Phillip A. Sharp

125.7k total citations · 55 hit papers
433 papers, 92.7k citations indexed

About

Phillip A. Sharp is a scholar working on Molecular Biology, Genetics and Cancer Research. According to data from OpenAlex, Phillip A. Sharp has authored 433 papers receiving a total of 92.7k indexed citations (citations by other indexed papers that have themselves been cited), including 359 papers in Molecular Biology, 125 papers in Genetics and 69 papers in Cancer Research. Recurrent topics in Phillip A. Sharp's work include RNA Research and Splicing (165 papers), RNA and protein synthesis mechanisms (115 papers) and Virus-based gene therapy research (97 papers). Phillip A. Sharp is often cited by papers focused on RNA Research and Splicing (165 papers), RNA and protein synthesis mechanisms (115 papers) and Virus-based gene therapy research (97 papers). Phillip A. Sharp collaborates with scholars based in United States, Japan and United Kingdom. Phillip A. Sharp's co-authors include Arnold Berk, Margaret S. Ebert, Maria M. Konarska, Joel R. Neilson, John G. Doench, Christopher B. Burge, Richard A. Young, Joe Sambrook, Richard A. Padgett and Michael T. McManus and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Phillip A. Sharp

431 papers receiving 88.0k citations

Hit Papers

Histone H3K27ac separate... 1973 2026 1990 2008 2010 1977 2015 2000 2007 500 1000 1.5k 2.0k 2.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Histone H3K27ac separates active from poised enhancers and predicts developmental state
    2010 2.9k citations Menno P. Creyghton, Albert W. Cheng et al. Proceedings of the National Academy of Sciences profile →
  2. Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids
    1977 2.8k citations Phillip A. Sharp et al. profile →
  3. In vivo genome editing using Staphylococcus aureus Cas9
    2015 2.0k citations Phillip A. Sharp, Feng Zhang et al. profile →
  4. RNAi
    2000 2.0k citations Phillip A. Sharp et al. profile →
  5. MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells
    2007 1.7k citations Joel R. Neilson, Phillip A. Sharp et al. profile →
  6. Detection of two restriction endonuclease activities in Haemophilus parainfluenzae using analytical agarose-ethidium bromide electrophoresis
    1973 1.4k citations Phillip A. Sharp et al. profile →
  7. Targeted Deletion Reveals Essential and Overlapping Functions of the miR-17∼92 Family of miRNA Clusters
    2008 1.3k citations Andrea Ventura, Roderick T. Bronson et al. profile →
  8. Specificity of microRNA target selection in translational repression
    2004 1.3k citations Phillip A. Sharp et al. profile →
  9. Roles for MicroRNAs in Conferring Robustness to Biological Processes
    2012 1.3k citations Phillip A. Sharp et al. profile →
  10. A Phase Separation Model for Transcriptional Control
    2017 1.2k citations Krishna Shrinivas, Richard A. Young et al. profile →
  11. SPLICING OF MESSENGER RNA PRECURSORS
    1986 1.2k citations Phillip A. Sharp et al. profile →
  12. DNA-dependent transcription of adenovirus genes in a soluble whole-cell extract.
    1980 1.1k citations Phillip A. Sharp et al. Proceedings of the National Academy of Sciences profile →
  13. Lentivirus-delivered stable gene silencing by RNAi in primary cells
    2003 1.1k citations Phillip A. Sharp et al. profile →
