Natasja Brooijmans

3.7k citations

42 papers · 2.6k indexed · 1 hit paper · h-index 24

Computational Theory and Mathematics top 0.5%
- Computational Drug Discovery Methods 11
Molecular Biology top 5%
- PI3K/AKT/mTOR signaling in cancer 17
- Protein Kinase Regulation and GTPase Signaling 5
- Protein Structure and Dynamics 4
- Fibroblast Growth Factor Research 4
Organic Chemistry top 2%
- Quinazolinone synthesis and applications 4
Toxicology top 5%
Genetics top 10%
- Chronic Lymphocytic Leukemia Research 5
Ecology, Evolution, Behavior and Systematics
- Fungal Plant Pathogen Control 3

Co-authors: Irwin D. Kuntz Tarek S. Mansour Irwin Hollander Ker Yu Semiramis Ayral‐Kaloustian Demetri T. Moustakas Eric F. Pettersen Robert C. Rizzo
Cited by: Computational Theory and Mathematics Molecular Biology Organic Chemistry
Journals: PLoS ONE (1 paper)Cancer Research (1 paper)Journal of Medicinal Chemistry (10 papers)
Partner nations: United States Canada Switzerland

In The Last Decade

Natasja Brooijmans

41 papers receiving 2.5k citations

Hit Papers

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Peers

Countries citing papers authored by Natasja Brooijmans

Since Specialization

Citations

This map shows the geographic impact of Natasja Brooijmans's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Natasja Brooijmans with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Natasja Brooijmans more than expected).

