Matthew P. Jacobson

28.8k citations

200 papers · 17.2k indexed · 5 hit papers · h-index 63

Molecular Biology top 0.2%
Computational Theory and Mathematics top 0.1%
Materials Chemistry top 2%
Organic Chemistry top 0.5%
Oncology top 2%

Co-authors: Richard A. Friesner Diane L. Barber Tyler Day Barry Honig Bradley A. Webb Michael S. Chimenti Chaya S. Rapp Woody Sherman
Topics: Protein Structure and Dynamics (58 papers)Enzyme Structure and Function (38 papers)Computational Drug Discovery Methods (27 papers)
Cited by: Molecular Biology Computational Theory and Mathematics Spectroscopy
Journals: Nature Proceedings of the National Academy of Sciences Journal of the American Chemical Society
Partner nations: United States China United Kingdom

In The Last Decade

Matthew P. Jacobson

197 papers receiving 17.0k citations

Hit Papers

5 papers align trajectories

What are hit papers?

Hit papers significantly outperform the citation benchmark for their cohort. A paper qualifies if it has ≥500 total citations, achieves ≥1.5× the top-1% citation threshold for papers in the same subfield and year (this is the minimum needed to enter the top 1%, not the average within it), or reaches the top citation threshold in at least one of its specific research topics.

A hierarchical approach to all‐atom protein loop prediction

2004 1.9k citations Matthew P. Jacobson et al. profile →
Dysregulated pH: a perfect storm for cancer progression

2011 1.8k citations Matthew P. Jacobson, Diane L. Barber et al. profile →
Novel Procedure for Modeling Ligand/Receptor Induced Fit Effects

2005 1.6k citations Matthew P. Jacobson et al. Journal of Medicinal Chemistry profile →
On the Role of the Crystal Environment in Determining Protein Side-chain Conformations

2002 989 citations Matthew P. Jacobson et al. profile →
Gasdermin D pore structure reveals preferential release of mature interleukin-1

2021 423 citations Shiyu Xia, Zhibin Zhang et al. Nature profile →

Peers

Countries citing papers authored by Matthew P. Jacobson

Since Specialization

Citations

This map shows the geographic impact of Matthew P. Jacobson's research. It shows the number of citations coming from papers published by authors working in each country. You can also color the map by specialization and compare the number of citations received by Matthew P. Jacobson with the expected number of citations based on a country's size and research output (numbers larger than one mean the country cites Matthew P. Jacobson more than expected).

Fields of papers citing papers by Matthew P. Jacobson

Since Specialization

Physical SciencesHealth SciencesLife SciencesSocial Sciences

This network shows the impact of papers produced by Matthew P. Jacobson. Nodes represent research fields, and links connect fields that are likely to share authors. Colored nodes show fields that tend to cite the papers produced by Matthew P. Jacobson. The network helps show where Matthew P. Jacobson may publish in the future.

Co-authorship network of co-authors of Matthew P. Jacobson

This figure shows the co-authorship network connecting the top 25 collaborators of Matthew P. Jacobson. A scholar is included among the top collaborators of Matthew P. Jacobson based on the total number of citations received by their joint publications. Widths of edges represent the number of papers authors have co-authored together. Node borders signify the number of papers an author published with Matthew P. Jacobson. Matthew P. Jacobson is excluded from the visualization to improve readability, since they are connected to all nodes in the network.

