Klaas Schildknegt

965 citations

25 papers · 738 indexed · h-index 15

Organic Chemistry top 5%
- Synthesis and Biological Evaluation 4
- Synthesis and Catalytic Reactions 2
- Asymmetric Synthesis and Catalysis 2
Pharmaceutical Science top 5%
- Chemical Reactions and Isotopes 5
Pharmacology top 5%
- Cholinesterase and Neurodegenerative Diseases 2
- Pharmacogenetics and Drug Metabolism 2
Biochemistry
Inorganic Chemistry
Molecular Biology
- Chemical Synthesis and Analysis 4
Cellular and Molecular Neuroscience
- Neuroscience and Neuropharmacology Research 2

Co-authors: Jeffrey Aubé Rajesh Iyengar Ken S. Feldman Konstantinos A. Agrios Gregory L. Milligan Craig J. Mossman Pankaj Desai Aruna Sambandam
Cited by: Organic Chemistry Pharmaceutical Science Pharmacology
Journals: Journal of the American Chemical Society (2 papers)Journal of Medicinal Chemistry (2 papers)The Journal of Organic Chemistry (4 papers)
Partner nations: United States United Kingdom Sweden

In The Last Decade

Klaas Schildknegt

24 papers receiving 717 citations

Peers

Countries citing papers authored by Klaas Schildknegt

Since Specialization

Citations

This map shows the geographic impact of Klaas Schildknegt's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Klaas Schildknegt with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Klaas Schildknegt more than expected).

Fields of papers citing papers by Klaas Schildknegt

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Klaas Schildknegt. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Klaas Schildknegt. The network helps show where Klaas Schildknegt may publish in the future.

Co-authorship network

The 25 scholars most cited alongside Klaas Schildknegt, linked wherever they have co-authored with each other. Click a name or a connecting line to browse the papers they share.

Border = papers with Klaas Schildknegt Line = papers co-authored together Klaas Schildknegt links everyone, so they are left out of the graph.

