Michael Zientek

1.7k citations

32 papers · 1.1k indexed · h-index 18

Impact in

Pharmacology top 0.5%
- Pharmacogenetics and Drug Metabolism
- Drug-Induced Hepatotoxicity and Protection
Biochemistry top 5%
- Eicosanoids and Hypertension Pharmacology

Papers in

Pharmacology 21
- Pharmacogenetics and Drug Metabolism 21
Computational Theory and Mathematics 11
- Computational Drug Discovery Methods 11

Co-authors: Kuresh Youdim R. Scott Obach Ying Jiang Deepak Dalvie J. Matthew Hutzler Theunis C. Goosen Robert L. Walsky Sue Zhou
Journals: Drug Metabolism and Disposition (15 papers)Chemical Research in Toxicology (3 papers)Drug Metabolism and Pharmacokinetics (2 papers)Molecular Pharmaceutics (1 paper)ACS Medicinal Chemistry Letters (1 paper)
Partner nations: United States United Kingdom Japan

In The Last Decade

Michael Zientek

32 papers receiving 1.1k citations

Peers

Countries citing papers authored by Michael Zientek

Since Specialization

Citations

This map shows the geographic impact of Michael Zientek's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Michael Zientek with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Michael Zientek more than expected).

Fields of papers citing papers by Michael Zientek

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Michael Zientek. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Michael Zientek. The network helps show where Michael Zientek may publish in the future.

Co-authors

The 25 scholars most cited alongside Michael Zientek, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Michael Zientek Line = papers co-authored together Michael Zientek links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Establishing a physiologically based pharmacokinetic framework for aldehyde oxidase and dual aldehyde oxidase‐CYP substrates CPT Pharmacometrics & Systems Pharmacology ·Lus Alberto Oliveira Dall, Jayaprakasam Bolleddula, Andrzej Krzanowski, Kuan-Lin Yeh, Robert S. Jones, Priyanka Kulkarni, Darren Moss, Vincent Peterkin, Dandan Tian, J Bignon, Karthik Venkatakrishnan, Michael Zientek, Jill Barber, J. Brian Houston, Aleksandra Galetin, Daniel Scotcher	2024	1
2	Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation Drug Metabolism and Disposition ·Lus Alberto Oliveira Dall, Jayaprakasam Bolleddula, Shirly John, Lionel Cheruzel, Robert S. Jones, Darren Moss, Fátima Ortega-Muro, Yannick Parmentier, Vincent Peterkin, Dandan Tian, Karthik Venkatakrishnan, Michael Zientek, Jill Barber, J. Brian Houston, Aleksandra Galetin, Daniel Scotcher	2023	6
3	Industry Perspective on the Pharmacokinetic and Absorption, Distribution, Metabolism, and Excretion Characterization of Heterobifunctional Protein Degraders Drug Metabolism and Disposition ·新井高, AA Adekunle, Sara C. Humphreys, David O. Nettleton, Colin Phipps, Andy Pike, Caroline Rynn, Paul Scott‐Stevens, Donglu Zhang, Michael Zientek	2023	29
4	Dissecting Parameters Contributing to the Underprediction of Aldehyde Oxidase-Mediated Metabolic Clearance of Drugs Drug Metabolism and Disposition ·曲格平, Dilip Kumar Singh, О В Колесова, S. Cyrus Khojasteh, Bernard P. Murray, Michael Zientek, Robert S. Jones, Priyanka Kulkarni, Bill J. Smith, Scott Heyward, Ciarán N. Cronin, Bhagwat Prasad	2023	6
5	Direct Comparison of the Prediction of the Unbound Brain-to-Plasma Partitioning Utilizing Machine Learning Approach and Mechanistic Neuropharmacokinetic Model The AAPS Journal ·Yohei Kosugi, Ema Albrechtová, J. B. BLOER, Sho Sato, Natalie Hosea, Michael Zientek	2021	10
6	Contribution of Extrahepatic Aldehyde Oxidase Activity to Human Clearance Drug Metabolism and Disposition ·Kirk Kozminski, Jangir Selimkhanov, Scott Heyward, Michael Zientek	2021	14
7	Clearance Prediction of Targeted Covalent Inhibitors by In Vitro-In Vivo Extrapolation of Hepatic and Extrahepatic Clearance Mechanisms Drug Metabolism and Disposition ·Louis Leung, Xin Yang, Timothy J. Strelevitz, Justin I. Montgomery, Matthew F. Brown, Michael Zientek, Christopher Banfield, A. Gilbert, Atli Thorarensen, Martin E. Dowty	2016	25
8	In Vitro Kinetic Characterization of Axitinib Metabolism Drug Metabolism and Disposition ·Michael Zientek, Theunis C. Goosen, Elaine Tseng, Jing Lin, Andreas Rhoby, Gregory S. Walker, Ping Kang, Ying Jiang, Octavian Dava Putra, Bozhen Chan, Bill J. Smith	2015	30
9	Reaction Phenotyping: Advances in the Experimental Strategies Used to Characterize the Contribution of Drug-Metabolizing Enzymes Drug Metabolism and Disposition ·Michael Zientek, Kuresh Youdim	2014	86
10	Relative Contributions of Cytochrome CYP3A4 Versus CYP3A5 for CYP3A-Cleared Drugs Assessed In Vitro Using a CYP3A4-Selective Inactivator (CYP3cide) Drug Metabolism and Disposition ·Elaine Tseng, Robert L. Walsky, Pedro Alvarado-Sosa, Jennifer J. Harris, Rachel E. Kosa, Theunis C. Goosen, Michael Zientek, R. Scott Obach	2014	84
11	Simultaneous Determination of Multiple CYP Inhibition Constants using a Cocktail-Probe Approach Methods in molecular biology ·Michael Zientek, Kuresh Youdim	2013	9
12	Selective Mechanism-Based Inactivation of CYP3A4 by CYP3cide (PF-04981517) and Its Utility as an In Vitro Tool for Delineating the Relative Roles of CYP3A4 versus CYP3A5 in the Metabolism of Drugs Drug Metabolism and Disposition ·Robert L. Walsky, R. Scott Obach, Ruth Hyland, Ping Kang, Sue Zhou, Nader Dhamer, Kieran F. Geoghegan, Christopher J. Helal, Gregory S. Walker, Theunis C. Goosen, Michael Zientek	2012	74
13	Strategies for a comprehensive understanding of metabolism by aldehyde oxidase Expert Opinion on Drug Metabolism & Toxicology ·J. Matthew Hutzler, R. Scott Obach, Deepak Dalvie, Michael Zientek	2012	76
14	Use of a Multistaged Time-Dependent Inhibition Assay to Assess the Impact of Intestinal Metabolism on Drug-Drug Interaction Potential Drug Metabolism and Disposition ·Michael Zientek, Deepak Dalvie	2011	3
15	In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase Drug Metabolism and Disposition ·Michael Zientek, Ying Jiang, Kuresh Youdim, R. Scott Obach	2010	98
16	Quantifying and Predicting the Promiscuity and Isoform Specificity of Small-Molecule Cytochrome P450 Inhibitors Drug Metabolism and Disposition ·Abhinav Nath, Michael Zientek, Benjamin J. Burke, Ying Jiang, William M. Atkins	2010	16
17	Development of an in vitro drug–drug interaction assay to simultaneously monitor five cytochrome P450 isoforms and performance assessment using drug library compounds Journal of Pharmacological and Toxicological Methods ·Michael Zientek, Howard Miller, A. Montevecchi, Fitrianis Sholehah, Риехакайнен Елена Игоревна, Archie Thurston, Caroline Lee, Ruth Hyland, Odette A. Fahmi, Douglas Burdette	2008	46
18	Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection Drug Metabolism and Disposition ·J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar, Timothy S. Tracy	2008	32
19	Analytical approaches to determine cytochrome P450 inhibitory potential of new chemical entities in drug discovery Journal of Chromatography B ·A. Montevecchi, Nalini Sadagopan, Michael Zientek, Valentina G. Sideleva, Lucinda H. Cohen	2006	41
20	Characterization of endothelin converting enzyme from intact cells of a permanent human endothelial cell line EA.hy926 IUBMB Life ·Kyunghye Ahn, Sharon Pan, Michael Zientek, Pamela M. Guy, Yew Kuan Toh	1996	4

