Christopher B. Newgard

65.7k total citations · 17 hit papers
397 papers, 44.6k citations indexed

About

Christopher B. Newgard is a scholar working on Molecular Biology, Surgery and Physiology. According to data from OpenAlex, Christopher B. Newgard has authored 397 papers receiving a total of 44.6k indexed citations (citations by other indexed papers that have themselves been cited), including 227 papers in Molecular Biology, 170 papers in Surgery and 155 papers in Physiology. Recurrent topics in Christopher B. Newgard's work include Pancreatic function and diabetes (158 papers), Adipose Tissue and Metabolism (103 papers) and Metabolism, Diabetes, and Cancer (89 papers). Christopher B. Newgard is often cited by papers focused on Pancreatic function and diabetes (158 papers), Adipose Tissue and Metabolism (103 papers) and Metabolism, Diabetes, and Cancer (89 papers). Christopher B. Newgard collaborates with scholars based in United States, Canada and Spain. Christopher B. Newgard's co-authors include Olga Ilkayeva, James R. Bain, Deborah M. Muoio, Michael J. Muehlbauer, Robert D. Stevens, Svati H. Shah, Roger H. Unger, Julie McGarry, Hans E. Hohmeier and Brett R. Wenner and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Christopher B. Newgard

392 papers receiving 43.9k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance

2009 2.4k citations Christopher B. Newgard, Jie An et al. profile →
Mitochondrial Overload and Incomplete Fatty Acid Oxidation Contribute to Skeletal Muscle Insulin Resistance

2008 1.6k citations Dorothy H. Slentz, Olga Ilkayeva et al. profile →
Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1

2001 1.5k citations Christopher B. Newgard et al. profile →
SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation

2010 1.4k citations Matthew D. Hirschey, Tadahiro Shimazu et al. profile →
Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor

2012 1.3k citations Tadahiro Shimazu, Matthew D. Hirschey et al. Science profile →
Molecular and metabolic mechanisms of insulin resistance and β-cell failure in type 2 diabetes

2008 920 citations Deborah M. Muoio, Christopher B. Newgard Nature Reviews Molecular Cell Biology profile →
Interplay between Lipids and Branched-Chain Amino Acids in Development of Insulin Resistance

2012 827 citations Christopher B. Newgard profile →
Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion.

2000 760 citations Hans E. Hohmeier, Christopher B. Newgard et al. profile →
Direct antidiabetic effect of leptin through triglyceride depletion of tissues

1997 567 citations May-Yun Wang, Christopher B. Newgard et al. Proceedings of the National Academy of Sciences profile →
Metabolomics and Metabolic Diseases: Where Do We Stand?

2016 544 citations Christopher B. Newgard profile →
Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children

2016 542 citations Christopher B. Newgard et al. Science profile →
Chapter 8 Use of Recombinant Adenovirus for Metabolic Engineering of Mammalian Cells

1994 528 citations Thomas Becker, Christopher B. Newgard et al. profile →
Hyperlipidemic Effects of Dietary Saturated Fats Mediated through PGC-1β Coactivation of SREBP

2005 513 citations Christopher B. Newgard et al. profile →
Circadian Clock NAD ⁺ Cycle Drives Mitochondrial Oxidative Metabolism in Mice

2013 507 citations Clara Bien Peek, Kathryn Moynihan Ramsey et al. Science profile →
Cafeteria Diet Is a Robust Model of Human Metabolic Syndrome With Liver and Adipose Inflammation: Comparison to High‐Fat Diet

2011 464 citations Michael J. Muehlbauer, Christopher B. Newgard et al. Obesity profile →
Mechanisms controlling pancreatic islet cell function in insulin secretion

2021 380 citations Jonathan E. Campbell, Christopher B. Newgard Nature Reviews Molecular Cell Biology profile →
Insulin action, type 2 diabetes, and branched-chain amino acids: A two-way street

2021 183 citations Phillip J. White, Robert W. McGarrah et al. Molecular Metabolism profile →

Peers

Countries citing papers authored by Christopher B. Newgard

Since Specialization

Citations

This map shows the geographic impact of Christopher B. Newgard's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Christopher B. Newgard with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Christopher B. Newgard more than expected).

