Hans Clevers

249.8k total citations · 82 hit papers
728 papers, 159.5k citations indexed

About

Hans Clevers is a scholar working on Molecular Biology, Oncology and Genetics. According to data from OpenAlex, Hans Clevers has authored 728 papers receiving a total of 159.5k indexed citations (citations by other indexed papers that have themselves been cited), including 450 papers in Molecular Biology, 251 papers in Oncology and 159 papers in Genetics. Recurrent topics in Hans Clevers's work include Cancer Cells and Metastasis (192 papers), Wnt/β-catenin signaling in development and cancer (172 papers) and Cancer-related gene regulation (116 papers). Hans Clevers is often cited by papers focused on Cancer Cells and Metastasis (192 papers), Wnt/β-catenin signaling in development and cancer (172 papers) and Cancer-related gene regulation (116 papers). Hans Clevers collaborates with scholars based in Netherlands, United States and Germany. Hans Clevers's co-authors include Nick Barker, Johan H. van Es, Roel Nusse, Marc van de Wetering, Toshiro Sato, Maaike van den Born, Harry Begthel, Eduard Batlle, Daniel E. Stange and Hugo J.G. Snippert and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Hans Clevers

716 papers receiving 157.4k citations

Hit Papers

Single Lgr5 stem cells build crypt-vil... 1988 2026 2000 2013 2009 2006 2012 2007 1997 1000 2.0k 3.0k 4.0k 5.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    2009 5.1k citations Toshiro Sato, Marc van de Wetering et al. Nature profile →
  2. Wnt/β-Catenin Signaling in Development and Disease
    2006 4.6k citations Hans Clevers Cell profile →
  3. Wnt/β-Catenin Signaling and Disease
    2012 4.4k citations Hans Clevers et al. Cell profile →
  4. Identification of stem cells in small intestine and colon by marker gene Lgr5
    2007 4.3k citations Nick Barker, Johan H. van Es et al. Nature profile →
  5. Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
    1997 3.3k citations Nick Barker, Hans Clevers et al. Science profile →
  6. Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities
    2017 3.1k citations Hans Clevers et al. Cell profile →
  7. Wnt signalling in stem cells and cancer
    2005 2.9k citations Hans Clevers et al. Nature profile →
  8. Constitutive Transcriptional Activation by a β-Catenin-Tcf Complex in APC −/− Colon Carcinoma
    1997 2.9k citations Nick Barker, Hans Clevers et al. Science profile →
  9. Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium
    2011 2.6k citations Toshiro Sato, Johan H. van Es et al. profile →
  10. Modeling Development and Disease with Organoids
    2016 2.2k citations Hans Clevers Cell profile →
  11. Cancer stem cells revisited
    2017 1.9k citations Hans Clevers et al. Nature Medicine profile →
  12. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    2010 1.9k citations Toshiro Sato, Johan H. van Es et al. Nature profile →
  13. The β-Catenin/TCF-4 Complex Imposes a Crypt Progenitor Phenotype on Colorectal Cancer Cells
    2002 1.6k citations Marc van de Wetering, Wim de Lau et al. Cell profile →
  14. Crypt stem cells as the cells-of-origin of intestinal cancer
    2008 1.6k citations Nick Barker, Johan H. van Es et al. Nature profile →
  15. XTcf-3 Transcription Factor Mediates β-Catenin-Induced Axis Formation in Xenopus Embryos
    1996 1.6k citations Marc van de Wetering, Jeroen P. Roose et al. Cell profile →
  16. The cancer stem cell: premises, promises and challenges
    2011 1.5k citations Hans Clevers Nature Medicine profile →
  17. Intestinal Crypt Homeostasis Results from Neutral Competition between Symmetrically Dividing Lgr5 Stem Cells
