Marian DiFiglia

26.9k citations

156 papers · 18.4k indexed · 8 hit papers · h-index 63

Cellular and Molecular Neuroscience top 0.02%
- Genetic Neurodegenerative Diseases 88
- Neuroscience and Neuropharmacology Research 31
Neurology top 0.1%
- Neurological disorders and treatments 37
Molecular Biology top 0.2%
- Mitochondrial Function and Pathology 57
- Muscle Physiology and Disorders 24
- RNA Interference and Gene Delivery 12
- Ion channel regulation and function 12
Developmental Neuroscience top 0.5%
Neurology top 0.5%
- Neurological disorders and treatments 37
Cell Biology
- Cellular transport and secretion 10

Co-authors: Neil Aronin Ellen Sapp Jean Paul Vonsattel Kathryn Chase Stephen W. Davies Gillian P. Bates J.-P. G. Vonsattel Kimberly B. Kegel
Cited by: Cellular and Molecular Neuroscience Neurology Molecular Biology
Partner nations: United States China Canada

In The Last Decade

Marian DiFiglia

155 papers receiving 18.2k citations

Hit Papers

8 papers align trajectories log scale

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

2018 Exosomes Produced from 3D Cultures of MSCs by Tangential Flow Filtration Show Higher Yield and Improved Activity
2016 Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencing
2016 High‐resolution proteomic and lipidomic analysis of exosomes and microvesicles from different cell sources
1998 Huntington Disease
1997 Aggregation of Huntingtin in Neuronal Intranuclear Inclusions and Dystrophic Neurites in Brain
1997 Formation of Neuronal Intranuclear Inclusions Underlies the Neurological Dysfunction in Mice Transgenic for the HD Mutation
1995 Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons
1985 Evidence for Degenerative and Regenerative Changes in Neostriatal Spiny Neurons in Huntington's Disease

Peers

Countries citing papers authored by Marian DiFiglia

Since Specialization

Citations

This map shows the geographic impact of Marian DiFiglia's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marian DiFiglia with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marian DiFiglia more than expected).