All Works

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20 of 20 papers shown

#	Work
1	The Metabolism of Lufotrelvir, a Prodrug Investigated for the Treatment of SARS-COV2 in Humans Following Intravenous Administration Drug Metabolism and Disposition ·N. Cheruvu,Esther van Duijn,Pieter A. Spigt,Ioana Barbu,Sima S. Toussi,Klaas Schildknegt,Rhys Jones,R. Scott Obach	2023	5
2	Deuterated active pharmaceutical ingredients: A science‐based proposal for synthesis, analysis, and control. Part 1: Framing the problem Journal of Labelled Compounds and Radiopharmaceuticals ·Boris A. Czeskis,Charles S. Elmore,Anthony R. Haight,David Hesk,Brad D. Maxwell,Scott A. Miller,Thomas Raglione,Klaas Schildknegt,John F. Traverse,Peng Wang	2019	21
3	Identification and Development of an Irreversible Monoacylglycerol Lipase (MAGL) Positron Emission Tomography (PET) Radioligand with High Specificity Journal of Medicinal Chemistry ·Lei Zhang,Christopher R. Butler,Kevin Maresca,Akihiro Takano,Sangram Nag,Zhisheng Jia,Ryosuke Arakawa,Justin R. Piro,Tarek A. Samad,Deborah L. Smith,Deane M. Nason,Steven V. O’Neil,Laura A. McAllister,Klaas Schildknegt,Patrick Trapa,Timothy J. McCarthy,Anabella Villalobos,Christer Halldin	2019	19
4	Metabolism of a 5HT6 Antagonist, 2-Methyl-1-(Phenylsulfonyl)-4-(Piperazin-1-yl)-1H-Benzo[d]imidazole (SAM-760): Impact of Sulfonamide Metabolism on Diminution of a Ketoconazole-Mediated Clinical Drug-Drug Interaction Drug Metabolism and Disposition ·Aarti Sawant‐Basak,R. Scott Obach,Angela C. Doran,Peter Lockwood,Klaas Schildknegt,Hongying Gao,Jessica Mancuso,Susanna Tse,Thomas A. Comery	2018	6
5	Identification of a Novel Positron Emission Tomography (PET) Ligand for Imaging β-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE-1) in Brain Journal of Medicinal Chemistry ·Lei Zhang,Laigao Chen,Jason K. Dutra,Elizabeth Beck,Sangram Nag,Akihiro Takano,Nahid Amini,Ryosuke Arakawa,Michael A. Brodney,Leanne M. Buzon,Shawn D. Doran,Lorraine F. Lanyon,Timothy J. McCarthy,Kelly R. Bales,Charles E. Nolan,Brian T. O’Neill,Klaas Schildknegt,Christer Halldin,Anabella Villalobos	2018	15
6	Novel Application of the Two‐Period Microtracer Approach to Determine Absolute Oral Bioavailability and Fraction Absorbed of Ertugliflozin Clinical and Translational Science ·Sangeeta Raje,Ernesto Callegari,Vaishali Sahasrabudhe,Alfin D. N. Vaz,Haihong Shi,Eric Fluhler,Eric Woolf,Klaas Schildknegt,Kyle Matschke,Christine Alvey,Susan Zhou,Dimitris Papadopoulos,Robert J. Fountaine,Didier Saur,Steven G. Terra,Lloyd Stevens,Daniel Gaunt,David L. Cutler	2018	33
7	Identification and Profiling of a Selective and Brain Penetrant Radioligand for in Vivo Target Occupancy Measurement of Casein Kinase 1 (CK1) Inhibitors ACS Chemical Neuroscience ·Travis T. Wager,Paul Galatsis,Ramalakshmi Y. Chandrasekaran,Todd W. Butler,Jianke Li,Lei Zhang,Scot Mente,Chakrapani Subramanyam,Shenping Liu,Angela C. Doran,Cheng Chang,Katherine Fisher,Sarah Grimwood,Joseph R. Hedde,M. Marconi,Klaas Schildknegt	2017	21
8	Determination of Antibody–Drug Conjugate Released Payload Species Using Directed in Vitro Assays and Mass Spectrometric Interrogation Bioconjugate Chemistry ·Andrew J. Bessire,T. Eric Ballard,Manoj B. Charati,Justin D. Cohen,Michael Green,My‐Hanh Lam,Frank Loganzo,Birte Nolting,Betsy S. Pierce,Sujiet Puthenveetil,Lee R. Roberts,Klaas Schildknegt,Chakrapani Subramanyam	2016	26
9	Deuterium Isotope Effects on Drug Pharmacokinetics. I. System-Dependent Effects of Specific Deuteration with Aldehyde Oxidase Cleared Drugs Drug Metabolism and Disposition ·Raman Sharma,Timothy J. Strelevitz,Hongying Gao,Alan Clark,Klaas Schildknegt,R. Scott Obach,Sharon L. Ripp,Douglas K. Spracklin,Larry M. Tremaine,Alfin D. N. Vaz	2011	81
10	Metabolism, Pharmacokinetics, and Excretion of the 5-Hydroxytryptamine1B Receptor Antagonist Elzasonan in Humans Drug Metabolism and Disposition ·Amin Kamel,R. Scott Obach,Kevin Colizza,Weiwei Wang,Thomas N. O’Connell,Richard V. Coelho,Ryan M. Kelley,Klaas Schildknegt	2010	7
11	10th international symposium on the synthesis and applications of isotopes and isotopically labelled compounds—applications of isotopes in organic and bioorganic reaction mechanisms Session 4, Wednesday, June 17, 2009 Journal of Labelled Compounds and Radiopharmaceuticals ·Klaas Schildknegt,Wähälä Kristiina	2010	0
12	Genotoxicity of 2-(3-Chlorobenzyloxy)-6-(piperazinyl)pyrazine, a Novel 5-Hydroxytryptamine2c Receptor Agonist for the Treatment of Obesity: Role of Metabolic Activation Drug Metabolism and Disposition ·Amit S. Kalgutkar,Deepak Dalvie,Jiri Aubrecht,Evan B. Smith,Stephanie L. Coffing,Jennifer Cheung,Chandra Vage,Mary E. Lame,Phoebe Chiang,Kim F. McClure,Tristan S. Maurer,Richard V. Coelho,Victor F. Soliman,Klaas Schildknegt	2007	36
13	An efficient large‐scale synthesis of 1H‐indazole‐[3‐¹⁴C]carboxylic acid Journal of Labelled Compounds and Radiopharmaceuticals ·Richard V. Coelho,Klaas Schildknegt	2007	2
14	Revisiting a Classic Approach to the Aspidosperma Alkaloids: An Intramolecular Schmidt Reaction Mediated Synthesis of (+)-Aspidospermidine The Journal of Organic Chemistry ·Rajesh Iyengar,Klaas Schildknegt,Martha Morton,Jeffrey Aubé	2005	87
15	Regiocontrol in an Intramolecular Schmidt Reaction: Total Synthesis of (+)-Aspidospermidine Organic Letters ·Rajesh Iyengar,Klaas Schildknegt,Jeffrey Aubé	2000	83
16	The Synthesis of an Aminohexyl-containing Analog of the Chromanol Leukotriene B4 Receptor Antagonist CP-195543: A Scaffold for the Preparation of Derivatized Analogs Heterocycles ·Lawrence A. Reiter,Brian P. Jones,Klaas Schildknegt,Kathyrn F. Wright,Henry J. Showell,James P. Dittami,Keith E. McCarthy	2000	1
17	Mannich reactions using benzyl azide as a latent N-(phenylamino)methylating agent Tetrahedron Letters ·Klaas Schildknegt,Konstantinos A. Agrios,Jeffrey Aubé	1998	17
18	Preparation of Five-Membered Nitrogen-Containing Heterocycles via [Three-Atom + Two-Atom] Combination of Tosylamide Anions with Phenyl(propynyl)iodonium Triflate The Journal of Organic Chemistry ·Ken S. Feldman,Michelle M. Bruendl,Klaas Schildknegt	1995	33
19	Thioamide and Thioester Cyclopentane Synthesis via Trimethyltin Radical Catalyzed Alkenylation of Substituted (Thiocarbonyl)cyclopropanes The Journal of Organic Chemistry ·Ken S. Feldman,Klaas Schildknegt	1994	10
20	<title>Negative chemical amplification resist systems based on polyhydroxystyrenes and N-substituted imides or aldehydes</title> Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE ·Hiroshi Itô,Klaas Schildknegt,Eugene A. Mash	1991	1

