Christoph Lengauer

44.9k citations

129 papers · 31.7k indexed · 20 hit papers · h-index 66

Molecular Biology top 0.05%
Oncology top 0.05%
Cancer Research top 0.05%
Cell Biology top 0.05%
Pathology and Forensic Medicine top 0.05%

Co-authors: Bert Vogelstein Kenneth W. Kinzler Harith Rajagopalan Victor E. Velculescu Todd Waldman Fred Bunz Sanford D. Markowitz James K. V. Willson
Topics: Genetic factors in colorectal cancer (27 papers)Microtubule and mitosis dynamics (26 papers)Cancer Genomics and Diagnostics (26 papers)
Cited by: Cancer Research Oncology Cell Biology
Journals: Nature Science Cell
Partner nations: United States Germany Austria

In The Last Decade

Christoph Lengauer

128 papers receiving 31.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Genetic instabilities in human cancers

1998 3.2k citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
Requirement for p53 and p21 to Sustain G ₂ Arrest After DNA Damage

1998 2.5k citations Christoph Lengauer, Kenneth W. Kinzler et al. Science profile →
Genetic instability in colorectal cancers

1997 1.6k citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
Genes Expressed in Human Tumor Endothelium

2000 1.5k citations Carlo Rago, Victor E. Velculescu et al. Science profile →
Mutations of mitotic checkpoint genes in human cancers

1998 1.2k citations Christoph Lengauer, James K. V. Willson et al. Nature profile →
Is a p53-Regulated Inhibitor of G2/M Progression

1997 1.0k citations Christoph Lengauer, Sam Thiagalingam et al. Molecular Cell profile →
RAF/RAS oncogenes and mismatch-repair status

2002 990 citations Harith Rajagopalan, Christoph Lengauer et al. Nature profile →
DNMT1 and DNMT3b cooperate to silence genes in human cancer cells

2002 979 citations Andrew P. Feinberg, Christoph Lengauer et al. Nature profile →
Disruption of p53 in human cancer cells alters the responses to therapeutic agents

1999 883 citations Christoph Lengauer, Kenneth W. Kinzler et al. profile →
14-3-3σ is required to prevent mitotic catastrophe after DNA damage

1999 740 citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
Mutant PIK3CA promotes cell growth and invasion of human cancer cells

2005 727 citations Yardena Samuels, Luis A. Díaz et al. Cancer Cell profile →
Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells

2009 724 citations Jihye Yun, Carlo Rago et al. Science profile →
Somatic mutations of the mitochondrial genome in human colorectal tumours

1998 689 citations Christoph Lengauer, James K. V. Willson et al. Nature Genetics profile →
The landscape of kinase fusions in cancer

2014 657 citations Nicolas Stransky, Joseph L. Kim et al. profile →
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21

1996 637 citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
Aneuploidy and cancer

2004 566 citations Harith Rajagopalan, Christoph Lengauer Nature profile →
Genetic instability and darwinian selection in tumours

1999 546 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
A Phosphatase Associated with Metastasis of Colorectal Cancer

2001 537 citations Victor E. Velculescu, Carlo Rago et al. Science profile →
Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers

1996 501 citations Sam Thiagalingam, Christoph Lengauer et al. Nature Genetics profile →
Targeting cancer with kinase inhibitors

2015 335 citations Nicolas Stransky, Christoph Lengauer et al. profile →

Peers

Countries citing papers authored by Christoph Lengauer

Since Specialization

Citations

This map shows the geographic impact of Christoph Lengauer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Lengauer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Lengauer more than expected).

Fields of papers citing papers by Christoph Lengauer

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Lengauer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Lengauer. The network helps show where Christoph Lengauer may publish in the future.

