Hans Clevers

249.8k citations

728 papers · 159.5k indexed · 82 hit papers · h-index 190

Oncology top 0.01%
- Cancer Cells and Metastasis 192
Molecular Biology top 0.01%
- Wnt/β-catenin signaling in development and cancer 172
- Cancer-related gene regulation 116
- Epigenetics and DNA Methylation 60
- Pluripotent Stem Cells Research 55
Cancer Research top 0.01%
Aging top 0.05%
Genetics top 0.01%
- Digestive system and related health 97
Pathology and Forensic Medicine
- Genetic factors in colorectal cancer 47
Immunology
- Immune Cell Function and Interaction 41

Co-authors: Nick Barker Johan H. van Es Roel Nusse Marc van de Wetering Toshiro Sato Maaike van den Born Harry Begthel Eduard Batlle
Cited by: Oncology Molecular Biology Cancer Research
Journals: Proceedings of the National Academy of Sciences (37 papers)Cell (34 papers)Nature (32 papers)
Partner nations: Netherlands United States Germany

In The Last Decade

Hans Clevers

716 papers receiving 157.4k citations

Hit Papers

15 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2020 Nature
2019 Science
2018 Nature Reviews Gastroenterology & Hepatology
2018 Cell
2018 Nature reviews. Cancer
2017 Trends in Molecular Medicine
2017 Cell
2017 Nature Medicine
2016 Nature
2016 Nature Protocols
2016 Nature
2016 Nature Protocols
2016 Cell
2016 Cell stem cell
2015 Nature
2015 Nature
2014 Genes & Development
2014 Gastroenterology
2014 Cell
2014 Science
2013 Nature
2013 Nature Medicine
2013 Cell
2013 Annual Review of Physiology
2013 Cell stem cell
2013 Science
2013 The EMBO Journal
2013 Cell
2012 Cell
2012 Cell
2012 Gastroenterology
2012 Nature
2012 The EMBO Journal
2012 Science
2012 Nature Cell Biology
2012 Nature Medicine
2011 Nature Medicine
2011 Gastroenterology
2011 Cell stem cell
2011 Nature
2011 Nature Medicine
2010 Cell stem cell
2010 Science
2010 Science
2010 Nature
2010 Cell
2009 Cell
2009 Nature
2008 Annual Review of Physiology
2008 Nature
2008 Nature Genetics
2007 Nature
2006 Nature Reviews Drug Discovery
2006 Cell
2005 Nature Cell Biology
2005 Developmental Cell
2005 Nature
2005 Nature Cell Biology
2005 Nature
2005 Genes & Development
2005 Science
2004 Science
2004 Genes & Development
2003 Genes & Development
2003 Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
2003 Nature Genetics
2002 Cell
2002 Molecular and Cellular Biology
2002 Cell
2001 Nature reviews. Cancer
2001 Nature Cell Biology
2000 Cell
1999 Nature
1998 Nature
1998 Nature Genetics
1998 Nature
1997 Cell
1997 Science
1997 Science
1996 Cell
1995 Nature Medicine
1988 Annual Review of Immunology

Peers

Countries citing papers authored by Hans Clevers

Since Specialization

Citations

This map shows the geographic impact of Hans Clevers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hans Clevers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hans Clevers more than expected).

