Christopher J. Helal

4.8k total citations · 2 hit papers
36 papers, 3.4k citations indexed

About

Christopher J. Helal is a scholar working on Organic Chemistry, Molecular Biology and Pharmaceutical Science. According to data from OpenAlex, Christopher J. Helal has authored 36 papers receiving a total of 3.4k indexed citations (citations by other indexed papers that have themselves been cited), including 28 papers in Organic Chemistry, 15 papers in Molecular Biology and 5 papers in Pharmaceutical Science. Recurrent topics in Christopher J. Helal's work include Chemical Synthesis and Analysis (9 papers), Synthesis and Catalytic Reactions (6 papers) and Phosphodiesterase function and regulation (6 papers). Christopher J. Helal is often cited by papers focused on Chemical Synthesis and Analysis (9 papers), Synthesis and Catalytic Reactions (6 papers) and Phosphodiesterase function and regulation (6 papers). Christopher J. Helal collaborates with scholars based in United States, Canada and China. Christopher J. Helal's co-authors include E. J. Corey, Neal W. Sach, William Farrell, Joseph W. Tucker, Paul Richardson, Xinjun Hou, Plato Α. Magriotis, Thomas A. Chappie, Matthew R. Reese and John M. Humphrey and has published in prestigious journals such as Science, Journal of the American Chemical Society and Angewandte Chemie International Edition.

In The Last Decade

Christopher J. Helal

36 papers receiving 3.3k citations

Hit Papers

align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method

1998 1.2k citations E. J. Corey, Christopher J. Helal Angewandte Chemie International Edition profile →
A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow

2018 333 citations Joseph W. Tucker, Christopher J. Helal et al. Science profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Christopher J. Helal United States	23	2.3k	1.1k	889	440	344	36	3.4k
Paul Helquist United States	37	3.2k 1.4×	1.6k 1.4×	840 0.9×	251 0.6×	253 0.7×	169	4.9k
Xingshu Li China	37	2.8k 1.2×	1.1k 1.0×	1.1k 1.3×	343 0.8×	890 2.6×	132	4.3k
Scott E. Schaus United States	41	5.1k 2.2×	1.8k 1.5×	1.3k 1.5×	211 0.5×	302 0.9×	102	6.4k
Frank Lovering United States	19	3.7k 1.6×	1.6k 1.4×	560 0.6×	163 0.4×	380 1.1×	28	5.2k
Jacek Młynarski Poland	29	2.0k 0.8×	909 0.8×	729 0.8×	197 0.4×	129 0.4×	112	2.9k
Jack Bikker United States	12	2.6k 1.1×	1.3k 1.1×	380 0.4×	123 0.3×	272 0.8×	18	3.8k
Mitsuhiro Arisawa Japan	35	3.4k 1.5×	1.2k 1.0×	472 0.5×	136 0.3×	209 0.6×	193	4.2k
Petr Váchal United States	23	3.9k 1.7×	1.0k 0.9×	982 1.1×	520 1.2×	65 0.2×	34	4.8k
Wei‐Min Dai China	41	5.2k 2.3×	1.6k 1.4×	552 0.6×	342 0.8×	556 1.6×	225	6.7k
Tracey Pirali Italy	27	2.8k 1.2×	1.6k 1.4×	432 0.5×	123 0.3×	243 0.7×	67	4.2k

Countries citing papers authored by Christopher J. Helal

Since Specialization

Citations

This map shows the geographic impact of Christopher J. Helal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher J. Helal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher J. Helal more than expected).

Fields of papers citing papers by Christopher J. Helal

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher J. Helal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher J. Helal. The network helps show where Christopher J. Helal may publish in the future.

