Ellen Sapp

13.3k total citations · 5 hit papers
79 papers, 9.7k citations indexed

About

Ellen Sapp is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Ellen Sapp has authored 79 papers receiving a total of 9.7k indexed citations (citations by other indexed papers that have themselves been cited), including 66 papers in Molecular Biology, 58 papers in Cellular and Molecular Neuroscience and 24 papers in Neurology. Recurrent topics in Ellen Sapp's work include Genetic Neurodegenerative Diseases (58 papers), Mitochondrial Function and Pathology (40 papers) and Neurological disorders and treatments (23 papers). Ellen Sapp is often cited by papers focused on Genetic Neurodegenerative Diseases (58 papers), Mitochondrial Function and Pathology (40 papers) and Neurological disorders and treatments (23 papers). Ellen Sapp collaborates with scholars based in United States, China and Canada. Ellen Sapp's co-authors include Marian DiFiglia, Neil Aronin, Kathryn Chase, J.-P. G. Vonsattel, Stephen W. Davies, Gillian P. Bates, Kimberly B. Kegel, Anastasia Khvorova, Reka A. Haraszti and Marie-Cécile Didiot and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Ellen Sapp

78 papers receiving 9.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 2.3k citations Marian DiFiglia, Ellen Sapp et al. profile →
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1995 580 citations Marian DiFiglia, Ellen Sapp et al. Neuron profile →
High‐resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

2016 571 citations Reka A. Haraszti, Marie-Cécile Didiot et al. profile →
Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

2018 413 citations Reka A. Haraszti, Rachael Miller et al. Molecular Therapy profile →
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

2016 406 citations Marie-Cécile Didiot, Lauren M Hall et al. Molecular Therapy profile →

Peers

Countries citing papers authored by Ellen Sapp

Since Specialization

Citations

This map shows the geographic impact of Ellen Sapp's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ellen Sapp with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ellen Sapp more than expected).

Fields of papers citing papers by Ellen Sapp

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ellen Sapp. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ellen Sapp. The network helps show where Ellen Sapp may publish in the future.