  14. Connecting microRNA Genes to the Core Transcriptional Regulatory Circuitry of Embryonic Stem Cells
    2008 1.1k citations Stuart S. Levine, Garrett M. Frampton et al. profile →
  15. Gene silencing in mammals by small interfering RNAs
    2002 1.1k citations Michael T. McManus, Phillip A. Sharp profile →
  16. A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes
    1986 1.1k citations Phillip A. Sharp et al. profile →
  17. Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites
    2008 1.1k citations Rickard Sandberg, Joel R. Neilson et al. Science profile →
  18. c-Myc Regulates Transcriptional Pause Release
    2010 977 citations Peter B. Rahl, Ryan A. Flynn et al. profile →
  19. siRNAs can function as miRNAs
    2003 965 citations Phillip A. Sharp et al. profile →
  20. Spliced segments at the 5′ terminus of adenovirus 2 late mRNA
    1977 934 citations Phillip A. Sharp et al. Proceedings of the National Academy of Sciences profile →
  21. Five intermediate complexes in transcription initiation by RNA polymerase II
    1989 921 citations Stephen Buratowski, Phillip A. Sharp et al. profile →
  22. Killing the messenger: short RNAs that silence gene expression
    2003 918 citations Phillip A. Sharp et al. profile →
  23. Embryonic Stem Cell-Specific MicroRNAs
    2003 896 citations Phillip A. Sharp et al. profile →
  24. Splicing of Messenger RNA Precursors
    1987 856 citations Phillip A. Sharp Science profile →
  25. Predictive Identification of Exonic Splicing Enhancers in Human Genes
    2002 846 citations Phillip A. Sharp, Christopher B. Burge et al. Science profile →
  26. TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation
    2005 837 citations Jeong‐Ho Hong, Eun Sook Hwang et al. Science profile →
  27. Spliced early mRNAs of simian virus 40
    1978 739 citations Phillip A. Sharp et al. Proceedings of the National Academy of Sciences profile →
  28. An RNA polymerase II transcription factor binds to an upstream element in the adenovirus major late promoter
    1985 724 citations Phillip A. Sharp et al. profile →
  29. Suppression of non-small cell lung tumor development by the let-7 microRNA family
    2008 707 citations Phillip A. Sharp, Tyler Jacks et al. Proceedings of the National Academy of Sciences profile →
  30. Divergent Transcription from Active Promoters
    2008 696 citations J. Mauro Calabrese, Stuart S. Levine et al. Science profile →
  31. MicroRNA Functions in Stress Responses
    2010 678 citations Anthony K. L. Leung, Phillip A. Sharp profile →
  32. Pre-early adenovirus 5 gene product regulates synthesis of early viral messenger RNAs
    1979 674 citations Phillip A. Sharp et al. profile →
  33. A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes
    1986 667 citations Phillip A. Sharp et al. profile →
  34. Human CCAAT-binding proteins have heterologous subunits
    1988 666 citations Phillip A. Sharp et al. profile →
  35. The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products.
    1988 659 citations Phillip A. Sharp et al. profile →
  36. Targeted mRNA degradation by double-stranded RNA in vitro
    1999 641 citations Phillip A. Sharp et al. profile →
  37. Genome-wide CRISPR Screen in a Mouse Model of Tumor Growth and Metastasis
    2015 633 citations Sidi Chen, Feng Zhang et al. profile →