About Michael Zientek

Michael Zientek is a scholar working on Pharmacology, Computational Theory and Mathematics, Biochemistry, Spectroscopy and Transplantation, having authored 32 papers that have together received 1.1k indexed citations. Recurring topics across this work include Pharmacogenetics and Drug Metabolism (21 papers), Computational Drug Discovery Methods (11 papers), Analytical Chemistry and Chromatography (6 papers), Drug Transport and Resistance Mechanisms (5 papers), Alcohol Consumption and Health Effects (4 papers), Eicosanoids and Hypertension Pharmacology (3 papers), Metabolomics and Mass Spectrometry Studies (2 papers) and Metabolism and Genetic Disorders (2 papers). The work is most often cited by research in Pharmacology (671 citations), Biochemistry (111 citations), Computational Theory and Mathematics (208 citations), Oncology (310 citations) and Spectroscopy (127 citations). Michael Zientek has collaborated with scholars based in United States, United Kingdom and Japan. Frequent co-authors include Kuresh Youdim, R. Scott Obach, Ying Jiang, Deepak Dalvie, J. Matthew Hutzler, Theunis C. Goosen, Robert L. Walsky, Sue Zhou, Ping Kang and Elaine Tseng. Their work appears in journals such as Drug Metabolism and Disposition, Chemical Research in Toxicology, Drug Metabolism and Pharmacokinetics, Molecular Pharmaceutics and ACS Medicinal Chemistry Letters.

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