Xinjun Hou

4.9k citations

42 papers · 3.0k indexed · 2 hit papers · h-index 25

Impact in

Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods
Pharmacology top 2%
- Cholinesterase and Neurodegenerative Diseases

Papers in ⓘ

Computational Theory and Mathematics 10
- Computational Drug Discovery Methods 9
Pharmacology 7
- Cholinesterase and Neurodegenerative Diseases 5

Co-authors: Patrick R. Verhoest (10 shared papers)Travis T. Wager (9 shared papers)Anabella Villalobos (7 shared papers)Hernán G. Solari (3 shared papers)Robert Gilmore (3 shared papers)Gabriel B. Mindlin (3 shared papers)Yvonne Will (1 shared paper)Ramalakshmi Y. Chandrasekaran (1 shared paper)
Journals: Journal of Medicinal Chemistry (8 papers)Bioorganic & Medicinal Chemistry Letters (7 papers)ACS Chemical Neuroscience (4 papers)INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY (3 papers)Nature Communications (2 papers)
Partner nations: United States China United Kingdom

In The Last Decade

Xinjun Hou

40 papers receiving 2.9k citations

Hit Papers

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Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery 2016 · 391 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 ACS Chemical Neuroscience
2010 ACS Chemical Neuroscience

Peers

Countries citing papers authored by Xinjun Hou

Since Specialization

Citations

This map shows the geographic impact of Xinjun Hou's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Xinjun Hou with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Xinjun Hou more than expected).

Fields of papers citing papers by Xinjun Hou

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Xinjun Hou. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Xinjun Hou. The network helps show where Xinjun Hou may publish in the future.

Co-authors

The 25 scholars most cited alongside Xinjun Hou, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Xinjun Hou Line = papers co-authored together Xinjun Hou links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

Showing the 20 most-cited of 42 papers — load more, or switch the sort, to bring in the rest.