    2010 1.4k citations Laurens G. van der Flier, Toshiro Sato et al. Cell profile →
  18. Stem Cells, Self-Renewal, and Differentiation in the Intestinal Epithelium
    2008 1.4k citations Laurens G. van der Flier, Hans Clevers profile →
  19. Linking Colorectal Cancer to Wnt Signaling
    2000 1.3k citations Hans Clevers et al. Cell profile →
  20. Depletion of epithelial stem-cell compartments in the small intestine of mice lacking Tcf-4
    1998 1.3k citations Nick Barker, Hans Clevers et al. profile →
  21. Caught up in a Wnt storm: Wnt signaling in cancer
    2003 1.3k citations Johan H. van Es, Hans Clevers et al. profile →
  22. Canonical Wnt Signaling in Differentiated Osteoblasts Controls Osteoclast Differentiation
    2005 1.2k citations Hans Clevers et al. profile →
  23. Notch/γ-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    2005 1.2k citations Johan H. van Es, Mariëlle van Gijn et al. Nature profile →
  24. Lgr5+ve Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
    2010 1.2k citations Nick Barker, Pekka Kujala et al. profile →
  25. Organoids in cancer research
    2018 1.2k citations Jarno Drost, Hans Clevers Nature reviews. Cancer profile →
  26. In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration
    2013 1.1k citations Sylvia F. Boj, Johan H. van Es et al. Nature profile →
  27. Designer matrices for intestinal stem cell and organoid culture
    2016 1.1k citations Hans Clevers, Matthias P. Lütolf et al. Nature profile →
  28. Armadillo Coactivates Transcription Driven by the Product of the Drosophila Segment Polarity Gene dTCF
    1997 1.0k citations Marc van de Wetering, Rossana Cavallo et al. Cell profile →
  29. An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control
    2014 1.0k citations Hans Clevers et al. Science profile →
  30. Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients
    2013 1.0k citations Johanna F. Dekkers, Hans Clevers et al. profile →
  31. Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling
    2011 976 citations Wim de Lau, Nick Barker et al. Nature profile →
  32. Coexistence of Quiescent and Active Adult Stem Cells in Mammals
    2010 920 citations Hans Clevers et al. Science profile →
  33. β-Catenin and TCF Mediate Cell Positioning in the Intestinal Epithelium by Controlling the Expression of EphB/EphrinB
    2002 889 citations Marc van de Wetering, Hans Clevers et al. Cell profile →
  34. The Intestinal Crypt, A Prototype Stem Cell Compartment
    2013 873 citations Hans Clevers Cell profile →
  35. Growing Self-Organizing Mini-Guts from a Single Intestinal Stem Cell: Mechanism and Applications
    2013 870 citations Toshiro Sato, Hans Clevers Science profile →
  36. Negative Feedback Loop of Wnt Signaling through Upregulation of Conductin/Axin2 in Colorectal and Liver Tumors
    2002 868 citations Marc van de Wetering, Hans Clevers et al. profile →
  37. Single-cell messenger RNA sequencing reveals rare intestinal cell types
    2015 847 citations Onur Başak, Hans Clevers et al. Nature profile →
  38. Lineage Tracing Reveals Lgr5 + Stem Cell Activity in Mouse Intestinal Adenomas
    2012 822 citations Maaike van den Born, Johan H. van Es et al. Science profile →
  39. Canonical Wnt signals are essential for homeostasis of the intestinal epithelium
    2003 796 citations Alex Gregorieff, Harry Begthel et al. profile →
  40. Sequential cancer mutations in cultured human intestinal stem cells
    2015 789 citations Jarno Drost, Ruben van Boxtel et al. Nature profile →
  41. Notch1 functions as a tumor suppressor in mouse skin