Fields of papers citing papers by Natasja Brooijmans

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Natasja Brooijmans. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Natasja Brooijmans. The network helps show where Natasja Brooijmans may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Natasja Brooijmans, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Natasja Brooijmans Line = papers co-authored together Natasja Brooijmans links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts Cancer Discovery ·Leonard Buckbinder,David J. St. Jean,Trang Tieu,Brendon Ladd,Brendan J. Hilbert,Weixue Wang,Jacob T. Alltucker,Samantha Manimala,Gregory V. Kryukov,Natasja Brooijmans,Gregory Dowdell,Philip Jonsson,Michael Huff,Angel Guzman-Perez,Erica L. Jackson,Marcus D. Goncalves,Darrin D. Stuart	2023	41
2	Precision Oncology Comes of Age: Designing Best-in-Class Small Molecules by Integrating Two Decades of Advances in Chemistry, Target Biology, and Data Science Cancer Discovery ·Darrin D. Stuart,Angel Guzman-Perez,Natasja Brooijmans,Erica L. Jackson,Gregory V. Kryukov,Adam A. Friedman,Axel Hoos	2023	9
3	First Selective Small Molecule Inhibitor of FGFR4 for the Treatment of Hepatocellular Carcinomas with an Activated FGFR4 Signaling Pathway Cancer Discovery ·Margit Hagel,Chandra Miduturu,Michael P. Sheets,Nooreen Rubin,Weifan Weng,Nicolas Stransky,Neil Bifulco,Joseph L. Kim,Brian L. Hodous,Natasja Brooijmans,Adam Shutes,Christopher Winter,Christoph Lengauer,Nancy E. Kohl,Timothy J. Guzi	2015	247
4	Inside the Mind of a Medicinal Chemist: The Role of Human Bias in Compound Prioritization during Drug Discovery PLoS ONE ·Peter S. Kutchukian,Nadya Vasilyeva,Jordan Xu,Mika Lindvall,Michael P. Dillon,Meir Glick,John D. Coley,Natasja Brooijmans	2012	47
5	Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors Bioorganic & Medicinal Chemistry Letters ·Christoph M. Dehnhardt,Aranapakam M. Venkatesan,Zecheng Chen,Efren Delos-Santos,Semiramis Ayral‐Kaloustian,Natasja Brooijmans,Ker Yu,Irwin Hollander,Larry Feldberg,Judy Lucas,Robert Mallon	2011	30
6	4-Substituted-7-azaindoles bearing a ureidobenzofuranone moiety as potent and selective, ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR) Bioorganic & Medicinal Chemistry Letters ·Hwei‐Ru Tsou,Gloria MacEwan,Gary H. Birnberg,Nan Zhang,Natasja Brooijmans,Lourdes Toral‐Barza,Irwin Hollander,Semiramis Ayral‐Kaloustian,Ker Yu	2010	19
7	A lead discovery strategy driven by a comprehensive analysis of proteases in the peptide substrate space Protein Science ·Sai Chetan K. Sukuru,Florian Nigsch,Jean Quancard,Martin Renatus,Rajiv Chopra,Natasja Brooijmans,Д. А. Михайлов,Zhan Deng,Allen Cornett,Jeremy L. Jenkins,Ulrich Hommel,John W. Davies,Meir Glick	2010	5
8	A Protein Relational Database and Protein Family Knowledge Bases to Facilitate Structure‐Based Design Analyses Chemical Biology & Drug Design ·Dominick Mobilio,Gary Walker,Natasja Brooijmans,Ramaswamy Nilakantan,R. Aldrin Denny,Jason DeJoannis,Eric Feyfant,Rupesh K. Kowticwar,Jyoti Mankala,Satish Palli,Sairam Punyamantula,Maneesh Tatipally,Reji K. John,Christine Humblet	2010	7
9	Novel benzofuran-3-one indole inhibitors of PI3 kinase-α and the mammalian target of rapamycin: Hit to lead studies Bioorganic & Medicinal Chemistry Letters ·Matthew G. Bursavich,Natasja Brooijmans,Lawrence Feldberg,Irwin Hollander,Stephen Kim,Sabrina Lombardi,Kaapjoo Park,Robert Mallon,A. Gilbert	2010	26
10	Chemical space sampling by different scoring functions and crystal structures Journal of Computer-Aided Molecular Design ·Natasja Brooijmans,Christine Humblet	2010	16
11	Chemical Space Sampling in Virtual Screening by Different Crystal Structures Chemical Biology & Drug Design ·Natasja Brooijmans,Christine Humblet	2010	4
12	Biased retrieval of chemical series in receptor-based virtual screening Journal of Computer-Aided Molecular Design ·Natasja Brooijmans,Jason B. Cross,Christine Humblet	2010	3
13	Novel purine and pyrazolo[3,4-d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies Bioorganic & Medicinal Chemistry Letters ·A. Gilbert,Paweł Nowak,Natasja Brooijmans,Matthew G. Bursavich,Christoph M. Dehnhardt,Efren Delos Santos,Larry Feldberg,Irwin Hollander,Stephen Kim,Sabrina Lombardi,Kaapjoo Park,Aranapakam M. Venkatesan,Robert Mallon	2009	32
14	Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors Bioorganic & Medicinal Chemistry Letters ·Aranapakam M. Venkatesan,Christoph M. Dehnhardt,Zecheng Chen,Efren Delos Santos,Osvaldo dos Santos,Matthew G. Bursavich,A. Gilbert,John W. Ellingboe,Semiramis Ayral‐Kaloustian,Gulnaz Khafizova,Natasja Brooijmans,Robert Mallon,Irwin Hollander,Larry Feldberg,Judy Lucas,Ker Yu,Jay Gibbons,Robert T. Abraham,Tarek S. Mansour	2009	23
15	Discovery of 3,6-dihydro-2H-pyran as a morpholine replacement in 6-aryl-1H-pyrazolo[3,4-d]pyrimidines and 2-arylthieno[3,2-d]pyrimidines: ATP-competitive inhibitors of the mammalian target of rapamycin (mTOR) Bioorganic & Medicinal Chemistry Letters ·Joshua A. Kaplan,Jeroen C. Verheijen,Natasja Brooijmans,Lourdes Toral‐Barza,Irwin Hollander,Ker Yu,Arie Zask	2009	41
16	5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCθ: Optimization of enzymatic and functional activity Bioorganic & Medicinal Chemistry ·L. Nathan Tumey,Niala Bhagirath,Agnes Brennan,Natasja Brooijmans,Julie Lee,Xiaoke Yang,Diane H. Boschelli	2009	25
17	A structural informatics approach to mine kinase knowledge bases Drug Discovery Today ·Natasja Brooijmans,Dominick Mobilio,Gary Walker,Ramaswamy Nilakantan,R. Aldrin Denny,Eric Feyfant,David Diller,Jack Bikker,Christine Humblet	2009	7
18	Structure-based optimization of PKCθ inhibitors Biochemical Society Transactions ·Lidia Mosyak,Zhang‐Bao Xu,Diane Joseph‐McCarthy,Natasja Brooijmans,W.S. Somers,Divya Chaudhary	2007	7
19	Stability of macromolecular complexes Proteins Structure Function and Bioinformatics ·Natasja Brooijmans,Kim A. Sharp,Irwin D. Kuntz	2002	69
20	The Intrinsic Electrostatic Potential and the Intermediate Ring of Charge in the Acetylcholine Receptor Channel The Journal of General Physiology ·Gary G. Wilson,Juan M. Pascual,Natasja Brooijmans,Diana Murray,Arthur Karlin	2000	49

About Natasja Brooijmans

Natasja Brooijmans is a scholar working on Computational Theory and Mathematics, Molecular Biology and Genetics, having authored 42 papers that have together received 2.6k indexed citations. Recurring topics across this work include PI3K/AKT/mTOR signaling in cancer (17 papers), Computational Drug Discovery Methods (11 papers), Chronic Lymphocytic Leukemia Research (5 papers), Protein Kinase Regulation and GTPase Signaling (5 papers), Protein Structure and Dynamics (4 papers), Fibroblast Growth Factor Research (4 papers), Quinazolinone synthesis and applications (4 papers) and Fungal Plant Pathogen Control (3 papers). The work is most often cited by research in Computational Theory and Mathematics (666 citations), Molecular Biology (1.8k citations) and Organic Chemistry (733 citations). Natasja Brooijmans has collaborated with scholars based in United States, Canada and Switzerland. Frequent co-authors include Irwin D. Kuntz, Tarek S. Mansour, Irwin Hollander, Ker Yu, Semiramis Ayral‐Kaloustian, Demetri T. Moustakas, Eric F. Pettersen, Robert C. Rizzo, Scott C.‐H. Pegg and P. Therese Lang. Their work appears in journals such as PLoS ONE, Cancer Research and Journal of Medicinal Chemistry.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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