Clifford B. Saper

75.1k total citations · 27 hit papers
304 papers, 55.5k citations indexed

About

Clifford B. Saper is a scholar working on Endocrine and Autonomic Systems, Cognitive Neuroscience and Cellular and Molecular Neuroscience. According to data from OpenAlex, Clifford B. Saper has authored 304 papers receiving a total of 55.5k indexed citations (citations by other indexed papers that have themselves been cited), including 156 papers in Endocrine and Autonomic Systems, 149 papers in Cognitive Neuroscience and 91 papers in Cellular and Molecular Neuroscience. Recurrent topics in Clifford B. Saper's work include Sleep and Wakefulness Research (119 papers), Neuroscience of respiration and sleep (80 papers) and Circadian rhythm and melatonin (70 papers). Clifford B. Saper is often cited by papers focused on Sleep and Wakefulness Research (119 papers), Neuroscience of respiration and sleep (80 papers) and Circadian rhythm and melatonin (70 papers). Clifford B. Saper collaborates with scholars based in United States, Canada and Japan. Clifford B. Saper's co-authors include Joel K. Elmquist, Thomas E. Scammell, Arthur D. Loewy, Jun Lu, Jun Lu, Patrick M. Fuller, Thomas C. Chou, Joshua J. Gooley, Charlotte E. Lee and Jeffrey S. Flier and has published in prestigious journals such as Nature, Science and New England Journal of Medicine.

In The Last Decade

Clifford B. Saper

302 papers receiving 54.3k citations

Hit Papers

Narcolepsy in orexin Knoc... 1976 2026 1992 2009 1999 2005 2001 1980 1976 500 1000 1.5k 2.0k
What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

