Frank M. LaFerla

55.8k citations

248 papers · 36.7k indexed · 9 hit papers · h-index 97

Biological Psychiatry top 0.02%
- Tryptophan and brain disorders 23
Neurology top 0.01%
- Neuroinflammation and Neurodegeneration Mechanisms 42
Physiology top 0.01%
- Alzheimer's disease research and treatments 192
Cellular and Molecular Neuroscience top 0.05%
- Neuroscience and Neuropharmacology Research 47
- Nuclear Receptors and Signaling 27
Developmental Neuroscience top 0.1%
- Neurogenesis and neuroplasticity mechanisms 16
Pharmacology
- Cholinesterase and Neurodegenerative Diseases 51
Computational Theory and Mathematics
- Computational Drug Discovery Methods 19

Co-authors: Salvatore Oddo Henry Querfurth Kim N. Green Antonella Caccamo Masashi Kitazawa Lauren M. Billings Mark P. Mattson Mathew Blurton‐Jones
Cited by: Biological Psychiatry Neurology Physiology
Journals: New England Journal of Medicine (2 papers)Proceedings of the National Academy of Sciences (8 papers)Journal of the American Chemical Society (1 paper)
Partner nations: United States Spain Canada

In The Last Decade

Frank M. LaFerla

245 papers receiving 36.2k citations

Hit Papers

9 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2010 New England Journal of Medicine
2009 Proceedings of the National Academy of Sciences
2007 Nature reviews. Neuroscience
2006 Journal of Neuroscience
2005 Journal of Neuroscience
2005 Neuron
2004 Neuron
2003 Neuron
2002 Nature reviews. Neuroscience

Peers

Countries citing papers authored by Frank M. LaFerla

Since Specialization

Citations

This map shows the geographic impact of Frank M. LaFerla's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Frank M. LaFerla with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Frank M. LaFerla more than expected).

