Harry T. Orr

32.4k total citations · 9 hit papers
242 papers, 24.5k citations indexed

About

Harry T. Orr is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Immunology. According to data from OpenAlex, Harry T. Orr has authored 242 papers receiving a total of 24.5k indexed citations (citations by other indexed papers that have themselves been cited), including 162 papers in Molecular Biology, 135 papers in Cellular and Molecular Neuroscience and 54 papers in Immunology. Recurrent topics in Harry T. Orr's work include Genetic Neurodegenerative Diseases (129 papers), Mitochondrial Function and Pathology (107 papers) and T-cell and B-cell Immunology (38 papers). Harry T. Orr is often cited by papers focused on Genetic Neurodegenerative Diseases (129 papers), Mitochondrial Function and Pathology (107 papers) and T-cell and B-cell Immunology (38 papers). Harry T. Orr collaborates with scholars based in United States, Poland and France. Harry T. Orr's co-authors include Huda Y. Zoghbi, Lisa Duvick, Jack L. Strominger, Antonio Servadio, H. Brent Clark, B H Koller, Laura P.W. Ranum, Daniel E. Geraghty, Barbara Antalffy and Christopher J. Cummings and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Harry T. Orr

237 papers receiving 23.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Expansion of an unstable trinucleotide CAG repeat in spinocerebellar ataxia type 1

1993 1.3k citations Harry T. Orr, Sandro Banfi et al. profile →
Trinucleotide Repeat Disorders

2007 1.1k citations Harry T. Orr, Huda Y. Zoghbi profile →
Glutamine Repeats and Neurodegeneration

2000 1.0k citations Huda Y. Zoghbi, Harry T. Orr profile →
Ataxin-1 Nuclear Localization and Aggregation

1998 815 citations H. Brent Clark, Huda Y. Zoghbi et al. profile →
Genetic Linkage Evidence for a Familial Alzheimer's Disease Locus on Chromosome 14

1992 683 citations Harry T. Orr et al. profile →
Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1

1998 635 citations Harry T. Orr, Huda Y. Zoghbi et al. profile →
Identification of genes that modify ataxin-1-induced neurodegeneration

2000 510 citations Harry T. Orr, Huda Y. Zoghbi et al. profile →
Major histocompatibility antigens: The human (HLA-A,-B,-C) and murine (H-2K, H-2D) class I molecules

1981 444 citations Harry T. Orr, Jack L. Strominger et al. profile →
Mutation of the E6-AP Ubiquitin Ligase Reduces Nuclear Inclusion Frequency While Accelerating Polyglutamine-Induced Pathology in SCA1 Mice

1999 409 citations Yaling Sun, Harry T. Orr et al. Neuron profile →

Peers

Countries citing papers authored by Harry T. Orr

Since Specialization

Citations

This map shows the geographic impact of Harry T. Orr's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Harry T. Orr with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Harry T. Orr more than expected).

Fields of papers citing papers by Harry T. Orr

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Harry T. Orr. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Harry T. Orr. The network helps show where Harry T. Orr may publish in the future.