  1. Narcolepsy in orexin Knockout Mice
    1999 2.3k citations Christopher M. Sinton, Joel K. Elmquist et al. profile →
  2. Hypothalamic regulation of sleep and circadian rhythms
    2005 1.9k citations Clifford B. Saper, Thomas E. Scammell et al. profile →
  3. Differential expression of orexin receptors 1 and 2 in the rat brain
    2001 1.3k citations Jacob Marcus, Charlotte E. Lee et al. The Journal of Comparative Neurology profile →
  4. Efferent connections of the parabrachial nucleus in the rat
    1980 1.0k citations Clifford B. Saper et al. profile →
  5. Direct hypothalamo-autonomic connections
    1976 995 citations Clifford B. Saper et al. profile →
  6. Sleep State Switching
    2010 938 citations Clifford B. Saper, Patrick M. Fuller et al. profile →
  7. From Lesions to Leptin
    1999 934 citations Joel K. Elmquist, Carol F. Elias et al. profile →
  8. Subnuclear organization of the efferent connections of the parabrachial nucleus in the rat
    1984 894 citations Clifford B. Saper et al. profile →
  9. Distributions of leptin receptor mRNA isoforms in the rat brain
    1998 862 citations Joel K. Elmquist, Rexford S. Ahima et al. The Journal of Comparative Neurology profile →
  10. The Need to Feed
    2002 857 citations Clifford B. Saper, Joel K. Elmquist et al. profile →
  11. Distribution of cholinergic neurons in rat brain: Demonstrated by the immunocytochemical localization of choline acetyltransferase
    1983 844 citations Clifford B. Saper, Allan I. Levey et al. The Journal of Comparative Neurology profile →
  12. Connections of the parabrachial nucleus with the nucleus of the solitary tract and the medullary reticular formation in the rat
    1990 840 citations Clifford B. Saper et al. The Journal of Comparative Neurology profile →
  13. Expression of ghrelin receptor mRNA in the rat and the mouse brain
    2005 835 citations Charlotte E. Lee, Clifford B. Saper et al. The Journal of Comparative Neurology profile →
  14. A putative flip–flop switch for control of REM sleep
    2006 819 citations Clifford B. Saper et al. profile →
  15. Activation of Ventrolateral Preoptic Neurons During Sleep
    1996 753 citations Clifford B. Saper et al. Science profile →
  16. Chemically defined projections linking the mediobasal hypothalamus and the lateral hypothalamic area
    1998 702 citations Carol F. Elias, Clifford B. Saper et al. The Journal of Comparative Neurology profile →
  17. Pathophysiology of REM sleep behaviour disorder and relevance to neurodegenerative disease
    2007 647 citations Clifford B. Saper et al. profile →
  18. Leptin Activates Hypothalamic CART Neurons Projecting to the Spinal Cord
    1998 634 citations Carol F. Elias, Joseph F. Kelly et al. profile →
  19. Cortical projections arising from the basal forebrain: A study of cholinergic and noncholinergic components employing combined retrograde tracing and immunohistochemical localization of choline acetyltransferase
    1984 634 citations Clifford B. Saper et al. Neuroscience profile →
  20. The α2-Adrenoceptor Agonist Dexmedetomidine Converges on an Endogenous Sleep-promoting Pathway to Exert Its Sedative Effects
    2003 619 citations Clifford B. Saper et al. profile →
  21. The Central Autonomic Nervous System: Conscious Visceral Perception and Autonomic Pattern Generation
    2002 602 citations Clifford B. Saper profile →
  22. Evidence for a viscerotopic sensory representation in the cortex and thalamus in the rat
    1987 595 citations Clifford B. Saper et al. The Journal of Comparative Neurology profile →
  23. Organization of cerebral cortical afferent systems in the rat. II. Magnocellular basal nucleus
    1984 593 citations Clifford B. Saper The Journal of Comparative Neurology profile →
  24. Leptin Regulation of Neuroendocrine Systems
    2000 588 citations Rexford S. Ahima, Clifford B. Saper et al. profile →
  25. Innervation of Histaminergic Tuberomammillary Neurons by GABAergic and Galaninergic Neurons in the Ventrolateral Preoptic Nucleus of the Rat
    1998 533 citations Joel K. Elmquist, Clifford B. Saper et al. Journal of Neuroscience profile →
  26. Convergence of autonomic and limbic connections in the insular cortex of the rat
    1982 483 citations Clifford B. Saper The Journal of Comparative Neurology profile →
  27. An autoradiographic study of the efferent connections of the lateral hypothalamic area in the rat
    1979 434 citations Clifford B. Saper et al. The Journal of Comparative Neurology profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name h Career Trend Papers Cites
Clifford B. Saper United States 122 27.6k 25.8k 16.1k 9.1k 9.1k 304 55.5k
Masashi Yanagisawa Japan 116 19.4k 0.7× 16.4k 0.6× 6.5k 0.4× 10.1k 1.1× 27.6k 3.0× 527 64.7k
Gary Aston‐Jones United States 97 8.9k 0.3× 20.6k 0.8× 16.5k 1.0× 5.8k 0.6× 3.3k 0.4× 250 36.4k
Floyd E. Bloom United States 120 7.1k 0.3× 13.5k 0.5× 28.1k 1.7× 3.2k 0.3× 6.8k 0.8× 470 52.5k
Dick F. Swaab Netherlands 102 11.3k 0.4× 7.3k 0.3× 7.3k 0.5× 4.7k 0.5× 6.6k 0.7× 684 39.2k
Joel K. Elmquist United States 105 28.4k 1.0× 9.3k 0.4× 5.3k 0.3× 3.6k 0.4× 13.9k 1.5× 228 43.6k
Eric J. Nestler United States 157 6.6k 0.2× 15.0k 0.6× 47.0k 2.9× 3.3k 0.4× 11.0k 1.2× 667 92.0k
Robert Y. Moore United States 77 13.8k 0.5× 10.0k 0.4× 11.9k 0.7× 2.9k 0.3× 4.0k 0.4× 183 25.5k
Larry W. Swanson United States 107 12.3k 0.4× 13.2k 0.5× 19.4k 1.2× 941 0.1× 4.0k 0.4× 236 48.1k
Miklós Palkovits Hungary 95 12.2k 0.4× 10.9k 0.4× 33.4k 2.1× 841 0.1× 9.6k 1.1× 692 62.5k
Luı́s de Lecea United States 71 12.9k 0.5× 15.3k 0.6× 8.0k 0.5× 7.4k 0.8× 1.8k 0.2× 203 24.4k

Countries citing papers authored by Clifford B. Saper

Since Specialization
Citations

This map shows the geographic impact of Clifford B. Saper's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Clifford B. Saper with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Clifford B. Saper more than expected).

Fields of papers citing papers by Clifford B. Saper

Since Specialization
Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Clifford B. Saper. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Clifford B. Saper. The network helps show where Clifford B. Saper may publish in the future.

