Matthew D. Hirschey

17.8k total citations · 5 hit papers
82 papers, 11.9k citations indexed

About

Matthew D. Hirschey is a scholar working on Geriatrics and Gerontology, Physiology and Molecular Biology. According to data from OpenAlex, Matthew D. Hirschey has authored 82 papers receiving a total of 11.9k indexed citations (citations by other indexed papers that have themselves been cited), including 41 papers in Geriatrics and Gerontology, 40 papers in Physiology and 39 papers in Molecular Biology. Recurrent topics in Matthew D. Hirschey's work include Sirtuins and Resveratrol in Medicine (41 papers), Adipose Tissue and Metabolism (34 papers) and Biochemical effects in animals (15 papers). Matthew D. Hirschey is often cited by papers focused on Sirtuins and Resveratrol in Medicine (41 papers), Adipose Tissue and Metabolism (34 papers) and Biochemical effects in animals (15 papers). Matthew D. Hirschey collaborates with scholars based in United States, Denmark and Canada. Matthew D. Hirschey's co-authors include Eric Verdin, Tadahiro Shimazu, Danica Chen, Katharine Brown, Xiaolei Qiu, David B. Lombard, Gregory R. Wagner, Marcia C. Haigis, Bjoern Schwer and Olga Ilkayeva and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Matthew D. Hirschey

78 papers receiving 11.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

2010 1.4k citations Matthew D. Hirschey, Tadahiro Shimazu et al. profile →
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

2012 1.3k citations Tadahiro Shimazu, Matthew D. Hirschey et al. Science profile →
Calorie Restriction Reduces Oxidative Stress by SIRT3-Mediated SOD2 Activation

2010 1.1k citations Matthew D. Hirschey, Eric Verdin et al. Cell Metabolism profile →
Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

2007 1.0k citations Raúl Mostoslavsky, Matthew D. Hirschey et al. profile →
Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling

2010 528 citations Eric Verdin, Matthew D. Hirschey et al. Trends in Biochemical Sciences profile →

Peers

Countries citing papers authored by Matthew D. Hirschey

Since Specialization

Citations

This map shows the geographic impact of Matthew D. Hirschey's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Matthew D. Hirschey with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Matthew D. Hirschey more than expected).

Fields of papers citing papers by Matthew D. Hirschey

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Matthew D. Hirschey. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Matthew D. Hirschey. The network helps show where Matthew D. Hirschey may publish in the future.

Co-authorship network of co-authors of Matthew D. Hirschey

This figure shows the co-authorship network connecting the top 25 collaborators of Matthew D. Hirschey. A scholar is included among the top collaborators of Matthew D. Hirschey based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Matthew D. Hirschey. Matthew D. Hirschey is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

