Patrick R. Verhoest

7.3k citations

56 papers · 3.4k indexed · 2 hit papers · h-index 25

Impact in

Biological Psychiatry top 2%
Pharmacology top 1%
- Cholinesterase and Neurodegenerative Diseases

Papers in

Biological Psychiatry 3
Obstetrics and Gynecology 7
- Pregnancy and preeclampsia studies 6

Co-authors: Xinjun Hou Travis T. Wager Anabella Villalobos Amos B. Smith Kevin P. C. Minbiole Michael Schelhaas Yvonne Will Ramalakshmi Y. Chandrasekaran
Journals: Journal of Medicinal Chemistry (10 papers)ACS Chemical Neuroscience (4 papers)Bioorganic & Medicinal Chemistry Letters (4 papers)Journal of Pharmacology and Experimental Therapeutics (3 papers)Tetrahedron Letters (3 papers)
Partner nations: United States France Switzerland

In The Last Decade

Patrick R. Verhoest

54 papers receiving 3.3k citations

Hit Papers

align trajectories log scale

Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery 2016 · 391 citations

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if any of the following hold:

it has ≥500 total citations;
it reaches ≥1.5× the top-1% citation threshold for papers in the same subfield and year (the threshold is the minimum needed to enter the top 1%, not the average within it);
it reaches the top citation threshold in at least one of its specific research topics.

2016 ACS Chemical Neuroscience
2010 ACS Chemical Neuroscience

Peers

Countries citing papers authored by Patrick R. Verhoest

Since Specialization

Citations

This map shows the geographic impact of Patrick R. Verhoest's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Patrick R. Verhoest with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Patrick R. Verhoest more than expected).

Fields of papers citing papers by Patrick R. Verhoest

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Patrick R. Verhoest. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Patrick R. Verhoest. The network helps show where Patrick R. Verhoest may publish in the future.