All Works

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20 of 20 papers shown

#	Work	Indexed citations
1	A role for pH dynamics regulating transcription factor DNA-binding selectivity 2025 ·Nucleic Acids Research ·(unknown),Diego Garrido Ruiz,Matthew P. Jacobson,(unknown)	1
2	BCR::ABL1 kinase N-lobe mutants confer moderate to high degrees of resistance to asciminib 2024 ·Blood ·(unknown),Diego Garrido Ruiz,RosaAnna DeFilippis,(unknown),Delphine Réa,(unknown),(unknown),Feifei Hu,(unknown),Yibing Shan,Oliver Hantschel,Matthew P. Jacobson,Neil P. Shah	15
3	Searching for molecular hypoxia sensors among oxygen-dependent enzymes 2023 ·eLife ·(unknown),Susan Q. Shen,Philip E. Bickler,Matthew P. Jacobson,Lani F. Wu,Steven J. Altschuler	28
4	In Vitro Biosynthetic Pathway Investigations of Neuroprotectin D1 (NPD1) and Protectin DX (PDX) by Human 12-Lipoxygenase, 15-Lipoxygenase-1, and 15-Lipoxygenase-2 2021 ·Biochemistry ·Wan‐Chen Tsai,Chakrapani Kalyanaraman,Adriana Yamaguchi,Michael Holinstat,Matthew P. Jacobson,Theodore R. Holman	19
5	Analogs of the Dopamine Metabolite 5,6-Dihydroxyindole Bind Directly to and Activate the Nuclear Receptor Nurr1 2021 ·ACS Chemical Biology ·(unknown),(unknown),Wilian A. Cortopassi,Yoshie Iizuka,(unknown),Matthew P. Jacobson,Pamela M. England	16
6	Protomer alignment modulates specificity of RNA substrate recognition by Ire1 2021 ·eLife ·Weihan Li,(unknown),Diego Garrido Ruiz,Mark Voorhies,Carlos Rondón,Anita Sil,R. Dyche Mullins,Matthew P. Jacobson,Jirka Peschek,Peter Walter	8
7	Gasdermin D pore structure reveals preferential release of mature interleukin-1breakdown → 2021 ·Nature ·Shiyu Xia,Zhibin Zhang,Venkat Giri Magupalli,Juan Lorenzo Pablo,Ying Dong,Setu M. Vora,Longfei Wang,Tian‐Min Fu,Matthew P. Jacobson,Anna Greka,Judy Lieberman,Jianbin Ruan,Hao Wu	423
8	A Crowding Barrier to Protein Inhibition in Colloidal Aggregates 2021 ·Journal of Medicinal Chemistry ·Parnian Lak,Henry O’Donnell,Xuewen Du,Matthew P. Jacobson,Brian K. Shoichet	5
9	Role of Human 15-Lipoxygenase-2 in the Biosynthesis of the Lipoxin Intermediate, 5S,15S-diHpETE, Implicated with the Altered Positional Specificity of Human 15-Lipoxygenase-1 2020 ·Biochemistry ·Steve Perry,Thomas Horn,Benjamin E. Tourdot,Adriana Yamaguchi,Chakrapani Kalyanaraman,(unknown),(unknown),Michael Holinstat,Matthew P. Jacobson,Theodore R. Holman	14
10	Biosynthesis of the Maresin Intermediate, 13S,14S-Epoxy-DHA, by Human 15-Lipoxygenase and 12-Lipoxygenase and Its Regulation through Negative Allosteric Modulators 2020 ·Biochemistry ·Cody J. Freedman,(unknown),Benjamin E. Tourdot,Chakrapani Kalyanaraman,Steve Perry,Michael Holinstat,Matthew P. Jacobson,Theodore R. Holman	28
11	ATP-Competitive Inhibitors Midostaurin and Avapritinib Have Distinct Resistance Profiles in Exon 17–Mutant KIT 2019 ·Cancer Research ·(unknown),Wilian A. Cortopassi,Diego Garrido Ruiz,(unknown),Kibeom Jang,(unknown),Na Zhang,Rosaura Esteve‐Puig,Matthew P. Jacobson,Neil P. Shah	26
12	Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro 2019 ·Biochemistry ·Victoria Butler,Wilian A. Cortopassi,(unknown),Austin L. Wang,(unknown),Matthew P. Jacobson,Aimee W. Kao	27
13	Tau repeat regions contain conserved histidine residues that modulate microtubule-binding in response to changes in pH 2019 ·Journal of Biological Chemistry ·Rabab A. Charafeddine,Wilian A. Cortopassi,Parnian Lak,Ruensern Tan,Richard J. McKenney,Matthew P. Jacobson,Diane L. Barber,Torsten Wittmann	15
14	Prediction of enzymatic pathways by integrative pathway mapping 2018 ·eLife ·Sara Calhoun,Magdalena Korczynska,(unknown),Brian San Francisco,Suwen Zhao,Dmitry A. Rodionov,M.W. Vetting,Nawar Al-Obaidi,Henry J. Lin,Matthew J. O’Meara,David A. Scott,John H. Morris,Daniel Russel,Steven C. Almo,Andrei L. Osterman,J.A. Gerlt,Matthew P. Jacobson,Brian K. Shoichet,Andrej Săli	30
15	Inhibitor binding mode and allosteric regulation of Na+-glucose symporters 2018 ·Nature Communications ·Paola Bisignano,Chiara E. Ghezzi,Hyunil Jo,Nicholas F. Polizzi,Thorsten Althoff,Chakrapani Kalyanaraman,Rosmarie Friemann,Matthew P. Jacobson,Ernest M. Wright,Michael Grabe	39
16	Probing the Electrostatic and Steric Requirements for Substrate Binding in Human Platelet-Type 12-Lipoxygenase 2018 ·Biochemistry ·Ansari M. Aleem,Wan‐Chen Tsai,(unknown),(unknown),Joshua D. Deschamps,Chakrapani Kalyanaraman,Matthew P. Jacobson,Theodore R. Holman	16
17	Cancer-associated arginine-to-histidine mutations confer a gain in pH sensing to mutant proteins 2017 ·Science Signaling ·Katharine A. White,Diego Garrido Ruiz,Zachary A. Szpiech,Nicolas Strauli,Ryan D. Hernandez,Matthew P. Jacobson,Diane L. Barber	55
18	Development of 5N-Bicalutamide, a High-Affinity Reversible Covalent Antiandrogen 2017 ·ACS Chemical Biology ·Felipe de Jesus Cortez,Phuong Nguyen,Charles Truillet,Boxue Tian,Kristopher Kuchenbecker,Michael J. Evans,(unknown),Matthew P. Jacobson,Robert J. Fletterick,Pamela M. England	11
19	Chemical–biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target 2013 ·Beilstein Journal of Organic Chemistry ·(unknown),Clifford Bryant,Cláudia M. Calvet,Patricia S. Doyle,Shamila S. Gunatilleke,Siegfried S. F. Leung,Kenny K. H. Ang,Steven Chen,Jiří Gut,Juan A. Osés-Prieto,Jonathan B. Johnston,Michelle R. Arkin,Alma L. Burlingame,Jack Taunton,Matthew P. Jacobson,(unknown),Larissa M. Podust,Adam R. Renslo	31
20	Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily 2012 ·Proceedings of the National Academy of Sciences ·Tiit Lukk,A. Sakai,Chakrapani Kalyanaraman,Shoshana Brown,H.J. Imker,Ling Song,А.А. Федоров,E.V. Fedorov,R. Toro,B. Hillerich,R.D. Seidel,Y. Patskovsky,M.W. Vetting,Satish K. Nair,Patricia C. Babbitt,Steven C. Almo,J.A. Gerlt,Matthew P. Jacobson	45

