Leslie M. Thompson

21.1k citations

128 papers · 12.1k indexed · 6 hit papers · h-index 52

Molecular Biology top 0.5%
Cellular and Molecular Neuroscience top 0.1%
Genetics top 0.5%
Neurology top 0.5%
Physiology top 2%

Co-authors: Aleksey Kazantsev Joan S. Steffan Joan Marsh Yazhen Zhu David E. Housman Judit Pallos John J. Wasmuth Gillian P. Bates
Topics: Genetic Neurodegenerative Diseases (80 papers)Mitochondrial Function and Pathology (51 papers)Muscle Physiology and Disorders (23 papers)
Cited by: Cellular and Molecular Neuroscience Aging Molecular Biology
Journals: Nature Science Cell
Partner nations: United States United Kingdom Italy

In The Last Decade

Leslie M. Thompson

123 papers receiving 11.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 988 citations Leslie M. Thompson, Yazhen Zhu et al. profile →
Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

2001 964 citations Joan S. Steffan, László Bodai et al. profile →
The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

2000 849 citations Joan S. Steffan, Aleksey Kazantsev et al. Proceedings of the National Academy of Sciences profile →
Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease

2003 667 citations Emma Hockly, Victoria M. Richon et al. Proceedings of the National Academy of Sciences profile →
Therapeutic application of histone deacetylase inhibitors for central nervous system disorders

2008 578 citations Aleksey Kazantsev, Leslie M. Thompson profile →
SUMO Modification of Huntingtin and Huntington's Disease Pathology

2004 547 citations Joan S. Steffan, Namita Agrawal et al. Science profile →

Peers

Countries citing papers authored by Leslie M. Thompson

Since Specialization

Citations

This map shows the geographic impact of Leslie M. Thompson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Leslie M. Thompson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Leslie M. Thompson more than expected).

Fields of papers citing papers by Leslie M. Thompson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Leslie M. Thompson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Leslie M. Thompson. The network helps show where Leslie M. Thompson may publish in the future.

