Karen J. Coffman

2.7k citations

18 papers · 414 indexed · h-index 11

Neurology top 10%
- Parkinson's Disease Mechanisms and Treatments 2
Pharmacology top 10%
- Cholinesterase and Neurodegenerative Diseases 4
Organic Chemistry
- Synthesis of heterocyclic compounds 2
- Synthesis and Reactions of Organic Compounds 2
- Synthesis and Biological Evaluation 2
Cellular and Molecular Neuroscience
Physiology
- Alzheimer's disease research and treatments 5
Physical and Theoretical Chemistry
- Chemical Reactions and Mechanisms 3
Computational Theory and Mathematics
- Computational Drug Discovery Methods 2

Co-authors: Patrick R. Verhoest Richard F. Smith Michael A. Brodney Christopher Houle Stefanus J. Steyn Ravi G. Kurumbail Zdenek Berger Elie Needle
Cited by: Neurology Pharmacology Organic Chemistry
Journals: Journal of Medicinal Chemistry (4 papers)Alzheimer s & Dementia (2 papers)Bioorganic & Medicinal Chemistry Letters (2 papers)
Partner nations: United States China United Kingdom

In The Last Decade

Karen J. Coffman

18 papers receiving 404 citations

Peers

Countries citing papers authored by Karen J. Coffman

Since Specialization

Citations

This map shows the geographic impact of Karen J. Coffman's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Karen J. Coffman with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Karen J. Coffman more than expected).

Fields of papers citing papers by Karen J. Coffman

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Karen J. Coffman. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Karen J. Coffman. The network helps show where Karen J. Coffman may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Karen J. Coffman, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Karen J. Coffman Line = papers co-authored together Karen J. Coffman links everyone, so they are left out of the graph.

All Works

Sort: Min cites: Since: Top N: Style:

18 of 18 papers shown

#	Work
1	Design of Next-Generation DGAT2 Inhibitor PF-07202954 with Longer Predicted Half-Life ACS Medicinal Chemistry Letters ·Kevin J. Filipski,David J. Edmonds,Michelle R. Garnsey,Ta-Wen Liu,Karen J. Coffman,Kentaro Futatsugi,Jack C. Lee,Steven V. O’Neil,Ahmad Dardiri,Deane M. Nason,J Gosset,Christine C. Orozco,Mitch Trauernicht,ShehlaNajibi Sidik,Jemy A. Gutierrez,N. Sinaei,Trenton T. Ross,Ingrid A. Stock,Gregory J. Tesz,Robert Dullea	2023	1
2	Imaging Leucine-Rich Repeat Kinase 2 In Vivo with ¹⁸F-Labeled Positron Emission Tomography Ligand Journal of Medicinal Chemistry ·Zhen Chen,Jiahui Chen,Laigao Chen,Harriet Camp Lounsbery,Jian Rong,Hualong Fu,Tuo Shao,Karen J. Coffman,Stefanus J. Steyn,April T. Davenport,James B. Daunais,Ahmed Haider,GuoRui-feng,Lee Josephson,Hsiao‐Ying Wey,Lei Zhang,Steven H. Liang	2022	10
3	Scalable, Telescoped Hydrogenolysis–Enzymatic Decarboxylation Process for the Asymmetric Synthesis of (R)-α-Heteroaryl Propionic Acids Organic Process Research & Development ·Gary Boyle,Scott P. France,李寒月,Deane M. Nason,孝義三上,Roger M. Howard,Karen J. Coffman,Qingyi Yang,Aaron Smith,Edelweiss Evrard,Wei Li,vinod pached,Lixia Yang,Zhiguang Chen,Qingli Zhang,Kateřina Klečková,吴秋红	2020	8
4	Two Routes to 4-Fluorobenzisoxazol-3-one in the Synthesis of a 5-HT₄Partial Agonist Organic Process Research & Development ·Daniel W. Widlicka,John C. Murray,Karen J. Coffman,Rabia Güleç,Michael A. Brodney,김병덕,Brian Samas	2016	7
5	Discovery and Preclinical Profiling of 3-[4-(Morpholin-4-yl)-7 H -pyrrolo[2,3- d ]pyrimidin-5-yl]benzonitrile (PF-06447475), a Highly Potent, Selective, Brain Penetrant, and in Vivo Active LRRK2 Kinase Inhibitor Journal of Medicinal Chemistry ·Jaclyn L. Henderson,Bethany L. Kormos,Matthew M. Hayward,Karen J. Coffman,J. Jasti,Ravi G. Kurumbail,Travis T. Wager,Patrick R. Verhoest,G. Stephen Noell,Yi Chen,Elie Needle,Zdenek Berger,Stefanus J. Steyn,Christopher Houle,Warren D. Hirst,Paul Galatsis	2014	140
6	Metabolism of a Serotonin-4 Receptor Partial Agonist 4-{4-[4-Tetrahydrofuran-3-yloxy)-Benzo[d]Isoxazol-3-yloxymethyl]-Piperidin-1-ylmethyl}-Tetrahydropyran-4-ol (TBPT): Identification of an Unusual Pharmacologically Active Cyclized Oxazolidine Metabolite in Human Journal of Pharmaceutical Sciences ·Aarti Sawant‐Basak,Karen J. Coffman,Gregory S. Walker,Tim F. Ryder,Elaine Tseng,Emily Miller,Süleyman Özbek,Michelle Vanase‐Frawley,John W. Wong,Michael A. Brodney,Sylvi Wulandari,R. Scott Obach	2013	12
7	Design and Discovery of 6-[(3S,4S)-4-Methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one (PF-04447943), a Selective Brain Penetrant PDE9A Inhibitor for the Treatment of Cognitive Disorders Journal of Medicinal Chemistry ·Patrick R. Verhoest,Kari R. Fonseca,Xinjun Hou,Agisni Fatihaturrohmah,Michael L. Corman,Christopher J. Helal,Michelle M. Claffey,Jamison B. Tuttle,Karen J. Coffman,J. F. Hu,Frederick Nelson,Robin J. Kleiman,Frank S. Menniti,Christopher J. Schmidt,Michelle Vanase‐Frawley,Spiros Liras	2012	53
8	Identification of Multiple 5-HT₄Partial Agonist Clinical Candidates for the Treatment of Alzheimer’s Disease Journal of Medicinal Chemistry ·Michael A. Brodney,David E. Johnson,Aarti Sawant‐Basak,Karen J. Coffman,F miftahuddin,莊宜珈,Katherine Fisher,Hieke,Nobuaki Waizumi,Laura McDowell,Αλέξανδρος Παπανικολάου,Betty Pettersen,Anne W. Schmidt,Elaine Tseng,K J Stutzman-Engwall,David M. Rubitski,Michelle Vanase‐Frawley,Sarah Grimwood	2012	36
9	6-Amino-4-(pyrimidin-4-yl)pyridones: Novel glycogen synthase kinase-3β inhibitors Bioorganic & Medicinal Chemistry Letters ·Karen J. Coffman,Michael A. Brodney,James M. Cook,Lorraine F. Lanyon,Jayvardhan Pandit,Subas M. Sakya,Joel B. Schachter,Koushik Yadagiri,Matthew D. Wessel	2011	25
10	Pharmacodynamics and Pharmacokinetics of the γ-Secretase Inhibitor PF-3084014 Journal of Pharmacology and Experimental Therapeutics ·Thomas A. Lanz,Kathleen M. Wood,K. Richter,Charles E. Nolan,Stacey L. Becker,Nikolay Pozdnyakov,R. MacLarenl,Ping Du,Christine Oborski,Douglas E. Wood,Antony Sami Auxilia,James E. Finley,Sharon Sokolowski,Carol Hicks,Karen J. Coffman,Kieran F. Geoghegan,Michael A. Brodney,Dane Liston,Barbara Tate	2010	39
11	P1‐259: Aβ variability and effect of gamma secretase inhibition on cerebrospinal fluid levels of Aβ in healthy volunteers Alzheimer s & Dementia ·Holly Soares,Bích Hà Nguyễn,Keisuke HAMASAKI,Dane Liston,Carmen Guillén Lorente,Karen J. Coffman,Barbara Tate,Ruolun Qiu,Ellen Q. Wang,Xiaoxi Li,Grace W. M. Chew,Subhashis Banerjee,Stanford S. Jhee,Larry Ereshefsky,Terence Fullerton	2009	8
12	P2‐375: Efficacy of the novel γ‐secretase inhibitor, PF‐3084014, in reducing Aβ in brain, CSF, and plasma in guinea pigs and Tg2576 mice Alzheimer s & Dementia ·Kathleen M. Wood,Thomas A. Lanz,Karen J. Coffman,Stacey L. Becker,F Sanz,Charles E. Nolan,K. Richter,James E. Finley,J.A. Marshall,Michael A. Brodney,Barbara Tate	2008	11
13	Synthesis and structure-activity relationships of CP-122,721, a second-generation NK-1 receptor antagonist Bioorganic & Medicinal Chemistry Letters ·Terry Rosen,Karen J. Coffman,Stafford McLean,H H Frankel,Dianne K. Bryce,Курбангалиева Алина Мираславовна,Megumi Tsuchiya,Atsushi Nagahisa,Neslihan Gezer,John Lowe	1998	28
14	ChemInform Abstract: Amidrazones. Part 9. Convenient Synthesis of 1‐Alkyl‐1‐phenylhydrazines and α,β‐Unsaturated Amidrazones via Base‐Promoted Reactions of 1,1‐Disubstituted‐ 3‐amino‐4,5‐dihydro‐1H‐pyrazolium Salts. Chemischer Informationsdienst ·L. D. Liozner,Susan Joyce,William J. Ryan,Karen J. Coffman,J. L. Ong,Brenda R. Simons,Dingshan Yu,Harrington Al	1986	4
15	Amidrazones 9. Convenient Syntheses of 1-Alkyl-1-Phenylhydrazines and α,β-Unsaturated Amidrazones Via Base-Promoted Reactions of 1,1-Disubstituted-3-Amino-4,5-Dihydro-1H-Pyrazolium Salts Synthetic Communications ·Richard F. Smith,Susan Joyce,William J. Ryan,Karen J. Coffman,J. L. Ong,Brenda R. Simons,Dingshan Yu,Harrington Al	1986	10
16	ChemInform Abstract: AMIDRAZONES. 8. SYNTHESIS OF 1,2,4‐OXADIAZOLES BY THERMOLYSIS OF N3‐ACYLAMIDRAZONE YLIDES Chemischer Informationsdienst ·L. D. Liozner,Karen J. Coffman,龍太郎森脇	1983	1
17	Amidrazones. 8. Synthesis of 1,2,4‐oxdiazoles by thermolysis of N³‐acylamidrazone ylides Journal of Heterocyclic Chemistry ·Richard F. Smith,Karen J. Coffman,Hermann Stauffer	1983	5
18	Deamination of Quaternary Hydrazinium Halides. A Convenient Synthesis of Tertiary Amines Synthetic Communications ·Richard F. Smith,Karen J. Coffman	1982	16

