René Bernards

77.9k total citations · 17 hit papers
322 papers, 44.6k citations indexed

About

René Bernards is a scholar working on Molecular Biology, Oncology and Cancer Research. According to data from OpenAlex, René Bernards has authored 322 papers receiving a total of 44.6k indexed citations (citations by other indexed papers that have themselves been cited), including 233 papers in Molecular Biology, 137 papers in Oncology and 70 papers in Cancer Research. Recurrent topics in René Bernards's work include Cancer-related Molecular Pathways (58 papers), Ubiquitin and proteasome pathways (42 papers) and Virus-based gene therapy research (32 papers). René Bernards is often cited by papers focused on Cancer-related Molecular Pathways (58 papers), Ubiquitin and proteasome pathways (42 papers) and Virus-based gene therapy research (32 papers). René Bernards collaborates with scholars based in Netherlands, United States and United Kingdom. René Bernards's co-authors include Thijn R. Brummelkamp, Reuven Agami, Roderick L. Beijersbergen, Stephen Friend, Laura van ‘t Veer, Ron Kerkhoven, Robert A. Weinberg, Annette M.G. Dirac, Marc J. van de Vijver and Sebastian Nijman and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

René Bernards

317 papers receiving 43.5k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

Gene expression profiling predicts clinical outcome of breast cancer

2002 7.0k citations Hongyue Dai, Marc J. van de Vijver et al. profile →
A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

2002 3.7k citations Thijn R. Brummelkamp, René Bernards et al. profile →
A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 2.2k citations Stephen Friend, René Bernards et al. profile →
A Genomic and Functional Inventory of Deubiquitinating Enzymes

2005 1.5k citations Thijn R. Brummelkamp, René Bernards et al. Cell profile →
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR

2012 1.5k citations Anirudh Prahallad, Chong Sun et al. profile →
A Functional Genetic Approach Identifies the PI3K Pathway as a Major Determinant of Trastuzumab Resistance in Breast Cancer

2007 1.2k citations E. Marielle Hijmans, Roderick L. Beijersbergen et al. profile →
Stable suppression of tumorigenicity by virus-mediated RNA interference

2002 914 citations Thijn R. Brummelkamp, René Bernards et al. profile →
A large-scale RNAi screen in human cells identifies new components of the p53 pathway

2004 850 citations E. Marielle Hijmans, Jasper Mullenders et al. profile →
Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

2003 778 citations Thijn R. Brummelkamp, René Bernards et al. profile →
Metastasis genes: A progression puzzle

2002 636 citations René Bernards et al. profile →
CDK-Independent Activation of Estrogen Receptor by Cyclin D1

1997 607 citations René Bernards et al. Cell profile →
Exploiting senescence for the treatment of cancer

2022 499 citations Liqin Wang, René Bernards et al. profile →
Expression of class I major histocompatibility antigens switched off by highly oncogenic adenovirus 12 in transformed rat cells

1983 492 citations René Bernards et al. profile →
Evolving therapeutic landscape of advanced hepatocellular carcinoma

2022 450 citations René Bernards, Wenxin Qin et al. profile →
Rational combinations of targeted cancer therapies: background, advances and challenges

2022 280 citations Haojie Jin, Liqin Wang et al. profile →
Precision treatment in advanced hepatocellular carcinoma

2024 188 citations René Bernards, Wenxin Qin et al. profile →
Hepatocellular carcinoma: signaling pathways and therapeutic advances

2025 62 citations René Bernards, Wenxin Qin et al. profile →

Peers

Countries citing papers authored by René Bernards

Since Specialization

Citations

This map shows the geographic impact of René Bernards's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by René Bernards with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites René Bernards more than expected).

Fields of papers citing papers by René Bernards

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by René Bernards. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by René Bernards. The network helps show where René Bernards may publish in the future.

