Marcia C. Haigis

34.8k total citations · 20 hit papers
128 papers, 24.7k citations indexed

About

Marcia C. Haigis is a scholar working on Molecular Biology, Geriatrics and Gerontology and Cancer Research. According to data from OpenAlex, Marcia C. Haigis has authored 128 papers receiving a total of 24.7k indexed citations (citations by other indexed papers that have themselves been cited), including 77 papers in Molecular Biology, 39 papers in Geriatrics and Gerontology and 37 papers in Cancer Research. Recurrent topics in Marcia C. Haigis's work include Sirtuins and Resveratrol in Medicine (39 papers), Cancer, Hypoxia, and Metabolism (34 papers) and Adipose Tissue and Metabolism (28 papers). Marcia C. Haigis is often cited by papers focused on Sirtuins and Resveratrol in Medicine (39 papers), Cancer, Hypoxia, and Metabolism (34 papers) and Adipose Tissue and Metabolism (28 papers). Marcia C. Haigis collaborates with scholars based in United States, Germany and Japan. Marcia C. Haigis's co-authors include Leonard Guarente, David Sinclair, Jessica B. Spinelli, Lydia W.S. Finley, Elma Zaganjor, Sejal Vyas, Ilaria Elia, Arlene H. Sharpe, Alexandra S. Bause and John M. Asara and has published in prestigious journals such as Nature, Science and Cell.

In The Last Decade

Marcia C. Haigis

123 papers receiving 24.5k citations

Hit Papers

Mammalian Sirtuins: Biological Insights and Disease Relev... 2004 2026 2011 2018 2010 2013 2016 2018 2011 500 1000 1.5k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Mammalian Sirtuins: Biological Insights and Disease Relevance
    2010 1.7k citations Marcia C. Haigis et al. profile →
  2. Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
    2013 1.5k citations Marcia C. Haigis et al. profile →
  3. Mitochondria and Cancer
    2016 1.3k citations Sejal Vyas, Elma Zaganjor et al. profile →
  4. The multifaceted contributions of mitochondria to cellular metabolism
    2018 1.2k citations Marcia C. Haigis et al. profile →
  5. Pancreatic cancers require autophagy for tumor growth
    2011 1.2k citations Alexandra S. Bause, Marcia C. Haigis et al. profile →
  6. Mammalian sirtuins—emerging roles in physiology, aging, and calorie restriction
    2006 1.1k citations Marcia C. Haigis et al. profile →
  7. PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
    2014 1.1k citations Karina N. Gonzalez Herrera, Marcia C. Haigis et al. profile →
  8. Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation
    2007 1.0k citations Marcia C. Haigis et al. profile →
  9. SIRT4 Inhibits Glutamate Dehydrogenase and Opposes the Effects of Calorie Restriction in Pancreatic β Cells
    2006 930 citations Marcia C. Haigis, Kevin M. Haigis et al. profile →