About Karen J. Coffman

Karen J. Coffman is a scholar working on Physical and Theoretical Chemistry, Organic Chemistry and Pharmacology, having authored 18 papers that have together received 414 indexed citations. Recurring topics across this work include Alzheimer's disease research and treatments (5 papers), Cholinesterase and Neurodegenerative Diseases (4 papers), Chemical Reactions and Mechanisms (3 papers), Synthesis of heterocyclic compounds (2 papers), Computational Drug Discovery Methods (2 papers), Parkinson's Disease Mechanisms and Treatments (2 papers), Synthesis and Reactions of Organic Compounds (2 papers) and Synthesis and Biological Evaluation (2 papers). The work is most often cited by research in Neurology (100 citations), Pharmacology (100 citations) and Organic Chemistry (124 citations). Karen J. Coffman has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Patrick R. Verhoest, Richard F. Smith, Michael A. Brodney, Christopher Houle, Stefanus J. Steyn, Ravi G. Kurumbail, Zdenek Berger, Elie Needle, Matthew M. Hayward and Jaclyn L. Henderson. Their work appears in journals such as Journal of Medicinal Chemistry, Alzheimer s & Dementia, Bioorganic & Medicinal Chemistry Letters, Organic Process Research & Development and Journal of Pharmaceutical Sciences.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

Explore authors with similar magnitude of impact