Christopher J. Helal

4.8k citations

36 papers · 3.4k indexed · 2 hit papers · h-index 23

Organic Chemistry top 0.5%
- Synthesis and Catalytic Reactions 6
- Click Chemistry and Applications 5
- Organoboron and organosilicon chemistry 5
- Chemical synthesis and alkaloids 4
Inorganic Chemistry top 1%
- Asymmetric Hydrogenation and Catalysis 5
Pharmaceutical Science top 2%
Pharmacology top 5%
- Cholinesterase and Neurodegenerative Diseases 3
Pharmacology top 5%
- Cholinesterase and Neurodegenerative Diseases 3
Molecular Biology
- Chemical Synthesis and Analysis 9
- Phosphodiesterase function and regulation 6

Co-authors: E. J. Corey Neal W. Sach William Farrell Joseph W. Tucker Paul Richardson Xinjun Hou Plato Α. Magriotis Thomas A. Chappie
Cited by: Organic Chemistry Inorganic Chemistry Pharmaceutical Science
Journals: Science (1 paper)Journal of the American Chemical Society (1 paper)Angewandte Chemie International Edition (2 papers)
Partner nations: United States Canada China

In The Last Decade

Christopher J. Helal

36 papers receiving 3.3k citations

Hit Papers

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Peers

Countries citing papers authored by Christopher J. Helal

Since Specialization

Citations

This map shows the geographic impact of Christopher J. Helal's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher J. Helal with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher J. Helal more than expected).

