Marcy E. MacDonald

38.6k total citations · 7 hit papers
183 papers, 22.2k citations indexed

About

Marcy E. MacDonald is a scholar working on Molecular Biology, Cellular and Molecular Neuroscience and Neurology. According to data from OpenAlex, Marcy E. MacDonald has authored 183 papers receiving a total of 22.2k indexed citations (citations by other indexed papers that have themselves been cited), including 138 papers in Molecular Biology, 134 papers in Cellular and Molecular Neuroscience and 48 papers in Neurology. Recurrent topics in Marcy E. MacDonald's work include Genetic Neurodegenerative Diseases (132 papers), Mitochondrial Function and Pathology (85 papers) and Neurological disorders and treatments (42 papers). Marcy E. MacDonald is often cited by papers focused on Genetic Neurodegenerative Diseases (132 papers), Mitochondrial Function and Pathology (85 papers) and Neurological disorders and treatments (42 papers). Marcy E. MacDonald collaborates with scholars based in United States, United Kingdom and Canada. Marcy E. MacDonald's co-authors include James F. Gusella, Richard H. Myers, Jean‐Paul Vonsattel, Mabel P. Duyao, Peter W. Faber, Francesca Persichetti, Elena Cattaneo, Michael R. Hayden, Chiara Zuccato and John B. Penney and has published in prestigious journals such as Science, Cell and Proceedings of the National Academy of Sciences.

In The Last Decade

Marcy E. MacDonald

182 papers receiving 21.8k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes

1993 6.5k citations Marcy E. MacDonald Cell profile →
Loss of Huntingtin-Mediated BDNF Gene Transcription in Huntington's Disease

2001 1.0k citations Blair R. Leavitt, Marcy E. MacDonald et al. profile →
Huntingtin Controls Neurotrophic Support and Survival of Neurons by Enhancing BDNF Vesicular Transport along Microtubules

2004 891 citations Marcy E. MacDonald et al. Cell profile →
Detection of Huntington's disease decades before diagnosis: the Predict-HD study

2007 605 citations Jane S. Paulsen, Douglas R. Langbehn et al. profile →
Relationship between trinucleotide repeat expansion and phenotypic variation in Huntington's disease

1993 558 citations Marcy E. MacDonald et al. Nature Genetics profile →
CAG repeat number governs the development rate of pathology in Huntington's disease

1997 541 citations Jean‐Paul Vonsattel, Marcy E. MacDonald et al. profile →
Inactivation of the Mouse Huntington's Disease Gene Homolog Hdh

1995 534 citations Mabel P. Duyao, Jean‐Paul Vonsattel et al. profile →

Peers — A (Enhanced Table)

Peers by citation overlap · career bar shows stage (early→late) cites · hero ref

Name	h						Papers	Cites
Marcy E. MacDonald United States	68	16.1k	16.0k	7.1k	1.9k	1.9k	183	22.2k
Gillian P. Bates United Kingdom	80	20.2k 1.3×	21.3k 1.3×	7.7k 1.1×	1.9k 1.0×	2.2k 1.2×	233	28.4k
Henry L. Paulson United States	73	10.1k 0.6×	13.7k 0.9×	4.0k 0.6×	1.9k 1.0×	1.3k 0.7×	223	17.7k
Ole Isacson United States	89	13.4k 0.8×	13.3k 0.8×	7.0k 1.0×	1.9k 1.0×	3.5k 1.8×	295	25.2k
Blair R. Leavitt Canada	70	14.4k 0.9×	13.5k 0.8×	7.5k 1.1×	1.2k 0.6×	1.4k 0.7×	230	20.9k
Marian DiFiglia United States	63	13.2k 0.8×	12.8k 0.8×	5.2k 0.7×	614 0.3×	1.4k 0.7×	156	18.4k
Elena Cattaneo Italy	66	9.8k 0.6×	12.7k 0.8×	3.1k 0.4×	1.4k 0.7×	2.0k 1.1×	218	19.2k
Kenneth H. Fischbeck United States	66	9.4k 0.6×	13.1k 0.8×	4.4k 0.6×	2.1k 1.1×	1.3k 0.7×	207	18.9k
Shoji Tsuji Japan	65	6.7k 0.4×	8.8k 0.6×	6.7k 0.9×	1.4k 0.8×	3.3k 1.7×	507	17.1k
Alexandra Dürr France	71	16.5k 1.0×	11.9k 0.7×	12.3k 1.7×	1.3k 0.7×	2.0k 1.1×	374	23.6k
Michael Sendtner Germany	75	8.2k 0.5×	10.0k 0.6×	2.6k 0.4×	1.3k 0.7×	1.3k 0.7×	225	20.1k

Countries citing papers authored by Marcy E. MacDonald

Since Specialization

Citations

This map shows the geographic impact of Marcy E. MacDonald's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Marcy E. MacDonald with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Marcy E. MacDonald more than expected).

Fields of papers citing papers by Marcy E. MacDonald

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Marcy E. MacDonald. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Marcy E. MacDonald. The network helps show where Marcy E. MacDonald may publish in the future.

