Kai Simons

102.3k total citations · 35 hit papers
416 papers, 82.7k citations indexed

About

Kai Simons is a scholar working on Molecular Biology, Cell Biology and Physiology. According to data from OpenAlex, Kai Simons has authored 416 papers receiving a total of 82.7k indexed citations (citations by other indexed papers that have themselves been cited), including 254 papers in Molecular Biology, 168 papers in Cell Biology and 80 papers in Physiology. Recurrent topics in Kai Simons's work include Lipid Membrane Structure and Behavior (125 papers), Cellular transport and secretion (118 papers) and Erythrocyte Function and Pathophysiology (47 papers). Kai Simons is often cited by papers focused on Lipid Membrane Structure and Behavior (125 papers), Cellular transport and secretion (118 papers) and Erythrocyte Function and Pathophysiology (47 papers). Kai Simons collaborates with scholars based in Germany, United States and Finland. Kai Simons's co-authors include Elina Ikonen, Derek Toomre, Daniel Lingwood, Robert G. Parton, Ari Helenius, Patrick Keller, Gerrit van Meer, Andrej Shevchenko, Robert Ehehalt and Gareth Griffiths and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Kai Simons

413 papers receiving 80.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Functional rafts in cell membranes

1997 8.0k citations Kai Simons et al. profile →
Lipid rafts and signal transduction

2000 5.1k citations Kai Simons et al. profile →
Lipid Rafts As a Membrane-Organizing Principle

2009 3.5k citations Kai Simons et al. profile →
Solubilization of membranes by detergents

1975 2.6k citations Kai Simons et al. profile →
The small GTPase rab5 functions as a regulatory factor in the early endocytic pathway

1992 1.2k citations Kai Simons et al. profile →
The multiple faces of caveolae

2007 1.1k citations Kai Simons et al. profile →
Lipid sorting in epithelial cells

1988 1.1k citations Kai Simons et al. profile →
Alzheimer's disease β-amyloid peptides are released in association with exosomes

2006 1.1k citations Lawrence Rajendran, Masanori Honsho et al. Proceedings of the National Academy of Sciences profile →
How Cells Handle Cholesterol

2000 1.1k citations Kai Simons et al. profile →
Lipid Domain Structure of the Plasma Membrane Revealed by Patching of Membrane Components

1998 1.0k citations Paul Verkade, Kai Simons et al. The Journal of Cell Biology profile →
Localization of low molecular weight GTP binding proteins to exocytic and endocytic compartments

1990 1.0k citations Kai Simons et al. profile →
The trans Golgi Network: Sorting at the Exit Site of the Golgi Complex

1986 1.0k citations Kai Simons et al. profile →
Revitalizing membrane rafts: new tools and insights

2010 994 citations Kai Simons, Mathias J. Gerl profile →
Cholesterol depletion inhibits the generation of β-amyloid in hippocampal neurons

1998 986 citations Patrick Keller, Kai Simons et al. Proceedings of the National Academy of Sciences profile →
Amyloidogenic processing of the Alzheimer β-amyloid precursor protein depends on lipid rafts

2003 901 citations Robert Ehehalt, Patrick Keller et al. The Journal of Cell Biology profile →
Cholesterol, lipid rafts, and disease

2002 836 citations Kai Simons, Robert Ehehalt Journal of Clinical Investigation profile →
Sphingolipid–Cholesterol Rafts Diffuse as Small Entities in the Plasma Membrane of Mammalian Cells

2000 821 citations Patrick Keller, Kai Simons et al. The Journal of Cell Biology profile →
Cholesterol, lipid rafts, and disease

2002 805 citations Kai Simons, Robert Ehehalt Journal of Clinical Investigation profile →
Membrane Organization and Lipid Rafts

2011 801 citations Kai Simons, Júlio L. Sampaio profile →
Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry

2009 790 citations Christer S. Ejsing, Júlio L. Sampaio et al. Proceedings of the National Academy of Sciences profile →
VIP21/caveolin is a cholesterol-binding protein.

1995 751 citations Teymuras V. Kurzchalia, Kai Simons et al. Proceedings of the National Academy of Sciences profile →
Cell Surface Polarity in Epithelia

1985 745 citations Kai Simons et al. profile →
The mannose 6-phosphate receptor and the biogenesis of lysosomes

1988 717 citations Kai Simons et al. profile →
Caveolae, DIGs, and the dynamics of sphingolipid—cholesterol microdomains

1997 692 citations Kai Simons et al. profile →
On the entry of semliki forest virus into BHK-21 cells

1980 653 citations Kai Simons et al. The Journal of Cell Biology profile →
Regulated internalization of caveolae.