Co-authorship network of co-authors of René Bernards

This figure shows the co-authorship network connecting the top 25 collaborators of René Bernards. A scholar is included among the top collaborators of René Bernards based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with René Bernards. René Bernards is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Deciphering the role of the MALT1–RC3H1 axis in regulating GPX4 protein stability 2024 ·Proceedings of the National Academy of Sciences ·Jun Wang, Long Liao, Beiping Miao, Bo Yang, Botai Li, Xuhui Ma, (unknown), Shanshan Wu, Jia He, Qianqian Zhang, Shuyi Ji, Guang‐Zhi Jin, Jianming Zhang, Ying Cao, Hui Wang, Wenxin Qin, Chong Sun, René Bernards, Cun Wang	5
2	A phase II open‐label study with atezolizumab (atezo) in combination with bevacizumab (bev) in patients (pts) with advanced chemotherapy-resistant colorectal cancer (CRC) and MSI‐like molecular signature: The MoTriColor Consortium CT3 study. 2024 ·Journal of Clinical Oncology ·Élena Elez, Salvatore Siena, Andrea Sartore‐Bianchi, Fortunato Ciardiello, Erika Martinelli, Sabine Tejpar, (unknown), Andrés Cervantes, Ramón Salazar, (unknown), (unknown), Sanne C.F.A. Huijberts, (unknown), (unknown), (unknown), Gaetan de Schaetzen, Vı́ctor Moreno, René Bernards, Rodrigo Dienstmann, Josep Tabernero	2
3	1630P Phase I/Ib study of SHP2-ERK inhibition in KRASm pancreatic cancer (SHERPA trial) and preclinical identification of potential resistance markers 2023 ·Annals of Oncology ·(unknown), Antonio Mulero‐Sánchez, (unknown), Astrid Bosma, René Bernards, Alwin D. R. Huitema, Emile E. Voest, Sara Mainardi, Frans L. Opdam	2
4	The next big questions in cancer research 2023 ·Cell ·Sherene Loi, Jeffrey Settleman, Johanna A. Joyce, (unknown), René Bernards, Jia Fan, Juanita L. Merchant, Javid J. Moslehi, William R. Sellers	9
5	Identification of Autophagy-Related Genes as Targets for Senescence Induction Using a Customizable CRISPR-Based Suicide Switch Screen 2021 ·Molecular Cancer Research ·Arnout Schepers, Fleur Jochems, Cor Lieftink, Liqin Wang, Ziva Pogacar, Rodrigo Leite de Oliveira, Giulia De Conti, Roderick L. Beijersbergen, René Bernards	5
6	The Cancer SENESCopedia: A delineation of cancer cell senescence 2021 ·Cell Reports ·Fleur Jochems, Bram Thijssen, Giulia De Conti, (unknown), Ziva Pogacar, (unknown), Liqin Wang, Arnout Schepers, Cun Wang, Haojie Jin, Roderick L. Beijersbergen, Rodrigo Leite de Oliveira, Lodewyk F.A. Wessels, René Bernards	122
7	Adaptive Resistance to Dual BRAF/MEK Inhibition in BRAF-Driven Tumors through Autocrine FGFR Pathway Activation 2019 ·Clinical Cancer Research ·Victoria E. Wang, Jenny Y. Xue, Dennie T. Frederick, Yi Cao, Eva Lin, Catherine Wilson, Anatoly Urisman, David P. Carbone, Keith T. Flaherty, René Bernards, Piro Lito, Jeff Settleman, Frank McCormick	37
8	Comparative Network Reconstruction using mixed integer programming 2018 ·Bioinformatics ·Evert Bosdriesz, Anirudh Prahallad, Bertram Klinger, Anja Sieber, Astrid Bosma, René Bernards, Nils Blüthgen, Lodewyk F.A. Wessels	6
9	PIM Kinases Are a Potential Prognostic Biomarker and Therapeutic Target in Neuroblastoma 2018 ·Molecular Cancer Therapeutics ·Diede Brunen, (unknown), Cor Lieftink, Roderick L. Beijersbergen, René Bernards	27