Co-authorship network of co-authors of Christopher J. Helal

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher J. Helal. A scholar is included among the top collaborators of Christopher J. Helal based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher J. Helal. Christopher J. Helal is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

Bernier, Louise, Jotham W. Coe, William Farrell, et al.. (2019). High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates. Angewandte Chemie. 131(51). 18576–18580. 19 indexed citations

Stepan, Antonia F., Tuan P. Tran, Christopher J. Helal, et al.. (2018). Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189. ACS Medicinal Chemistry Letters. 9(2). 68–72. 25 indexed citations

Tucker, Joseph W., et al.. (2018). A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flow. Science. 359(6374). 429–434. 333 indexed citations breakdown →

Helal, Christopher J., et al.. (2018). Increased building block access through collaboration. Drug Discovery Today. 23(8). 1458–1462. 9 indexed citations

Mukherjee, Paramita, Rongqiang Liu, Edelweiss Evrard, et al.. (2018). Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides. Organic Letters. 20(3). 812–815. 112 indexed citations

Shah, Akshay A., et al.. (2017). Parallel Synthesis of 1H-Pyrazolo[3,4-d]pyrimidines via Condensation of N-Pyrazolylamides and Nitriles. ACS Combinatorial Science. 19(11). 675–680. 5 indexed citations

Knauber, Thomas, Ramalakshmi Y. Chandrasekaran, Joseph W. Tucker, et al.. (2017). Ru/Ni Dual Catalytic Desulfinative Photoredox C_sp²–C_sp³ Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides. Organic Letters. 19(24). 6566–6569. 62 indexed citations

Chen, Laigao, Nabeel Nabulsi, Mika Naganawa, et al.. (2016). Preclinical Evaluation of ¹⁸F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme. Journal of Nuclear Medicine. 57(9). 1448–1453. 11 indexed citations

Zhang, Lei, Anabella Villalobos, Elizabeth M. Beck, et al.. (2013). Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand. Journal of Medicinal Chemistry. 56(11). 4568–4579. 142 indexed citations

10.

Walsky, Robert L., R. Scott Obach, Ruth Hyland, et al.. (2012). Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs. Drug Metabolism and Disposition. 40(9). 1686–1697. 74 indexed citations

11.

Chappie, Thomas A., Christopher J. Helal, & Xinjun Hou. (2012). Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition. Journal of Medicinal Chemistry. 55(17). 7299–7331. 74 indexed citations

12.

Helal, Christopher J., Zhijun Kang, Thomas G. Gant, et al.. (2009). Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters. 19(19). 5703–5707. 40 indexed citations

13.

Helal, Christopher J., Mark A. Sanner, Christopher B. Cooper, et al.. (2004). Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease. Bioorganic & Medicinal Chemistry Letters. 14(22). 5521–5525. 86 indexed citations

14.

Helal, Christopher J., et al.. (2004). Stereoselective Synthesis of cis-1,3-Disubstituted Cyclobutyl Kinase Inhibitors. Organic Letters. 6(11). 1853–1856. 15 indexed citations

15.

Corey, E. J. & Christopher J. Helal. (1998). Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Method. Angewandte Chemie International Edition. 37(15). 1986–2012. 1152 indexed citations breakdown →

16.

Corey, E. J. & Christopher J. Helal. (1997). An Efficient Catalytic Stereoselective Route to a Key Intermediate for the Synthesis of the Long-Lived PGI2 Analog ZK 96480 (CicaprostTM). Tetrahedron Letters. 38(43). 7511–7514. 22 indexed citations

17.

Corey, E. J. & Christopher J. Helal. (1996). Asymmetric synthesis of (S)-carbinoxamine. New aspects of oxazaborolidine-catalyzed enantioselective carbonyl reduction. Tetrahedron Letters. 37(32). 5675–5678. 87 indexed citations

18.

Corey, E. J. & Christopher J. Helal. (1996). Catalytic enantioselective synthesis of the second generation histamine antagonist cetirizine hydrochloride. Tetrahedron Letters. 37(28). 4837–4840. 86 indexed citations

19.

Helal, Christopher J., Plato Α. Magriotis, & E. J. Corey. (1996). Direct Catalytic Enantioselective Reduction of Achiral α,β-Ynones. Strong Remote Steric Effects Across the C−C Triple Bond. Journal of the American Chemical Society. 118(44). 10938–10939. 116 indexed citations

20.

Corey, E. J. & Christopher J. Helal. (1995). Novel electronic effects of remote substituents on the oxazaborolidine-catalyzed enantioselective reduction of ketones. Tetrahedron Letters. 36(50). 9153–9156. 144 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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