1994 647 citations Kai Simons et al. The Journal of Cell Biology profile →
Lipidomics: coming to grips with lipid diversity

2010 637 citations Andrej Shevchenko, Kai Simons profile →
Subcellular targeting strategies for drug design and delivery

2009 586 citations Lawrence Rajendran, Kai Simons et al. profile →
Infectious entry pathway of influenza virus in a canine kidney cell line.

1981 576 citations Kai Simons et al. The Journal of Cell Biology profile →
Resistance of cell membranes to different detergents

2003 560 citations Sebastian Schuck, Masanori Honsho et al. Proceedings of the National Academy of Sciences profile →
De novo formation of caveolae in lymphocytes by expression of VIP21-caveolin.

1995 501 citations Kai Simons et al. Proceedings of the National Academy of Sciences profile →
A functional assay for proteins involved in establishing an epithelial occluding barrier: identification of a uvomorulin-like polypeptide.

1986 453 citations Kai Simons et al. The Journal of Cell Biology profile →
Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation

1983 447 citations Kai Simons et al. profile →
Nucleotide sequence of cDNA coding for Semliki Forest virus membrane glycoproteins

1980 369 citations Kai Simons et al. profile →
Genome-wide association analysis of plasma lipidome identifies 495 genetic associations

2023 103 citations Rubina Tabassum, Sanni Ruotsalainen et al. profile →

Peers

Countries citing papers authored by Kai Simons

Since Specialization

Citations

This map shows the geographic impact of Kai Simons's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Kai Simons with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Kai Simons more than expected).

Fields of papers citing papers by Kai Simons

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Kai Simons. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Kai Simons. The network helps show where Kai Simons may publish in the future.