Fields of papers citing papers by Hans Clevers

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hans Clevers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hans Clevers. The network helps show where Hans Clevers may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Hans Clevers, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Hans Clevers Line = papers co-authored together Hans Clevers links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work
1	Lactate controls cancer stemness and plasticity through epigenetic regulationbreakdown → Cell Metabolism ·Roslynn Mertens,R. J. Ferrier,Rutger N.U. Kok,Yi-Jer Tsai,Hannah K. Neikes,Ninouk Akkerman,O. V. Butkevich,R. Plana,Setsuko YOSHIDA,Edwin C.A. Stigter,Yvonne Vercoulen,Jarno Drost,Hans Clevers,Michiel Vermeulen,Jeroen S. van Zon,Sander J. Tans,Boudewijn Burgering,Maria J. Rodríguez Colman	2025	22
2	Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools STAR Protocols ·Jean Barakat,Altmann Udo,Johan H. van Es,Ruben van Boxtel,Hans Clevers,Maarten H. Geurts	2024	5
3	Paecilomycone Inhibits Quorum Sensing in Gram-Negative Bacteria Microbiology Spectrum ·禎二門脇,A. Romero,Marie Bannier-Hélaouët,Hans Clevers,Jeroen den Hertog	2023	4
4	Dual Targeting of CDK4/6 and BCL2 Pathways Augments Tumor Response in Estrogen Receptor–Positive Breast Cancer Clinical Cancer Research ·James R. Whittle,François Vaillant,Elliot Surgenor,Antonia N. Policheni,Göknur Giner,Bianca D. Capaldo,Zheng-Yuan Zhou,Daskalakis Georgios,Johanna F. Dekkers,Norman Sachs,Hans Clevers,Andrew Fellowes,J Schmitte,Huiling Xu,Stephen B. Fox,Marco J. Herold,Gordon K. Smyth,Daniel H.D. Gray,Jane E. Visvader,Geoffrey J. Lindeman	2020	70
5	The potential and challenges of patient-derived organoids in guiding the multimodality treatment of upper gastrointestinal malignancies Open Biology ·Georg Busslinger,I.W. Sukerayasa,Irma Kánter Coronel,Richard van Hillegersberg,Jelle P. Ruurda,Hans Clevers,Michiel F.G. de Maat	2020	9
6	Organoid cultures of early-onset colorectal cancers reveal distinct and rare genetic profiles Gut ·Helen H.N. Yan,Hoi Cheong Siu,Siu Lun Ho,Sarah S K Yue,Yang Gao,Wai Yin Tsui,Dessy Chan,April Chan,Jason W.H. Wong,Song Baozheng,Bernard C. H. Lee,Annie S Y Chan,Anthony K W Chan,С. В. Иваненко,Arthur Cheung,Wai Lun Law,Oswens Siu‐Hung Lo,Siu Tsan Yuen,Hans Clevers,Suet Yi Leung	2020	82
7	Frizzled-7 Is Required for Wnt Signaling in Gastric Tumors with and Without Apc Mutations Cancer Research ·Dustin J. Flanagan,Nick Barker,N. V. Chernomyrdin,Elizabeth A. Mason,Austin Gurney,Valérie S. Méniel,Sarah Koushyar,Emil Ainsworth Jochumsen,Matthias Ernst,Helen Pearson,Alex Boussioutas,Hans Clevers,Toby J. Phesse,Elizabeth Vincan	2019	84
8	Troy+ brain stem cells cycle through quiescence and regulate their number by sensing niche occupancy Proceedings of the National Academy of Sciences ·Onur Başak,Teresa G. Krieger,Mauro J. Muraro,Kay Wiebrands,Daniel E. Stange,Bleu Knight,N.C. Rivron,Marc van de Wetering,Johan H. van Es,Alexander van Oudenaarden,Benjamin D. Simons,Hans Clevers	2018	121
9	Lineage-dependent spatial and functional organization of the mammalian enteric nervous system Science ·Reena Lasrado,Werend Boesmans,Jens Kleinjung,Carmen Pin,Donald M. Bell,Leena Bhaw,Sarah McCallum,Hui Zong,Liqun Luo,Hans Clevers,Pieter Vanden Berghe,Vassilis Pachnis	2017	123
10	Reg4 ⁺ deep crypt secretory cells function as epithelial niche for Lgr5 ⁺ stem cells in colon Proceedings of the National Academy of Sciences ·Nobuo Sasaki,Norman Sachs,Kay Wiebrands,Saskia I. J. Ellenbroek,Arianna Fumagalli,Anna Lyubimova,Harry Begthel,Maaike van den Born,Johan H. van Es,Wouter R. Karthaus,Vivian Li,Carmen López‐Iglesias,Peter J. Peters,Jacco van Rheenen,Alexander van Oudenaarden,Hans Clevers	2016	206
11	RNF43 germline and somatic mutation in serrated neoplasia pathway and its association with BRAF mutation Gut ·Helen H.N. Yan,Mootaz El Shaigi,Siu Lun Ho,Wai K. Leung,Wai Lun Law,Janet F. Y. Lee,Anthony K W Chan,Wai Yin Tsui,Annie S Y Chan,Bernard C. H. Lee,Sarah S K Yue,Song Baozheng,Hans Clevers,Siu Tsan Yuen,Suet Yi Leung	2016	138