Co-authorship network of co-authors of Christoph Lengauer

This figure shows the co-authorship network connecting the top 25 collaborators of Christoph Lengauer. A scholar is included among the top collaborators of Christoph Lengauer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christoph Lengauer. Christoph Lengauer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis 2019 ·Leukemia ·Johannes Lübke,Nicole Naumann,(unknown),Juliana Schwaab,Georgia Metzgeroth,Erica N Evans,Alexandra K. Gardino,Christoph Lengauer,Wolf‐Karsten Hofmann,Alice Fabarius,Nicholas C.P. Cross,Andreas Reiter,Mohamad Jawhar	33
2	Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors 2018 ·Clinical Cancer Research ·Yemarshet K. Gebreyohannes,Agnieszka Woźniak,(unknown),Jasmien Wellens,Jasmien Cornillie,Ulla Vanleeuw,Erica N Evans,Alexandra K. Gardino,Christoph Lengauer,Maria Dêbiec‐Rychter,Raf Sciot,Patrick Schöffski	57
3	Concomitant Inhibition of PI3Kβ and BRAF or MEK in PTEN-Deficient/ BRAF -Mutant Melanoma Treatment: Preclinical Assessment of SAR260301 Oral PI3K β -Selective Inhibitor 2016 ·Molecular Cancer Therapeutics ·(unknown),(unknown),Loı̈c Vincent,Mikhail Levit,(unknown),Frank Halley,Cécile Delorme,Christoph Lengauer,Carlos Garcı́a-Echeverrı́a,Angéla Virone-Oddos	17
4	First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway 2015 ·Cancer Discovery ·Margit Hagel,Chandra Miduturu,Michael P. Sheets,Nooreen Rubin,Weifan Weng,Nicolas Stransky,Neil Bifulco,Joseph L. Kim,Brian L. Hodous,Natasja Brooijmans,Adam Shutes,Christopher Winter,Christoph Lengauer,Nancy E. Kohl,Timothy J. Guzi	247
5	Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors 2014 ·Bioorganic & Medicinal Chemistry Letters ·Victor Certal,Frank Halley,Angéla Virone-Oddos,Bruno Filoche-Rommé,Jean‐Christophe Carry,(unknown),(unknown),(unknown),(unknown),(unknown),Andreas Karlsson,Véronique Charrier,(unknown),Loı̈c Vincent,(unknown),Christoph Lengauer,Carlos Garcı́a-Echeverrı́a,Laurent Schio	5
6	The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells 2010 ·Cancer Research ·Zainab Jagani,Dmitri Wiederschain,Alice Loo,Dan He,Rebecca Mosher,Paul Fordjour,John E. Monahan,Michael Morrissey,(unknown),Christoph Lengauer,Markus Warmuth,William R. Sellers,Marion Dorsch	48
7	Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cellsbreakdown → 2009 ·Science ·Jihye Yun,Carlo Rago,Ian Cheong,(unknown),Philipp Angenendt,Harith Rajagopalan,Kerstin Schmidt,James K. V. Willson,Sandy D. Markowitz,Shibin Zhou,Luis A. Díaz,Victor E. Velculescu,Christoph Lengauer,Kenneth W. Kinzler,Bert Vogelstein,Nickolas Papadopoulos	724
8	Crystal structure of human CDK4 in complex with a D-type cyclin 2009 ·Proceedings of the National Academy of Sciences ·Philip J. Day,Anne Cleasby,Ian J. Tickle,Marc O’Reilly,(unknown),Finn P. Holding,Rachel McMenamin,Jeff Yon,Rajiv Chopra,Christoph Lengauer,Harren Jhoti	176
9	PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers 2009 ·Cancer Research ·Susan Wee,Zainab Jagani,Kay X. Xiang,Alice Loo,Marion Dorsch,Yung‐Mae Yao,William R. Sellers,Christoph Lengauer,Frank Stegmeier	354
10	Single-vector inducible lentiviral RNAi system for oncology target validation 2009 ·Cell Cycle ·Dmitri Wiederschain,(unknown),Lin Chen,Alice Loo,Guizhi Yang,Alan Huang,Yan Chen,Giordano Caponigro,(unknown),Christoph Lengauer,William R. Sellers,John D. Benson	306