  38. siRNA-directed inhibition of HIV-1 infection
    2002 631 citations Phillip A. Sharp et al. profile →
  39. Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132
    2010 613 citations Dieter Edbauer, Joel R. Neilson et al. Neuron profile →
  40. MicroRNA sponges: Progress and possibilities
    2010 607 citations Phillip A. Sharp et al. profile →
  41. A High-Efficiency HeLa Cell Nuclear Transcription Extract
    1988 595 citations David J. Shapiro, Phillip A. Sharp et al. DNA profile →
  42. Molecular cloning of an enhancer binding protein:Isolation by screening of an expression library with a recognition site DNA
    1988 593 citations Phillip A. Sharp et al. profile →
  43. RNA interference—2001
    2001 586 citations Phillip A. Sharp profile →
  44. CRISPR-mediated direct mutation of cancer genes in the mouse liver
    2014 580 citations Wen Xue, Sidi Chen et al. profile →
  45. Speculations on RNA splicing
    1981 576 citations Phillip A. Sharp profile →
  46. The RNAi revolution
    2004 550 citations Phillip A. Sharp et al. profile →
  47. Structure of the adenovirus 2 early mRNAs
    1978 535 citations Phillip A. Sharp et al. profile →
  48. Short RNAs Repress Translation after Initiation in Mammalian Cells
    2006 533 citations Phillip A. Sharp et al. profile →
  49. Recognition of cap structure in splicing in vitro of mRNA precursors
    1984 518 citations Phillip A. Sharp et al. profile →
  50. Cre-lox-regulated conditional RNA interference from transgenes
    2004 500 citations Andrea Ventura, Alexander Meissner et al. Proceedings of the National Academy of Sciences profile →
  51. Pol II phosphorylation regulates a switch between transcriptional and splicing condensates
    2019 455 citations Yang Guo, John C. Manteiga et al. profile →
  52. Viral DNA in transformed cells
    1974 390 citations Phillip A. Sharp et al. profile →
  53. RNA-Mediated Feedback Control of Transcriptional Condensates
    2020 365 citations Krishna Shrinivas, Nancy M. Hannett et al. profile →
  54. [35] In Vitro transcription: Whole-cell extract
    1983 286 citations Phillip A. Sharp et al. profile →
  55. Separation and characterization of factors mediating accurate transcription by RNA polymerase II.
    1982 283 citations Phillip A. Sharp et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Phillip A. Sharp United States 156 76.5k 18.8k 17.3k 8.3k 7.3k 433 92.7k
Nahum Sonenberg Canada 160 77.5k 1.0× 12.8k 0.7× 8.7k 0.5× 9.1k 1.1× 7.1k 1.0× 673 97.8k
Rudolf Jaenisch United States 179 107.3k 1.4× 14.1k 0.7× 33.2k 1.9× 10.4k 1.3× 7.6k 1.0× 590 136.9k
Robert Tjian United States 136 56.0k 0.7× 4.2k 0.2× 13.9k 0.8× 6.8k 0.8× 8.0k 1.1× 337 69.6k
T Gingeras United States 65 33.3k 0.4× 8.4k 0.4× 7.0k 0.4× 7.7k 0.9× 4.0k 0.6× 134 51.6k
Gregory J. Hannon United States 142 84.2k 1.1× 35.0k 1.9× 10.4k 0.6× 6.6k 0.8× 14.5k 2.0× 320 104.6k
Inder M. Verma United States 140 43.7k 0.6× 13.1k 0.7× 18.8k 1.1× 13.4k 1.6× 11.2k 1.5× 400 69.1k
Aviv Regev United States 129 61.9k 0.8× 20.4k 1.1× 6.4k 0.4× 11.4k 1.4× 7.3k 1.0× 319 80.8k
Thomas A. Kunkel United States 113 42.0k 0.5× 8.4k 0.4× 9.1k 0.5× 2.3k 0.3× 5.6k 0.8× 405 51.9k
Pierre Chambon France 183 80.6k 1.1× 7.7k 0.4× 45.3k 2.6× 15.8k 1.9× 13.3k 1.8× 702 117.0k
Richard A. Young United States 134 59.3k 0.8× 7.2k 0.4× 7.6k 0.4× 6.2k 0.7× 6.1k 0.8× 287 70.5k

