Michael A. Brodney

2.0k citations

38 papers · 1.1k indexed · h-index 20

Impact in

Organic Chemistry top 2%
- Chemical synthesis and alkaloids
- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Cyclopropane Reaction Mechanisms
- Synthetic Organic Chemistry Methods
Pharmacology top 5%
- Cholinesterase and Neurodegenerative Diseases

Papers in

Organic Chemistry 23
- Synthetic Organic Chemistry Methods 7
- Chemical synthesis and alkaloids 6
- Synthesis and Catalytic Reactions 5
- Asymmetric Synthesis and Catalysis 5
- Cyclopropane Reaction Mechanisms 5
Pharmaceutical Science 4

Co-authors: Albert Padwa Tianhua Wu Martin Dimitroff Kyosuke Satake Stephen M. Lynch Joseph P. MarinoBing LiuScott M. Sheehan
Journals: The Journal of Organic Chemistry (10 papers)Bioorganic & Medicinal Chemistry Letters (3 papers)Journal of Medicinal Chemistry (3 papers)ACS Medicinal Chemistry Letters (2 papers)Journal of Pharmacology and Experimental Therapeutics (2 papers)
Partner nations: United States Sweden Australia

In The Last Decade

Michael A. Brodney

38 papers receiving 1.1k citations

Peers

Countries citing papers authored by Michael A. Brodney

Since Specialization

Citations

This map shows the geographic impact of Michael A. Brodney's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael A. Brodney with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael A. Brodney more than expected).