Co-authorship network of co-authors of Leslie M. Thompson

This figure shows the co-authorship network connecting the top 25 collaborators of Leslie M. Thompson. A scholar is included among the top collaborators of Leslie M. Thompson based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Leslie M. Thompson. Leslie M. Thompson is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Single-nucleus multi-omics identifies shared and distinct pathways in Pick’s and Alzheimer’s disease 2025 ·Science Advances ·(unknown),(unknown),Samuel Morabito,Jennifer Stocksdale,Emily Miyoshi,(unknown),Nora Emerson,(unknown),Negin Rahimzadeh,(unknown),Justine Silva,(unknown),Elizabeth Head,Leslie M. Thompson,Vivek Swarup	0
2	Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells 2024 ·Neurobiology of Disease ·Carrie Sheeler,(unknown),Lisa Duvick,Leslie M. Thompson,Ying Zhang,Harry T. Orr,Marija Cvetanović	2
3	Multiomics of iPSC‐derived ApoE3‐ and ApoE4 astrocytes and microglia uncovers cell type specific dysregulation of immunometabolism 2023 ·Alzheimer s & Dementia ·Rik van der Kant,(unknown),(unknown),Femke M. Feringa,(unknown),(unknown),(unknown),Amanda McQuade,Ricardo Miramontes,(unknown),(unknown),Leslie M. Thompson,Alessandro Ori‬‬,Deborah Kronenberg‐Versteeg,Yassene Mohammed,Martin Kampmann,Martin Giera	0
4	HD and SCA1: Tales from two 30-year journeys since gene discovery 2023 ·Neuron ·Leslie M. Thompson,Harry T. Orr	10
5	An RNA-targeting CRISPR–Cas13d system alleviates disease-related phenotypes in Huntington’s disease models 2022 ·Nature Neuroscience ·Kathryn H. Morelli,Qian Wu,Maya L. Gosztyla,Hongshuai Liu,(unknown),Chuangchuang Zhang,Jiaxu Chen,Ryan J. Marina,(unknown),(unknown),(unknown),(unknown),(unknown),Leslie M. Thompson,Wenzhen Duan,G Yeo	60
6	Huntington’s disease mice and human brain tissue exhibit increased G3BP1 granules and TDP43 mislocalization 2021 ·Journal of Clinical Investigation ·(unknown),Thai B. Nguyen,Whitney England,Ryan G. Lim,Anthony Q. Vu,Ricardo Miramontes,Lauren M. Byrne,Sebastian Markmiller,Alice Lau,(unknown),Maurice A. Curtis,(unknown),G Yeo,Christie D. Fowler,Jack C. Reidling,Edward J. Wild,Robert C. Spitale,Leslie M. Thompson	39
7	Microglia Do Not Restrict SARS-CoV-2 Replication following Infection of the Central Nervous System of K18-Human ACE2 Transgenic Mice 2021 ·Journal of Virology ·(unknown),Yu‐Ting Cheng,(unknown),(unknown),Lindsay A. Hohsfield,(unknown),Ricardo Miramontes,Jie Wu,(unknown),(unknown),Jennifer Stocksdale,(unknown),William H. Yong,John R. Teijaro,Robert A. Edwards,Kim N. Green,Leslie M. Thompson,Thomas E. Lane	17
8	Faulty neuronal determination and cell polarization are reverted by modulating HD early phenotypes 2018 ·Proceedings of the National Academy of Sciences ·Paola Conforti,Dario Besusso,Vittoria Dickinson Bocchi,Andrea Faedo,E. Cesana,Grazisa Rossetti,Valeria Ranzani,Clive N. Svendsen,Leslie M. Thompson,Mauro Toselli,Gerardo Biella,Massimiliano Pagani,Elena Cattaneo	122
9	The ubiquitin conjugating enzyme Ube2W regulates solubility of the Huntington's disease protein, huntingtin 2017 ·Neurobiology of Disease ·Bo Wang,Li Zeng,Sean Merillat,Svetlana Fischer,Joseph Ochaba,Leslie M. Thompson,Sami J. Barmada,K. Matthew Scaglione,Henry L. Paulson	22
10	Neonatal immune-tolerance in mice does not prevent xenograft rejection 2014 ·Experimental Neurology ·Virginia B. Mattis,Dustin R. Wakeman,Colton M. Tom,Hemraj B. Dodiya,(unknown),Andrew Tran,Ksenija Bernau,Loren Ornelas,Anais Sahabian,Jack C. Reidling,Dhruv Sareen,Leslie M. Thompson,Jeffrey H. Kordower,Clive N. Svendsen	26
11	Methylene Blue Modulates Huntingtin Aggregation Intermediates and Is Protective in Huntington's Disease Models 2012 ·Journal of Neuroscience ·Emily M. Sontag,Gregor P. Lotz,Namita Agrawal,Andrew Tran,Rebecca Aron,Guocheng Yang,Mihaela Necula,Alice Lau,Steven Finkbeiner,Charles Glabe,Joan Marsh,Paul J. Muchowski,Leslie M. Thompson	78
12	Mithramycin Is a Gene-Selective Sp1 Inhibitor That Identifies a Biological Intersection between Cancer and Neurodegeneration 2011 ·Journal of Neuroscience ·Sama F. Sleiman,Brett Langley,Manuela Basso,(unknown),Xia Li,(unknown),Madan K. Kharel,Hengchang Guo,Joan Marsh,Leslie M. Thompson,Lata Mahishi,Preeti Ahuja,W. Robb MacLellan,Daniel H. Geschwind,Giovanni Coppola,Jürgen Rohr,Rajiv R. Ratan	111
13	SIRT2 inhibition achieves neuroprotection by decreasing sterol biosynthesis 2010 ·Proceedings of the National Academy of Sciences ·Ruth Luthi‐Carter,David Taylor,Judit Pallos,Emmanuel Lambert,Allison Amore,Alex Parker,Hilary Moffitt,Donna L. Smith,Heike Runne,Özgün Gökçe,Alexandre Kuhn,Zhongmin Xiang,Michele M. Maxwell,Steven A. Reeves,Gillian P. Bates,Christian Néri,Leslie M. Thompson,Joan Marsh,Aleksey Kazantsev	263
14	Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo 2010 ·Journal of Biological Chemistry ·Justin Legleiter,(unknown),Gregor P. Lotz,Ellen Sapp,(unknown),Marian DiFiglia,Leslie M. Thompson,Paul J. Muchowski	176
15	Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau 2008 ·Journal of Neuroscience ·Kim N. Green,Joan S. Steffan,Hilda Martínez‐Coria,Xuemin Sun,Steven S. Schreiber,Leslie M. Thompson,Frank M. LaFerla	319
16	Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington’s disease 2008 ·Human Molecular Genetics ·Judit Pallos,László Bodai,Tamás Lukácsovich,Judith Purcell,Joan S. Steffan,Leslie M. Thompson,Joan Marsh	217
17	Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid 2007 ·Neurobiology of Disease ·(unknown),Leslie M. Thompson,Aldons J. Lusis,Richard C. Davis,Oswald Steward	3
18	A potent small molecule inhibits polyglutamine aggregation in Huntington's disease neurons and suppresses neurodegeneration in vivo 2005 ·Proceedings of the National Academy of Sciences ·Xiaoqian Zhang,Donna L. Smith,Anatoli B. Meriin,Sabine Engemann,(unknown),(unknown),(unknown),Michele M. Maxwell,Joan Marsh,Leslie M. Thompson,Erich E. Wanker,Anne B. Young,David E. Housman,Gillian P. Bates,Michael Y. Sherman,Aleksey Kazantsev	199
19	SUMO Modification of Huntingtin and Huntington's Disease Pathologybreakdown → 2004 ·Science ·Joan S. Steffan,Namita Agrawal,Judit Pallos,Erica Rockabrand,Lloyd C. Trotman,Natalia Slepko,Katalin Illes,Tamás Lukácsovich,Yazhen Zhu,Elena Cattaneo,Pier Paolo Pandolfi,Leslie M. Thompson,Joan Marsh	547
20	Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's diseasebreakdown → 2003 ·Proceedings of the National Academy of Sciences ·Emma Hockly,Victoria M. Richon,(unknown),Donna L. Smith,Xianbo Zhou,Eddie Rosa,Kirupa Sathasivam,Shabnam Ghazi‐Noori,Amarbirpal Mahal,Philip A. S. Lowden,Joan S. Steffan,Joan Marsh,Leslie M. Thompson,Cathryn M. Lewis,Paul A. Marks,Gillian P. Bates	667

About Leslie M. Thompson

Leslie M. Thompson is a scholar working on Cellular and Molecular Neuroscience, Aging and Molecular Biology, having authored 128 papers that have together received 12.1k indexed citations. Recurring topics across this work include Genetic Neurodegenerative Diseases (80 papers), Mitochondrial Function and Pathology (51 papers) and Muscle Physiology and Disorders (23 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (5.8k citations), Aging (289 citations) and Molecular Biology (9.1k citations). Leslie M. Thompson has collaborated with scholars based in United States, United Kingdom and Italy. Frequent co-authors include Aleksey Kazantsev, Joan S. Steffan, Joan Marsh, Yazhen Zhu, David E. Housman, Judit Pallos, John J. Wasmuth, Gillian P. Bates, Rita Shiang and László Bodai. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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