Ellen Sapp

13.3k total citations · 5 hit papers
79 papers, 9.7k citations indexed

About

Ellen Sapp is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Ellen Sapp has authored 79 papers receiving a total of 9.7k indexed citations (citations by other indexed papers that have themselves been cited), including 66 papers in Molecular Biology, 58 papers in Cellular and Molecular Neuroscience and 24 papers in Neurology. Recurrent topics in Ellen Sapp's work include Genetic Neurodegenerative Diseases (58 papers), Mitochondrial Function and Pathology (40 papers) and Neurological disorders and treatments (23 papers). Ellen Sapp is often cited by papers focused on Genetic Neurodegenerative Diseases (58 papers), Mitochondrial Function and Pathology (40 papers) and Neurological disorders and treatments (23 papers). Ellen Sapp collaborates with scholars based in United States, China and Canada. Ellen Sapp's co-authors include Marian DiFiglia, Neil Aronin, Kathryn Chase, J.-P. G. Vonsattel, Gillian P. Bates, Stephen W. Davies, Kimberly B. Kegel, Anastasia Khvorova, Reka A. Haraszti and Marie-Cécile Didiot and has published in prestigious journals such as Science, Proceedings of the National Academy of Sciences and Nucleic Acids Research.

In The Last Decade

Ellen Sapp

78 papers receiving 9.5k citations

Hit Papers

align trajectories sort by overperformance

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain

1997 2.3k citations Marian DiFiglia, Ellen Sapp et al. profile →
Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons

1995 580 citations Marian DiFiglia, Ellen Sapp et al. profile →
High‐resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources

2016 571 citations Reka A. Haraszti, Ellen Sapp et al. profile →
Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity

2018 413 citations Reka A. Haraszti, Rachael Miller et al. Molecular Therapy profile →
Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing

2016 406 citations Andrew H. Coles, Reka A. Haraszti et al. Molecular Therapy profile →

Author Peers

Peers are selected by citation overlap in the author's most active subfields. citations · hero ref

Author						Papers	Cites
Ellen Sapp	7.7k	6.2k	2.6k	1.0k	956	79	9.7k
Sandrine Humbert	6.2k 0.8×	4.5k 0.7×	1.2k 0.5×	1.4k 1.3×	320 0.3×	86	8.2k
Lawrence Wrabetz	3.6k 0.5×	4.7k 0.8×	885 0.3×	2.1k 2.0×	353 0.4×	150	7.9k
M. Laura Feltri	3.4k 0.4×	4.8k 0.8×	896 0.4×	1.9k 1.9×	326 0.3×	150	7.7k
Felipe A. Court	3.2k 0.4×	2.4k 0.4×	1.1k 0.4×	1.5k 1.5×	471 0.5×	88	6.3k
Vladimir L. Buchman	3.1k 0.4×	3.1k 0.5×	3.9k 1.5×	1.1k 1.0×	302 0.3×	142	8.1k
Zuoshang Xu	5.2k 0.7×	1.4k 0.2×	3.6k 1.4×	1.1k 1.1×	1.3k 1.4×	86	9.3k
Frank Rigo	8.6k 1.1×	1.6k 0.2×	2.2k 0.9×	346 0.3×	1.3k 1.3×	141	11.2k
Jeffery L. Twiss	4.5k 0.6×	3.0k 0.5×	458 0.2×	1.1k 1.0×	372 0.4×	98	6.9k
Luís Pereira de Almeida	3.9k 0.5×	2.4k 0.4×	848 0.3×	229 0.2×	828 0.9×	148	6.1k
Shihua Li	4.8k 0.6×	3.7k 0.6×	1.3k 0.5×	614 0.6×	108 0.1×	114	6.3k

Countries citing papers authored by Ellen Sapp

Since Specialization

Citations

This map shows the geographic impact of Ellen Sapp's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Ellen Sapp with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Ellen Sapp more than expected).

Fields of papers citing papers by Ellen Sapp

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Ellen Sapp. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Ellen Sapp. The network helps show where Ellen Sapp may publish in the future.