Co-authorship network of co-authors of Kai Simons

This figure shows the co-authorship network connecting the top 25 collaborators of Kai Simons. A scholar is included among the top collaborators of Kai Simons based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Kai Simons. Kai Simons is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Lipidome‐ and Genome‐Wide Study to Understand Sex Differences in Circulatory Lipids 2022 ·Journal of the American Heart Association ·Rubina Tabassum, Sanni Ruotsalainen, (unknown), Mathias J. Gerl, Christian Klose, Taru Tukiainen, Matti Pirinen, Kai Simons, Elisabeth Widén, Samuli Ripatti	38
2	Shotgun mass spectrometry-based lipid profiling identifies and distinguishes between chronic inflammatory diseases 2021 ·EBioMedicine ·Rune Matthiesen, Chris Lauber, Júlio L. Sampaio, Neuza Domingues, (unknown), Mathias J. Gerl, Jorge Almeida, (unknown), Pedro de Araújo Gonçalves, Jorge Ferreira, Cláudia Borbinha, João Pedro Marto, (unknown), (unknown), Miguel Viana‐Baptista, José Delgado Alves, Kai Simons, Winchil L.C. Vaz, Otília V. Vieira	15
3	Adverse Effects of Refeeding on the Plasma Lipidome in Young Individuals With Anorexia Nervosa? 2021 ·Journal of the American Academy of Child & Adolescent Psychiatry ·Friederike I. Tam, Mathias J. Gerl, Christian Klose, Michał A. Surma, Joseph A. King, Maria Seidel, Kerstin Weidner, Veit Roessner, Kai Simons, Stefan Ehrlich	11
4	Binding of canonical Wnt ligands to their receptor complexes occurs in ordered plasma membrane environments 2017 ·FEBS Journal ·Erdinç Sezgin, (unknown), Xue Wen Ng, Cathleen Teh, Kai Simons, Gilbert Weidinger, Thorsten Wohland, Christian Eggeling, Günes Özhan	41
5	Hopanoids as functional analogues of cholesterol in bacterial membranes 2015 ·Proceedings of the National Academy of Sciences ·James Sáenz, (unknown), Alexander S. Bradley, Thibaut J. Lagny, Oksana Lavrynenko, Martyna Broda, Kai Simons	164
6	Quantitative analysis of the lipidomes of the influenza virus envelope and MDCK cell apical membrane 2012 ·The Journal of Cell Biology ·Mathias J. Gerl, Júlio L. Sampaio, Severino Urban, Lucie Kalvodova, Jean‐Marc Verbavatz, Beth Binnington, Dirk Lindemann, Clifford A. Lingwood, Andrej Shevchenko, Cornelia Schroeder, Kai Simons	218
7	The Lipidomes of Vesicular Stomatitis Virus, Semliki Forest Virus, and the Host Plasma Membrane Analyzed by Quantitative Shotgun Mass Spectrometry 2009 ·Journal of Virology ·Lucie Kalvodova, Júlio L. Sampaio, Sandra M. Cordo, Christer S. Ejsing, Andrej Shevchenko, Kai Simons	88
8	Global analysis of the yeast lipidome by quantitative shotgun mass spectrometry breakdown → 2009 ·Proceedings of the National Academy of Sciences ·Christer S. Ejsing, Júlio L. Sampaio, Vineeth Surendranath, Eva Duchoslav, Kim Ekroos, Robin W. Klemm, Kai Simons, Andrej Shevchenko	790
9	Segregation of sphingolipids and sterols during formation of secretory vesicles at the trans-Golgi network 2009 ·The Journal of Cell Biology ·Robin W. Klemm, Christer S. Ejsing, Michał A. Surma, Hermann-Josef Kaiser, Mathias J. Gerl, Júlio L. Sampaio, (unknown), Charles Ferguson, Tomasz J. Prószyński, Andrej Shevchenko, Kai Simons	316
10	Plasma membrane polarization during mating in yeast cells 2006 ·The Journal of Cell Biology ·Tomasz J. Prószyński, Robin W. Klemm, Michel Bagnat, Katharina Gaus, Kai Simons	57
11	Phase coexistence and connectivity in the apical membrane of polarized epithelial cells 2006 ·Proceedings of the National Academy of Sciences ·Doris Meder, Maria João Moreno, Paul Verkade, Winchil L.C. Vaz, Kai Simons	137
12	Alzheimer's disease β-amyloid peptides are released in association with exosomes breakdown → 2006 ·Proceedings of the National Academy of Sciences ·Lawrence Rajendran, Masanori Honsho, Tobias Zahn, Patrick Keller, Kathrin Geiger, Paul Verkade, Kai Simons	1067
13	Gp135/podocalyxin and NHERF-2 participate in the formation of a preapical domain during polarization of MDCK cells 2005 ·The Journal of Cell Biology ·Doris Meder, Anna Shevchenko, Kai Simons, Joachim Füllekrug	161
14	A genome-wide visual screen reveals a role for sphingolipids and ergosterol in cell surface delivery in yeast 2005 ·Proceedings of the National Academy of Sciences ·Tomasz J. Prószyński, Robin W. Klemm, (unknown), Peggy P. Hsu, Yvonne Gloor, (unknown), Karol Kozak, Hannes Grabner, (unknown), Michel Bagnat, Kai Simons, Christiane Walch-Solimena	117
15	Disturbed cellular lipid efflux and HDL maturation in caveolin-1 deficient mice 2005 ·FEBS Journal ·Gerhard Liebisch, Soazig Le Lay, Andreas Böttcher, (unknown), Teymuras V. Kurzchalia, Kai Simons, Gerd Schmitz	1
16	Generation of single and double knockdowns in polarized epithelial cells by retrovirus-mediated RNA interference 2004 ·Proceedings of the National Academy of Sciences ·Sebastian Schuck, Aki Manninen, Masanori Honsho, Joachim Füllekrug, Kai Simons	82
17	Cell surface polarization during yeast mating 2002 ·Proceedings of the National Academy of Sciences ·Michel Bagnat, Kai Simons	193
18	Cholesterol, lipid rafts, and disease breakdown → 2002 ·Journal of Clinical Investigation ·Kai Simons, Robert Ehehalt	805
19	VIP17/MAL, a proteolipid in apical transport vesicles 1995 ·FEBS Letters ·Daniele Zacchetti, (unknown), (unknown), Klaus Fiedler, Kai Simons	99
20	[37] Immunoelectron microscopy using thin, frozen sections: Application to studies of the intracellular transport of Semliki Forest virus spike glycoproteins 1983 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Gareth Griffiths, Kai Simons, Graham Warren, K. T. Tokuyasu	191

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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