    2003 776 citations Hans Clevers, Freddy Radtke et al. profile →
  42. Lgr5 marks cycling, yet long-lived, hair follicle stem cells
    2008 758 citations Nick Barker, Johan H. van Es et al. profile →
  43. APC, Signal transduction and genetic instability in colorectal cancer
    2001 741 citations Riccardo Fodde, Ron Smits et al. Nature reviews. Cancer profile →
  44. A functional CFTR assay using primary cystic fibrosis intestinal organoids
    2013 734 citations Johanna F. Dekkers, Hans Clevers et al. Nature Medicine profile →
  45. Wnt Signaling through Inhibition of β-Catenin Degradation in an Intact Axin1 Complex
    2012 713 citations Hans Clevers et al. Cell profile →
  46. Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptors
    2012 694 citations Marc van de Wetering, Johan H. van Es et al. Nature profile →
  47. The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse
    2011 688 citations Hans Clevers et al. profile →
  48. FoxM1 is required for execution of the mitotic programme and chromosome stability
    2005 672 citations Hans Clevers et al. profile →
  49. Tales from the crypt: new insights into intestinal stem cells
    2018 656 citations Helmuth Gehart, Hans Clevers profile →
  50. The T Cell Receptor/CD3 Complex: A Dynamic Protein Ensemble
    1988 655 citations Hans Clevers et al. profile →
  51. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    2004 636 citations Hans Clevers et al. profile →
  52. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell
    2012 627 citations Shiro Yui, Tetsuya Nakamura et al. Nature Medicine profile →
  53. In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection
    2014 609 citations Marc van de Wetering, Harry Begthel et al. profile →
  54. Cancer modeling meets human organoid technology
    2019 604 citations Hans Clevers et al. Science profile →
  55. Disease Modeling in Stem Cell-Derived 3D Organoid Systems
    2017 601 citations Hans Clevers et al. profile →
  56. Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids
    2018 588 citations Helmuth Gehart, Carmen López‐Iglesias et al. Cell profile →
  57. Drosophila Tcf and Groucho interact to repress Wingless signalling activity
    1998 587 citations Rossana Cavallo, Rachel T. Cox et al. Nature profile →
  58. Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin
    2010 585 citations Andrea Haegebarth, Johan H. van Es et al. Science profile →
  59. Dll1+ secretory progenitor cells revert to stem cells upon crypt damage
    2012 584 citations Johan H. van Es, Toshiro Sato et al. profile →
  60. De Novo Crypt Formation and Juvenile Polyposis on BMP Inhibition in Mouse Intestine
    2004 584 citations Anna-Pavlina G. Haramis, Harry Begthel et al. Science profile →
  61. Mining the Wnt pathway for cancer therapeutics
    2006 582 citations Nick Barker, Hans Clevers profile →
  62. Reparative inflammation takes charge of tissue regeneration
    2016 581 citations Hans Clevers et al. Nature profile →
  63. The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors
    1998 572 citations Jeroen P. Roose, Marc van de Wetering et al. Nature profile →
  64. The Lgr5 intestinal stem cell signature: robust expression of proposed quiescent ‘+4’ cell markers
    2012 562 citations Marc van de Wetering, Johan H. van Es et al. The EMBO Journal profile →
  65. Culture and establishment of self-renewing human and mouse adult liver and pancreas 3D organoids and their genetic manipulation
    2016 553 citations Sylvia F. Boj, Hans Clevers et al. profile →