Fields of papers citing papers by Michael A. Brodney

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael A. Brodney. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael A. Brodney. The network helps show where Michael A. Brodney may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael A. Brodney, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael A. Brodney Line = papers co-authored together Michael A. Brodney links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189 ACS Medicinal Chemistry Letters ·Antonia F. Stepan, Tuan P. Tran, Christopher J. Helal, Maria S. Brown, Cheng Chang, Rebecca E. O’Connor, Michael De Vivo, Shawn D. Doran, Ethan L. Fisher, Stephen Jenkinson, David A. Karanian, Bethany L. Kormos, Raman Sharma, Gregory S. Walker, S. S. Lee, H. Zwingelberg, Michael A. Brodney, Travis T. Wager, Patrick R. Verhoest, R. Scott Obach	2018	25
2	Harnessing biosynthesis and quantitative NMR for late stage functionalization of lead molecules: Application to the M1 positive allosteric modulator (PAM) program Bioorganic & Medicinal Chemistry Letters ·Michael A. Brodney, Raman Sharma, John T. Lazzaro, Gregory S. Walker, R. Scott Obach	2018	9
3	Quantitative Analysis of ¹⁸F-PF-06684511, a Novel PET Radioligand for Selective β-Secretase 1 Imaging, in Nonhuman Primate Brain Journal of Nuclear Medicine ·Akihiro Takano, Laigao Chen, Sangram Nag, Michael A. Brodney, Ryosuke Arakawa, Cheng Chang, Nahid Amini, Shawn D. Doran, Jason K. Dutra, Timothy J. McCarthy, Charles E. Nolan, Brian T. O’Neill, Anabella Villalobos, Lei Zhang, Christer Halldin	2018	6
4	Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain Journal of Medicinal Chemistry ·Lei Zhang, Laigao Chen, Jason K. Dutra, Elizabeth Beck, Sangram Nag, Akihiro Takano, Nahid Amini, Ryosuke Arakawa, Michael A. Brodney, Leanne M. Buzon, Shawn D. Doran, Lorraine F. Lanyon, Timothy J. McCarthy, Kelly R. Bales, Charles E. Nolan, Brian T. O’Neill, Klaas Schildknegt, Christer Halldin, Anabella Villalobos	2018	15
5	Biosynthesis of Fluorinated Analogs of Drugs Using Human Cytochrome P450 Enzymes Followed by Deoxyfluorination and Quantitative Nuclear Magnetic Resonance Spectroscopy to Improve Metabolic Stability Drug Metabolism and Disposition ·R. Scott Obach, Gregory S. Walker, Michael A. Brodney	2016	23
6	Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors Nature Communications ·Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David Riddell, Douglas S. Johnson	2016	59
7	Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT₄Partial Agonist Organic Process Research & Development ·Daniel W. Widlicka, John C. Murray, Karen J. Coffman, Rabia Güleç, Michael A. Brodney, 김병덕, Brian Samas	2016	7
8	Design, synthesis and evaluation of [3H]PF-7191, a highly specific nociceptin opioid peptide (NOP) receptor radiotracer for in vivo receptor occupancy (RO) studies Bioorganic & Medicinal Chemistry Letters ·Lei Zhang, F miftahuddin, Michael A. Brodney, Julie Cianfrogna, Susan E. Drozda, Sarah Grimwood, Michelle Vanase‐Frawley, Anabella Villalobos	2014	15
9	Metabolism of a Serotonin-4 Receptor Partial Agonist 4-{4-[4-Tetrahydrofuran-3-yloxy)-Benzo[d]Isoxazol-3-yloxymethyl]-Piperidin-1-ylmethyl}-Tetrahydropyran-4-ol (TBPT): Identification of an Unusual Pharmacologically Active Cyclized Oxazolidine Metabolite in Human Journal of Pharmaceutical Sciences ·Aarti Sawant‐Basak, Karen J. Coffman, Gregory S. Walker, Tim F. Ryder, Elaine Tseng, Emily Miller, Süleyman Özbek, Michelle Vanase‐Frawley, John W. Wong, Michael A. Brodney, Sylvi Wulandari, R. Scott Obach	2013	12
10	Cerebrospinal Fluid β-Amyloid Turnover in the Mouse, Dog, Monkey and Human Evaluated by Systematic Quantitative Analyses Neurodegenerative Diseases ·Yasong Lu, Hugh A. Barton, Louis Leung, Liming Zhang, Éva Hajós‐Korcsok, Charles E. Nolan, Jianhua Liu, Stacey L. Becker, Kathleen M. Wood, Ashley Robshaw, 阮学, Brian T. O’Neill, Michael A. Brodney, David Riddell	2012	18
11	Cerebrospinal Fluid Amyloid-β (Aβ) as an Effect Biomarker for Brain Aβ Lowering Verified by Quantitative Preclinical Analyses Journal of Pharmacology and Experimental Therapeutics ·Yasong Lu, David Riddell, Éva Hajós‐Korcsok, Kelly R. Bales, Kathleen M. Wood, Charles E. Nolan, Ashley Robshaw, Liming Zhang, Louis Leung, Stacey L. Becker, Elaine Tseng, U. Baer, Emily Happy Miller, Sarah M. Osgood, Brian T. O’Neill, Michael A. Brodney, Douglas S. Johnson, Martin Pettersson	2012	24
12	Spirocyclic Sulfamides as β-Secretase 1 (BACE-1) Inhibitors for the Treatment of Alzheimer’s Disease: Utilization of Structure Based Drug Design, WaterMap, and CNS Penetration Studies To Identify Centrally Efficacious Inhibitors Journal of Medicinal Chemistry ·Michael A. Brodney, Gabriela Barreiro, Kevin Ogilvie, Éva Hajós‐Korcsok, John C. Murray, F.F. Vajdos, Claude Ambroise, Curt Christoffersen, Katherine Fisher, Lorraine F. Lanyon, Jianhua Liu, Charles E. Nolan, Jane M. Withka, Kris A. Borzilleri, Ivan Efremov, Christine Oborski, Alison E. Varghese, Brian T. O’Neill	2012	44
13	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors Bioorganic & Medicinal Chemistry Letters ·Karen J. Coffman, Michael A. Brodney, James M. Cook, Lorraine F. Lanyon, Jayvardhan Pandit, Subas M. Sakya, Joel B. Schachter, Koushik Yadagiri, Matthew D. Wessel	2011	25
14	Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014 Journal of Pharmacology and Experimental Therapeutics ·Thomas A. Lanz, Kathleen M. Wood, K. Richter, Charles E. Nolan, Stacey L. Becker, Nikolay Pozdnyakov, R. MacLarenl, Ping Du, Christine Oborski, Douglas E. Wood, Antony Sami Auxilia, James E. Finley, Sharon Sokolowski, Carol Hicks, Karen J. Coffman, Kieran F. Geoghegan, Michael A. Brodney, Dane Liston, Barbara Tate	2010	39
15	P2‐375: Efficacy of the novel γ‐secretase inhibitor, PF‐3084014, in reducing Aβ in brain, CSF, and plasma in guinea pigs and Tg2576 mice Alzheimer s & Dementia ·Kathleen M. Wood, Thomas A. Lanz, Karen J. Coffman, Stacey L. Becker, F Sanz, Charles E. Nolan, K. Richter, James E. Finley, J.A. Marshall, Michael A. Brodney, Barbara Tate	2008	11
16	A New Strategy toward Indole Alkaloids Involving an Intramolecular Cycloaddition/Rearrangement Cascade The Journal of Organic Chemistry ·Albert Padwa, Michael A. Brodney, Stephen M. Lynch, Paitoon Rashatasakhon, Qiu Wang, Hongjun Zhang	2004	32
17	Preparation and Diels-Alder reaction of a 2-amido substituted furan: Tert-butyl 3a-methyl-5-oxo-2,3,3a, 4,5,6-hexahydroindole-1-carboxylate: (1H-lndole-1-carboxylic acid, 2,3,3a, 4,5,6-hexahydro-3a-methyl-5-oxo-, 1,1-dimethylethyl ester) Organic Syntheses ·Albert Padwa, Michael A. Brodney, Stephen M. Lynch, Sivaraman Dandapani, Dennis P. Curran	2002	11
18	Utilization of the Intramolecular Cycloaddition−Cationic π-Cyclization of an Isomünchnone Derivative for the Synthesis of (±)-Lycopodine The Journal of Organic Chemistry ·Albert Padwa, Michael A. Brodney, Joseph P. Marino, Scott M. Sheehan	1997	84
19	Electrophilic Aromatic Substitution on Pyridine Rings. Intramolecular Cyclization Using N-Acyliminium Ions Tetrahedron Letters ·Michael A. Brodney, Albert Padwa	1997	19
20	Tandem Dipolar Cycloaddition−Mannich Cyclization as an Approach to Tricyclic Nitrogen Heterocycles The Journal of Organic Chemistry ·Albert Padwa, Michael A. Brodney, Joseph P. Marino, Martin H. Osterhout, Alan T. Price	1997	31