Fields of papers citing papers by Christopher B. Newgard

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Christopher B. Newgard. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Christopher B. Newgard. The network helps show where Christopher B. Newgard may publish in the future.

Co-authorship network of co-authors of Christopher B. Newgard

This figure shows the co-authorship network connecting the top 25 collaborators of Christopher B. Newgard. A scholar is included among the top collaborators of Christopher B. Newgard based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Christopher B. Newgard. Christopher B. Newgard is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	Fiber Intervention Study in Prader-Willi Syndrome: Insights into Metabolic and Microbiota Shifts 2025 ·The Journal of Clinical Endocrinology & Metabolism ·Qiming Tan, Peng Ye, Edward C. Deehan, (unknown), (unknown), (unknown), Eytan Wine, Karen Madsen, Catherine J. Field, Mohammadreza Pakseresht, Olga Ilkayeva, Christopher B. Newgard, Jens Walter, Hein M. Tun, Andrea M. Haqq	1
2	Mutant IDH regulates glycogen metabolism from early cartilage development to malignant chondrosarcoma formation 2023 ·Cell Reports ·(unknown), Raymond Poon, (unknown), Puviindran Nadesan, Makoto Nakagawa, (unknown), (unknown), (unknown), Joan J. Guinovart, Jordi Durán, Christopher B. Newgard, Jay S. Wunder, Benjamin A. Alman	13
3	De novo lipogenesis fuels adipocyte autophagosome and lysosome membrane dynamics 2023 ·Nature Communications ·Leslie A. Rowland, Adı́lson Guilherme, Felipe Henriques, (unknown), (unknown), (unknown), Mark Kelly, (unknown), Gregory Hendricks, Meixia Pan, Xianlin Han, Olga Ilkayeva, Christopher B. Newgard, Michael Czech	28
4	Mitochondrial metabolites predict adverse cardiovascular events in individuals with diabetes 2023 ·JCI Insight ·Jessica A. Regan, Robert J. Mentz, (unknown), Jennifer B. Green, L. Truby, Olga Ilkayeva, Christopher B. Newgard, John B. Buse, Harald Sourij, C. David Sjöström, Naveed Sattar, Robert W. McGarrah, Yinggan Zheng, Darren K. McGuire, Eberhard Standl, Paul W. Armstrong, Eric D. Peterson, Adrian F. Hernandez, Rury R. Holman, Svati H. Shah	9
5	Maternal Metabolites Associated With Gestational Diabetes Mellitus and a Postpartum Disorder of Glucose Metabolism 2021 ·The Journal of Clinical Endocrinology & Metabolism ·Yu Liu, Alan Kuang, James R. Bain, Michael J. Muehlbauer, Olga Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, Denise Scholtens, William L. Lowe	17
6	Muscle Krüppel-like factor 15 regulates lipid flux and systemic metabolic homeostasis 2021 ·Journal of Clinical Investigation ·Liyan Fan, David R. Sweet, Domenick A. Prosdocimo, Vinesh Vinayachandran, E. Ricky Chan, Rongli Zhang, Olga Ilkayeva, Yuan Lü, (unknown), (unknown), Christopher B. Newgard, Mukesh K. Jain	20
7	Mechanisms controlling pancreatic islet cell function in insulin secretion breakdown → 2021 ·Nature Reviews Molecular Cell Biology ·Jonathan E. Campbell, Christopher B. Newgard	380
8	NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding 2021 ·Nature Metabolism ·Daniel C. Levine, (unknown), Hee‐Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, (unknown), (unknown), Yumiko Kobayashi, Biliana Marcheva, Peng Gao, Olga Ilkayeva, Chiaki Omura, Kathryn Moynihan Ramsey, Christopher B. Newgard, Grant D. Barish, Clara Bien Peek, Navdeep S. Chandel, Milan Mrksich, Joseph Bass	50