About Matthew P. Jacobson

Matthew P. Jacobson is a scholar working on Molecular Biology, Spectroscopy and Computational Theory and Mathematics, having authored 200 papers that have together received 17.2k indexed citations. Recurring topics across this work include Protein Structure and Dynamics (58 papers), Enzyme Structure and Function (38 papers) and Computational Drug Discovery Methods (27 papers). The work is most often cited by research in Molecular Biology (11.4k citations), Computational Theory and Mathematics (2.6k citations) and Spectroscopy (1.4k citations). Matthew P. Jacobson has collaborated with scholars based in United States, China and United Kingdom. Frequent co-authors include Richard A. Friesner, Diane L. Barber, Tyler Day, Barry Honig, Bradley A. Webb, Michael S. Chimenti, Chaya S. Rapp, Woody Sherman, Ramy Farid and David L. Pincus. Their work appears in journals such as Nature, Proceedings of the National Academy of Sciences and Journal of the American Chemical Society.

Rankless uses publication and citation data sourced from OpenAlex, an open and comprehensive bibliographic database. While OpenAlex provides broad and valuable coverage of the global research landscape, it—like all bibliographic datasets—has inherent limitations. These include incomplete records, variations in author disambiguation, differences in journal indexing, and delays in data updates. As a result, some metrics and network relationships displayed in Rankless may not fully capture the entirety of a scholar's output or impact.

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