Christoph Lengauer

44.9k total citations · 20 hit papers
129 papers, 31.7k citations indexed

About

Christoph Lengauer is a scholar working on Molecular Biology, Pathology and Forensic Medicine and Genetics. According to data from OpenAlex, Christoph Lengauer has authored 129 papers receiving a total of 31.7k indexed citations (citations by other indexed papers that have themselves been cited), including 87 papers in Molecular Biology, 35 papers in Pathology and Forensic Medicine and 34 papers in Genetics. Recurrent topics in Christoph Lengauer's work include Genetic factors in colorectal cancer (27 papers), Microtubule and mitosis dynamics (26 papers) and Cancer Genomics and Diagnostics (26 papers). Christoph Lengauer is often cited by papers focused on Genetic factors in colorectal cancer (27 papers), Microtubule and mitosis dynamics (26 papers) and Cancer Genomics and Diagnostics (26 papers). Christoph Lengauer collaborates with scholars based in United States, Germany and Austria. Christoph Lengauer's co-authors include Bert Vogelstein, Kenneth W. Kinzler, Harith Rajagopalan, Victor E. Velculescu, Todd Waldman, Fred Bunz, Sanford D. Markowitz, James K. V. Willson, Carlo Rago and Daniel P. Cahill and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Christoph Lengauer

128 papers receiving 31.0k citations

Hit Papers

Genetic instabilities in human cancers 1996 2026 2006 2016 1998 1998 1997 2000 1998 1000 2.0k 3.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Genetic instabilities in human cancers
    1998 3.2k citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
  2. Requirement for p53 and p21 to Sustain G 2 Arrest After DNA Damage
    1998 2.5k citations Christoph Lengauer, Kenneth W. Kinzler et al. Science profile →
  3. Genetic instability in colorectal cancers
    1997 1.6k citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
  4. Genes Expressed in Human Tumor Endothelium
    2000 1.5k citations Carlo Rago, Victor E. Velculescu et al. Science profile →
  5. Mutations of mitotic checkpoint genes in human cancers
    1998 1.2k citations Christoph Lengauer, James K. V. Willson et al. Nature profile →
  6. Is a p53-Regulated Inhibitor of G2/M Progression
    1997 1.0k citations Christoph Lengauer, Sam Thiagalingam et al. Molecular Cell profile →
  7. RAF/RAS oncogenes and mismatch-repair status
    2002 990 citations Harith Rajagopalan, Christoph Lengauer et al. Nature profile →
  8. DNMT1 and DNMT3b cooperate to silence genes in human cancer cells
    2002 979 citations Andrew P. Feinberg, Christoph Lengauer et al. Nature profile →
  9. Disruption of p53 in human cancer cells alters the responses to therapeutic agents
    1999 883 citations Christoph Lengauer, Kenneth W. Kinzler et al. profile →
  10. 14-3-3σ is required to prevent mitotic catastrophe after DNA damage
    1999 740 citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
  11. Mutant PIK3CA promotes cell growth and invasion of human cancer cells
    2005 727 citations Yardena Samuels, Luis A. Díaz et al. Cancer Cell profile →
  12. Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells
    2009 724 citations Jihye Yun, Carlo Rago et al. Science profile →
  13. Somatic mutations of the mitochondrial genome in human colorectal tumours
    1998 689 citations Christoph Lengauer, James K. V. Willson et al. Nature Genetics profile →
  14. The landscape of kinase fusions in cancer
    2014 657 citations Nicolas Stransky, Joseph L. Kim et al. profile →
  15. Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21
    1996 637 citations Christoph Lengauer, Kenneth W. Kinzler et al. Nature profile →
  16. Aneuploidy and cancer
    2004 566 citations Harith Rajagopalan, Christoph Lengauer Nature profile →
  17. Genetic instability and darwinian selection in tumours
    1999 546 citations Kenneth W. Kinzler, Bert Vogelstein et al. profile →
  18. A Phosphatase Associated with Metastasis of Colorectal Cancer
    2001 537 citations Victor E. Velculescu, Carlo Rago et al. Science profile →
  19. Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers
    1996 501 citations Sam Thiagalingam, Christoph Lengauer et al. Nature Genetics profile →
  20. Targeting cancer with kinase inhibitors
    2015 335 citations Nicolas Stransky, Christoph Lengauer et al. profile →

Peers

Christoph Lengauer
Sanford D. Markowitz United States
Michael B. Kastan United States
Jiří Bártek Denmark
Thomas Ried United States
Lynda Chin United States
Frank McCormick United States
Channing J. Der United States
Moshe Oren Israel
Daniel Birnbaum France
Julian Downward United Kingdom
Sanford D. Markowitz United States
Christoph Lengauer
Citations per year, relative to Christoph Lengauer Christoph Lengauer (= 1×) peers Sanford D. Markowitz

Countries citing papers authored by Christoph Lengauer

Since Specialization
Citations

This map shows the geographic impact of Christoph Lengauer's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christoph Lengauer with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christoph Lengauer more than expected).

Fields of papers citing papers by Christoph Lengauer

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christoph Lengauer. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christoph Lengauer. The network helps show where Christoph Lengauer may publish in the future.