Co-authorship network of co-authors of Ellen Sapp

This figure shows the co-authorship network connecting the top 25 collaborators of Ellen Sapp. A scholar is included among the top collaborators of Ellen Sapp based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Ellen Sapp. Ellen Sapp is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Miller, Rachael, Ellen Sapp, Nicholas McHugh, et al.. (2024). Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation. Molecular Therapy — Nucleic Acids. 35(4). 102359–102359. 5 indexed citations

Belgrad, Jillian, Qi Tang, Ashley Summers, et al.. (2024). A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system. Nucleic Acids Research. 52(11). 6099–6113. 8 indexed citations

Allen, Sarah E., Daniel O’Reilly, Rachael Miller, et al.. (2024). mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo. Nucleic Acid Therapeutics. 34(4). 164–172. 1 indexed citations

Li, Yan, et al.. (2024). Chronic pharmacologic manipulation of dopamine transmission ameliorates metabolic disturbance in Trappc9-linked brain developmental syndrome. JCI Insight. 9(15).

Sapp, Ellen, Suzanne J. Reid, Bianca A. Trombetta, et al.. (2023). Levels of Synaptic Proteins in Brain and Neurofilament Light Chain in Cerebrospinal Fluid and Plasma of OVT73 Huntington’s Disease Sheep Support a Prodromal Disease State. Journal of Huntington s Disease. 12(3). 201–213. 1 indexed citations

Wang, Ping, Yan Li, Ellen Sapp, et al.. (2022). Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease. The Journal of Cell Biology. 221(10). 7 indexed citations

Oikemus, Sarah, Edith L. Pfister, Ellen Sapp, et al.. (2021). Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities. Human Gene Therapy. 33(1-2). 25–36. 10 indexed citations

Sapp, Ellen, Heather Richardson, Petr Vodička, et al.. (2019). Huntingtin associates with the actin cytoskeleton and α-actinin isoforms to influence stimulus dependent morphology changes. PLoS ONE. 14(2). e0212337–e0212337. 24 indexed citations

Sapp, Ellen, Ningzhe Zhang, Petr Vodička, et al.. (2018). Rac1 Activity Is Modulated by Huntingtin and Dysregulated in Models of Huntington’s Disease. Journal of Huntington s Disease. 8(1). 53–69. 24 indexed citations

10.

Kovalenko, Marina, Austen J. Milnerwood, Jason St. Claire, et al.. (2018). HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. Journal of Huntington s Disease. 7(1). 17–33. 25 indexed citations

11.

Godinho, Bruno M.D.C., Nils Henninger, James Bouley, et al.. (2018). Transvascular Delivery of Hydrophobically Modified siRNAs: Gene Silencing in the Rat Brain upon Disruption of the Blood-Brain Barrier. Molecular Therapy. 26(11). 2580–2591. 29 indexed citations

12.

Vodička, Petr, Kathryn Chase, Ellen Sapp, et al.. (2016). Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HD^Q175/Q7 Mice. Journal of Huntington s Disease. 5(3). 249–260. 37 indexed citations

13.

Choudhury, Sourav, Damien J. Cabral, Allison M. Keeler, et al.. (2015). Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector. Molecular Therapy. 24(4). 726–735. 91 indexed citations

14.

Li, Xueyi, et al.. (2012). Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington’s disease mice. Biochemical and Biophysical Research Communications. 421(4). 727–730. 29 indexed citations

15.

Fox, Jonathan H., Jibrin Kama, Zhen Lü, et al.. (2011). Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein. Journal of Biological Chemistry. 286(20). 18320–18330. 52 indexed citations

16.

Legleiter, Justin, Gregor P. Lotz, Ellen Sapp, et al.. (2010). Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo. Journal of Biological Chemistry. 285(19). 14777–14790. 176 indexed citations

17.

Li, Xueyi, Antonio Valencia, Ellen Sapp, et al.. (2010). Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease. Journal of Neuroscience. 30(13). 4552–4561. 126 indexed citations

18.

Li, Xueyi, Ellen Sapp, Kathryn Chase, et al.. (2009). Disruption of Rab11 activity in a knock-in mouse model of Huntington's disease. Neurobiology of Disease. 36(2). 374–383. 61 indexed citations

19.

DiFiglia, Marian, Miguel Sena‐Esteves, Kathryn Chase, et al.. (2007). Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits. Proceedings of the National Academy of Sciences. 104(43). 17204–17209. 324 indexed citations

20.

Sapp, Ellen, Kimberly B. Kegel, Neil Aronin, et al.. (2001). Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain. Journal of Neuropathology & Experimental Neurology. 60(2). 161–172. 411 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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