Fields of papers citing papers by Christopher J. Helal

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher J. Helal. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher J. Helal. The network helps show where Christopher J. Helal may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Christopher J. Helal, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Christopher J. Helal Line = papers co-authored together Christopher J. Helal links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	High‐Throughput Ligand Screening Enables the Enantioselective Conjugate Borylation of Cyclobutenones to Access Synthetically Versatile Tertiary Cyclobutylboronates Angewandte Chemie ·Helen A. Clement,Michele Boghi,Rory M. McDonald,Louise Bernier,Jotham W. Coe,William Farrell,Christopher J. Helal,Matthew R. Reese,Neal W. Sach,Jack C. Lee,Dennis G. Hall	2019	19
2	Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189 ACS Medicinal Chemistry Letters ·Antonia F. Stepan,Tuan P. Tran,Christopher J. Helal,Maria S. Brown,Cheng Chang,Rebecca E. O’Connor,Michael De Vivo,Shawn D. Doran,Ethan L. Fisher,Stephen Jenkinson,David A. Karanian,Bethany L. Kormos,Raman Sharma,Gregory S. Walker,Ann S. Wright,Edward X. Yang,Michael A. Brodney,Travis T. Wager,Patrick R. Verhoest,R. Scott Obach	2018	25
3	A platform for automated nanomole-scale reaction screening and micromole-scale synthesis in flowbreakdown → Science ·Damith Perera,Joseph W. Tucker,Shalini Brahmbhatt,Christopher J. Helal,Ashley Chong,William Farrell,Paul Richardson,Neal W. Sach	2018	333
4	Increased building block access through collaboration Drug Discovery Today ·Christopher J. Helal,Alessandra Bartolozzi,Steven D. Goble,Neelakanda S. Mani,Angel Guzmán-Pérez,Ajay K. Ohri,Zhicai Shi,Chakrapani Subramanyam	2018	9
5	Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides Organic Letters ·Hua Zhou,Paramita Mukherjee,Rongqiang Liu,Edelweiss Evrard,Dianpeng Wang,John M. Humphrey,Todd W. Butler,Lise R. Hoth,Jeffrey B. Sperry,Sylvie K. Sakata,Christopher J. Helal,Christopher W. am Ende	2018	112
6	Parallel Synthesis of 1H-Pyrazolo[3,4-d]pyrimidines via Condensation of N-Pyrazolylamides and Nitriles ACS Combinatorial Science ·Akshay A. Shah,Lois K. Chenard,Joseph W. Tucker,Christopher J. Helal	2017	5
7	Ru/Ni Dual Catalytic Desulfinative Photoredox C_sp²–C_sp³ Cross-Coupling of Alkyl Sulfinate Salts and Aryl Halides Organic Letters ·Thomas Knauber,Ramalakshmi Y. Chandrasekaran,Joseph W. Tucker,Jinshan Michael Chen,Matthew R. Reese,Danica A. Rankic,Neal W. Sach,Christopher J. Helal	2017	62
8	Preclinical Evaluation of ¹⁸F-PF-05270430, a Novel PET Radioligand for the Phosphodiesterase 2A Enzyme Journal of Nuclear Medicine ·Laigao Chen,Nabeel Nabulsi,Mika Naganawa,Kenneth Zasadny,Marc B. Skaddan,Lei Zhang,Soheila Najafzadeh,Shu-fei Lin,Christopher J. Helal,Tracey Boyden,Cheng Chang,Jim Ropchan,Richard E. Carson,Anabella Villalobos,Yiyun Huang	2016	11
9	Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand Journal of Medicinal Chemistry ·Lei Zhang,Anabella Villalobos,Elizabeth M. Beck,Thomas Bocan,Thomas A. Chappie,Laigao Chen,Sarah Grimwood,Steven D. Heck,Christopher J. Helal,Xinjun Hou,John M. Humphrey,Jiemin Lu,Marc B. Skaddan,Timothy J. McCarthy,Patrick R. Verhoest,Travis T. Wager,Kenneth Zasadny	2013	142
10	Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs Drug Metabolism and Disposition ·Robert L. Walsky,R. Scott Obach,Ruth Hyland,Ping Kang,Sue Zhou,Michael West,Kieran F. Geoghegan,Christopher J. Helal,Gregory S. Walker,Theunis C. Goosen,Michael Zientek	2012	74
11	Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition Journal of Medicinal Chemistry ·Thomas A. Chappie,Christopher J. Helal,Xinjun Hou	2012	74
12	Potent and cellularly active 4-aminoimidazole inhibitors of cyclin-dependent kinase 5/p25 for the treatment of Alzheimer’s disease Bioorganic & Medicinal Chemistry Letters ·Christopher J. Helal,Zhijun Kang,John C. Lucas,Thomas G. Gant,Michael K. Ahlijanian,Joel B. Schachter,K. Richter,James M. Cook,Frank S. Menniti,Kristin Kelly,Scot Mente,Jayvardhan Pandit,Natalie Hosea	2009	40
13	Discovery and SAR of 2-aminothiazole inhibitors of cyclin-dependent kinase 5/p25 as a potential treatment for Alzheimer’s disease Bioorganic & Medicinal Chemistry Letters ·Christopher J. Helal,Mark A. Sanner,Christopher B. Cooper,Thomas G. Gant,Mavis D. Adam,John C. Lucas,Zhijun Kang,Stanley Kupchinsky,Michael K. Ahlijanian,Bonnie F. Tate,Frank S. Menniti,Kristin N. Kelly,Marcia F. Peterson	2004	86
14	Stereoselective Synthesis of cis-1,3-Disubstituted Cyclobutyl Kinase Inhibitors Organic Letters ·Christopher J. Helal,Zhijun Kang,John C. Lucas,Brooks R. Bohall	2004	15
15	Reduction of Carbonyl Compounds with Chiral Oxazaborolidine Catalysts: A New Paradigm for Enantioselective Catalysis and a Powerful New Synthetic Methodbreakdown → Angewandte Chemie International Edition ·E. J. Corey,Christopher J. Helal	1998	1152
16	An Efficient Catalytic Stereoselective Route to a Key Intermediate for the Synthesis of the Long-Lived PGI2 Analog ZK 96480 (CicaprostTM) Tetrahedron Letters ·E. J. Corey,Christopher J. Helal	1997	22
17	Asymmetric synthesis of (S)-carbinoxamine. New aspects of oxazaborolidine-catalyzed enantioselective carbonyl reduction Tetrahedron Letters ·E. J. Corey,Christopher J. Helal	1996	87
18	Catalytic enantioselective synthesis of the second generation histamine antagonist cetirizine hydrochloride Tetrahedron Letters ·E. J. Corey,Christopher J. Helal	1996	86
19	Direct Catalytic Enantioselective Reduction of Achiral α,β-Ynones. Strong Remote Steric Effects Across the C−C Triple Bond Journal of the American Chemical Society ·Christopher J. Helal,Plato Α. Magriotis,E. J. Corey	1996	116
20	Novel electronic effects of remote substituents on the oxazaborolidine-catalyzed enantioselective reduction of ketones Tetrahedron Letters ·E. J. Corey,Christopher J. Helal	1995	144

About Christopher J. Helal

Christopher J. Helal is a scholar working on Organic Chemistry, Pharmaceutical Science and Inorganic Chemistry, having authored 36 papers that have together received 3.4k indexed citations. Recurring topics across this work include Chemical Synthesis and Analysis (9 papers), Synthesis and Catalytic Reactions (6 papers), Phosphodiesterase function and regulation (6 papers), Click Chemistry and Applications (5 papers), Organoboron and organosilicon chemistry (5 papers), Asymmetric Hydrogenation and Catalysis (5 papers), Chemical synthesis and alkaloids (4 papers) and Cholinesterase and Neurodegenerative Diseases (3 papers). The work is most often cited by research in Organic Chemistry (2.3k citations), Inorganic Chemistry (889 citations) and Pharmaceutical Science (175 citations). Christopher J. Helal has collaborated with scholars based in United States, Canada and China. Frequent co-authors include E. J. Corey, Neal W. Sach, William Farrell, Joseph W. Tucker, Paul Richardson, Xinjun Hou, Plato Α. Magriotis, Thomas A. Chappie, Matthew R. Reese and John M. Humphrey. Their work appears in journals such as Science, Journal of the American Chemical Society and Angewandte Chemie International Edition.

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