Co-authorship network of co-authors of Christoph Lengauer

This figure shows the co-authorship network connecting the top 25 collaborators of Christoph Lengauer. A scholar is included among the top collaborators of Christoph Lengauer based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christoph Lengauer. Christoph Lengauer is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Lübke, Johannes, Nicole Naumann, Juliana Schwaab, et al.. (2019). Inhibitory effects of midostaurin and avapritinib on myeloid progenitors derived from patients with KIT D816V positive advanced systemic mastocytosis. Leukemia. 33(5). 1195–1205. 33 indexed citations
2.
Gebreyohannes, Yemarshet K., Agnieszka Woźniak, Jasmien Wellens, et al.. (2018). Robust Activity of Avapritinib, Potent and Highly Selective Inhibitor of Mutated KIT, in Patient-derived Xenograft Models of Gastrointestinal Stromal Tumors. Clinical Cancer Research. 25(2). 609–618. 57 indexed citations
3.
Vincent, Loı̈c, Mikhail Levit, Frank Halley, et al.. (2016). Concomitant Inhibition of PI3Kβ and BRAF or MEK in PTEN-Deficient/ BRAF -Mutant Melanoma Treatment: Preclinical Assessment of SAR260301 Oral PI3K β -Selective Inhibitor. Molecular Cancer Therapeutics. 15(7). 1460–1471. 17 indexed citations
4.
Hagel, Margit, Chandra Miduturu, Michael P. Sheets, et al.. (2015). First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway. Cancer Discovery. 5(4). 424–437. 247 indexed citations
5.
Certal, Victor, Frank Halley, Angéla Virone-Oddos, et al.. (2014). Preparation and optimization of new 4-(2-(indolin-1-yl)-2-oxoethyl)-2-morpholinothiazole-5-carboxylic acid and amide derivatives as potent and selective PI3Kβ inhibitors. Bioorganic & Medicinal Chemistry Letters. 24(6). 1506–1510. 5 indexed citations
6.
Jagani, Zainab, Dmitri Wiederschain, Alice Loo, et al.. (2010). The Polycomb Group Protein Bmi-1 Is Essential for the Growth of Multiple Myeloma Cells. Cancer Research. 70(13). 5528–5538. 48 indexed citations
7.
Yun, Jihye, Carlo Rago, Ian Cheong, et al.. (2009). Glucose Deprivation Contributes to the Development of KRAS Pathway Mutations in Tumor Cells. Science. 325(5947). 1555–1559. 724 indexed citations breakdown →
8.
Day, Philip J., Anne Cleasby, Ian J. Tickle, et al.. (2009). Crystal structure of human CDK4 in complex with a D-type cyclin. Proceedings of the National Academy of Sciences. 106(11). 4166–4170. 176 indexed citations
9.
Wee, Susan, Zainab Jagani, Kay X. Xiang, et al.. (2009). PI3K Pathway Activation Mediates Resistance to MEK Inhibitors in KRAS Mutant Cancers. Cancer Research. 69(10). 4286–4293. 354 indexed citations
10.
Wiederschain, Dmitri, Lin Chen, Alice Loo, et al.. (2009). Single-vector inducible lentiviral RNAi system for oncology target validation. Cell Cycle. 8(3). 498–504. 306 indexed citations
11.
Wee, Susan, Dmitri Wiederschain, Sauveur-Michel Maira, et al.. (2008). PTEN-deficient cancers depend on PIK3CB. Proceedings of the National Academy of Sciences. 105(35). 13057–13062. 411 indexed citations
12.
Samuels, Yardena, Luis A. Díaz, Oleg Schmidt‐Kittler, et al.. (2005). Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell. 7(6). 561–573. 727 indexed citations breakdown →
13.
Rajagopalan, Harith & Christoph Lengauer. (2004). CIN-ful cancers. Cancer Chemotherapy and Pharmacology. 54 Suppl 1. S65–8. 18 indexed citations
14.
Krasner, Alan, Arunthathi Thiagalingam, Christopher T. Jones, et al.. (2000). Cloning and chromosomal localization of the human BARX2 homeobox protein gene. Gene. 250(1-2). 171–180. 20 indexed citations
15.
Yan, Hai, Nickolas Papadopoulos, Giancarlo Marra, et al.. (2000). Conversion of diploidy to haploidy. Nature. 403(6771). 723–724. 200 indexed citations
16.
Lengauer, Christoph, Kenneth W. Kinzler, & Bert Vogelstein. (1998). Genetic instabilities in human cancers. Nature. 396(6712). 643–649. 3228 indexed citations breakdown →
17.
Zhou, Shibin, Leigh Zawel, Christoph Lengauer, K. W. Kinzler, & Bert Vogelstein. (1998). Characterization of Human FAST-1, a TGFβ and Activin Signal Transducer. Molecular Cell. 2(1). 121–127. 208 indexed citations
18.
Thiagalingam, Sam, Christoph Lengauer, Mieke Schutte, et al.. (1996). Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers. Nature Genetics. 13(3). 343–346. 501 indexed citations breakdown →
19.
Lengauer, Christoph, Andreas Weith, Nicole Endlich, et al.. (1991). Painting of defined chromosomal regions by in situ suppression hybridization of libraries from laser-microdissected chromosomes. Cytogenetic and Genome Research. 56(1). 27–30. 35 indexed citations
20.
Lengauer, Christoph, Harold Riethman, & Thomas Cremer. (1990). Painting of human chromosomes with probes generated from hybrid cell lines by PCR with Alu and L1 primers. Human Genetics. 86(1). 1–6. 53 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact

Breakdown of academic impact, for papers by Sanford D. Markowitz Breakdown of academic impact, for papers by Michael B. Kastan Breakdown of academic impact, for papers by Jiří Bártek Breakdown of academic impact, for papers by Thomas Ried Breakdown of academic impact, for papers by Lynda Chin Breakdown of academic impact, for papers by Frank McCormick Breakdown of academic impact, for papers by Channing J. Der Breakdown of academic impact, for papers by Moshe Oren Breakdown of academic impact, for papers by Daniel Birnbaum Breakdown of academic impact, for papers by Julian Downward
Rankless by CCL
2026