Countries citing papers authored by Phillip A. Sharp

Since Specialization
Citations

This map shows the geographic impact of Phillip A. Sharp's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Phillip A. Sharp with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Phillip A. Sharp more than expected).

Fields of papers citing papers by Phillip A. Sharp

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Phillip A. Sharp. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Phillip A. Sharp. The network helps show where Phillip A. Sharp may publish in the future.

Co-authorship network of co-authors of Phillip A. Sharp

This figure shows the co-authorship network connecting the top 25 collaborators of Phillip A. Sharp. A scholar is included among the top collaborators of Phillip A. Sharp based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Phillip A. Sharp. Phillip A. Sharp is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Manteiga, John C., Lena K. Afeyan, Krishna Shrinivas, et al.. (2019). Pol II phosphorylation regulates a switch between transcriptional and splicing condensates. DSpace@MIT (Massachusetts Institute of Technology). 1 indexed citations
2.
Suzuki, Hiroshi, Richard A. Young, & Phillip A. Sharp. (2017). Super-Enhancer-Mediated RNA Processing Revealed by Integrative MicroRNA Network Analysis. DSpace@MIT (Massachusetts Institute of Technology). 8 indexed citations
3.
Sigova, Alla A., Brian J. Abraham, Ji Xiong, et al.. (2015). Transcription factor trapping by RNA in gene regulatory elements. Science. 350(6263). 978–981. 361 indexed citations
4.
Xue, Wen, Sidi Chen, Hao Yin, et al.. (2014). CRISPR-mediated direct mutation of cancer genes in the mouse liver. RePEc: Research Papers in Economics. 1 indexed citations
5.
Zamudio, Jesse R., Timothy Kelly, & Phillip A. Sharp. (2014). Argonaute-Bound Small RNAs from Promoter-Proximal RNA Polymerase II. DSpace@MIT (Massachusetts Institute of Technology). 1 indexed citations
6.
Edbauer, Dieter, Joel R. Neilson, Kelly A. Foster, et al.. (2010). Regulation of Synaptic Structure and Function by FMRP-Associated MicroRNAs miR-125b and miR-132. Neuron. 65(3). 373–384. 613 indexed citations breakdown →
7.
Goldberg, Michael S., Deyin Xing, Yin Ren, et al.. (2010). Nanoparticle-mediated delivery of siRNA targeting Parp1 extends survival of mice bearing tumors derived from Brca1-deficient ovarian cancer cells. Proceedings of the National Academy of Sciences. 108(2). 745–750. 83 indexed citations
8.
Creyghton, Menno P., Albert W. Cheng, G. Grant Welstead, et al.. (2010). Histone H3K27ac separates active from poised enhancers and predicts developmental state. Proceedings of the National Academy of Sciences. 107(50). 21931–21936. 2891 indexed citations breakdown →
9.
Sandberg, Rickard, Joel R. Neilson, Arup Kumar Sarma, Phillip A. Sharp, & Christopher B. Burge. (2008). Proliferating Cells Express mRNAs with Shortened 3' Untranslated Regions and Fewer MicroRNA Target Sites. Science. 320(5883). 1643–1647. 1067 indexed citations breakdown →
10.
Calabrese, J. Mauro, Stuart S. Levine, G Yeo, et al.. (2008). Divergent Transcription from Active Promoters. Science. 322(5909). 1849–1851. 696 indexed citations breakdown →
11.
Schild‐Poulter, Caroline, et al.. (2007). DNA-PK phosphorylation sites on Oct-1 promote cell survival following DNA damage. Oncogene. 26(27). 3980–3988. 38 indexed citations
12.
Leung, Anthony K. L., J. Mauro Calabrese, & Phillip A. Sharp. (2006). Quantitative analysis of Argonaute protein reveals microRNA-dependent localization to stress granules. Proceedings of the National Academy of Sciences. 103(48). 18125–18130. 297 indexed citations
13.
Tantin, Dean, Caroline Schild‐Poulter, Victoria Wang, Robert J.G. Haché, & Phillip A. Sharp. (2005). The Octamer Binding Transcription Factor Oct-1 Is a Stress Sensor. Cancer Research. 65(23). 10750–10758. 95 indexed citations
14.
Hong, Jeong‐Ho, Eun Sook Hwang, Michael T. McManus, et al.. (2005). TAZ, a Transcriptional Modulator of Mesenchymal Stem Cell Differentiation. Science. 309(5737). 1074–1078. 837 indexed citations breakdown →
15.
Ventura, Andrea, Alexander Meissner, Christopher P. Dillon, et al.. (2004). Cre-lox-regulated conditional RNA interference from transgenes. Proceedings of the National Academy of Sciences. 101(28). 10380–10385. 500 indexed citations breakdown →
16.
Sharp, Phillip A.. (1992). Nuclear processes and oncogenes. Academic Press eBooks. 11 indexed citations
17.
Buratowski, Stephen & Phillip A. Sharp. (1992). 9 Initiation of Transcription by RNA Polymerase II. Cold Spring Harbor Monograph Archive. 227–246. 4 indexed citations
18.
Shapiro, David J., et al.. (1988). A High-Efficiency HeLa Cell Nuclear Transcription Extract. DNA. 7(1). 47–55. 595 indexed citations breakdown →
19.
Botchan, Michael R., Terri Grodzicker, & Phillip A. Sharp. (1985). DNA tumor viruses: control of gene expression and replication : abstracts of papers presented at the Third Cold Spring Harbor Meeting on Cancer Cells, September 4-September 8, 1985. 5 indexed citations
20.
Kaufman, Randal J., Phillip A. Sharp, & Samuel A. Latt. (1983). Evolution of Chromosomal Regions Containing Transfected and Amplified Dihydrofolate Reductase Sequences. Molecular and Cellular Biology. 3(4). 699–711. 35 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Nahum Sonenberg Breakdown of academic impact, for papers by Rudolf Jaenisch Breakdown of academic impact, for papers by Robert Tjian Breakdown of academic impact, for papers by T Gingeras Breakdown of academic impact, for papers by Gregory J. Hannon Breakdown of academic impact, for papers by Inder M. Verma Breakdown of academic impact, for papers by Aviv Regev Breakdown of academic impact, for papers by Thomas A. Kunkel Breakdown of academic impact, for papers by Pierre Chambon Breakdown of academic impact, for papers by Richard A. Young
Rankless by CCL
2026