  66. Self-Renewal and Cancer of the Gut: Two Sides of a Coin
    2005 552 citations Freddy Radtke, Hans Clevers Science profile →
  67. Isolation and in vitro expansion of human colonic stem cells
    2011 550 citations Toshiro Sato, Hans Clevers et al. Nature Medicine profile →
  68. Transcription Factor Achaete Scute-Like 2 Controls Intestinal Stem Cell Fate
    2009 546 citations Laurens G. van der Flier, Mariëlle van Gijn et al. Cell profile →
  69. Mutations in the APC tumour suppressor gene cause chromosomal instability
    2001 545 citations Riccardo Fodde, Jeroen Kuipers et al. profile →
  70. Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures
    2014 539 citations Jarno Drost, Ruben van Boxtel et al. Cell profile →
  71. Unlimited in vitro expansion of adult bi-potent pancreas progenitors through the Lgr5/R-spondin axis
    2013 535 citations Sylvia F. Boj, Toshiro Sato et al. The EMBO Journal profile →
  72. Homeostatic mini-intestines through scaffold-guided organoid morphogenesis
    2020 534 citations Mikhail Nikolaev, Hans Clevers et al. Nature profile →
  73. Wnt signalling induces maturation of Paneth cells in intestinal crypts
    2005 518 citations Johan H. van Es, Alex Gregorieff et al. profile →
  74. Wnt signaling in the intestinal epithelium: from endoderm to cancer
    2005 516 citations Alex Gregorieff, Hans Clevers profile →
  75. The drug resistance-related protein LRP is the human major vault protein
    1995 512 citations Hans Clevers et al. Nature Medicine profile →
  76. The TAK1–NLK–MAPK-related pathway antagonizes signalling between β-catenin and transcription factor TCF
    1999 507 citations Nick Barker, Hans Clevers et al. Nature profile →
  77. The R-spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength
    2014 489 citations Wim de Lau, Hans Clevers et al. profile →
  78. Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells
    2012 488 citations Johan H. van Es, Hans Clevers et al. profile →
  79. Paneth Cells: Maestros of the Small Intestinal Crypts
    2013 481 citations Hans Clevers et al. profile →
  80. Organoid culture systems for prostate epithelial and cancer tissue
    2016 447 citations Jarno Drost, Hans Clevers et al. profile →
  81. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
    2013 395 citations Onur Başak, Pekka Kujala et al. Cell profile →
  82. De Novo Prediction of Stem Cell Identity using Single-Cell Transcriptome Data
    2016 370 citations Maaike van den Born, Johan H. van Es et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Hans Clevers Netherlands 190 98.0k 53.3k 24.3k 18.5k 17.2k 728 159.5k
Douglas Hanahan United States 109 79.7k 0.8× 43.8k 0.8× 13.4k 0.6× 36.5k 2.0× 8.9k 0.5× 230 137.2k
Robert A. Weinberg United States 176 135.1k 1.4× 95.3k 1.8× 18.3k 0.8× 56.3k 3.0× 9.8k 0.6× 382 223.8k
Kenneth W. Kinzler United States 163 79.7k 0.8× 49.2k 0.9× 14.8k 0.6× 37.4k 2.0× 8.4k 0.5× 381 131.7k
Joan Massagué United States 184 95.5k 1.0× 47.2k 0.9× 9.3k 0.4× 22.6k 1.2× 7.6k 0.4× 362 137.5k
Zena Werb United States 151 45.6k 0.5× 35.3k 0.7× 7.9k 0.3× 33.6k 1.8× 9.0k 0.5× 416 110.4k
Bert Vogelstein United States 204 134.2k 1.4× 91.6k 1.7× 28.7k 1.2× 56.8k 3.1× 15.9k 0.9× 553 229.5k
Irving L. Weissman United States 182 59.2k 0.6× 30.0k 0.6× 8.1k 0.3× 11.4k 0.6× 11.7k 0.7× 836 131.7k
Judah Folkman United States 141 62.8k 0.6× 24.5k 0.5× 5.6k 0.2× 29.5k 1.6× 10.4k 0.6× 395 105.2k
Michael Karin United States 229 113.1k 1.2× 45.8k 0.9× 15.3k 0.6× 56.6k 3.1× 13.4k 0.8× 652 212.6k
Craig B. Thompson United States 182 91.8k 0.9× 25.3k 0.5× 7.1k 0.3× 44.6k 2.4× 7.5k 0.4× 515 151.3k