About Klaas Schildknegt

Klaas Schildknegt is a scholar working on Pharmaceutical Science, Organic Chemistry and Pharmacology, having authored 25 papers that have together received 738 indexed citations. Recurring topics across this work include Chemical Reactions and Isotopes (5 papers), Chemical Synthesis and Analysis (4 papers), Synthesis and Biological Evaluation (4 papers), Neuroscience and Neuropharmacology Research (2 papers), Cholinesterase and Neurodegenerative Diseases (2 papers), Synthesis and Catalytic Reactions (2 papers), Pharmacogenetics and Drug Metabolism (2 papers) and Asymmetric Synthesis and Catalysis (2 papers). The work is most often cited by research in Organic Chemistry (493 citations), Pharmaceutical Science (81 citations) and Pharmacology (109 citations). Klaas Schildknegt has collaborated with scholars based in United States, United Kingdom and Sweden. Frequent co-authors include Jeffrey Aubé, Rajesh Iyengar, Ken S. Feldman, Konstantinos A. Agrios, Gregory L. Milligan, Craig J. Mossman, Pankaj Desai, Aruna Sambandam, R. Scott Obach and Alfin D. N. Vaz. Their work appears in journals such as Journal of the American Chemical Society, Journal of Medicinal Chemistry and The Journal of Organic Chemistry.

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