Co-authorship network of co-authors of Harry T. Orr

This figure shows the co-authorship network connecting the top 25 collaborators of Harry T. Orr. A scholar is included among the top collaborators of Harry T. Orr based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Harry T. Orr. Harry T. Orr is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Expanded ATXN1 alters transcription and calcium signaling in SCA1 human motor neurons differentiated from induced pluripotent stem cells 2024 ·Neurobiology of Disease ·Carrie Sheeler, (unknown), Lisa Duvick, Leslie M. Thompson, Ying Zhang, Harry T. Orr, Marija Cvetanović	2
2	HD and SCA1: Tales from two 30-year journeys since gene discovery 2023 ·Neuron ·Leslie M. Thompson, Harry T. Orr	10
3	Cross-species genetic screens identify transglutaminase 5 as a regulator of polyglutamine-expanded ataxin-1 2022 ·Journal of Clinical Investigation ·(unknown), Ismael Al‐Ramahi, Hyun-Hwan Jeong, (unknown), Tao Lin, Carolyn J. Adamski, Laura A. Lavery, (unknown), Ronald Richman, Vitaliy V. Bondar, (unknown), Jean‐Pierre Revelli, Harry T. Orr, Zhandong Liu, Juan Botas, Huda Y. Zoghbi	7
4	Reduction of mutant ATXN1 rescues premature death in a conditional SCA1 mouse model 2022 ·JCI Insight ·James P. Orengo, Larissa Nitschke, Meike E. van der Heijden, (unknown), Harry T. Orr, Huda Y. Zoghbi	7
5	Modulation of ATXN1 S776 phosphorylation reveals the importance of allele-specific targeting in SCA1 2021 ·JCI Insight ·Larissa Nitschke, (unknown), (unknown), (unknown), James P. Orengo, (unknown), (unknown), Ying-Wooi Wan, Zhandong Liu, Harry T. Orr, Huda Y. Zoghbi	12
6	Dual targeting of brain region‐specific kinases potentiates neurological rescue in Spinocerebellar ataxia type 1 2021 ·The EMBO Journal ·(unknown), Laura A. Lavery, Maxime W.C. Rousseaux, (unknown), (unknown), Ying‐Wooi Wan, (unknown), Won–Ho Kim, Ismael Al‐Ramahi, (unknown), Carolyn J. Adamski, Vitaliy V. Bondar, Ambika Tewari, (unknown), (unknown), Hari Krishna Yalamanchili, Harry T. Orr, Zhandong Liu, Juan Botas, Huda Y. Zoghbi	13
7	Altered Capicua expression drives regional Purkinje neuron vulnerability through ion channel gene dysregulation in spinocerebellar ataxia type 1 2020 ·Human Molecular Genetics ·Ravi Chopra, David D. Bushart, (unknown), Dhananjay Yellajoshyula, (unknown), (unknown), (unknown), (unknown), Warunee Dansithong, Daniel R. Scoles, Stefan M. Pulst, Harry T. Orr, Vikram G. Shakkottai	14
8	Motor neuron degeneration correlates with respiratory dysfunction in SCA1 2018 ·Disease Models & Mechanisms ·James P. Orengo, Meike E. van der Heijden, Shuang Hao, Jianrong Tang, Harry T. Orr, Huda Y. Zoghbi	24
9	Antisense oligonucleotide–mediated ataxin-1 reduction prolongs survival in SCA1 mice and reveals disease-associated transcriptome profiles 2018 ·JCI Insight ·(unknown), Holly Kordasiewicz, Brennon O’Callaghan, (unknown), (unknown), Lisa Duvick, Eric E. Swayze, (unknown), (unknown), Michael A. Benneyworth, (unknown), (unknown), Chen Zhao, Judit Perez Ortiz, H. Brent Clark, Gülin Öz, Sarah N. Larson, Huda Y. Zoghbi, Christine Henzler, Harry T. Orr	87
10	Diminishing return for mechanistic therapeutics with neurodegenerative disease duration? 2016 ·BioEssays ·David C. Rubinsztein, Harry T. Orr	23
11	Assessing recovery from neurodegeneration in spinocerebellar ataxia 1: Comparison of in vivo magnetic resonance spectroscopy with motor testing, gene expression and histology 2014 ·Neurobiology of Disease ·Gülin Öz, (unknown), (unknown), (unknown), Lynn E. Eberly, Harry T. Orr, H. Brent Clark	14
12	The Unstable Repeats—Three Evolving Faces of Neurological Disease 2013 ·Neuron ·David L. Nelson, Harry T. Orr, Stephen T. Warren	148
13	Partial loss of Tip60 slows mid-stage neurodegeneration in a spinocerebellar ataxia type 1 (SCA1) mouse model 2011 ·Human Molecular Genetics ·(unknown), J. Michael Andresen, Lisa Duvick, John Lough, Huda Y. Zoghbi, Harry T. Orr	46
14	Lithium Therapy Improves Neurological Function and Hippocampal Dendritic Arborization in a Spinocerebellar Ataxia Type 1 Mouse Model 2007 ·PLoS Medicine ·Kei Watase, Jennifer R. Gatchel, Yaling Sun, Effat S. Emamian, Richard Atkinson, Ronald Richman, Hidehiro Mizusawa, Harry T. Orr, Chad A. Shaw, Huda Y. Zoghbi	128
15	Targeted Deletion of a SingleSca8Ataxia Locus Allele in Mice Causes Abnormal Gait, Progressive Loss of Motor Coordination, and Purkinje Cell Dendritic Deficits 2006 ·Journal of Neuroscience ·Yungui He, Tao Zu, Kellie Benzow, Harry T. Orr, H. Brent Clark, Michael D. Koob	55
16	Mice Lacking Ataxin-1 Display Learning Deficits and Decreased Hippocampal Paired-Pulse Facilitation 1998 ·Journal of Neuroscience ·Antoni Matilla‐Dueñas, Erik D. Roberson, Sandro Banfi, (unknown), Dawna L. Armstrong, Eric N. Burright, Harry T. Orr, J. David Sweatt, Huda Y. Zoghbi, Martin M. Matzuk	167
17	Spinocerebellar ataxia type 1 1995 ·PubMed ·Huda Y. Zoghbi, Harry T. Orr	139
18	Sequence of a murine cDNA, pcp-4, that encodes the homolog of the rat brain-specific antigen PEP-19 1990 ·Nucleic Acids Research ·(unknown), Harry T. Orr	10
19	Use of Southern blotting to analyze the size and restriction fragment polymorphism of HLA class I DNA in the human population 1983 ·Transplantation Proceedings ·Harry T. Orr	10
20	Structure of crossreactive human histocompatibility antigens HLA-A28 and HLA-A2: possible implications for the generation of HLA polymorphism. 1982 ·Proceedings of the National Academy of Sciences ·José A. Łópez de Castro, Jack L. Strominger, Douglas M. Strong, Harry T. Orr	93

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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