Co-authors

The 25 scholars most cited alongside Patrick R. Verhoest, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Patrick R. Verhoest Line = papers co-authored together Patrick R. Verhoest links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	Innovation in breakthrough drugs and vaccines: Development risk, patient impact, and value Drug Discovery Today ·Andrew E. Prigodich, Shuntai Wang, Patrick R. Verhoest, Nicholas W. Warne, Charlotte Allerton, John E. Burkhardt, Kathy Fernando, Mikael Dolsten	2021	2
2	Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189 ACS Medicinal Chemistry Letters ·Antonia F. Stepan, Tuan P. Tran, Christopher J. Helal, Maria S. Brown, Cheng Chang, Rebecca E. O’Connor, Michael De Vivo, Shawn D. Doran, Ethan L. Fisher, Stephen Jenkinson, David A. Karanian, Bethany L. Kormos, Raman Sharma, Gregory S. Walker, Ann S. Wright, Edward X. Yang, Michael A. Brodney, Travis T. Wager, Patrick R. Verhoest, R. Scott Obach	2018	25
3	Quantitative Translational Analysis of Brain Kynurenic Acid Modulation via Irreversible Kynurenine Aminotransferase II Inhibition Molecular Pharmacology ·Cheng Chang, Kari R. Fonseca, Cheryl Li, W. Elliott Horner, Laura E. Zawadzke, Michelle A. Salafia, Kathryn Welch, Christine A. Strick, Brian Campbell, Steve S. Gernhardt, Haojing Rong, Aarti Sawant‐Basak, Jennifer L. Liras, Amy B. Dounay, Jamison B. Tuttle, Patrick R. Verhoest, Tristan S. Maurer	2018	7
4	Central Nervous System Multiparameter Optimization Desirability: Application in Drug Discovery ACS Chemical Neuroscience ·Travis T. Wager, Xinjun Hou, Patrick R. Verhoest, Anabella Villalobos Hit paper breakdown →	2016	391
5	Identification of Phosphorylation Consensus Sequences and Endogenous Neuronal Substrates of the Psychiatric Risk Kinase TNIK Journal of Pharmacology and Experimental Therapeutics ·Qi Wang, Steve Amato, David M. Rubitski, Matthew M. Hayward, Bethany L. Kormos, Patrick R. Verhoest, Li Xu, Nicholas J. Brandon, Michael Ehlers	2015	29
6	Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 H -pyrrolo[2,3- d ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor Journal of Medicinal Chemistry ·Jaclyn L. Henderson, Bethany L. Kormos, Matthew M. Hayward, Karen J. Coffman, J. Jasti, Ravi G. Kurumbail, Travis T. Wager, Patrick R. Verhoest, G. Stephen Noell, Yi Chen, Elie Needle, Zdenek Berger, Stefanus J. Steyn, Christopher Houle, Warren D. Hirst, Paul Galatsis	2014	140
7	Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin Bioorganic & Medicinal Chemistry Letters ·Martin Pettersson, Douglas S. Johnson, John M. Humphrey, Christopher W. am Ende, Edelweiss Evrard, Ivan Efremov, Gregory W. Kauffman, Antonia F. Stepan, Cory M. Stiff, Longfei Xie, Kelly R. Bales, Éva Hajós‐Korcsok, Heather E. Murrey, Leslie R. Pustilnik, Stefanus J. Steyn, Kathleen M. Wood, Patrick R. Verhoest	2014	13
8	Kinase domain inhibition of leucine rich repeat kinase 2 (LRRK2) using a [1,2,4]triazolo[4,3-b]pyridazine scaffold Bioorganic & Medicinal Chemistry Letters ·Paul Galatsis, Jaclyn L. Henderson, Bethany L. Kormos, Seungil Han, Ravi G. Kurumbail, Travis T. Wager, Patrick R. Verhoest, G. Stephen Noell, Yi Chen, Elie Needle, Zdenek Berger, Stefanus J. Steyn, Christopher Houle, Warren D. Hirst	2014	23
9	Design and Selection Parameters to Accelerate the Discovery of Novel Central Nervous System Positron Emission Tomography (PET) Ligands and Their Application in the Development of a Novel Phosphodiesterase 2A PET Ligand Journal of Medicinal Chemistry ·Lei Zhang, Anabella Villalobos, Elizabeth M. Beck, Thomas Bocan, Thomas A. Chappie, Laigao Chen, Sarah Grimwood, Steven D. Heck, Christopher J. Helal, Xinjun Hou, John M. Humphrey, Jiemin Lu, Marc B. Skaddan, Timothy J. McCarthy, Patrick R. Verhoest, Travis T. Wager, Kenneth Zasadny	2013	142
10	PF-04859989 as a template for structure-based drug design: Identification of new pyrazole series of irreversible KAT II inhibitors with improved lipophilic efficiency Bioorganic & Medicinal Chemistry Letters ·Amy B. Dounay, Marie Anderson, Bruce M. Bechle, Edelweiss Evrard, Xinmin Gan, Jiyoung Kim, Laura A. McAllister, Jayvardhan Pandit, Suo‐Bao Rong, Michelle A. Salafia, Jamison B. Tuttle, Laura E. Zawadzke, Patrick R. Verhoest	2013	28
11	Pharmacological Characterization of 2-Methyl-N-((2′-(pyrrolidin-1-ylsulfonyl)biphenyl-4-yl)methyl)propan-1-amine (PF-04455242), a High-Affinity Antagonist Selective for κ-Opioid Receptors Journal of Pharmacology and Experimental Therapeutics ·S. Grimwood, Yang Lü, Anne W. Schmidt, Michelle Vanase‐Frawley, Aarti Sawant‐Basak, Emily Miller, Stafford McLean, John Freeman, Stephen T.C. Wong, Jay P. McLaughlin, Patrick R. Verhoest	2011	52
12	Strategies to optimize the brain availability of central nervous system drug candidates Expert Opinion on Drug Discovery ·Travis T. Wager, Anabella Villalobos, Patrick R. Verhoest, Xinjun Hou, Christopher L. Shaffer	2011	32
13	Synthesis of ortho-substituted nitroaromatics via improved Negishi coupling conditions Tetrahedron Letters ·Jamison B. Tuttle, Joseph M. Azzarelli, Bruce M. Bechle, Amy B. Dounay, Edelweiss Evrard, Xinmin Gan, Somraj Ghosh, Jaclyn L. Henderson, Jiyoung Kim, Vinod D. Parikh, Patrick R. Verhoest	2011	7
14	Moving beyond Rules: The Development of a Central Nervous System Multiparameter Optimization (CNS MPO) Approach To Enable Alignment of Druglike Properties ACS Chemical Neuroscience ·Travis T. Wager, Xinjun Hou, Patrick R. Verhoest, Anabella Villalobos Hit paper breakdown →	2010	687
15	Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1 H -pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1). Journal of Medicinal Chemistry ·Patrick R. Verhoest, Douglas S. Chapin, Michael L. Corman, Kari R. Fonseca, John F. Harms, Xinjun Hou, Eric S. Marr, Frank S. Menniti, Frederick Nelson, Rebecca E. O’Connor, Jayvardhan Pandit, Caroline Proulx-LaFrance, Anne W. Schmidt, Christopher J. Schmidt, Judith A. Suiciak, Spiros Liras	2009	172
16	Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia Journal of Pharmacology and Experimental Therapeutics ·C J Schmidt, Douglas S. Chapin, J. Cianfrogna, Michael L. Corman, Mihály Hajós, John F. Harms, William E. Hoffman, Lorraine A. Lebel, Sheryl A. McCarthy, Fredrick R. Nelson, Caroline Proulx-LaFrance, Mark J. Majchrzak, Andres D. Ramirez, Karl T. Schmidt, P A Seymour, Judith A. Siuciak, F. David Tingley, Robert D. Williams, Patrick R. Verhoest, Frank S. Menniti	2008	238
17	Cancers gynécologiques et mammaires dans le département de la Somme Revue d Épidémiologie et de Santé Publique ·J. Peng, N Raverdy, H Foulques, Patrick R. Verhoest, A. Thulliez, A Lorriaux, A. Dubreuil	2004	1
18	Treatment of CIN after menopause European Journal of Obstetrics & Gynecology and Reproductive Biology ·J.-C. Boulanger, Jean Gondry, Patrick R. Verhoest, Cécile Capsie, S Najas	2001	10
19	Plasma Renin Activity, Blood Uric Acid and Plasma Volume in Pregnancy-Induced Hypertension The Nephron journals/Nephron journals ·P Fiévet, L. Pleskov, I. Desailly, A. Carayon, J.F. de Frémont, B Coevoet, E Comoy, J.E. Demory, Patrick R. Verhoest, J.-C. Boulanger	1985	15
20	Increased adrenergic activity during pregnancy-induced hypertension European Heart Journal ·P Fiévet, B Coevoet, Michel Andréjak, E Comoy, Faézeh Legrand, C. Galy, J.-C. Boulanger, Patrick R. Verhoest, M. Viste, A. Fournier	1982	0