#	Work
1	Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties ACS Chemical Neuroscience ·Travis T. Wager, Xinjun Hou, Patrick R. Verhoest, Anabella Villalobos Hit paper breakdown →	2010	687
2	Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery ACS Chemical Neuroscience ·Travis T. Wager, Xinjun Hou, Patrick R. Verhoest, Anabella Villalobos Hit paper breakdown →	2016	391
3	Defining Desirable Central Nervous System Drug Space through the Alignment of Molecular Properties, in Vitro ADME, and Safety Attributes ACS Chemical Neuroscience ·Travis T. Wager, Ramalakshmi Y. Chandrasekaran, Xinjun Hou, Matthew D. Troutman, Patrick R. Verhoest, Anabella Villalobos, Yvonne Will	2010	330
4	Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). Journal of Medicinal Chemistry ·Patrick R. Verhoest, Douglas S. Chapin, Michael L. Corman, Kari R. Fonseca, John F. Harms, Xinjun Hou, Eric S. Marr, Frank S. Menniti, Frederick Nelson, Rebecca E. O’Connor, Jayvardhan Pandit, Caroline Proulx-LaFrance, Anne W. Schmidt, Christopher J. Schmidt, Judith A. Suiciak, Spiros Liras	2009	172
5	Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand Journal of Medicinal Chemistry ·Lei Zhang, Anabella Villalobos, Elizabeth M. Beck, Thomas Bocan, Thomas A. Chappie, Laigao Chen, Sarah Grimwood, Steven D. Heck, Christopher J. Helal, Xinjun Hou, John M. Humphrey, Jiemin Lu, Marc B. Skaddan, Timothy J. McCarthy, Patrick R. Verhoest, Travis T. Wager, Kenneth Zasadny	2013	142
6	Classification of strange attractors by integers Physical Review Letters ·Gabriel B. Mindlin, Xinjun Hou, Hernán G. Solari, Robert Gilmore, Nicholas Tufillaro	1990	124
7	Topological analysis of chaotic time series data from the Belousov-Zhabotinskii reaction Journal of Nonlinear Science ·Gabriel B. Mindlin, Hernán G. Solari, Mario A. Natiello, Robert Gilmore, Xinjun Hou	1991	106
8	Structure-based design of novel human Pin1 inhibitors (I) Bioorganic & Medicinal Chemistry Letters ·Chuangxing Guo, Xinjun Hou, Liming Dong, Eleanor Dagostino, S.E. Greasley, Rose Ann Ferre, Joseph Marakovits, M. Catherine Johnson, David A. Matthews, Barbara Mroczkowski, Hans E. Parge, Todd VanArsdale, Ian Popoff, Joseph Piraino, Stephen A. Margosiak, James Thomson, Gerrit Los, Brion W. Murray	2009	91
9	Molecular Transformer unifies reaction prediction and retrosynthesis across pharma chemical space Chemical Communications ·Alpha A. Lee, Qingyi Yang, Vishnu Sresht, Peter Bolgar, Xinjun Hou, Jacquelyn Klug‐McLeod, Christopher R. Butler	2019	89
10	Quantitative Assessment of the Impact of Fluorine Substitution on P-Glycoprotein (P-gp) Mediated Efflux, Permeability, Lipophilicity, and Metabolic Stability Journal of Medicinal Chemistry ·Martin Pettersson, Xinjun Hou, Max Kühn, Travis T. Wager, Gregory W. Kauffman, Patrick R. Verhoest	2016	77
11	Current Landscape of Phosphodiesterase 10A (PDE10A) Inhibition Journal of Medicinal Chemistry ·Thomas A. Chappie, Christopher J. Helal, Xinjun Hou	2012	74
12	Structure-based design of novel human Pin1 inhibitors (II) Bioorganic & Medicinal Chemistry Letters ·Liming Dong, Joseph Marakovits, Xinjun Hou, Chuangxing Guo, S.E. Greasley, Eleanor Dagostino, Rose Ann Ferre, M. Catherine Johnson, Eugenia Kraynov, James Thomson, Ved Pathak, Brion W. Murray	2010	70
13	Structure-Based Design, Synthesis, and Biological Evaluation of Irreversible Human Rhinovirus 3C Protease Inhibitors. Part 7: Structure–Activity Studies of Bicyclic 2-Pyridone-Containing Peptidomimetics Bioorganic & Medicinal Chemistry Letters ·Peter S. Dragovich, Thomas J. Prins, Ru Zhou, Theodore Johnson, Edward L. Brown, Fausto C. Maldonado, Shella A. Fuhrman, L S Zalman, Amy K. Patick, David A. Matthews, Xinjun Hou, James W. Meador, Rose Ann Ferre, Stephen T. Worland	2002	63
14	Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of β-secretase inhibitors Nature Communications ·Andrea M. Zuhl, Charles E. Nolan, Michael A. Brodney, Sherry Niessen, Kevin Atchison, Christopher Houle, David A. Karanian, Claude Ambroise, Jeffrey W. Brulet, Elizabeth M. Beck, Shawn D. Doran, Brian T. O’Neill, Christopher W. am Ende, Cheng Chang, Kieran F. Geoghegan, Graham M. West, Joshua C. Judkins, Xinjun Hou, David Riddell, Douglas S. Johnson	2016	59
15	Validation of Human MDR1-MDCK and BCRP-MDCK Cell Lines to Improve the Prediction of Brain Penetration Journal of Pharmaceutical Sciences ·Bo Feng, Mark A. West, Nandini C. Patel, Travis T. Wager, Xinjun Hou, Jillian G. Johnson, Larry M. Tremaine, Jennifer L. Liras	2019	55
16	Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders Journal of Medicinal Chemistry ·Patrick R. Verhoest, Kari R. Fonseca, Xinjun Hou, Caroline Proulx-LaFrance, Michael L. Corman, Christopher J. Helal, Michelle M. Claffey, Jamison B. Tuttle, Karen J. Coffman, Shenpinq Liu, Frederick Nelson, Robin J. Kleiman, Frank S. Menniti, Christopher J. Schmidt, Michelle Vanase‐Frawley, Spiros Liras	2012	53
17	An efficient algorithm for fast box counting Physics Letters A ·Xinjun Hou, Robert Gilmore, Gabriel B. Mindlin, Hernán G. Solari	1990	53
18	Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy Journal of Medicinal Chemistry ·Patrick R. Verhoest, Caroline Proulx-LaFrance, Michael L. Corman, Lois K. Chenard, Christopher J. Helal, Xinjun Hou, Robin J. Kleiman, Shenping Liu, Eric S. Marr, Frank S. Menniti, Christopher Schmidt, Michelle Vanase‐Frawley, Anne W. Schmidt, Robert D. Williams, Frederick Nelson, Kari R. Fonseca, Spiros Liras	2009	45
19	Dopamine D3 receptor antagonist reveals a cryptic pocket in aminergic GPCRs Scientific Reports ·Noelia Ferruz, Stefan Doerr, Michelle Vanase‐Frawley, Yaozhong Zou, Xiaohong Chen, Eric S. Marr, Robin T. Nelson, Bethany L. Kormos, Travis T. Wager, Xinjun Hou, Anabella Villalobos, Simone Sciabola, Gianni De Fabritiis	2018	44
20	Structure-based design of novel human Pin1 inhibitors (III): Optimizing affinity beyond the phosphate recognition pocket Bioorganic & Medicinal Chemistry Letters ·Chuangxing Guo, Xinjun Hou, Liming Dong, Joseph Marakovits, S.E. Greasley, Eleanor Dagostino, Rose Ann Ferre, M. Catherine Johnson, Paul S. Humphries, Haitao Li, Genevieve Paderes, Joseph Piraino, Eugenia Kraynov, Brion W. Murray	2014	38

About Xinjun Hou

Xinjun Hou is a scholar working on Computational Theory and Mathematics, Pharmacology, Molecular Biology, Biological Psychiatry and Pharmacology, having authored 42 papers that have together received 3.0k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (9 papers), Computational Drug Discovery Methods (9 papers), Phosphodiesterase function and regulation (6 papers), Signaling Pathways in Disease (5 papers), Microbial Community Ecology and Physiology (5 papers), Cholinesterase and Neurodegenerative Diseases (5 papers), Genomics and Phylogenetic Studies (4 papers) and Peptidase Inhibition and Analysis (4 papers). The work is most often cited by research in Computational Theory and Mathematics (692 citations), Pharmacology (526 citations), Molecular Biology (1.7k citations), Cellular and Molecular Neuroscience (391 citations) and Organic Chemistry (592 citations). Xinjun Hou has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Patrick R. Verhoest, Travis T. Wager, Anabella Villalobos, Hernán G. Solari, Robert Gilmore, Gabriel B. Mindlin, Yvonne Will, Ramalakshmi Y. Chandrasekaran, Matthew D. Troutman and Christopher J. Helal. Their work appears in journals such as Journal of Medicinal Chemistry, Bioorganic & Medicinal Chemistry Letters, ACS Chemical Neuroscience, INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY and Nature Communications.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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