10	FGFR1 Is a Potential Prognostic Biomarker and Therapeutic Target in Head and Neck Squamous Cell Carcinoma 2016 ·Clinical Cancer Research ·(unknown), Diede Brunen, Pauline M.W. van Kempen, Rob Noorlag, Remco de Bree, Cor Lieftink, Robert J.J. van Es, René Bernards, Stefan M. Willems	69
11	Mastermind-Like 3 Controls Proliferation and Differentiation in Neuroblastoma 2016 ·Molecular Cancer Research ·Guus J.J.E. Heynen, Ekaterina Nevedomskaya, (unknown), (unknown), Cor Lieftink, Andreas Schlicker, Wilbert Zwart, René Bernards, Prashanth Kumar Bajpe	15
12	Reduced NF1 Expression Confers Resistance to EGFR Inhibition in Lung Cancer 2014 ·Cancer Discovery ·Elza C. de Bruin, Catherine Cowell, Patricia H. Warne, Ming Jiang, Rebecca E. Saunders, Mary Ann Melnick, Scott Gettinger, Zenta Walther, Anna Wurtz, Guus J.J.E. Heynen, Daniëlle A.M. Heideman, Javier Gómez‐Román, Almudena García‐Castaño, Yixuan Gong, Marc Ladanyi, Harold Varmus, René Bernards, Egbert F. Smit, Katerina Politi, Julian Downward	154
13	USP9X Downregulation Renders Breast Cancer Cells Resistant to Tamoxifen 2014 ·Cancer Research ·Hendrika M. Oosterkamp, E. Marielle Hijmans, Thijn R. Brummelkamp, Sander Canisius, Lodewyk F.A. Wessels, Wilbert Zwart, René Bernards	37
14	Interleukin-1R–Associated Kinase 2 Is a Novel Modulator of the Transforming Growth Factor β Signaling Cascade 2010 ·Molecular Cancer Research ·Jasper Mullenders, Armida W. M. Fabius, (unknown), Hendrik J. Kuiken, Roderick L. Beijersbergen, René Bernards	1
15	Candidate Biomarkers of Response to an Experimental Cancer Drug Identified through a Large-scale RNA Interference Genetic Screen 2009 ·Clinical Cancer Research ·Jasper Mullenders, Wolfgang von der Saal, (unknown), (unknown), (unknown), Roderick L. Beijersbergen, Georg Tiefenthaler, Christian Klein, René Bernards	8
16	UNC45A Confers Resistance to Histone Deacetylase Inhibitors and Retinoic Acid 2009 ·Molecular Cancer Research ·Mirjam T. Epping, Lars A.T. Meijer, Johannes L. Bos, René Bernards	22
17	Analysis of the MammaPrint Breast Cancer Assay in a Predominantly Postmenopausal Cohort 2008 ·Clinical Cancer Research ·Ben S. Wittner, Dennis C. Sgroi, Paula D. Ryan, Tako J. Bruinsma, Annuska M. Glas, (unknown), Sonika Dahiya, Karleen Habin, René Bernards, Daniel A. Haber, Laura J. van’t Veer, Sridhar Ramaswamy	115
18	Phosphatidylinositol 3-Kinase Hyperactivation Results in Lapatinib Resistance that Is Reversed by the mTOR/Phosphatidylinositol 3-Kinase Inhibitor NVP-BEZ235 2008 ·Cancer Research ·Pieter J.A. Eichhorn, Magüi Gili, Maurizio Scaltriti, Violeta Serra, Marta Guzmán, Wouter Nijkamp, Roderick L. Beijersbergen, Vanesa Valero, Joan Seoane, René Bernards, José Baselga	378
19	A functional genetic screen identifies retinoic acid signaling as a target of histone deacetylase inhibitors 2007 ·Proceedings of the National Academy of Sciences ·Mirjam T. Epping, Liming Wang, Jane A. Plumb, Michèle Lieb, Hinrich Gronemeyer, Robert Brown, René Bernards	65
20	A Cell Proliferation Signature Is a Marker of Extremely Poor Outcome in a Subpopulation of Breast Cancer Patients 2005 ·Cancer Research ·Hongyue Dai, Laura van’t Veer, John R. Lamb, Yudong D. He, Mao Mao, Bernard M. Fine, René Bernards, Marc J. van de Vijver, Paul Deutsch, Alan B. Sachs, Roland Stoughton, Stephen Friend	207

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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