  10. SIRT3 Opposes Reprogramming of Cancer Cell Metabolism through HIF1α Destabilization
    2011 659 citations Lydia W.S. Finley, Jaewon J. Lee et al. Cancer Cell profile →
  11. SIRT5 Deacetylates Carbamoyl Phosphate Synthetase 1 and Regulates the Urea Cycle
    2009 616 citations Marcia C. Haigis et al. profile →
  12. Calorie restriction extends yeast life span by lowering the level of NADH
    2004 528 citations Marcia C. Haigis et al. profile →
  13. Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
    2010 528 citations Lydia W.S. Finley, Marcia C. Haigis et al. profile →
  14. Metabolites and the tumour microenvironment: from cellular mechanisms to systemic metabolism
    2021 434 citations Ilaria Elia, Marcia C. Haigis profile →
  15. Accumulation of succinate controls activation of adipose tissue thermogenesis
    2018 376 citations Marcia C. Haigis, Steven P. Gygi et al. profile →
  16. Lipid metabolism in sickness and in health: Emerging regulators of lipotoxicity
    2021 299 citations Haejin Yoon, Marcia C. Haigis et al. Molecular Cell profile →
  17. Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
    2019 280 citations Abhishek A. Chakraborty, Matti Myllykoski et al. Science profile →
  18. The aging lung: Physiology, disease, and immunity
    2021 260 citations Jared H. Rowe, Arlene H. Sharpe et al. profile →
  19. Tumor cells dictate anti-tumor immune responses by altering pyruvate utilization and succinate signaling in CD8+ T cells
    2022 196 citations Ilaria Elia, Jared H. Rowe et al. Cell Metabolism profile →
  20. Mitochondria: Their relevance during oocyte ageing
    2021 157 citations Marcia C. Haigis et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Marcia C. Haigis United States 65 13.7k 6.6k 5.7k 5.5k 5.3k 128 24.7k
Wei Gu United States 81 24.1k 1.8× 5.7k 0.9× 8.6k 1.5× 4.7k 0.9× 4.0k 0.8× 188 35.2k
Reuben J. Shaw United States 53 20.6k 1.5× 1.3k 0.2× 5.3k 0.9× 7.6k 1.4× 5.1k 1.0× 85 30.3k
John M. Denu United States 78 14.8k 1.1× 7.5k 1.1× 1.2k 0.2× 4.1k 0.7× 4.6k 0.9× 207 23.5k
David Gius United States 65 8.0k 0.6× 3.4k 0.5× 2.6k 0.5× 2.4k 0.4× 2.4k 0.5× 148 13.7k
Riekelt H. Houtkooper Netherlands 60 9.1k 0.7× 3.7k 0.6× 1.3k 0.2× 2.8k 0.5× 4.7k 0.9× 193 16.9k
Joseph A. Baur United States 53 6.8k 0.5× 5.2k 0.8× 1.1k 0.2× 2.4k 0.4× 5.0k 1.0× 116 16.0k
Domenico Accili United States 92 18.8k 1.4× 1.9k 0.3× 1.9k 0.3× 4.7k 0.9× 7.8k 1.5× 271 31.5k
Robert V. Farese United States 96 17.9k 1.3× 1.6k 0.2× 3.6k 0.6× 5.1k 0.9× 8.4k 1.6× 238 34.9k
Wilhelm Haas United States 53 11.0k 0.8× 1.7k 0.3× 1.5k 0.3× 2.0k 0.4× 2.3k 0.4× 101 15.3k
Ronald J. A. Wanders Netherlands 102 32.0k 2.3× 699 0.1× 3.2k 0.6× 3.0k 0.5× 8.2k 1.6× 828 42.4k