11	PTEN-deficient cancers depend on PIK3CB 2008 ·Proceedings of the National Academy of Sciences ·Susan Wee,Dmitri Wiederschain,Sauveur-Michel Maira,Alice Loo,Christine Miller,(unknown),Frank Stegmeier,(unknown),Christoph Lengauer	411
12	Mutant PIK3CA promotes cell growth and invasion of human cancer cellsbreakdown → 2005 ·Cancer Cell ·Yardena Samuels,Luis A. Díaz,Oleg Schmidt‐Kittler,Jordan M. Cummins,(unknown),Ian Cheong,Carlo Rago,David L. Huso,Christoph Lengauer,Kenneth W. Kinzler,Bert Vogelstein,Victor E. Velculescu	727
13	CIN-ful cancers 2004 ·Cancer Chemotherapy and Pharmacology ·Harith Rajagopalan,Christoph Lengauer	18
14	Cloning and chromosomal localization of the human BARX2 homeobox protein gene 2000 ·Gene ·Alan Krasner,(unknown),Arunthathi Thiagalingam,Christopher T. Jones,Christoph Lengauer,(unknown),(unknown),Linda M. Kalikin,Andrew P. Feinberg,Ethylin Wang Jabs,Alan Tunnacliffe,Stephen B. Baylin,Douglas W. Ball,Barry D. Nelkin	20
15	Conversion of diploidy to haploidy 2000 ·Nature ·Hai Yan,Nickolas Papadopoulos,Giancarlo Marra,Claudia Perrera,Josef Jiricny,C. Richard Boland,(unknown),Robert B. Chadwick,Albert de la Chapelle,(unknown),James R. Eshleman,Weishi Yuan,Sanford D. Markowitz,Steven J. Laken,Christoph Lengauer,K W Kinzler,Bert Vogelstein	200
16	Genetic instabilities in human cancersbreakdown → 1998 ·Nature ·Christoph Lengauer,Kenneth W. Kinzler,Bert Vogelstein	3228
17	Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer 1998 ·Molecular Cell ·Shibin Zhou,Leigh Zawel,Christoph Lengauer,K. W. Kinzler,Bert Vogelstein	208
18	Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancersbreakdown → 1996 ·Nature Genetics ·Sam Thiagalingam,Christoph Lengauer,(unknown),Mieke Schutte,Stephan A. Hahn,Joan Overhauser,James K. V. Willson,Sanford D. Markowitz,Stanley R. Hamilton,Scott E. Kern,K W Kinzler,Bert Vogelstein	501
19	Painting of defined chromosomal regions by in situ suppression hybridization of libraries from laser-microdissected chromosomes 1991 ·Cytogenetic and Genome Research ·Christoph Lengauer,(unknown),Andreas Weith,Nicole Endlich,Norbert Ponelies,Peter Lichter,Karl‐Otto Greulich,Thomas Cremer	35
20	Painting of human chromosomes with probes generated from hybrid cell lines by PCR with Alu and L1 primers 1990 ·Human Genetics ·Christoph Lengauer,Harold Riethman,Thomas Cremer	53

About Christoph Lengauer

Christoph Lengauer is a scholar working on Cancer Research, Pathology and Forensic Medicine and Cell Biology, having authored 129 papers that have together received 31.7k indexed citations. Recurring topics across this work include Genetic factors in colorectal cancer (27 papers), Microtubule and mitosis dynamics (26 papers) and Cancer Genomics and Diagnostics (26 papers). The work is most often cited by research in Cancer Research (7.4k citations), Oncology (11.7k citations) and Cell Biology (5.7k citations). Christoph Lengauer has collaborated with scholars based in United States, Germany and Austria. Frequent co-authors include Bert Vogelstein, Kenneth W. Kinzler, Harith Rajagopalan, Victor E. Velculescu, Todd Waldman, Fred Bunz, Sanford D. Markowitz, James K. V. Willson, Carlo Rago and Daniel P. Cahill. Their work appears in journals such as Nature, Science and Cell.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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