#	Work	Indexed citations
1	Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence 2024 ·Science Advances ·(unknown), (unknown), (unknown), (unknown), (unknown), Olga Ilkayeva, (unknown), (unknown), Jeffrey I. Everitt, James V. Alvarez, Gregory M. Palmer, Matthew D. Hirschey, Nirmala Ramanujam	5
2	Statin therapy inhibits fatty acid synthase via dynamic protein modifications 2022 ·Nature Communications ·(unknown), Gregory R. Wagner, Kristin A. Anderson, Scott B. Crown, Guofang Zhang, J. Will Thompson, Olga Ilkayeva, Robert D. Stevens, Paul A. Grimsrud, Rhushikesh A. Kulkarni, Donald S. Backos, Jordan L. Meier, Matthew D. Hirschey	18
3	Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice 2022 ·Journal of Biological Chemistry ·Dhaval P. Bhatt, Christine A. Mills, Kristin A. Anderson, Bárbara J. Henriques, (unknown), (unknown), Juan Liu, Olga Ilkayeva, (unknown), (unknown), Donald S. Backos, Michael B. Major, Paul A. Grimsrud, Cláudio M. Gomes, Matthew D. Hirschey	13
4	Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans 2021 ·Redox Biology ·Kathleen A. Hershberger, John P. Rooney, (unknown), (unknown), Rakesh Bodhicharla, Laura L. Maurer, Ian T. Ryde, (unknown), (unknown), Jonathan D. Hibshman, (unknown), Dhaval P. Bhatt, Olga Ilkayeva, Matthew D. Hirschey, Joel N. Meyer	17
5	Cellular energetics and mitochondrial uncoupling in canine aging 2019 ·GeroScience ·Justin W. Nicholatos, (unknown), (unknown), (unknown), Adam B. Francisco, (unknown), (unknown), Olga Ilkayeva, Frank K. Huynh, Maxim Dokukin, Dmytro O. Volkov, Michael A. Weinstein, Adam R. Boyko, Richard A. Miller, Igor Sokolov, Matthew D. Hirschey, Sergiy Libert	34
6	Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation 2017 ·Alcoholism Clinical and Experimental Research ·Mohammed A. Assiri, (unknown), Peter S. Harris, (unknown), Yongliang Liang, Colin T. Shearn, David J. Orlicky, James R. Roede, Matthew D. Hirschey, Donald S. Backos, Kristofer S. Fritz	25
7	Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling 2017 ·Cell Metabolism ·Heather J. Weir, Pallas Yao, Frank K. Huynh, Caroline C. Escoubas, Renata L. S. Gonçalves, Kristopher Burkewitz, Raymond Laboy, Matthew D. Hirschey, William B. Mair	275
8	Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways 2017 ·Journal of Biological Chemistry ·Yue Hu, Ivana Semova, Xiaowei Sun, Hong Mo Kang, (unknown), Anthony N. Hollenberg, David Masson, Matthew D. Hirschey, Ji Miao, Sudha B. Biddinger	14
9	SIRT4 Is a Lysine Deacylase that Controls Leucine Metabolism and Insulin Secretion 2017 ·Cell Metabolism ·Kristin A. Anderson, Frank K. Huynh, Kelsey H. Fisher‐Wellman, J. Darren Stuart, Brett S. Peterson, Jonathan D. Douros, Gregory R. Wagner, J. Will Thompson, Andreas S. Madsen, Michelle Green, R. Michael Sivley, Olga Ilkayeva, Robert D. Stevens, Donald S. Backos, John A. Capra, Christian A. Olsen, Jonathan E. Campbell, Deborah M. Muoio, Paul A. Grimsrud, Matthew D. Hirschey	256
10	Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADH 2016 ·Journal of Biological Chemistry ·Andreas S. Madsen, (unknown), (unknown), Kristin A. Anderson, Jonas S. Laursen, (unknown), Frank K. Huynh, Ana R. Colaço, Donald S. Backos, Peter Fristrup, Matthew D. Hirschey, Christian A. Olsen	83
11	From the Cover: Arsenite Uncouples Mitochondrial Respiration and Induces a Warburg-like Effect inCaenorhabditis elegans 2016 ·Toxicological Sciences ·Anthony L. Luz, (unknown), Dhaval P. Bhatt, Olga Ilkayeva, Laura L. Maurer, Matthew D. Hirschey, Joel N. Meyer	38
12	Neuronal CRTC-1 Governs Systemic Mitochondrial Metabolism and Lifespan via a Catecholamine Signal 2015 ·Cell ·Kristopher Burkewitz, Ianessa Morantte, Heather J. Weir, Robin W. Yeo, Yue Zhang, Frank K. Huynh, Olga Ilkayeva, Matthew D. Hirschey, Ana R. Grant, William B. Mair	139
13	Metabolic Regulation by Lysine Malonylation, Succinylation, and Glutarylation 2015 ·Molecular & Cellular Proteomics ·Matthew D. Hirschey, Yingming Zhao	336
14	Measurement of Fatty Acid Oxidation Rates in Animal Tissues and Cell Lines 2014 ·Methods in enzymology on CD-ROM/Methods in enzymology ·Frank K. Huynh, Michelle Green, Timothy R. Koves, Matthew D. Hirschey	117
15	Mitochondria, Energetics, Epigenetics, and Cellular Responses to Stress 2014 ·Environmental Health Perspectives ·Daniel T. Shaughnessy, Kimberly A. McAllister, Leroy Worth, Astrid C. Haugen, Joel N. Meyer, Frederick E. Domann, Bennett Van Houten, Raúl Mostoslavsky, Scott J. Bultman, Andrea Baccarelli, Thomas J. Begley, Robert W. Sobol, Matthew D. Hirschey, Trey Ideker, Janine H. Santos, William C. Copeland, Raymond R. Tice, David M. Balshaw, Frederick L. Tyson	210
16	Targeting sirtuins for the treatment of diabetes 2013 ·Diabetes Management ·Frank K. Huynh, Kathleen A. Hershberger, Matthew D. Hirschey	43
17	Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor breakdown → 2012 ·Science ·Tadahiro Shimazu, Matthew D. Hirschey, John C. Newman, Wenjuan He, Kotaro Shirakawa, Natacha Le Moan, Carrie A. Grueter, (unknown), Laura R. Saunders, Robert Stevens, Christopher B. Newgard, Robert V. Farese, Rafael de Cabo, Scott M. Ulrich, Katerina Akassoglou, Eric Verdin	1329
18	Hepatic Insulin Signaling Is Required for Obesity-Dependent Expression of SREBP-1c mRNA but Not for Feeding-Dependent Expression 2012 ·Cell Metabolism ·Joel T. Haas, Ji Miao, Dipanjan Chanda, Yanning Wang, Enpeng Zhao, Mary E. Haas, Matthew D. Hirschey, Bhavapriya Vaitheesvaran, Robert V. Farese, Irwin J. Kurland, Mark J. Graham, Rosanne M. Crooke, Fabienne Foufelle, Sudha B. Biddinger	155
19	Whole-organism screening for gluconeogenesis identifies activators of fasting metabolism 2012 ·Nature Chemical Biology ·Philipp Gut, Bernat Baeza-Raja, Olov Andersson, (unknown), Joseph Hsiao, Daniel Hesselson, Katerina Akassoglou, Eric Verdin, Matthew D. Hirschey, Didier Y. R. Stainier	141
20	Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling breakdown → 2010 ·Trends in Biochemical Sciences ·Eric Verdin, Matthew D. Hirschey, Lydia W.S. Finley, Marcia C. Haigis	528

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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