9	Metabolomic and genetic associations with insulin resistance in pregnancy 2020 ·Diabetologia ·Yu Liu, Alan Kuang, Octavious Talbot, James R. Bain, Michael J. Muehlbauer, M. Geoffrey Hayes, Olga Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, Denise Scholtens, William L. Lowe	32
10	Identification of a small molecule that stimulates human β-cell proliferation and insulin secretion, and protects against cytotoxic stress in rat insulinoma cells 2020 ·PLoS ONE ·Hans E. Hohmeier, Lu Zhang, Brandon L. Taylor, Samuel B. Stephens, Danhong Lu, Peter McNamara, Bryan Laffitte, Christopher B. Newgard	19
11	Effect of Progressive Weight Loss on Lactate Metabolism: A Randomized Controlled Trial 2018 ·Obesity ·Maria Chondronikola, Faidon Magkos, Jun Yoshino, Adewole L. Okunade, Bruce W. Patterson, Michael J. Muehlbauer, Christopher B. Newgard, Samuel Klein	18
12	Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing 2018 ·Nucleic Acids Research ·Jonathan M. Haldeman, Amanda E. Conway, Michelle Arlotto, Dorothy H. Slentz, Deborah M. Muoio, Thomas Becker, Christopher B. Newgard	23
13	John Denis McGarry, PhD: A Remembrance of a Master Metabolic Physiologist 2018 ·Diabetes Care ·Christopher B. Newgard	0
14	Maternal BMI and Glycemia Impact the Fetal Metabolome 2017 ·Diabetes Care ·William L. Lowe, James R. Bain, Michael Nodzenski, Anna C. Reisetter, Michael J. Muehlbauer, Robert D. Stevens, Olga Ilkayeva, Lynn P. Lowe, Boyd E. Metzger, Christopher B. Newgard, Denise Scholtens	83
15	Metabolomics applied to islet nutrient sensing mechanisms 2017 ·Diabetes Obesity and Metabolism ·Mette V. Jensen, Jessica Gooding, Mourad Ferdaoussi, Xiao‐Qing Dai, Brett S. Peterson, Patrick E. MacDonald, Christopher B. Newgard	16
16	Branched-chain amino acid restriction in Zucker-fatty rats improves muscle insulin sensitivity by enhancing efficiency of fatty acid oxidation and acyl-glycine export 2016 ·Molecular Metabolism ·Phillip J. White, Amanda L. Lapworth, Jie An, Liping Wang, Robert W. McGarrah, Robert D. Stevens, Olga Ilkayeva, Tabitha George, Michael J. Muehlbauer, James R. Bain, Jeff K. Trimmer, M. Julia Brosnan, Tim Rolph, Christopher B. Newgard	202
17	Suppression of Oxidative Stress by β-Hydroxybutyrate, an Endogenous Histone Deacetylase Inhibitor breakdown → 2012 ·Science ·Tadahiro Shimazu, Matthew D. Hirschey, John C. Newman, Wenjuan He, Kotaro Shirakawa, Natacha Le Moan, Carrie A. Grueter, (unknown), Laura R. Saunders, Robert Stevens, Christopher B. Newgard, Robert V. Farese, Rafael de Cabo, Scott M. Ulrich, Katerina Akassoglou, Eric Verdin	1329
18	Leptin therapy in insulin-deficient type I diabetes 2010 ·Proceedings of the National Academy of Sciences ·May-Yun Wang, Lijun Chen, Gregory O. Clark, Young Lee, Robert D. Stevens, Olga Ilkayeva, Brett R. Wenner, James R. Bain, Maureen Charron, Christopher B. Newgard, Roger H. Unger	262
19	Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease 2008 ·Science ·Atul R. Chopra, Jean‐François Louet, Pradip Saha, Jie An, Francesco J. DeMayo, Jianming Xu, Brian York, Saul J. Karpen, Milton J. Finegold, David D. Moore, Lawrence Chan, Christopher B. Newgard, Bert W. O’Malley	133
20	Isolation of a Mycoplasma -specific binding peptide from an unbiased phage-displayed peptide library 2005 ·Molecular BioSystems ·(unknown), (unknown), Kausar N. Samli, Jonathan C. Schisler, Christopher B. Newgard, Stephen Albert Johnston, Kathlynn C. Brown	17

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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