Fields of papers citing papers by Marian DiFiglia

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marian DiFiglia. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marian DiFiglia. The network helps show where Marian DiFiglia may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Marian DiFiglia, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Marian DiFiglia Line = papers co-authored together Marian DiFiglia links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo Sarah E. Allen,Daniel O’Reilly,Rachael Miller,Ellen Sapp,Ashley Summers,Joseph Paquette,Dimas Echeverria,Brianna Bramato,Nicholas McHugh,Ken Yamada,Neil Aronin,Marian DiFiglia,Anastasia Khvorova	2024	1
2	Nacc1 Mutation in Mice Models Rare Neurodevelopmental Disorder with Underlying Synaptic Dysfunction Mark Deehan,Josine Marie Kothuis,Ellen Sapp,Kathryn Chase,Yuting Ke,Connor Seeley,Maria Iuliano,Emily Kim,Lori Kennington,Rachael Miller,Adel Boudi,Kai Shing,Xueyi Li,Edith L. Pfister,Christelle Anaclet,Michael H. Brodsky,Kimberly B. Kegel-Gleason,Neil Aronin,Marian DiFiglia	2024	2
3	Early whole-body mutant huntingtin lowering averts changes in proteins and lipids important for synapse function and white matter maintenance in the LacQ140 mouse model Kai Shing,Ellen Sapp,Adel Boudi,Sophia Liu,Connor Seeley,Deanna M. Marchionini,Marian DiFiglia,Kimberly B. Kegel-Gleason	2023	5
4	Impaired XK recycling for importing manganese underlies striatal vulnerability in Huntington's disease Gaurav Chhetri,Yuting Ke,Ping Wang,Muhammad Usman,Yan Li,Ellen Sapp,Jing Wang,Arabinda Ghosh,Md. Ariful Islam,Xiaolong Wang,Adel Boudi,Marian DiFiglia,Xueyi Li	2022	7
5	Allele-Specific Knockdown of Mutant Huntingtin Protein via Editing at Coding Region Single Nucleotide Polymorphism Heterozygosities Sarah Oikemus,Edith L. Pfister,Ellen Sapp,Kathryn Chase,Lori Kennington,Edward Hudgens,Rachael Miller,Lihua Julie Zhu,Akanksh Chaudhary,Eric Mick,Miguel Sena‐Esteves,Scot A. Wolfe,Marian DiFiglia,Neil Aronin,Michael H. Brodsky	2021	10
6	Trappc9 deficiency in mice impairs learning and memory by causing imbalance of dopamine D1 and D2 neurons Yuting Ke,Meiqian Weng,Gaurav Chhetri,Muhammad Usman,Yan Li,Qing Yu,Yingzhuo Ding,Zejian Wang,Xiaolong Wang,Pinky Sultana,Marian DiFiglia,Xueyi Li	2020	25
7	HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction Marina Kovalenko,Austen J. Milnerwood,James V. Giordano,Jason St. Claire,Jolene R. Guide,Mary Stromberg,Tammy Gillis,Ellen Sapp,Marian DiFiglia,Marcy E. MacDonald,Jeffrey B. Carroll,Jong‐Min Lee,Susan Tappan,Lynn A. Raymond,Vanessa C. Wheeler	2018	25
8	Exosome-mediated Delivery of Hydrophobically Modified siRNA for Huntingtin mRNA Silencingbreakdown → Marie-Cécile Didiot,Lauren M Hall,Andrew H. Coles,Reka A. Haraszti,Bruno M.D.C. Godinho,Kathryn Chase,Ellen Sapp,Socheata Ly,Julia F. Alterman,Matthew Hassler,Dimas Echeverria,Lakshmi Raj,Dylan Morrissey,Marian DiFiglia,Neil Aronin,Anastasia Khvorova	2016	406
9	Widespread Central Nervous System Gene Transfer and Silencing After Systemic Delivery of Novel AAV-AS Vector Sourav Choudhury,Anne F Harris,Damien J. Cabral,Allison M. Keeler,Ellen Sapp,Jennifer S Ferreira,Heather Gray‐Edwards,Jacob A. Johnson,Aime K. Johnson,Qin Su,Lorelei Stoica,Marian DiFiglia,Neil Aronin,Douglas R. Martin,Guangping Gao,Miguel Sena‐Esteves	2015	91
10	Mutant Huntingtin Fragments Form Oligomers in a Polyglutamine Length-dependent Manner in Vitro and in Vivo Justin Legleiter,Emily J Mitchell,Gregor P. Lotz,Ellen Sapp,Che-Ping Ng,Marian DiFiglia,Leslie M. Thompson,Paul J. Muchowski	2010	176
11	The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease Jonathan H. Fox,Teal Connor,Vanita Chopra,Kate Dorsey,Jibrin Kama,Dorothée Bleckmann,Claudia Betschart,Daniël Hoyer,Stefan Frentzel,Marian DiFiglia,Paolo Paganetti,Steven M. Hersch	2010	76
12	Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors Kimberly B. Kegel,Ellen Sapp,J. Steven Alexander,Patrick Reeves,Dorothée Bleckmann,Linsday Sobin,Nicholas Masso,Antonio Valencia,Hyunkyung Jeong,Dimitri Krainc,James Palacino,Daniel Curtis,Rainer Kühn,Claudia Betschart,Miguel Sena‐Esteves,Neil Aronin,Paolo Paganetti,Marian DiFiglia	2010	16
13	Aberrant Rab11-Dependent Trafficking of the Neuronal Glutamate Transporter EAAC1 Causes Oxidative Stress and Cell Death in Huntington's Disease Xueyi Li,Antonio Valencia,Ellen Sapp,Nicholas Masso,J. Steven Alexander,Patrick Reeves,Kimberly B. Kegel,Neil Aronin,Marian DiFiglia	2010	126
14	Therapeutic silencing of mutant huntingtin with siRNA attenuates striatal and cortical neuropathology and behavioral deficits Marian DiFiglia,Miguel Sena‐Esteves,Kathryn Chase,Ellen Sapp,E. Pfister,Magdolna Sass,Jeffrey A. Yoder,Patrick Reeves,Raj Kumar Pandey,Kallanthottathil G. Rajeev,Muthiah Manoharan,Dinah W.Y. Sah,Phillip D. Zamore,Neil Aronin	2007	324
15	Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome Paul Kalanithi,Wei Zheng,Yuko Kataoka,Marian DiFiglia,Heidi Grantz,Clifford B. Saper,Michael L. Schwartz,James F. Leckman,Flora M. Vaccarino	2005	385
16	Huntingtin is degraded to small fragments by calpain after ischemic injury☆ Manho Kim,Jae‐Kyu Roh,Byung Woo Yoon,Lami Kang,Yun Joong Kim,Neil Aronin,Marian DiFiglia	2003	34
17	Early and Progressive Accumulation of Reactive Microglia in the Huntington Disease Brain Ellen Sapp,Kimberly B. Kegel,Neil Aronin,Tsutomu Hashikawa,Yasuo Uchiyama,Koujiro Tohyama,Pradeep G. Bhide,J.-P. G. Vonsattel,Marian DiFiglia	2001	411
18	CAG expansion affects the expression of mutant huntingtin in the Huntington's disease brain Neil Aronin,Kathryn Chase,Christine Young,Ellen Sapp,Cordula Schwarz,N. K. Matta,Ruth Kornreich,Bernhard Lanwehrmeyer,Edward J. Bird,M. Flint Beal,Jean-Paul G. Vonsattel,Thomas J. Smith,Robert E. Carraway,Frederick M. Boyce,Anne B. Young,John B. Penney,Marian DiFiglia	1995	140
19	Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity Andrew Freese,Seth P. Finklestein,Marian DiFiglia	1992	131
20	N-methyl-d-aspartate receptor activation in the neostriatum increases c-fos and fos-related antigens selectively in medium-sized neurons Neil Aronin,Kathryn Chase,Stephen M. Sagar,Frank R. Sharp,Marian DiFiglia	1991	75

About Marian DiFiglia

Marian DiFiglia is a scholar working on Cellular and Molecular Neuroscience, Neurology and Developmental Neuroscience, having authored 156 papers that have together received 18.4k indexed citations. Recurring topics across this work include Genetic Neurodegenerative Diseases (88 papers), Mitochondrial Function and Pathology (57 papers), Neurological disorders and treatments (37 papers), Neuroscience and Neuropharmacology Research (31 papers), Muscle Physiology and Disorders (24 papers), RNA Interference and Gene Delivery (12 papers), Ion channel regulation and function (12 papers) and Cellular transport and secretion (10 papers). The work is most often cited by research in Cellular and Molecular Neuroscience (13.2k citations), Neurology (5.2k citations) and Molecular Biology (12.8k citations). Marian DiFiglia has collaborated with scholars based in United States, China and Canada. Frequent co-authors include Neil Aronin, Ellen Sapp, Jean Paul Vonsattel, Kathryn Chase, Stephen W. Davies, Gillian P. Bates, J.-P. G. Vonsattel, Kimberly B. Kegel, Tauba Pasik and Erich E. Wanker.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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