12	TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype EMBO Molecular Medicine ·Evelyn Fessler,Jarno Drost,Sander R. van Hooff,Janneke F. Linnekamp,Xin Wang,Marnix Jansen,Felipe de Sousa e Melo,Pramudita R. Prasetyanti,Joep IJspeert,Marek Franitza,Peter Nürnberg,Carel J.M. van Noesel,Evelien Dekker,Louis Vermeulen,Hans Clevers,Jan Paul Medema	2016	120
13	Selection of Personalized Patient Therapy through the Use of Knowledge-Based Computational Models That Identify Tumor-Driving Signal Transduction Pathways Cancer Research ·Wim Verhaegh,T Sun,Márcia A. Inda,Pantelis Hatzis,Rogier Versteeg,Marcel Smid,John W.M. Martens,John A. Foekens,V. Delonglée,Hans Clevers,Anja van de Stolpe	2014	62
14	KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells Cancer Research ·Takeo Nakaya,Seishi Ogawa,Ichiro Manabe,Masami Tanaka,Masashi Sanada,Toshiro Sato,Makoto M. Taketo,Kazuki Nakao,Hans Clevers,Masashi Fukayama,Masahiko Kuroda,Ryozo Nagai	2014	57
15	An integral program for tissue renewal and regeneration: Wnt signaling and stem cell controlbreakdown → Science ·Hans Clevers,Kyle M. Loh,Roel Nusse	2014	1034
16	Lineage Tracing Reveals Lgr5 ⁺ Stem Cell Activity in Mouse Intestinal Adenomasbreakdown → Science ·Arnout Schepers,Hugo J.G. Snippert,Daniel E. Stange,Maaike van den Born,Johan H. van Es,Marc van de Wetering,Hans Clevers	2012	822
17	Cyclin D2–Cyclin-Dependent Kinase 4/6 Is Required for Efficient Proliferation and Tumorigenesis following Apc Loss Cancer Research ·Alicia M. Cole,Kevin Myant,Karen R. Reed,Rachel A. Ridgway,Dimitris Athineos,Gijs R. van den Brink,Vanesa Muncan,Hans Clevers,Alan R. Clarke,Peter Sicinski,Owen J. Sansom	2010	65
18	Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skinbreakdown → Science ·Hugo J.G. Snippert,Andrea Haegebarth,Maria Kasper,Viljar Jaks,Johan H. van Es,Nick Barker,Gladys Cajilima,Maaike van den Born,Harry Begthel,Robert G. Vries,Daniel E. Stange,Rune Toftgård,Hans Clevers	2010	585
19	Transcriptome Profile of Human Colorectal Adenomas Molecular Cancer Research ·Jacob Sabates–Bellver,Laurens G. van der Flier,Mariagrazia de Palo,Elisa Cattaneo,Caroline Maake,Hubert Rehrauer,Endre Laczkó,Michal A. Kurowski,Janusz M. Bujnicki,Mirco Menigatti,Judith Luz,Teresa Valentina Ranalli,Vito Gomes,Alfredo Pastorelli,Roberto Faggiani,M. Anti,Josef Jiricny,Hans Clevers,Giancarlo Marra	2007	406
20	Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia EMBO Reports ·Anna-Pavlina G. Haramis,Adam Hurlstone,坂井学,Harry Begthel,Maaike van den Born,G. Johan A. Offerhaus,Hans Clevers	2006	130

About Hans Clevers

Hans Clevers is a scholar working on Oncology, Molecular Biology and Genetics, having authored 728 papers that have together received 159.5k indexed citations. Recurring topics across this work include Cancer Cells and Metastasis (192 papers), Wnt/β-catenin signaling in development and cancer (172 papers), Cancer-related gene regulation (116 papers), Digestive system and related health (97 papers), Epigenetics and DNA Methylation (60 papers), Pluripotent Stem Cells Research (55 papers), Genetic factors in colorectal cancer (47 papers) and Immune Cell Function and Interaction (41 papers). The work is most often cited by research in Oncology (53.3k citations), Molecular Biology (98.0k citations) and Cancer Research (18.5k citations). Hans Clevers has collaborated with scholars based in Netherlands, United States and Germany. Frequent co-authors include Nick Barker, Johan H. van Es, Roel Nusse, Marc van de Wetering, Toshiro Sato, Maaike van den Born, Harry Begthel, Eduard Batlle, Daniel E. Stange and Hugo J.G. Snippert. Their work appears in journals such as Proceedings of the National Academy of Sciences, Cell, Nature, Gastroenterology and Cell stem cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact