojit, Evangeline Watson, Joshua D. Cohen, et al.. (2024). Identification of nonsense-mediated decay inhibitors that alter the tumor immune landscape. eLife. 13. 2 indexed citations
3.
Rettig, Eleni M., C. Conover Talbot, Mark Sausen, et al.. (2016). Whole-Genome Sequencing of Salivary Gland Adenoid Cystic Carcinoma. Cancer Prevention Research. 9(4). 265–274. 68 indexed citations
4.
Llosa, Nicolás J., Michael Cruise, Ada Tam, et al.. (2014). The Vigorous Immune Microenvironment of Microsatellite Instable Colon Cancer Is Balanced by Multiple Counter-Inhibitory Checkpoints. Cancer Discovery. 5(1). 43–51. 1112 indexed citations breakdown →
5.
Kinde, Isaac, Enrico Munari, Sheila F. Faraj, et al.. (2013). TERT Promoter Mutations Occur Early in Urothelial Neoplasia and Are Biomarkers of Early Disease and Disease Recurrence in Urine. Cancer Research. 73(24). 7162–7167. 200 indexed citations
6.
Willard, Melinda D., Mary E. Lajiness, Isabella H. Wulur, et al.. (2012). Somatic Mutations in CCK2R Alter Receptor Activity that Promote Oncogenic Phenotypes. Molecular Cancer Research. 10(6). 739–749. 15 indexed citations
7.
Wu, Jian, Hanno Matthaei, Anirban Maitra, et al.. (2011). Recurrent GNAS Mutations Define an Unexpected Pathway for Pancreatic Cyst Development. Science Translational Medicine. 3(92). 92ra66–92ra66. 562 indexed citations breakdown →
8.
Bettegowda, Chetan, Nishant Agrawal, Yuchen Jiao, et al.. (2011). Mutations in CIC and FUBP1 Contribute to Human Oligodendroglioma. Science. 333(6048). 1453–1455. 370 indexed citations
9.
Jones, Siân, Tian‐Li Wang, Ie‐Ming Shih, et al.. (2010). Frequent Mutations of Chromatin Remodeling Gene ARID1A in Ovarian Clear Cell Carcinoma. Science. 330(6001). 228–231. 923 indexed citations breakdown →
10.
Carter, Hannah, Sining Chen, Leyla Işık, et al.. (2009). Cancer-Specific High-Throughput Annotation of Somatic Mutations: Computational Prediction of Driver Missense Mutations. Cancer Research. 69(16). 6660–6667. 321 indexed citations
11.
Sur, Surojit, Raymond Pagliarini, Fred Bunz, et al.. (2009). A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53. Proceedings of the National Academy of Sciences. 106(10). 3964–3969. 230 indexed citations
12.
Jones, Siân, Wei-Dong Chen, Giovanni Parmigiani, et al.. (2008). Comparative lesion sequencing provides insights into tumor evolution. Proceedings of the National Academy of Sciences. 105(11). 4283–4288. 596 indexed citations breakdown →
13.
Huang, Chuan‐Hsiang, Diana Mandelker, Oleg Schmidt‐Kittler, et al.. (2007). The Structure of a Human p110α/p85α Complex Elucidates the Effects of Oncogenic PI3Kα Mutations. Science. 318(5857). 1744–1748. 446 indexed citations
14.
Cummins, Jordan M., Yiping He, Rebecca Leary, et al.. (2006). The colorectal microRNAome. Proceedings of the National Academy of Sciences. 103(10). 3687–3692. 757 indexed citations breakdown →
15.
Samuels, Yardena, Zhenghe Wang, Alberto Bardelli, et al.. (2004). High Frequency of Mutations of the PIK3CA Gene in Human Cancers. Science. 304(5670). 554–554. 2708 indexed citations breakdown →
16.
Wang, Zhenghe, Dong Shen, D. Williams Parsons, et al.. (2004). Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers. Science. 304(5674). 1164–1166. 412 indexed citations
17.
Yu, Jian, Zhenghe Wang, Kenneth W. Kinzler, Bert Vogelstein, & Lin Zhang. (2003). PUMA mediates the apoptotic response to p53 in colorectal cancer cells. Proceedings of the National Academy of Sciences. 100(4). 1931–1936. 491 indexed citations
18.
Chan, Timothy A., Zhenghe Wang, Long H. Dang, Bert Vogelstein, & Kenneth W. Kinzler. (2002). Targeted inactivation of CTNNB1 reveals unexpected effects of β-catenin mutation. Proceedings of the National Academy of Sciences. 99(12). 8265–8270. 108 indexed citations
19.
Zawel, Leigh, Jian Yu, C Torrance, et al.. (2002). DEC1 is a downstream target of TGF-β with sequence-specific transcriptional repressor activities. Proceedings of the National Academy of Sciences. 99(5). 2848–2853. 81 indexed citations
20.
Dang, Long H., Chetan Bettegowda, David L. Huso, Kenneth W. Kinzler, & Bert Vogelstein. (2001). Combination bacteriolytic therapy for the treatment of experimental tumors. Proceedings of the National Academy of Sciences. 98(26). 15155–15160. 446 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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