About Patrick R. Verhoest

Patrick R. Verhoest is a scholar working on Biological Psychiatry, Obstetrics and Gynecology, Pharmacology, Behavioral Neuroscience and Organic Chemistry, having authored 56 papers that have together received 3.4k indexed citations. Recurring topics across this work include Receptor Mechanisms and Signaling (13 papers), Phosphodiesterase function and regulation (9 papers), Cholinesterase and Neurodegenerative Diseases (8 papers), Computational Drug Discovery Methods (7 papers), Chemical synthesis and alkaloids (6 papers), Pregnancy and preeclampsia studies (6 papers), Chemical Synthesis and Analysis (5 papers) and Synthetic Organic Chemistry Methods (4 papers). The work is most often cited by research in Biological Psychiatry (149 citations), Pharmacology (690 citations), Computational Theory and Mathematics (579 citations), Organic Chemistry (1.0k citations) and Cellular and Molecular Neuroscience (506 citations). Patrick R. Verhoest has collaborated with scholars based in United States, France and Switzerland. Frequent co-authors include Xinjun Hou, Travis T. Wager, Anabella Villalobos, Amos B. Smith, Kevin P. C. Minbiole, Michael Schelhaas, Yvonne Will, Ramalakshmi Y. Chandrasekaran, Matthew D. Troutman and Jamison B. Tuttle. Their work appears in journals such as Journal of Medicinal Chemistry, ACS Chemical Neuroscience, Bioorganic & Medicinal Chemistry Letters, Journal of Pharmacology and Experimental Therapeutics and Tetrahedron Letters.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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