James R. Downing

90.9k citations

269 papers · 43.9k indexed · 15 hit papers · h-index 83

Impact in

Hematology top 0.01%
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
Cancer Research top 0.02%
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research

Papers in

Hematology 121
- Acute Myeloid Leukemia Research 96
- Chronic Myeloid Leukemia Treatments 38
Public Health, Environmental and Occupational Health 109
- Acute Lymphoblastic Leukemia research 108

Co-authors: Todd R. Golub Ching‐Hon Pui Mignon L. Loh Eric S. Lander Pablo Tamayo Jill P. Mesirov Hilary A. Coller M. A. Caligiuri
Journals: Blood (59 papers)Molecular and Cellular Biology (19 papers)Journal of Clinical Oncology (11 papers)Leukemia (10 papers)Nature (7 papers)
Partner nations: United States United Kingdom Germany

In The Last Decade

James R. Downing

255 papers receiving 42.9k citations

Hit Papers

15 papers align trajectories log scale

Data-Driven Phenotypic Dissection of AML Reveals Progenitor-like Cells that Correlate with Prognosis 2015 · 1.3k citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2015 Cell
2015 Journal of Clinical Oncology
2011 Nature
2009 The Lancet Oncology
2008 Nature
2008 Science
2007 Nature
2005 Nature
2004 New England Journal of Medicine
2002 Cancer Cell
1999 New England Journal of Medicine
1999 Science
1997 Cell
1996 Cell
1980 Endocrinology

Peers

Countries citing papers authored by James R. Downing

Since Specialization

Citations

This map shows the geographic impact of James R. Downing's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by James R. Downing with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites James R. Downing more than expected).

Fields of papers citing papers by James R. Downing

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by James R. Downing. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by James R. Downing. The network helps show where James R. Downing may publish in the future.