Countries citing papers authored by Marcia C. Haigis

Since Specialization
Citations

This map shows the geographic impact of Marcia C. Haigis's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marcia C. Haigis with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marcia C. Haigis more than expected).

Fields of papers citing papers by Marcia C. Haigis

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marcia C. Haigis. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marcia C. Haigis. The network helps show where Marcia C. Haigis may publish in the future.

Co-authorship network of co-authors of Marcia C. Haigis

This figure shows the co-authorship network connecting the top 25 collaborators of Marcia C. Haigis. A scholar is included among the top collaborators of Marcia C. Haigis based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Marcia C. Haigis. Marcia C. Haigis is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Hu, Songhua, et al.. (2025). Integrated analysis of transcriptional and metabolic responses to mitochondrial stress. Cell Reports Methods. 5(4). 101027–101027.
2.
He, Ben, Kyle D. Copps, Oliver Stöhr, et al.. (2025). Spatial regulation of glucose and lipid metabolism by hepatic insulin signaling. Cell Metabolism. 37(7). 1568–1583.e7. 3 indexed citations
3.
Slattery, Karen, Cong-Hui Yao, Joseph M. Crowley, et al.. (2025). Uptake of lipids from ascites drives NK cell metabolic dysfunction in ovarian cancer. Science Immunology. 10(107). eadr4795–eadr4795. 5 indexed citations
4.
Baldominos, Pilar, et al.. (2025). Decoding the spatial dynamics of tumor and immune cell interactions in solid cancers. Cancer Cell. 44(1). 1–5.
5.
Vyas, Sejal, Albert Park, Shakchhi Joshi, et al.. (2024). SIRT4 loss reprograms intestinal nucleotide metabolism to support proliferation following perturbation of homeostasis. Cell Reports. 43(4). 113975–113975. 6 indexed citations
6.
Georgiev, Peter, SeongJun Han, Thao H. Nguyen, et al.. (2024). Age-Associated Contraction of Tumor-Specific T Cells Impairs Antitumor Immunity. Cancer Immunology Research. 12(11). 1525–1541. 5 indexed citations
7.
Kurmi, Kiran, Dan Liang, Peter Georgiev, et al.. (2023). Metabolic modulation of mitochondrial mass during CD4+ T cell activation. Cell chemical biology. 30(9). 1064–1075.e8. 8 indexed citations
8.
Yao, Cong-Hui, Joon Seok Park, Kiran Kurmi, et al.. (2023). Uncoupled glycerol-3-phosphate shuttle in kidney cancer reveals that cytosolic GPD is essential to support lipid synthesis. Molecular Cell. 83(8). 1340–1349.e7. 22 indexed citations
9.
Wanderley, Carlos W., Daniel Michaud, Kiran Kurmi, et al.. (2023). 1111 Targeting lipid metabolism to improve PARP inhibitor response in BRCA-associated TNBC. SHILAP Revista de lepidopterología. A1223–A1223. 1 indexed citations
10.
Georgiev, Peter, Mehdi Benamar, SeongJun Han, et al.. (2023). Regulatory T cells in dominant immunologic tolerance. Journal of Allergy and Clinical Immunology. 153(1). 28–41. 14 indexed citations
11.
Rowe, Jared H., Ilaria Elia, Emily F. Gaudiano, et al.. (2023). Formate Supplementation Enhances Antitumor CD8+ T-cell Fitness and Efficacy of PD-1 Blockade. Cancer Discovery. 13(12). 2566–2583. 26 indexed citations
12.
Ringel, Alison E., William Yuan, João A. Paulo, et al.. (2021). Development of a colorimetric α-ketoglutarate detection assay for prolyl hydroxylase domain (PHD) proteins. Journal of Biological Chemistry. 296. 100397–100397. 15 indexed citations
13.
Kurmi, Kiran & Marcia C. Haigis. (2020). Nitrogen Metabolism in Cancer and Immunity. Trends in Cell Biology. 30(5). 408–424. 100 indexed citations
14.
Drijvers, Jefte M., Jacob E. Gillis, Thao H. Nguyen, et al.. (2020). Pharmacologic Screening Identifies Metabolic Vulnerabilities of CD8+ T Cells. Cancer Immunology Research. 9(2). 184–199. 137 indexed citations
15.
Chakraborty, Abhishek A., Matti Myllykoski, Alison E. Ringel, et al.. (2019). Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate. Science. 363(6432). 1217–1222. 280 indexed citations breakdown →
16.
Lee, Jaewon J., Robert A. H. van de Ven, Elma Zaganjor, et al.. (2018). Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3. Proceedings of the National Academy of Sciences. 115(27). 7057–7062. 61 indexed citations
17.
Malone, Clare F., Rachel Ingraham, William Barbosa, et al.. (2017). mTOR and HDAC Inhibitors Converge on the TXNIP/Thioredoxin Pathway to Cause Catastrophic Oxidative Stress and Regression of RAS-Driven Tumors. Cancer Discovery. 7(12). 1450–1463. 87 indexed citations
18.
Zaganjor, Elma, Sejal Vyas, & Marcia C. Haigis. (2017). SIRT4 Is a Regulator of Insulin Secretion. Cell chemical biology. 24(6). 656–658. 28 indexed citations
19.
Yang, Moon Hee, Gaëlle Laurent, Alexandra S. Bause, et al.. (2013). HDAC6 and SIRT2 Regulate the Acetylation State and Oncogenic Activity of Mutant K-RAS. Molecular Cancer Research. 11(9). 1072–1077. 110 indexed citations
20.
Haigis, Marcia C. & Bruce A. Yankner. (2010). The Aging Stress Response. Molecular Cell. 40(2). 333–344. 396 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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