Co-authorship network of co-authors of Ellen Sapp

This figure shows the co-authorship network connecting the top 25 collaborators of Ellen Sapp. A scholar is included among the top collaborators of Ellen Sapp based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ellen Sapp. Ellen Sapp is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo 2024 ·Nucleic Acid Therapeutics ·Sarah E. Allen, Daniel O’Reilly, Rachael Miller, Ellen Sapp, Ashley Summers, (unknown), Dimas Echeverria, (unknown), Nicholas McHugh, Ken Yamada, Neil Aronin, Marian DiFiglia, Anastasia Khvorova	1
2	Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction 2024 ·Journal of Neuroscience ·(unknown), (unknown), Ellen Sapp, Kathryn Chase, (unknown), (unknown), (unknown), Emily Kim, Lori Kennington, Rachael Miller, (unknown), (unknown), Xueyi Li, Edith L. Pfister, Christelle Anaclet, Michael H. Brodsky, Kimberly B. Kegel-Gleason, Neil Aronin, Marian DiFiglia	2
3	Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome 2024 ·JCI Insight ·Yan Li, (unknown), Ellen Sapp, (unknown), Zejian Wang, (unknown), Marian DiFiglia, (unknown)	0
4	Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model 2023 ·Neurobiology of Disease ·(unknown), Ellen Sapp, (unknown), Sophia Liu, (unknown), Deanna M. Marchionini, Marian DiFiglia, Kimberly B. Kegel-Gleason	5
5	Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease 2022 ·The Journal of Cell Biology ·(unknown), (unknown), Ping Wang, (unknown), Yan Li, Ellen Sapp, Jing Wang, Arabinda Ghosh, (unknown), Xiaolong Wang, (unknown), Marian DiFiglia, (unknown)	7
6	Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities 2021 ·Human Gene Therapy ·Sarah Oikemus, Edith L. Pfister, Ellen Sapp, Kathryn Chase, Lori Kennington, (unknown), Rachael Miller, Lihua Julie Zhu, (unknown), Eric Mick, Miguel Sena‐Esteves, Scot A. Wolfe, Marian DiFiglia, Neil Aronin, Michael H. Brodsky	10
7	Disposition of Proteins and Lipids in Synaptic Membrane Compartments Is Altered in Q175/Q7 Huntington’s Disease Mouse Striatum 2021 ·Frontiers in Synaptic Neuroscience ·(unknown), (unknown), Ellen Sapp, (unknown), (unknown), Xueyi Li, Marian DiFiglia, Kimberly B. Kegel-Gleason	11
8	Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes 2019 ·PLoS ONE ·(unknown), (unknown), (unknown), Ellen Sapp, Heather Richardson, Petr Vodička, J. Steven Alexander, Neil Aronin, Marian DiFiglia, Kimberly B. Kegel-Gleason	24
9	HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction 2018 ·Journal of Huntington s Disease ·Marina Kovalenko, Austen J. Milnerwood, (unknown), Jason St. Claire, Jolene R. Guide, (unknown), Tammy Gillis, Ellen Sapp, Marian DiFiglia, Marcy E. MacDonald, Jeffrey B. Carroll, Jong‐Min Lee, Susan Tappan, Lynn A. Raymond, Vanessa C. Wheeler	25
10	Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD^Q175/Q7 Mice 2016 ·Journal of Huntington s Disease ·Petr Vodička, Kathryn Chase, (unknown), (unknown), (unknown), Ellen Sapp, Kimberly B. Kegel-Gleason, Miguel Sena‐Esteves, Neil Aronin, Marian DiFiglia	37
11	Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing breakdown → 2016 ·Molecular Therapy ·Marie-Cécile Didiot, Lauren M Hall, Andrew H. Coles, Reka A. Haraszti, Bruno M.D.C. Godinho, Kathryn Chase, Ellen Sapp, Socheata Ly, Julia F. Alterman, Matthew Hassler, Dimas Echeverria, Lakshmi Raj, Dylan Morrissey, Marian DiFiglia, Neil Aronin, Anastasia Khvorova	406
12	Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector 2015 ·Molecular Therapy ·Sourav Choudhury, (unknown), Damien J. Cabral, Allison M. Keeler, Ellen Sapp, (unknown), Heather Gray‐Edwards, Jacob A. Johnson, Aime K. Johnson, Qin Su, Lorelei Stoica, Marian DiFiglia, Neil Aronin, Douglas R. Martin, Guangping Gao, Miguel Sena‐Esteves	91
13	Glucose transporter 3 is a rab11-dependent trafficking cargo and its transport to the cell surface is reduced in neurons of CAG140 Huntington’s disease mice 2014 ·Acta Neuropathologica Communications ·(unknown), (unknown), Ellen Sapp, (unknown), Ping Wang, Marian DiFiglia, Xueyi Li	45
14	Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo 2010 ·Journal of Biological Chemistry ·Justin Legleiter, (unknown), Gregor P. Lotz, Ellen Sapp, (unknown), Marian DiFiglia, Leslie M. Thompson, Paul J. Muchowski	176
15	Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors 2010 ·Molecular Neurodegeneration ·Kimberly B. Kegel, Ellen Sapp, J. Steven Alexander, Patrick Reeves, Dorothée Bleckmann, (unknown), Nicholas Masso, Antonio Valencia, Hyunkyung Jeong, Dimitri Krainc, James Palacino, Daniel Curtis, Rainer Kühn, Claudia Betschart, Miguel Sena‐Esteves, Neil Aronin, Paolo Paganetti, Marian DiFiglia	16
16	Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease 2010 ·Journal of Neuroscience ·Xueyi Li, Antonio Valencia, Ellen Sapp, Nicholas Masso, J. Steven Alexander, Patrick Reeves, Kimberly B. Kegel, Neil Aronin, Marian DiFiglia	126
17	Polyglutamine expansion in huntingtin increases its insertion into lipid bilayers 2009 ·Biochemical and Biophysical Research Communications ·Kimberly B. Kegel, (unknown), Ellen Sapp, Nicholas Masso, Erich E. Wanker, Marian DiFiglia, Wolfgang H. Goldmann	35
18	Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits 2007 ·Proceedings of the National Academy of Sciences ·Marian DiFiglia, Miguel Sena‐Esteves, Kathryn Chase, Ellen Sapp, E. Pfister, Magdolna Sass, Jeffrey A. Yoder, Patrick Reeves, Raj Kumar Pandey, Kallanthottathil G. Rajeev, Muthiah Manoharan, Dinah W.Y. Sah, Phillip D. Zamore, Neil Aronin	324
19	Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain 2001 ·Journal of Neuropathology & Experimental Neurology ·Ellen Sapp, Kimberly B. Kegel, Neil Aronin, Tsutomu Hashikawa, Yasuo Uchiyama, Koujiro Tohyama, Pradeep G. Bhide, J.-P. G. Vonsattel, Marian DiFiglia	411
20	CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain 1995 ·Neuron ·Neil Aronin, Kathryn Chase, (unknown), Ellen Sapp, (unknown), (unknown), Ruth Kornreich, (unknown), Edward J. Bird, M. Flint Beal, Jean-Paul G. Vonsattel, Thomas J. Smith, Robert E. Carraway, Frederick M. Boyce, (unknown), John B. Penney, Marian DiFiglia	140

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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