About Michael A. Brodney

Michael A. Brodney is a scholar working on Organic Chemistry, Pharmaceutical Science, Pharmacology, Computational Theory and Mathematics and Physiology, having authored 38 papers that have together received 1.1k indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (8 papers), Computational Drug Discovery Methods (8 papers), Synthetic Organic Chemistry Methods (7 papers), Chemical synthesis and alkaloids (6 papers), Synthesis and Catalytic Reactions (5 papers), Asymmetric Synthesis and Catalysis (5 papers), Cyclopropane Reaction Mechanisms (5 papers) and Drug Transport and Resistance Mechanisms (4 papers). The work is most often cited by research in Organic Chemistry (758 citations), Pharmacology (126 citations), Pharmacology (185 citations), Computational Theory and Mathematics (116 citations) and Pharmaceutical Science (38 citations). Michael A. Brodney has collaborated with scholars based in United States, Sweden and Australia. Frequent co-authors include Albert Padwa, Tianhua Wu, Martin Dimitroff, Kyosuke Satake, Stephen M. Lynch, Joseph P. Marino, Bing Liu, Scott M. Sheehan, Paul A. Wender and F. Christopher Bi. Their work appears in journals such as The Journal of Organic Chemistry, Bioorganic & Medicinal Chemistry Letters, Journal of Medicinal Chemistry, ACS Medicinal Chemistry Letters and Journal of Pharmacology and Experimental Therapeutics.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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