Co-authorship network of co-authors of Clifford B. Saper

This figure shows the co-authorship network connecting the top 25 collaborators of Clifford B. Saper. A scholar is included among the top collaborators of Clifford B. Saper based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Clifford B. Saper. Clifford B. Saper is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

20 of 20 papers shown
1.
Kahn, Richard, Harvinder Virk, Carl Laflamme, et al.. (2024). Antibody characterization is critical to enhance reproducibility in biomedical research. eLife. 13. 7 indexed citations
2.
Gompf, Heinrich S., Charles N. Allen, Lauren M. Hablitz, et al.. (2024). GABAergic signalling in the suprachiasmatic nucleus is required for coherent circadian rhythmicity. European Journal of Neuroscience. 60(11). 6652–6667. 1 indexed citations
3.
Luca, Roberto De, Stefano Nardone, Kevin P. Grace, et al.. (2022). Orexin neurons inhibit sleep to promote arousal. Nature Communications. 13(1). 4163–4163. 55 indexed citations
4.
Luca, Roberto De, Stefano Nardone, Kevin P. Grace, et al.. (2022). Orexin neurons inhibit sleep to promote arousal. Zenodo (CERN European Organization for Nuclear Research). 1 indexed citations
5.
Machado, Natalia, William D. Todd, Satvinder Kaur, & Clifford B. Saper. (2022). Median preoptic GABA and glutamate neurons exert differential control over sleep behavior. Current Biology. 32(9). 2011–2021.e3. 14 indexed citations
6.
Lombardi, Fabrizio, Pedro Bernaola‐Galván, Ramalingam Vetrivelan, et al.. (2019). Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake. Journal of Neuroscience. 40(1). 171–190. 34 indexed citations
7.
Gisabella, Barbara, Thomas E. Scammell, Sathyajit S. Bandaru, & Clifford B. Saper. (2019). Regulation of hippocampal dendritic spines following sleep deprivation. The Journal of Comparative Neurology. 528(3). 380–388. 34 indexed citations
8.
Venner, Anne, Takatoshi Mochizuki, Roberto De Luca, et al.. (2019). Reassessing the Role of Histaminergic Tuberomammillary Neurons in Arousal Control. Journal of Neuroscience. 39(45). 8929–8939. 34 indexed citations
9.
Saper, Clifford B. & Satvinder Kaur. (2018). Brain Circuitry for Arousal from Apnea. Cold Spring Harbor Symposia on Quantitative Biology. 83. 63–69. 11 indexed citations
10.
Bruinstroop, Eveline, Georgina Cano, Veronique VanderHorst, et al.. (2011). Spinal projections of the A5, A6 (locus coeruleus), and A7 noradrenergic cell groups in rats. The Journal of Comparative Neurology. 520(9). 1985–2001. 124 indexed citations
11.
Noseda, Rodrigo, Vanessa Kainz, Moshe Jakubowski, et al.. (2010). A neural mechanism for exacerbation of headache by light. Nature Neuroscience. 13(2). 239–245. 397 indexed citations
12.
Fuller, Patrick M., Jun Lü, & Clifford B. Saper. (2008). Differential Rescue of Light- and Food-Entrainable Circadian Rhythms. Science. 320(5879). 1074–1077. 204 indexed citations
13.
Saper, Clifford B.. (2006). Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms. Progress in brain research. 153. 243–252. 125 indexed citations
14.
Kalanithi, Paul, Wei Zheng, Yuko Kataoka, et al.. (2005). Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proceedings of the National Academy of Sciences. 102(37). 13307–13312. 385 indexed citations
15.
Yamamoto, Hiroshi, Charlotte E. Lee, Jacob Marcus, et al.. (2002). Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. Journal of Clinical Investigation. 110(1). 43–52. 388 indexed citations
16.
Yamamoto, Hiroshi, Charlotte E. Lee, Jacob Marcus, et al.. (2002). Glucagon-like peptide-1 receptor stimulation increases blood pressure and heart rate and activates autonomic regulatory neurons. Journal of Clinical Investigation. 110(1). 43–52. 26 indexed citations
17.
Elias, Carol F., Charlotte E. Lee, Joseph F. Kelly, et al.. (2001). Characterization of CART neurons in the rat and human hypothalamus. The Journal of Comparative Neurology. 432(1). 1–19. 340 indexed citations
18.
Holt, Daphne J., M.M. Herman, Thomas M. Hyde, et al.. (1999). Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. Neuroscience. 94(1). 21–31. 111 indexed citations
19.
Elmquist, Joel K., Rexford S. Ahima, Eleftheria Maratos–Flier, Jeffrey S. Flier, & Clifford B. Saper. (1997). Leptin Activates Neurons in Ventrobasal Hypothalamus and Brainstem. Endocrinology. 138(2). 839–842. 357 indexed citations
20.
Elmquist, Joel K., et al.. (1997). Leptin regulates NPY and MCH immunoreactivities in the mouse brain. The Society for Neuroscience Abstracts. 23. 145. 1 indexed citations

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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