Co-authorship network of co-authors of Marcy E. MacDonald

This figure shows the co-authorship network connecting the top 25 collaborators of Marcy E. MacDonald. A scholar is included among the top collaborators of Marcy E. MacDonald based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Marcy E. MacDonald. Marcy E. MacDonald is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

Sort: Min cites: Since: Top N: Style:

20 of 20 papers shown

Hong, Eun Pyo, Marcy E. MacDonald, Vanessa C. Wheeler, et al.. (2021). Huntington’s Disease Pathogenesis: Two Sequential Components. Journal of Huntington s Disease. 10(1). 35–51. 54 indexed citations

Oh, Hyejin, Seung Kwak, Susan L. Cotman, et al.. (2018). Novel DNA Aptamers that Bind to Mutant Huntingtin and Modify Its Activity. Molecular Therapy — Nucleic Acids. 11. 416–428. 13 indexed citations

Kovalenko, Marina, Austen J. Milnerwood, Jason St. Claire, et al.. (2018). HttQ111/+ Huntington’s Disease Knock-in Mice Exhibit Brain Region-Specific Morphological Changes and Synaptic Dysfunction. Journal of Huntington s Disease. 7(1). 17–33. 25 indexed citations

Lee, Jong‐Min, Kyung‐Hee Kim, Aram Shin, et al.. (2015). Sequence-Level Analysis of the Major European Huntington Disease Haplotype. The American Journal of Human Genetics. 97(3). 435–444. 17 indexed citations

Carroll, Jeffrey B., Amy Deik, Elisa Fossale, et al.. (2015). HdhQ111 Mice Exhibit Tissue Specific Metabolite Profiles that Include Striatal Lipid Accumulation. PLoS ONE. 10(8). e0134465–e0134465. 16 indexed citations

Staropoli, John F., Amel Karaa, Elaine T. Lim, et al.. (2012). A Homozygous Mutation in KCTD7 Links Neuronal Ceroid Lipofuscinosis to the Ubiquitin-Proteasome System. The American Journal of Human Genetics. 91(1). 202–208. 84 indexed citations

Jacobsen, Jessie C., Gillian Gregory, Juliana Woda, et al.. (2011). HD CAG-correlated gene expression changes support a simple dominant gain of function. Human Molecular Genetics. 20(14). 2846–2860. 57 indexed citations

Cao, Yi, John F. Staropoli, Janice A. Espinola, et al.. (2011). Distinct Early Molecular Responses to Mutations Causing vLINCL and JNCL Presage ATP Synthase Subunit C Accumulation in Cerebellar Cells. PLoS ONE. 6(2). e17118–e17118. 49 indexed citations

Gusella, James F. & Marcy E. MacDonald. (2009). Huntington's disease: the case for genetic modifiers. Genome Medicine. 1(8). 80–80. 88 indexed citations

10.

Gusella, James F., Marcy E. MacDonald, Karen Duff, et al.. (2007). Psychiatric Symptoms in Huntington's Disease before Diagnosis : The Predict-HD Study. Commentary. Biological Psychiatry. 62(12). 3 indexed citations

11.

Chen‐Plotkin, Alice, Ghazaleh Sadri‐Vakili, George J. Yohrling, et al.. (2006). Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease. Neurobiology of Disease. 22(2). 233–241. 90 indexed citations

12.

Zhang, Yu, Blair R. Leavitt, Jeremy M. Van Raamsdonk, et al.. (2006). Huntingtin inhibits caspase‐3 activation. The EMBO Journal. 25(24). 5896–5906. 78 indexed citations

13.

Altmann, Stephen M., Elisa Fossale, Michele M. Maxwell, et al.. (2006). Discovery of Bioactive Small-Molecule Inhibitor of Poly ADP-Ribose Polymerase: Implications for Energy-Deficient Cells. Chemistry & Biology. 13(7). 765–770. 8 indexed citations

14.

Pontikis, Charlie C., et al.. (2005). The mild neurodegenerative phenotype of CLN3(Delta ex7/8) knock-in mice is accompanied by prominent astrocytosis at the advanced stages of murine JNCL. Neuropathology and Applied Neurobiology. 31(2). 228–228. 1 indexed citations

15.

Seong, Ihn Sik, Elena V. Ivanova, Jong‐Min Lee, et al.. (2005). HD CAG repeat implicates a dominant property of huntingtin in mitochondrial energy metabolism. Human Molecular Genetics. 14(19). 2871–2880. 235 indexed citations

16.

Gao, Hanlin, Rose-Mary N. Boustany, Janice A. Espinola, et al.. (2002). Mutations in a Novel CLN6-Encoded Transmembrane Protein Cause Variant Neuronal Ceroid Lipofuscinosis in Man and Mouse. The American Journal of Human Genetics. 70(2). 324–335. 167 indexed citations

17.

MacDonald, Marcy E., Jean Paul Vonsattel, L. Adrienne Cupples, et al.. (1999). Evidence for the GluR6 gene associated with younger onset age of Huntington’s disease. Neurology. 53(6). 1330–1330. 98 indexed citations

18.

Jänne, Pasi A., Sharon F. Suchy, David J. Bernard, et al.. (1998). Functional overlap between murine Inpp5b and Ocrl1 may explain why deficiency of the murine ortholog for OCRL1 does not cause Lowe syndrome in mice.. Journal of Clinical Investigation. 101(10). 2042–2053. 140 indexed citations

19.

White, Jacqueline K., Wojtek Auerbach, Mabel P. Duyao, et al.. (1997). Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion. Nature Genetics. 17(4). 404–410. 398 indexed citations

20.

MacDonald, Marcy E.. (1993). A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell. 72(6). 971–983. 6516 indexed citations breakdown →

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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