Fields of papers citing papers by Frank M. LaFerla

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Frank M. LaFerla. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Frank M. LaFerla. The network helps show where Frank M. LaFerla may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Frank M. LaFerla, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Frank M. LaFerla Line = papers co-authored together Frank M. LaFerla links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	A CLU/APOJ GWAS AD risk variant suppresses the astrocytic response to plaques and reduces axonal and neuritic damage in 5xFAD mice Alzheimer s & Dementia ·Giedre Milinkeviciute,Katelynn Tran,Celia Da Cunha,Adrian Mendoza‐Arvilla,Laura Fernandez Garcia‐Agudo,Jonathan Neumann,Amber Walker,Shimako Kawauchi,Andrea J. Tenner,Frank M. LaFerla,Grant R. MacGregor,Kim N. Green	2023	1
2	Author Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation Scientific Reports ·Erika Castillo,Julio Leon,Guianfranco Mazzei,Nona Abolhassani,Naoki Haruyama,Takashi Saito,Takaomi C. Saido,Masaaki Hokama,Toru Iwaki,Tomoyuki Ohara,Toshiharu Ninomiya,Yutaka Kiyohara,Kunihiko Sakumi,Frank M. LaFerla,Yusaku Nakabeppu	2021	4
3	miR‐181a negatively modulates synaptic plasticity in hippocampal cultures and its inhibition rescues memory deficits in a mouse model of Alzheimer’s disease Aging Cell ·Carlos J. Rodríguez‐Ortiz,G. Aleph Prieto,Alessandra Cadete Martini,Stefânia Forner,Laura Trujillo‐Estrada,Frank M. LaFerla,David Baglietto‐Vargas,Carl W. Cotman,Masashi Kitazawa	2020	50
4	Model organism development and evaluation for late‐onset Alzheimer's disease: MODEL‐AD Alzheimer s & Dementia Translational Research & Clinical Interventions ·Adrian L. Oblak,Stefânia Forner,Paul R. Territo,Michael Sasner,Gregory W. Carter,Gareth R. Howell,Stacey J. Sukoff Rizzo,Benjamin A. Logsdon,Lara M. Mangravite,A Mortazavi,David Baglietto‐Vargas,Kim N. Green,Grant R. MacGregor,Marcelo A. Wood,Andrea J. Tenner,Frank M. LaFerla,Bruce T. Lamb,(unknown)	2020	62
5	Amyloid-beta impairs TOM1-mediated IL-1R1 signaling Proceedings of the National Academy of Sciences ·Alessandra Cadete Martini,Ángela Gómez-Arboledas,Stefânia Forner,Carlos J. Rodríguez‐Ortiz,Amanda McQuade,Emma Danhash,Jimmy Phan,Dominic I. Javonillo,Jordan-Vu Ha,Melanie Tram,Laura Trujillo‐Estrada,Celia Da Cunha,Rahasson R. Ager,José Carlos Dávila,Masashi Kitazawa,Mathew Blurton‐Jones,Antonia Gutiérrez,David Baglietto‐Vargas,Rodrigo Medeiros,Frank M. LaFerla	2019	22
6	Reversal of memory and neuropsychiatric symptoms and reduced tau pathology by selenium in 3xTg-AD mice Scientific Reports ·Ann Van der Jeugd,Arnaldo Parra‐Damas,Raquel Baeta-Corral,Carlos M. Soto-Faguás,Tariq Ahmed,Frank M. LaFerla,Lydia Giménez‐Llort,Rudi D’Hooge,Carlos A. Saura	2018	42
7	Sex-dependent co-occurrence of hypoxia and β-amyloid plaques in hippocampus and entorhinal cortex is reversed by long-term treatment with ubiquinol and ascorbic acid in the 3 × Tg-AD mouse model of Alzheimer's disease Molecular and Cellular Neuroscience ·Javier Frontiñán-Rubio,Francisco J. Sancho-Bielsa,Juan R. Peinado,Frank M. LaFerla,Lydia Giménez‐Llort,Mario Durán‐Prado,Francisco J. Alcaı́n	2018	18
8	Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation Scientific Reports ·Erika Castillo,Julio Leon,Guianfranco Mazzei,Nona Abolhassani,Naoki Haruyama,Takashi Saito,Takaomi C. Saido,Masaaki Hokama,Toru Iwaki,Tomoyuki Ohara,Toshiharu Ninomiya,Yutaka Kiyohara,Kunihiko Sakumi,Frank M. LaFerla,Yusaku Nakabeppu	2017	113
9	Short‐term modern life‐like stress exacerbates Aβ‐pathology and synapse loss in 3xTg‐AD mice Journal of Neurochemistry ·David Baglietto‐Vargas,Yuncai Chen,Dongjin Suh,Rahasson R. Ager,Carlos J. Rodríguez‐Ortiz,Rodrigo Medeiros,Kristoffer Myczek,Kim N. Green,Tallie Z. Baram,Frank M. LaFerla	2015	71
10	AF710B, a Novel M1/σ1 Agonist with Therapeutic Efficacy in Animal Models of Alzheimer's Disease Neurodegenerative Diseases ·Abraham Fisher,Ilya Bezprozvanny,Lili Wu,Daniel A. Ryskamp,Nira Bar-Ner,Niva Natan,Rachel Brandeis,Hanoch Elkon,Victoria Nahum,Eytan Gershonov,Frank M. LaFerla,Rodrigo Medeiros	2015	65
11	Mifepristone Alters Amyloid Precursor Protein Processing to Preclude Amyloid Beta and Also Reduces Tau Pathology Biological Psychiatry ·David Baglietto‐Vargas,Rodrigo Medeiros,Hilda Martínez‐Coria,Frank M. LaFerla,Kim N. Green	2013	82
12	Presenilin-null cells have altered two-pore calcium channel expression and lysosomal calcium: Implications for lysosomal function Brain Research ·Kara M. Neely Kayala,George D. Dickinson,Anet Minassian,Ken C. Walls,Kim N. Green,Frank M. LaFerla	2012	42
13	Soluble Amyloid Precursor Protein Induces Rapid Neural Differentiation of Human Embryonic Stem Cells Journal of Biological Chemistry ·Kristine Freude,Mahmud Penjwini,Joy Davis,Frank M. LaFerla,Mathew Blurton‐Jones	2011	62
14	Treatment with a C5aR Antagonist Decreases Pathology and Enhances Behavioral Performance in Murine Models of Alzheimer’s Disease The Journal of Immunology ·María Isabel Fonseca,Rahasson R. Ager,Shu-Hui Chu,Ozkan Yazan,Sam D. Sanderson,Frank M. LaFerla,Stephen M. Taylor,Trent M. Woodruff,Andrea J. Tenner	2009	232
15	Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau Journal of Neuroscience ·Kim N. Green,Joan S. Steffan,Hilda Martínez‐Coria,Xuemin Sun,Steven S. Schreiber,Leslie M. Thompson,Frank M. LaFerla	2008	319
16	Linking Calcium to Aβ and Alzheimer's Disease Neuron ·Kim N. Green,Frank M. LaFerla	2008	270
17	Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology Journal of Clinical Investigation ·Robert A. Rissman,Wayne W. Poon,Mathew Blurton‐Jones,Salvatore Oddo,Reidun Torp,Michael P. Vitek,Frank M. LaFerla,Troy T. Rohn,Carl W. Cotman	2004	405
18	Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia Journal of Clinical Investigation ·Vikram G. Shakkottai,Chin-hua Chou,Salvatore Oddo,Claudia A. Sailer,Hans-Günther Knaus,George A. Gutman,Michael E. Barish,Frank M. LaFerla,K. George Chandy	2004	97
19	Enhanced neuronal excitability in the absence of neurodegeneration induces cerebellar ataxia Journal of Clinical Investigation ·Vikram G. Shakkottai,Chin-hua Chou,Salvatore Oddo,Claudia A. Sailer,Hans‐Günther Knaus,George A. Gutman,Michael E. Barish,Frank M. LaFerla,K. George Chandy	2004	43
20	Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology Journal of Clinical Investigation ·Robert A. Rissman,Wayne W. Poon,Mathew Blurton‐Jones,Salvatore Oddo,Reidun Torp,Michael P. Vitek,Frank M. LaFerla,Troy T. Rohn,Carl W. Cotman	2004	365

About Frank M. LaFerla

Frank M. LaFerla is a scholar working on Biological Psychiatry, Physiology and Neurology, having authored 248 papers that have together received 36.7k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (192 papers), Cholinesterase and Neurodegenerative Diseases (51 papers), Neuroscience and Neuropharmacology Research (47 papers), Neuroinflammation and Neurodegeneration Mechanisms (42 papers), Nuclear Receptors and Signaling (27 papers), Tryptophan and brain disorders (23 papers), Computational Drug Discovery Methods (19 papers) and Neurogenesis and neuroplasticity mechanisms (16 papers). The work is most often cited by research in Biological Psychiatry (3.4k citations), Neurology (8.0k citations) and Physiology (23.2k citations). Frank M. LaFerla has collaborated with scholars based in United States, Spain and Canada. Frequent co-authors include Salvatore Oddo, Henry Querfurth, Kim N. Green, Antonella Caccamo, Masashi Kitazawa, Lauren M. Billings, Mark P. Mattson, Mathew Blurton‐Jones, Yama Akbari and James L. McGaugh. Their work appears in journals such as New England Journal of Medicine, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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