Countries citing papers authored by Hans Clevers

Since Specialization
Citations

This map shows the geographic impact of Hans Clevers's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Hans Clevers with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Hans Clevers more than expected).

Fields of papers citing papers by Hans Clevers

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Hans Clevers. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Hans Clevers. The network helps show where Hans Clevers may publish in the future.

Co-authorship network of co-authors of Hans Clevers

This figure shows the co-authorship network connecting the top 25 collaborators of Hans Clevers. A scholar is included among the top collaborators of Hans Clevers based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Hans Clevers. Hans Clevers is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kok, Rutger N.U., Hannah K. Neikes, Ninouk Akkerman, et al.. (2025). Lactate controls cancer stemness and plasticity through epigenetic regulation. Cell Metabolism. 37(4). 903–919.e10. 22 indexed citations breakdown →
2.
Krueger, Daniel, Willem Kasper Spoelstra, Rutger N.U. Kok, et al.. (2025). Epithelial tension controls intestinal cell extrusion. Science. 389(6764). eadr8753–eadr8753. 2 indexed citations
3.
Es, Johan H. van, et al.. (2024). Protocol to create isogenic disease models from adult stem cell-derived organoids using next-generation CRISPR tools. STAR Protocols. 5(3). 103189–103189. 5 indexed citations
4.
Lopes, Susana M. Chuva de Sousa, et al.. (2024). Binucleated human hepatocytes arise through late cytokinetic regression during endomitosis M phase. The Journal of Cell Biology. 223(8). 5 indexed citations
5.
Huang, Lulu, Jochem H. Bernink, Amir Giladi, et al.. (2024). Tuft cells act as regenerative stem cells in the human intestine. Nature. 634(8035). 929–935. 27 indexed citations
6.
Choudhuri, Avik, Brejnev Muhire, Eva M. Fast, et al.. (2023). PGE 2 alters chromatin through H2A.Z-variant enhancer nucleosome modification to promote hematopoietic stem cell fate. Proceedings of the National Academy of Sciences. 120(19). e2220613120–e2220613120. 5 indexed citations
7.
Williams, Justin, Femke Ringnalda, Natalia Moreno, et al.. (2023). Atypical teratoid/rhabdoid tumoroids reveal subgroup-specific drug vulnerabilities. Oncogene. 42(20). 1661–1671. 15 indexed citations
8.
Gehart, Helmuth, Johan H. van Es, Karien M. Hamer, et al.. (2019). Identification of Enteroendocrine Regulators by Real-Time Single-Cell Differentiation Mapping. Cell. 176(5). 1158–1173.e16. 219 indexed citations
9.
Janda, Claudia Y., Luke T. Dang, Changjiang You, et al.. (2017). Surrogate Wnt agonists that phenocopy canonical Wnt and β-catenin signalling. Nature. 545(7653). 234–237. 263 indexed citations breakdown →
10.
Flanagan, Dustin J., Nick Barker, Cameron J. Nowell, et al.. (2017). Loss of the Wnt receptor Frizzled7 in the gastric epithelium is deleterious and triggers rapid repopulation in vivo. Disease Models & Mechanisms. 10(8). 971–980. 20 indexed citations
11.
Başak, Onur, Jeroen Korving, Joep Beumer, et al.. (2014). Mapping early fate determination in L gr5 + crypt stem cells using a novel K i67‐ RFP allele. The EMBO Journal. 33(18). 2057–2068. 119 indexed citations
12.
Yui, Shiro, Tetsuya Nakamura, Toshiro Sato, et al.. (2012). Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell. Nature Medicine. 18(4). 618–623. 627 indexed citations breakdown →
13.
Faro, Ana, et al.. (2009). T-Cell Factor 4 (tcf7l2) Is the Main Effector of Wnt Signaling During Zebrafish Intestine Organogenesis. Zebrafish. 6(1). 59–68. 16 indexed citations
14.
Riccio, Orbicia, Mariëlle van Gijn, Luca Pellegrinet, et al.. (2008). Loss of intestinal crypt progenitor cells owing to inactivation of both Notch1 and Notch2 is accompanied by derepression of CDK inhibitors p27 Kip1 and p57 Kip2. EMBO Reports. 9(4). 377–383. 315 indexed citations breakdown →
15.
Barker, Nick, Johan H. van Es, Jeroen Kuipers, et al.. (2007). Identification of stem cells in small intestine and colon by marker gene Lgr5. Nature. 449(7165). 1003–1007. 4255 indexed citations breakdown →
16.
Sabates–Bellver, Jacob, Laurens G. van der Flier, Mariagrazia de Palo, et al.. (2007). Transcriptome Profile of Human Colorectal Adenomas. Molecular Cancer Research. 5(12). 1263–1275. 406 indexed citations
17.
Haramis, Anna-Pavlina G., Adam Hurlstone, Harry Begthel, et al.. (2006). Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia. EMBO Reports. 7(4). 444–449. 130 indexed citations
18.
Gregorieff, Alex, Rudolf Grosschedl, & Hans Clevers. (2004). Hindgut defects and transformation of the gastro‐intestinal tract in Tcf4−/−/Tcf1−/− embryos. The EMBO Journal. 23(8). 1825–1833. 102 indexed citations
19.
Fodde, Riccardo, Ron Smits, & Hans Clevers. (2001). APC, Signal transduction and genetic instability in colorectal cancer. Nature reviews. Cancer. 1(1). 55–67. 741 indexed citations breakdown →
20.
Cavallo, Rossana, Rachel T. Cox, Jeroen P. Roose, et al.. (1998). Drosophila Tcf and Groucho interact to repress Wingless signalling activity. Nature. 395(6702). 604–608. 587 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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