Co-authors

The 25 scholars most cited alongside James R. Downing, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with James R. Downing Line = papers co-authored together James R. Downing links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	The Global Platform for Access to Childhood Cancer Medicines: addressing inequities in childhood cancer care The Lancet Oncology ·James R. Downing, Tedros Adhanom Ghebreyesus	2025	0
2	Genome-wide CRISPR/Cas9 screen identifies etoposide response modulators associated with clinical outcomes in pediatric AML Blood Advances ·Nam Nguyen, Roya Rafiee, Abderrahmane Tagmount, Amin Sobh, Alex Loguinov, Angelica K. de Jesus Sosa, Abdelrahman H. Elsayed, Mohammed Gbadamosi, Nathan D. Seligson, Christopher R. Cogle, Jeffrey E. Rubnitz, Raul C. Ribeiro, James R. Downing, Xueyuan Cao, Stanley Pounds, Chris D. Vulpe, Jatinder K. Lamba	2022	9
3	Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8 ⁺ T cell responses Science Translational Medicine ·Anthony E. Zamora, Jeremy Chase Crawford, E. Kaitlynn Allen, Xi-zhi J. Guo, Jesse Bakke, Robert Carter, Hossam A. Abdelsamed, Ardiana Moustaki, Yongjin Li, Ti‐Cheng Chang, Walid Awad, Mari Dallas, Charles G. Mullighan, James R. Downing, Terrence L. Geiger, Taosheng Chen, Douglas R. Green, Ben Youngblood, Jinghui Zhang, Paul G. Thomas	2019	59
4	The Wave2 scaffold Hem-1 is required for transition of fetal liver hematopoiesis to bone marrow Nature Communications ·Lijian Shao, Jianhui Chang, Wei Feng, Xiaoyan Wang, Elizabeth A. Williamson, Ying Li, Amir Schajnovitz, David T. Scadden, Luke J. Mortensen, Charles P. Lin, Linheng Li, Ariel Paulson, James R. Downing, Daohong Zhou, Robert Hromas	2018	12
5	Polygenic Determinants for Subsequent Breast Cancer Risk in Survivors of Childhood Cancer: The St Jude Lifetime Cohort Study (SJLIFE) Clinical Cancer Research ·Zhaoming Wang, Qi Liu, Carmen L. Wilson, John Easton, Heather L. Mulder, Ti-Cheng Chang, Michael Rusch, Michael N. Edmonson, Stephen V. Rice, Matthew J. Ehrhardt, Rebecca M. Howell, Chimene Kesserwan, Gang Wu, Kim E. Nichols, James R. Downing, Melissa M. Hudson, Jinghui Zhang, Yutaka Yasui, Leslie L. Robison	2018	18
6	An unexpected protein interaction promotes drug resistance in leukemia Nature Communications ·Aaron Pitre, Yubin Ge, Wenwei Lin, Yao Wang, Yu Fukuda, Jamshid Temirov, Aaron H. Phillips, Jennifer L. Peters, Yiping Fan, Jing Ma, Amanda Nourse, Chandrima Sinha, Hai Lin, Richard W. Kriwacki, James R. Downing, Tanja A. Grüber, Victoria E. Centonze, Anjaparavanda P. Naren, Taosheng Chen, John D. Schuetz	2017	20
7	Redefining “rare” in paediatric cancers The Lancet Oncology ·Ching‐Hon Pui, Alberto S. Pappo, Amar Gajjar, James R. Downing	2016	3
8	Outcomes of Children With BCR-ABL1 –Like Acute Lymphoblastic Leukemia Treated With Risk-Directed Therapy Based on the Levels of Minimal Residual Disease Journal of Clinical Oncology ·Kathryn G. Roberts, Deqing Pei, Dario Campana, Debbie Payne-Turner, Yongjin Li, Cheng Cheng, John T. Sandlund, Sima Jeha, John Easton, Jared Becksfort, Jinghui Zhang, Elaine Coustan‐Smith, Susana C. Raimondi, Wing Leung, Mary V. Relling, William E. Evans, James R. Downing, Charles G. Mullighan, Ching‐Hon Pui	2014	165
9	Dominant Role of Oncogene Dosage and Absence of Tumor Suppressor Activity in Nras- Driven Hematopoietic Transformation Cancer Discovery ·Jin Xu, Kevin M. Haigis, Ari J. Firestone, Megan E. McNerney, Qing Li, Elizabeth L. Davis, Shann-Ching Chen, Joy Nakitandwe, James R. Downing, Tyler Jacks, Michelle M. Le Beau, Kevin Shannon	2013	47
10	Comparative Analysis of Different Approaches to Measure Treatment Response in Acute Myeloid Leukemia Journal of Clinical Oncology ·Hiroto Inaba, Elaine Coustan‐Smith, Xueyuan Cao, Stanley Pounds, Sheila Shurtleff, Kathleen Y. Wang, Susana C. Raimondi, Mihaela Onciu, Jeffrey Jacobsen, Raul C. Ribeiro, Gary V. Dahl, W. Paul Bowman, Jeffrey W. Taub, Barbara Degar, Wing Leung, James R. Downing, Ching‐Hon Pui, Jeffrey E. Rubnitz, Dario Campana	2012	136
11	Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia Blood ·Richard C. Harvey, Charles G. Mullighan, I‐Ming Chen, Walker Wharton, Fady M. Mikhail, Andrew J. Carroll, Huining Kang, Wei Liu, Kevin K. Dobbin, Malcolm A. Smith, William L. Carroll, Meenakshi Devidas, W. Paul Bowman, Bruce M. Camitta, Gregory H. Reaman, Stephen P. Hunger, James R. Downing, Cheryl L. Willman	2010	395
12	Mesenchymal cells regulate the response of acute lymphoblastic leukemia cells to asparaginase Journal of Clinical Investigation ·Shotaro Iwamoto, Keichiro Mihara, James R. Downing, Ching‐Hon Pui, Dario Campana	2007	246
13	Folate pathway gene expression differs in subtypes of acute lymphoblastic leukemia and influences methotrexate pharmacodynamics Journal of Clinical Investigation ·Leo Kager, Meyling Cheok, Wenjian Yang, Gianluigi Zaza, Qing Cheng, John C. Panetta, Ching‐Hon Pui, James R. Downing, Mary V. Relling, William E. Evans	2005	109
14	Global gene expression as a function of germline genetic variation Human Molecular Genetics ·Deborah French, Mark R. Wilkinson, Wenjian Yang, Luc de Chaisemartin, Edwin H. Cook, Soma Das, Mark J. Ratain, William E. Evans, James R. Downing, Ching‐Hon Pui, Mary V. Relling	2005	13
15	Expression of a conditional AML1-ETO oncogene bypasses embryonic lethality and establishes a murine model of human t(8;21) acute myeloid leukemia Cancer Cell ·Masakazu Higuchi, Darin P. O’Brien, Parasakthy Kumaravelu, Noel Lenny, Allen Eng Juh Yeoh, James R. Downing	2002	340
16	HERF1, a Novel Hematopoiesis-Specific RING Finger Protein, Is Required for Terminal Differentiation of Erythroid Cells Molecular and Cellular Biology ·Hironori Harada, Yuka Harada, Darin P. O’Brien, Dennis S. Rice, Clayton W. Naeve, James R. Downing	1999	46
17	The t(8;21) Fusion Product, AML-1–ETO, Associates with C/EBP-α, Inhibits C/EBP-α-Dependent Transcription, and Blocks Granulocytic Differentiation Molecular and Cellular Biology ·Jennifer J. Westendorf, Cindy M. Yamamoto, Noel Lenny, James R. Downing, Michael E. Selsted, Scott W. Hiebert	1998	237
18	Pathobiology and Clinical Significance of Molecular Genetic Findings in Childhood Tumors Advances in Pediatrics ·Jeffrey E. Rubnitz, James R. Downing, William M. Crist	1998	2
19	Multiple nitric oxide synthase systems in adult rat thymus revealed using NADPH diaphorase histochemistry. PubMed Central ·James R. Downing	1994	18
20	Quantitative analysis of cone photoreceptor–horizontal cell connectivity patterns in the retina of a cyprinid fish: Electron microscopy of functionally identified and HRP‐labelled horizontal cells The Journal of Comparative Neurology ·James R. Downing, Mustafa B.A. Djamgoz	1989	47

About James R. Downing

James R. Downing is a scholar working on Hematology, Public Health, Environmental and Occupational Health, Genetics, Cancer Research and Molecular Biology, having authored 269 papers that have together received 43.9k indexed citations. Recurring topics across this work include Acute Lymphoblastic Leukemia research (108 papers), Acute Myeloid Leukemia Research (96 papers), Chronic Myeloid Leukemia Treatments (38 papers), Childhood Cancer Survivors' Quality of Life (27 papers), Epigenetics and DNA Methylation (25 papers), Cancer Genomics and Diagnostics (25 papers), Protein Degradation and Inhibitors (17 papers) and Chronic Lymphocytic Leukemia Research (17 papers). The work is most often cited by research in Hematology (12.4k citations), Cancer Research (9.9k citations), Molecular Biology (26.7k citations), Public Health, Environmental and Occupational Health (10.1k citations) and Genetics (2.7k citations). James R. Downing has collaborated with scholars based in United States, United Kingdom and Germany. Frequent co-authors include Todd R. Golub, Ching‐Hon Pui, Mignon L. Loh, Eric S. Lander, Pablo Tamayo, Jill P. Mesirov, Hilary A. Coller, M. A. Caligiuri, C. Huard and C. D. Bloomfield. Their work appears in journals such as Blood, Molecular and Cellular Biology, Journal of Clinical Oncology, Leukemia and Nature.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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